1,718 research outputs found

    A Survey on Automatic Parameter Tuning for Big Data Processing Systems

    Get PDF
    Big data processing systems (e.g., Hadoop, Spark, Storm) contain a vast number of configuration parameters controlling parallelism, I/O behavior, memory settings, and compression. Improper parameter settings can cause significant performance degradation and stability issues. However, regular users and even expert administrators grapple with understanding and tuning them to achieve good performance. We investigate existing approaches on parameter tuning for both batch and stream data processing systems and classify them into six categories: rule-based, cost modeling, simulation-based, experiment-driven, machine learning, and adaptive tuning. We summarize the pros and cons of each approach and raise some open research problems for automatic parameter tuning.Peer reviewe

    Generation of metabolites by an automated online metabolism method using human liver microsomes with subsequent identification by LC-MS(n), and metabolism of 11 cathinones

    Get PDF
    Human liver microsomes (HLMs) are used to simulate human xenobiotic metabolism in vitro. In forensic and clinical toxicology, HLMs are popularly used to study the metabolism of new designer drugs for example. In this work, we present an automated online extraction system we developed for HLM experiments, which was compared to a classical offline approach. Furthermore, we present studies on the metabolism of 11 cathinones; for eight of these, the metabolism has not previously been reported. Metabolites were identified based on MS2 and MS3 scans. Fifty-three substances encompassing various classes of drugs were employed to compare the established offline and the new online methods. The metabolism of each of the following 11 cathinones was studied using the new method: 3,4-methylenedioxy-N-benzylcathinone, benzedrone, butylone, dimethylcathinone, ethylone, flephedrone, methedrone, methylone, methylethylcathinone, naphyrone, and pentylone. The agreement between the offline and the online methods was good; a total of 158 metabolites were identified. Using only the offline method, 156 (98.7%) metabolites were identified, while 151 (95.6%) were identified using only the online method. The metabolic pathways identified for the 11 cathinones included the reduction of the keto group, desalkylation, hydroxylation, and desmethylenation in cathinones containing a methylenedioxy moiety. Our method provides a straightforward approach to identifying metabolites which can then be added to the library utilized by our clinical toxicological screening method. The performance of our method compares well with that of an established offline HLM procedure, but is as automated as possibl

    Seamless Service Provisioning for Mobile Crowdsensing: Towards Integrating Forward and Spot Trading Markets

    Full text link
    The challenge of exchanging and processing of big data over Mobile Crowdsensing (MCS) networks calls for the new design of responsive and seamless service provisioning as well as proper incentive mechanisms. Although conventional onsite spot trading of resources based on real-time network conditions and decisions can facilitate the data sharing over MCS networks, it often suffers from prohibitively long service provisioning delays and unavoidable trading failures due to its reliance on timely analysis of complex and dynamic MCS environments. These limitations motivate us to investigate an integrated forward and spot trading mechanism (iFAST), which entails a new hybrid service trading protocol over the MCS network architecture. In iFAST, the sellers (i.e., mobile users with sensing resources) can provide long-term or temporary sensing services to the buyers (i.e., sensing task owners). iFast enables signing long-term contracts in advance of future transactions through a forward trading mode, via analyzing historical statistics of the market, for which the notion of overbooking is introduced and promoted. iFAST further enables the buyers with unsatisfying service quality to recruit temporary sellers through a spot trading mode, upon considering the current market/network conditions. We analyze the fundamental blocks of iFAST, and provide a case study to demonstrate its superior performance as compared to existing methods. Finally, future research directions on reliable service provisioning for next-generation MCS networks are summarized
    corecore