Action potential classification with dual channel intrafascicular electrodes

Journal ArticleUsing recordings of peripheral nerve activity made with carbon fiber intrafascicular electrodes, we compared the performance of three different recording techniques (single channel, differential, and dual channel) and four different unit classification methods (linear discriminant analysis, template matching, a novel time amplitude windowing technique, and neural networks) in terms of errors in waveform classification and artifact rejection. Dual channel recording provided uniformly superior unit separability, neural networks gave the lowest classification error rates, and template matching had the best artifact rejection performance

Nontraditional Approaches to Statistical Classification: Some Perspectives on Lp-Norm Methods

The body of literature on classification method which estimate boundaries between the groups (classes) by optimizing a function of the L_{p}-norm distances of observations in each group from these boundaries, is maturing fast. The number of published research articles on this topic, especially on mathematical programming (MP) formulations and techniques for L_{p}-norm classification, is now sizable. This paper highlights historical developments that have defined the field, and looks ahead at challenges that may shape new research directions in the next decade. In the first part, the paper summarizes basic concepts and ideas, and briefly reviews past research. Throughout, an attempt is made to integrate a number of the most important L_{p}-norm methods proposed to date within a unified framework, emphasizing their conceptual differences and similarities, rather than focusing on mathematical detail. In the second part, the paper discusses several potential directions for future research in this area. The long-term prospects of L_{p}-norm classification (and discriminant) research may well hinge upon whether or not the channels of communication between on the one hand researchers active in L_{p}-norm classification, who tend to have their roots primarily in decision sciences, the management sciences, computer sciences and engineering, and on the other hand practitioners and researchers in the statistical classification community, will be improved. This paper offers potential reasons for the lack of communication between these groups, and suggests ways in which L_{p}-norm research may be strengthened from a statistical viewpoint. The results obtained in L_{p}-norm classification studies are clearly relevant and of importance to all researchers and practitioners active in classification and discrimination analysis. The paper also briefly discusses artificial neural networks, a promising nontraditional method for classification which has recently emerged, and suggests that it may be useful to explore hybrid classification methods that take advantage of the complementary strengths of different methods, e.g., neural network and L_{p}-norm methods

Improved functional prediction of proteins by learning kernel combinations in multilabel settings

Background We develop a probabilistic model for combining kernel matrices to predict the function of proteins. It extends previous approaches in that it can handle multiple labels which naturally appear in the context of protein function. Results Explicit modeling of multilabels significantly improves the capability of learning protein function from multiple kernels. The performance and the interpretability of the inference model are further improved by simultaneously predicting the subcellular localization of proteins and by combining pairwise classifiers to consistent class membership estimates. Conclusion For the purpose of functional prediction of proteins, multilabels provide valuable information that should be included adequately in the training process of classifiers. Learning of functional categories gains from co-prediction of subcellular localization. Pairwise separation rules allow very detailed insights into the relevance of different measurements like sequence, structure, interaction data, or expression data. A preliminary version of the software can be downloaded from http://www.inf.ethz.ch/personal/vroth/KernelHMM/.ISSN:1471-210

매개분포근사를 통한 공정시스템 공학에서의 확률기계학습 접근법

학위논문(박사) -- 서울대학교대학원 : 공과대학 화학생물공학부, 2021.8. 이종민.With the rapid development of measurement technology, higher quality and vast amounts of process data become available. Nevertheless, process data are ‘scarce’ in many cases as they are sampled only at certain operating conditions while the dimensionality of the system is large. Furthermore, the process data are inherently stochastic due to the internal characteristics of the system or the measurement noises. For this reason, uncertainty is inevitable in process systems, and estimating it becomes a crucial part of engineering tasks as the prediction errors can lead to misguided decisions and cause severe casualties or economic losses. A popular approach to this is applying probabilistic inference techniques that can model the uncertainty in terms of probability. However, most of the existing probabilistic inference techniques are based on recursive sampling, which makes it difficult to use them for industrial applications that require processing a high-dimensional and massive amount of data. To address such an issue, this thesis proposes probabilistic machine learning approaches based on parametric distribution approximation, which can model the uncertainty of the system and circumvent the computational complexity as well. The proposed approach is applied for three major process engineering tasks: process monitoring, system modeling, and process design. First, a process monitoring framework is proposed that utilizes a probabilistic classifier for fault classification. To enhance the accuracy of the classifier and reduce the computational cost for its training, a feature extraction method called probabilistic manifold learning is developed and applied to the process data ahead of the fault classification. We demonstrate that this manifold approximation process not only reduces the dimensionality of the data but also casts the data into a clustered structure, making the classifier have a low dependency on the type and dimension of the data. By exploiting this property, non-metric information (e.g., fault labels) of the data is effectively incorporated and the diagnosis performance is drastically improved. Second, a probabilistic modeling approach based on Bayesian neural networks is proposed. The parameters of deep neural networks are transformed into Gaussian distributions and trained using variational inference. The redundancy of the parameter is autonomously inferred during the model training, and insignificant parameters are eliminated a posteriori. Through a verification study, we demonstrate that the proposed approach can not only produce high-fidelity models that describe the stochastic behaviors of the system but also produce the optimal model structure. Finally, a novel process design framework is proposed based on reinforcement learning. Unlike the conventional optimization methods that recursively evaluate the objective function to find an optimal value, the proposed method approximates the objective function surface by parametric probabilistic distributions. This allows learning the continuous action policy without introducing any cumbersome discretization process. Moreover, the probabilistic policy gives means for effective control of the exploration and exploitation rates according to the certainty information. We demonstrate that the proposed framework can learn process design heuristics during the solution process and use them to solve similar design problems.계측기술의 발달로 양질의, 그리고 방대한 양의 공정 데이터의 취득이 가능해졌다. 그러나 많은 경우 시스템 차원의 크기에 비해서 일부 운전조건의 공정 데이터만이 취득되기 때문에, 공정 데이터는 ‘희소’하게 된다. 뿐만 아니라, 공정 데이터는 시스템 거동 자체와 더불어 계측에서 발생하는 노이즈로 인한 본질적인 확률적 거동을 보인다. 따라서 시스템의 예측모델은 예측 값에 대한 불확실성을 정량적으로 기술하는 것이 요구되며, 이를 통해 오진을 예방하고 잠재적 인명 피해와 경제적 손실을 방지할 수 있다. 이에 대한 보편적인 접근법은 확률추정기법을 사용하여 이러한 불확실성을 정량화 하는 것이나, 현존하는 추정기법들은 재귀적 샘플링에 의존하는 특성상 고차원이면서도 다량인 공정데이터에 적용하기 어렵다는 근본적인 한계를 가진다. 본 학위논문에서는 매개분포근사에 기반한 확률기계학습을 적용하여 시스템에 내재된 불확실성을 모델링하면서도 동시에 계산 효율적인 접근 방법을 제안하였다. 먼저, 공정의 모니터링에 있어 가우시안 혼합 모델 (Gaussian mixture model)을 분류자로 사용하는 확률적 결함 분류 프레임워크가 제안되었다. 이때 분류자의 학습에서의 계산 복잡도를 줄이기 위하여 데이터를 저차원으로 투영시키는데, 이를 위한 확률적 다양체 학습 (probabilistic manifold learn-ing) 방법이 제안되었다. 제안하는 방법은 데이터의 다양체 (manifold)를 근사하여 데이터 포인트 사이의 쌍별 우도 (pairwise likelihood)를 보존하는 투영법이 사용된다. 이를 통하여 데이터의 종류와 차원에 의존도가 낮은 진단 결과를 얻음과 동시에 데이터 레이블과 같은 비거리적 (non-metric) 정보를 효율적으로 사용하여 결함 진단 능력을 향상시킬 수 있음을 보였다. 둘째로, 베이지안 심층 신경망(Bayesian deep neural networks)을 사용한 공정의 확률적 모델링 방법론이 제시되었다. 신경망의 각 매개변수는 가우스 분포로 치환되며, 변분추론 (variational inference)을 통하여 계산 효율적인 훈련이 진행된다. 훈련이 끝난 후 파라미터의 유효성을 측정하여 불필요한 매개변수를 소거하는 사후 모델 압축 방법이 사용되었다. 반도체 공정에 대한 사례 연구는 제안하는 방법이 공정의 복잡한 거동을 효과적으로 모델링 할 뿐만 아니라 모델의 최적 구조를 도출할 수 있음을 보여준다. 마지막으로, 분포형 심층 신경망을 사용한 강화학습을 기반으로 한 확률적 공정 설계 프레임워크가 제안되었다. 최적치를 찾기 위해 재귀적으로 목적 함수 값을 평가하는 기존의 최적화 방법론과 달리, 목적 함수 곡면 (objective function surface)을 매개화 된 확률분포로 근사하는 접근법이 제시되었다. 이를 기반으로 이산화 (discretization)를 사용하지 않고 연속적 행동 정책을 학습하며, 확실성 (certainty)에 기반한 탐색 (exploration) 및 활용 (exploi-tation) 비율의 제어가 효율적으로 이루어진다. 사례 연구 결과는 공정의 설계에 대한 경험지식 (heuristic)을 학습하고 유사한 설계 문제의 해를 구하는 데 이용할 수 있음을 보여준다.Chapter 1 Introduction 1 1.1. Motivation 1 1.2. Outline of the thesis 5 Chapter 2 Backgrounds and preliminaries 9 2.1. Bayesian inference 9 2.2. Monte Carlo 10 2.3. Kullback-Leibler divergence 11 2.4. Variational inference 12 2.5. Riemannian manifold 13 2.6. Finite extended-pseudo-metric space 16 2.7. Reinforcement learning 16 2.8. Directed graph 19 Chapter 3 Process monitoring and fault classification with probabilistic manifold learning 20 3.1. Introduction 20 3.2. Methods 25 3.2.1. Uniform manifold approximation 27 3.2.2. Clusterization 28 3.2.3. Projection 31 3.2.4. Mapping of unknown data query 32 3.2.5. Inference 33 3.3. Verification study 38 3.3.1. Dataset description 38 3.3.2. Experimental setup 40 3.3.3. Process monitoring 43 3.3.4. Projection characteristics 47 3.3.5. Fault diagnosis 50 3.3.6. Computational Aspects 56 Chapter 4 Process system modeling with Bayesian neural networks 59 4.1. Introduction 59 4.2. Methods 63 4.2.1. Long Short-Term Memory (LSTM) 63 4.2.2. Bayesian LSTM (BLSTM) 66 4.3. Verification study 68 4.3.1. System description 68 4.3.2. Estimation of the plasma variables 71 4.3.3. Dataset description 72 4.3.4. Experimental setup 72 4.3.5. Weight regularization during training 78 4.3.6. Modeling complex behaviors of the system 80 4.3.7. Uncertainty quantification and model compression 85 Chapter 5 Process design based on reinforcement learning with distributional actor-critic networks 89 5.1. Introduction 89 5.2. Methods 93 5.2.1. Flowsheet hashing 93 5.2.2. Behavioral cloning 99 5.2.3. Neural Monte Carlo tree search (N-MCTS) 100 5.2.4. Distributional actor-critic networks (DACN) 105 5.2.5. Action masking 110 5.3. Verification study 110 5.3.1. System description 110 5.3.2. Experimental setup 111 5.3.3. Result and discussions 115 Chapter 6 Concluding remarks 120 6.1. Summary of the contributions 120 6.2. Future works 122 Appendix 125 A.1. Proof of Lemma 1 125 A.2. Performance indices for dimension reduction 127 A.3. Model equations for process units 130 Bibliography 132 초 록 149박

Development of soft computing and applications in agricultural and biological engineering

Soft computing is a set of “inexact” computing techniques, which are able to model and analyze very complex problems. For these complex problems, more conventional methods have not been able to produce cost-effective, analytical, or complete solutions. Soft computing has been extensively studied and applied in the last three decades for scientific research and engineering computing. In agricultural and biological engineering, researchers and engineers have developed methods of fuzzy logic, artificial neural networks, genetic algorithms, decision trees, and support vector machines to study soil and water regimes related to crop growth, analyze the operation of food processing, and support decision-making in precision farming. This paper reviews the development of soft computing techniques. With the concepts and methods, applications of soft computing in the field of agricultural and biological engineering are presented, especially in the soil and water context for crop management and decision support in precision agriculture. The future of development and application of soft computing in agricultural and biological engineering is discussed

Machine Learning

Machine Learning can be defined in various ways related to a scientific domain concerned with the design and development of theoretical and implementation tools that allow building systems with some Human Like intelligent behavior. Machine learning addresses more specifically the ability to improve automatically through experience