Smoothness for Simultaneous Composition of Mechanisms with Admission

We study social welfare of learning outcomes in mechanisms with admission. In our repeated game there are $n$ bidders and $m$ mechanisms, and in each round each mechanism is available for each bidder only with a certain probability. Our scenario is an elementary case of simple mechanism design with incomplete information, where availabilities are bidder types. It captures natural applications in online markets with limited supply and can be used to model access of unreliable channels in wireless networks. If mechanisms satisfy a smoothness guarantee, existing results show that learning outcomes recover a significant fraction of the optimal social welfare. These approaches, however, have serious drawbacks in terms of plausibility and computational complexity. Also, the guarantees apply only when availabilities are stochastically independent among bidders. In contrast, we propose an alternative approach where each bidder uses a single no-regret learning algorithm and applies it in all rounds. This results in what we call availability-oblivious coarse correlated equilibria. It exponentially decreases the learning burden, simplifies implementation (e.g., as a method for channel access in wireless devices), and thereby addresses some of the concerns about Bayes-Nash equilibria and learning outcomes in Bayesian settings. Our main results are general composition theorems for smooth mechanisms when valuation functions of bidders are lattice-submodular. They rely on an interesting connection to the notion of correlation gap of submodular functions over product lattices.Comment: Full version of WINE 2016 pape

Incentives in dynamic markets

In this thesis, we consider a variety of combinatorial optimization problems within a common theme of uncertainty and selfish behavior. In our first scenario, the input is collected from selfish players. Here, we study extensions of the so-called smoothness framework for mechanisms, a very useful technique for bounding the inefficiency of equilibria, to the cases of varying mechanism availability and participation of risk-averse players. In both of these cases, our main results are general theorems for the class of (lambda,mu)-smooth mechanisms. We show that these mechanisms guarantee at most a (small) constant factor performance loss in the extended settings. In our second scenario, we do not have access to the exact numerical input. Within this context, we explore combinatorial extensions of the well-known secretary problem under the assumption that the incoming elements only reveal their ordinal position within the set of previously arrived elements. We first observe that many existing algorithms for special matroid structures maintain their competitive ratio in the ordinal model. In contrast, we provide a lower bound for algorithms that are oblivious to the matroid structure. Finally, we design new algorithms that obtain constant competitive ratios for a variety of combinatorial problems

Descending Price Optimally Coordinates Search

Investigating potential purchases is often a substantial investment under uncertainty. Standard market designs, such as simultaneous or English auctions, compound this with uncertainty about the price a bidder will have to pay in order to win. As a result they tend to confuse the process of search both by leading to wasteful information acquisition on goods that have already found a good purchaser and by discouraging needed investigations of objects, potentially eliminating all gains from trade. In contrast, we show that the Dutch auction preserves all of its properties from a standard setting without information costs because it guarantees, at the time of information acquisition, a price at which the good can be purchased. Calibrations to start-up acquisition and timber auctions suggest that in practice the social losses through poor search coordination in standard formats are an order of magnitude or two larger than the (negligible) inefficiencies arising from ex-ante bidder asymmetries.Comment: JEL Classification: D44, D47, D82, D83. 117 pages, of which 74 are appendi

Upper limb movement control after stroke and in healthy ageing: does intensive upper limb neurorehabilitation improve motor control and reduce motor impairment in the chronic phase of stroke?

Stroke affects people of all ages, but many are in the elderly population. 75% of stroke survivors have residual upper limb motor impairment and resultant disability. This thesis firstly examines upper limb motor control in chronic stroke. Evidence is emerging that high dose, high intensity complex neurorehabilitation interventions in chronic stroke patients produce unprecedented gains on clinical outcome scores of motor impairment, function and activity. But whether these clinical improvements represent behavioural repair or merely behavioural compensation remains undetermined. To address this question, upper limb movement kinematics, strength and joint range and clinical scores were measured in 52 chronic stroke patients before and after an intensive three-week treatment intervention. 29 chronic stroke patients who had not undergone treatment were similarly assessed, three-weeks apart. Significant improvements in motor control, arm strength and joint range in addition to gains on clinical scores were observed in the impaired arm of the intervention group. Crucially, changes in motor control occurred independently of changes in strength and joint range. Improvements in motor control were retained in a cohort of 28 patients in the intervention group, also assessed 6-weeks and 6-months after treatment had ended, demonstrating persistent changes in motor behaviour. These results suggest that behavioural restitution has occurred. Secondly, knowledge of the effects of normal healthy ageing on upper limb motor control is essential to informing research and delivery of clinical services. To this end, movement kinematics were measured in both arms of 57 healthy adults aged 22 to 82 years. A decline in motor control was observed as age increased, particularly in the non-dominant arm. However, motor control in healthy adults of all ages remained significantly better than in chronic stroke patients pre- and post-intervention. This thesis provides new evidence that treatment-driven improvements in motor control are achievable in the chronic post-stroke upper limb, which strongly suggests that motor control should remain a therapeutic target well beyond the current three to six-month post-stroke window. It will inform the continued development and delivery of high dose, high intensity upper limb neurorehabilitation treatment interventions for stroke patients of all ages

A spatial analysis of air pollution and environmental inequality in Beijing, 2000–2010

Whilst air pollution is a major problem in China, little is known about how it is distributed socially and how such distributions are changing over time. We use a fine-grained population census and air quality data for 2000 and 2010 to explore socio-spatial and temporal inequalities in air pollution for Beijing, using distributional analyses and spatial regression models. We find that environmental inequalities exist with respect to measures of social disadvantage, such as hukou migrant status, very young children (0–4 years), and the elderly (≥65 years). Our temporal analysis reveals that environmental inequality increases for migrants and the elderly, who bear a disproportionate and increasing share of declining air quality from 2000 to 2010. Regression results emphasise the spatial and temporal variations in environmental inequality, as the associations between air pollution and social demographics differ between different urban zones of Beijing; and their geographic patterns change significantly over time

Quantifying cognitive and mortality outcomes in older patients following acute illness using epidemiological and machine learning approaches

Introduction: Cognitive and functional decompensation during acute illness in older people are poorly understood. It remains unclear how delirium, an acute confusional state reflective of cognitive decompensation, is contextualised by baseline premorbid cognition and relates to long-term adverse outcomes. High-dimensional machine learning offers a novel, feasible and enticing approach for stratifying acute illness in older people, improving treatment consistency while optimising future research design. Methods: Longitudinal associations were analysed from the Delirium and Population Health Informatics Cohort (DELPHIC) study, a prospective cohort ≥70 years resident in Camden, with cognitive and functional ascertainment at baseline and 2-year follow-up, and daily assessments during incident hospitalisation. Second, using routine clinical data from UCLH, I constructed an extreme gradient-boosted trees predicting 600-day mortality for unselected acute admissions of oldest-old patients with mechanistic inferences. Third, hierarchical agglomerative clustering was performed to demonstrate structure within DELPHIC participants, with predictive implications for survival and length of stay. Results: i. Delirium is associated with increased rates of cognitive decline and mortality risk, in a dose-dependent manner, with an interaction between baseline cognition and delirium exposure. Those with highest delirium exposure but also best premorbid cognition have the “most to lose”. ii. High-dimensional multimodal machine learning models can predict mortality in oldest-old populations with 0.874 accuracy. The anterior cingulate and angular gyri, and extracranial soft tissue, are the highest contributory intracranial and extracranial features respectively. iii. Clinically useful acute illness subtypes in older people can be described using longitudinal clinical, functional, and biochemical features. Conclusions: Interactions between baseline cognition and delirium exposure during acute illness in older patients result in divergent long-term adverse outcomes. Supervised machine learning can robustly predict mortality in in oldest-old patients, producing a valuable prognostication tool using routinely collected data, ready for clinical deployment. Preliminary findings suggest possible discernible subtypes within acute illness in older people

DO "CAPITALIZATION EFFECTS" FOR PUBLIC GOODS REVEAL THE PUBLIC'S WILLINGNESS TO PAY?

abstract: This article develops a welfare theoretic framework for interpreting evidence on the impacts of public programs on housing markets. We extend Rosen's hedonic model to explain how housing prices capitalize exogenous shocks to public goods and externalities. The model predicts that trading between heterogeneous buyers and sellers will drive a wedge between these “capitalization effects” and welfare changes. We test this hypothesis in the context of changes in measures of school quality in five metropolitan areas. Results from boundary discontinuity designs suggest that capitalization effects understate parents’ willingness to pay for public school improvements by as much as 75%.This is the peer reviewed version of the article, which has been published in final form at http://dx.doi.org/10.1111/iere.1208

On Age-of-Information Aware Resource Allocation for Industrial Control-Communication-Codesign

Unter dem Überbegriff Industrie 4.0 wird in der industriellen Fertigung die zunehmende Digitalisierung und Vernetzung von industriellen Maschinen und Prozessen zusammengefasst. Die drahtlose, hoch-zuverlässige, niedrig-latente Kommunikation (engl. ultra-reliable low-latency communication, URLLC) – als Bestandteil von 5G gewährleistet höchste Dienstgüten, die mit industriellen drahtgebundenen Technologien vergleichbar sind und wird deshalb als Wegbereiter von Industrie 4.0 gesehen. Entgegen diesem Trend haben eine Reihe von Arbeiten im Forschungsbereich der vernetzten Regelungssysteme (engl. networked control systems, NCS) gezeigt, dass die hohen Dienstgüten von URLLC nicht notwendigerweise erforderlich sind, um eine hohe Regelgüte zu erzielen. Das Co-Design von Kommunikation und Regelung ermöglicht eine gemeinsame Optimierung von Regelgüte und Netzwerkparametern durch die Aufweichung der Grenze zwischen Netzwerk- und Applikationsschicht. Durch diese Verschränkung wird jedoch eine fundamentale (gemeinsame) Neuentwicklung von Regelungssystemen und Kommunikationsnetzen nötig, was ein Hindernis für die Verbreitung dieses Ansatzes darstellt. Stattdessen bedient sich diese Dissertation einem Co-Design-Ansatz, der beide Domänen weiterhin eindeutig voneinander abgrenzt, aber das Informationsalter (engl. age of information, AoI) als bedeutenden Schnittstellenparameter ausnutzt. Diese Dissertation trägt dazu bei, die Echtzeitanwendungszuverlässigkeit als Folge der Überschreitung eines vorgegebenen Informationsalterschwellenwerts zu quantifizieren und fokussiert sich dabei auf den Paketverlust als Ursache. Anhand der Beispielanwendung eines fahrerlosen Transportsystems wird gezeigt, dass die zeitlich negative Korrelation von Paketfehlern, die in heutigen Systemen keine Rolle spielt, für Echtzeitanwendungen äußerst vorteilhaft ist. Mit der Annahme von schnellem Schwund als dominanter Fehlerursache auf der Luftschnittstelle werden durch zeitdiskrete Markovmodelle, die für die zwei Netzwerkarchitekturen Single-Hop und Dual-Hop präsentiert werden, Kommunikationsfehlerfolgen auf einen Applikationsfehler abgebildet. Diese Modellierung ermöglicht die analytische Ableitung von anwendungsbezogenen Zuverlässigkeitsmetriken wie die durschnittliche Dauer bis zu einem Fehler (engl. mean time to failure). Für Single-Hop-Netze wird das neuartige Ressourcenallokationsschema State-Aware Resource Allocation (SARA) entwickelt, das auf dem Informationsalter beruht und die Anwendungszuverlässigkeit im Vergleich zu statischer Multi-Konnektivität um Größenordnungen erhöht, während der Ressourcenverbrauch im Bereich von konventioneller Einzelkonnektivität bleibt. Diese Zuverlässigkeit kann auch innerhalb eines Systems von Regelanwendungen, in welchem mehrere Agenten um eine begrenzte Anzahl Ressourcen konkurrieren, statistisch garantiert werden, wenn die Anzahl der verfügbaren Ressourcen pro Agent um ca. 10 % erhöht werden. Für das Dual-Hop Szenario wird darüberhinaus ein Optimierungsverfahren vorgestellt, das eine benutzerdefinierte Kostenfunktion minimiert, die niedrige Anwendungszuverlässigkeit, hohes Informationsalter und hohen durchschnittlichen Ressourcenverbrauch bestraft und so das benutzerdefinierte optimale SARA-Schema ableitet. Diese Optimierung kann offline durchgeführt und als Look-Up-Table in der unteren Medienzugriffsschicht zukünftiger industrieller Drahtlosnetze implementiert werden.:1. Introduction 1 1.1. The Need for an Industrial Solution . . . . . . . . . . . . . . . . . . . 3 1.2. Contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. Related Work 7 2.1. Communications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2. Control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3. Codesign . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.3.1. The Need for Abstraction – Age of Information . . . . . . . . 11 2.4. Dependability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2.5. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 3. Deriving Proper Communications Requirements 17 3.1. Fundamentals of Control Theory . . . . . . . . . . . . . . . . . . . . 18 3.1.1. Sampling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 3.1.2. Performance Requirements . . . . . . . . . . . . . . . . . . . 21 3.1.3. Packet Losses and Delay . . . . . . . . . . . . . . . . . . . . . 22 3.2. Joint Design of Control Loop with Packet Losses . . . . . . . . . . . . 23 3.2.1. Method 1: Reduced Sampling . . . . . . . . . . . . . . . . . . 23 3.2.2. Method 2: Markov Jump Linear System . . . . . . . . . . . . . 25 3.2.3. Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3.3. Focus Application: The AGV Use Case . . . . . . . . . . . . . . . . . . 31 3.3.1. Control Loop Model . . . . . . . . . . . . . . . . . . . . . . . 31 3.3.2. Control Performance Requirements . . . . . . . . . . . . . . . 33 3.3.3. Joint Modeling: Applying Reduced Sampling . . . . . . . . . . 34 3.3.4. Joint Modeling: Applying MJLS . . . . . . . . . . . . . . . . . 34 3.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 4. Modeling Control-Communication Failures 43 4.1. Communication Assumptions . . . . . . . . . . . . . . . . . . . . . . 43 4.1.1. Small-Scale Fading as a Cause of Failure . . . . . . . . . . . . 44 4.1.2. Connectivity Models . . . . . . . . . . . . . . . . . . . . . . . 46 4.2. Failure Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 4.2.1. Single-hop network . . . . . . . . . . . . . . . . . . . . . . . . 49 4.2.2. Dual-hop network . . . . . . . . . . . . . . . . . . . . . . . . 51 4.3. Performance Metrics . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 4.3.1. Mean Time to Failure . . . . . . . . . . . . . . . . . . . . . . . 54 4.3.2. Packet Loss Ratio . . . . . . . . . . . . . . . . . . . . . . . . . 55 4.3.3. Average Number of Assigned Channels . . . . . . . . . . . . . 57 4.3.4. Age of Information . . . . . . . . . . . . . . . . . . . . . . . . 57 4.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 5. Single Hop – Single Agent 61 5.1. State-Aware Resource Allocation . . . . . . . . . . . . . . . . . . . . 61 5.2. Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 5.3. Erroneous Acknowledgments . . . . . . . . . . . . . . . . . . . . . . 67 5.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 6. Single Hop – Multiple Agents 71 6.1. Failure Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 6.1.1. Admission Control . . . . . . . . . . . . . . . . . . . . . . . . 72 6.1.2. Transition Probabilities . . . . . . . . . . . . . . . . . . . . . . 73 6.1.3. Computational Complexity . . . . . . . . . . . . . . . . . . . 74 6.1.4. Performance Metrics . . . . . . . . . . . . . . . . . . . . . . . 75 6.2. Illustration Scenario . . . . . . . . . . . . . . . . . . . . . . . . . . . 76 6.3. Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 6.3.1. Verification through System-Level Simulation . . . . . . . . . 78 6.3.2. Applicability on the System Level . . . . . . . . . . . . . . . . 79 6.3.3. Comparison of Admission Control Schemes . . . . . . . . . . 80 6.3.4. Impact of the Packet Loss Tolerance . . . . . . . . . . . . . . . 82 6.3.5. Impact of the Number of Agents . . . . . . . . . . . . . . . . . 84 6.3.6. Age of Information . . . . . . . . . . . . . . . . . . . . . . . . 84 6.3.7. Channel Saturation Ratio . . . . . . . . . . . . . . . . . . . . 86 6.3.8. Enforcing Full Channel Saturation . . . . . . . . . . . . . . . 86 6.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88 7. Dual Hop – Single Agent 91 7.1. State-Aware Resource Allocation . . . . . . . . . . . . . . . . . . . . 91 7.2. Optimization Targets . . . . . . . . . . . . . . . . . . . . . . . . . . . 92 7.3. Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 7.3.1. Extensive Simulation . . . . . . . . . . . . . . . . . . . . . . . 96 7.3.2. Non-Integer-Constrained Optimization . . . . . . . . . . . . . 98 7.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 8. Conclusions and Outlook 105 8.1. Key Results and Conclusions . . . . . . . . . . . . . . . . . . . . . . . 105 8.2. Future Work . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 A. DC Motor Model 111 Bibliography 113 Publications of the Author 127 List of Figures 129 List of Tables 131 List of Operators and Constants 133 List of Symbols 135 List of Acronyms 137 Curriculum Vitae 139In industrial manufacturing, Industry 4.0 refers to the ongoing convergence of the real and virtual worlds, enabled through intelligently interconnecting industrial machines and processes through information and communications technology. Ultrareliable low-latency communication (URLLC) is widely regarded as the enabling technology for Industry 4.0 due to its ability to fulfill highest quality-of-service (QoS) comparable to those of industrial wireline connections. In contrast to this trend, a range of works in the research domain of networked control systems have shown that URLLC’s supreme QoS is not necessarily required to achieve high quality-ofcontrol; the co-design of control and communication enables to jointly optimize and balance both quality-of-control parameters and network parameters through blurring the boundary between application and network layer. However, through the tight interlacing, this approach requires a fundamental (joint) redesign of both control systems and communication networks and may therefore not lead to short-term widespread adoption. Therefore, this thesis instead embraces a novel co-design approach which keeps both domains distinct but leverages the combination of control and communications by yet exploiting the age of information (AoI) as a valuable interface metric. This thesis contributes to quantifying application dependability as a consequence of exceeding a given peak AoI with the particular focus on packet losses. The beneficial influence of negative temporal packet loss correlation on control performance is demonstrated by means of the automated guided vehicle use case. Assuming small-scale fading as the dominant cause of communication failure, a series of communication failures are mapped to an application failure through discrete-time Markov models for single-hop (e.g, only uplink or downlink) and dual-hop (e.g., subsequent uplink and downlink) architectures. This enables the derivation of application-related dependability metrics such as the mean time to failure in closed form. For single-hop networks, an AoI-aware resource allocation strategy termed state-aware resource allocation (SARA) is proposed that increases the application reliability by orders of magnitude compared to static multi-connectivity while keeping the resource consumption in the range of best-effort single-connectivity. This dependability can also be statistically guaranteed on a system level – where multiple agents compete for a limited number of resources – if the provided amount of resources per agent is increased by approximately 10 %. For the dual-hop scenario, an AoI-aware resource allocation optimization is developed that minimizes a user-defined penalty function that punishes low application reliability, high AoI, and high average resource consumption. This optimization may be carried out offline and each resulting optimal SARA scheme may be implemented as a look-up table in the lower medium access control layer of future wireless industrial networks.:1. Introduction 1 1.1. The Need for an Industrial Solution . . . . . . . . . . . . . . . . . . . 3 1.2. Contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. Related Work 7 2.1. Communications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2. Control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3. Codesign . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.3.1. The Need for Abstraction – Age of Information . . . . . . . . 11 2.4. Dependability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2.5. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 3. Deriving Proper Communications Requirements 17 3.1. Fundamentals of Control Theory . . . . . . . . . . . . . . . . . . . . 18 3.1.1. Sampling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 3.1.2. Performance Requirements . . . . . . . . . . . . . . . . . . . 21 3.1.3. Packet Losses and Delay . . . . . . . . . . . . . . . . . . . . . 22 3.2. Joint Design of Control Loop with Packet Losses . . . . . . . . . . . . 23 3.2.1. Method 1: Reduced Sampling . . . . . . . . . . . . . . . . . . 23 3.2.2. Method 2: Markov Jump Linear System . . . . . . . . . . . . . 25 3.2.3. Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3.3. Focus Application: The AGV Use Case . . . . . . . . . . . . . . . . . . 31 3.3.1. Control Loop Model . . . . . . . . . . . . . . . . . . . . . . . 31 3.3.2. Control Performance Requirements . . . . . . . . . . . . . . . 33 3.3.3. Joint Modeling: Applying Reduced Sampling . . . . . . . . . . 34 3.3.4. Joint Modeling: Applying MJLS . . . . . . . . . . . . . . . . . 34 3.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 4. Modeling Control-Communication Failures 43 4.1. Communication Assumptions . . . . . . . . . . . . . . . . . . . . . . 43 4.1.1. Small-Scale Fading as a Cause of Failure . . . . . . . . . . . . 44 4.1.2. Connectivity Models . . . . . . . . . . . . . . . . . . . . . . . 46 4.2. Failure Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 4.2.1. Single-hop network . . . . . . . . . . . . . . . . . . . . . . . . 49 4.2.2. Dual-hop network . . . . . . . . . . . . . . . . . . . . . . . . 51 4.3. Performance Metrics . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 4.3.1. Mean Time to Failure . . . . . . . . . . . . . . . . . . . . . . . 54 4.3.2. Packet Loss Ratio . . . . . . . . . . . . . . . . . . . . . . . . . 55 4.3.3. Average Number of Assigned Channels . . . . . . . . . . . . . 57 4.3.4. Age of Information . . . . . . . . . . . . . . . . . . . . . . . . 57 4.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 5. Single Hop – Single Agent 61 5.1. State-Aware Resource Allocation . . . . . . . . . . . . . . . . . . . . 61 5.2. Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 5.3. Erroneous Acknowledgments . . . . . . . . . . . . . . . . . . . . . . 67 5.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 6. Single Hop – Multiple Agents 71 6.1. Failure Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 6.1.1. Admission Control . . . . . . . . . . . . . . . . . . . . . . . . 72 6.1.2. Transition Probabilities . . . . . . . . . . . . . . . . . . . . . . 73 6.1.3. Computational Complexity . . . . . . . . . . . . . . . . . . . 74 6.1.4. Performance Metrics . . . . . . . . . . . . . . . . . . . . . . . 75 6.2. Illustration Scenario . . . . . . . . . . . . . . . . . . . . . . . . . . . 76 6.3. Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 6.3.1. Verification through System-Level Simulation . . . . . . . . . 78 6.3.2. Applicability on the System Level . . . . . . . . . . . . . . . . 79 6.3.3. Comparison of Admission Control Schemes . . . . . . . . . . 80 6.3.4. Impact of the Packet Loss Tolerance . . . . . . . . . . . . . . . 82 6.3.5. Impact of the Number of Agents . . . . . . . . . . . . . . . . . 84 6.3.6. Age of Information . . . . . . . . . . . . . . . . . . . . . . . . 84 6.3.7. Channel Saturation Ratio . . . . . . . . . . . . . . . . . . . . 86 6.3.8. Enforcing Full Channel Saturation . . . . . . . . . . . . . . . 86 6.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88 7. Dual Hop – Single Agent 91 7.1. State-Aware Resource Allocation . . . . . . . . . . . . . . . . . . . . 91 7.2. Optimization Targets . . . . . . . . . . . . . . . . . . . . . . . . . . . 92 7.3. Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 7.3.1. Extensive Simulation . . . . . . . . . . . . . . . . . . . . . . . 96 7.3.2. Non-Integer-Constrained Optimization . . . . . . . . . . . . . 98 7.4. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 8. Conclusions and Outlook 105 8.1. Key Results and Conclusions . . . . . . . . . . . . . . . . . . . . . . . 105 8.2. Future Work . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 A. DC Motor Model 111 Bibliography 113 Publications of the Author 127 List of Figures 129 List of Tables 131 List of Operators and Constants 133 List of Symbols 135 List of Acronyms 137 Curriculum Vitae 13

Time-dependent metabolic phenotyping of inflammatory dysregulation

A rich and functional description of a patient health status is the fundamental basis for the personalisation of treatment and the targeting of interventions. The function of inflammation in the healing process as well as its involvement in most major diseases is well established, yet the specific mechanism by which it contributes to the pathogenesis is still not fully understood. If conditions arising from a dysregulation of the inflammatory process are to be treated before they become irreversible, a novel understanding of these pathologies must be achieved and a stratification of patients based on their inflammatory status undertaken. The work presented in this thesis aims to deliver new analytical and statistical approaches to support the investigation of the time-dependent dysregulation of inflammation. Lipid mediators have been described as exerting a major role in the initiation and regulation of the inflammatory response, yet analytical platforms for their large-scale characterisation in human biofluids are lacking. This thesis reports the validation of an assay for the simultaneous quantification of pro- and anti-inflammatory signalling molecules in multiple human biofluids. The coverage of the assay in each biofluid is subsequently established, characterising inflammatory signalling across biological compartments. A second study explores the assay’s applicability in a clinical context; investigating the relationship between lipid mediators, current clinical markers of inflammation and post-operative complications. Characterising the interplay between signalling and regulatory networks is key to understanding a living system’s response to perturbations, yet few statistical approaches are suited for the detection of time-dependent patterns in short and irregularly sampled longitudinal datasets. This thesis reports the development of a statistical approach to support the identification of altered time-trajectories in such studies. The method’s wide applicability is subsequently demonstrated on two investigations covering the diversity of metabolic phenotyping data generation platforms. This thesis is a proof of concept for the characterisation of patient-specific inflammatory status in a clinical context and the identification of altered time-dependent patterns. Both analytical and statistical developments have been motivated by the needs of real world applications and provide a template for the characterisation and analysis of the molecular basis for treatment.Open Acces