The detection and classification of blast cell in Leukaemia Acute Promyelocytic Leukaemia (AML M3) blood using simulated annealing and neural networks

This paper was delivered at AIME 2011: 13th Conference on Artifical Intelligence in Medicine.This paper presents a method for the detection and classification of blast cells in M3 with others sub-types using simulated annealing and neural networks. In this paper, we increased our test result from 10 images to 20 images. We performed Hill Climbing, Simulated Annealing and Genetic Algorithms for detecting the blast cells. As a result, simulated annealing is the “best” heuristic search for detecting the leukaemia cells. From the detection, we performed features extraction on the blast cells and we classifying based on M3 and other sub-types using neural networks. We received convincing result which has targeting around 97% in classifying of M3 with other sub-types. Our results are based on real world image data from a Haematology Department.Universiti Sains Islam Malaysia and the Ministry of Higher Education, Malaysi

A niching memetic algorithm for simultaneous clustering and feature selection

Clustering is inherently a difficult task, and is made even more difficult when the selection of relevant features is also an issue. In this paper we propose an approach for simultaneous clustering and feature selection using a niching memetic algorithm. Our approach (which we call NMA_CFS) makes feature selection an integral part of the global clustering search procedure and attempts to overcome the problem of identifying less promising locally optimal solutions in both clustering and feature selection, without making any a priori assumption about the number of clusters. Within the NMA_CFS procedure, a variable composite representation is devised to encode both feature selection and cluster centers with different numbers of clusters. Further, local search operations are introduced to refine feature selection and cluster centers encoded in the chromosomes. Finally, a niching method is integrated to preserve the population diversity and prevent premature convergence. In an experimental evaluation we demonstrate the effectiveness of the proposed approach and compare it with other related approaches, using both synthetic and real data

Joint co-clustering: co-clustering of genomic and clinical bioimaging data

AbstractFor better understanding the genetic mechanisms underlying clinical observations, and better defining a group of potential candidates for protein-family-inhibiting therapy, it is interesting to determine the correlations between genomic, clinical data and data coming from high resolution and fluorescent microscopy. We introduce a computational method, called joint co-clustering, that can find co-clusters or groups of genes, bioimaging parameters and clinical traits that are believed to be closely related to each other based on the given empirical information. As bioimaging parameters, we quantify the expression of growth factor receptor EGFR/erb-B family in non-small cell lung carcinoma (NSCLC) through a fully-automated computer-aided analysis approach. This immunohistochemical analysis is usually performed by pathologists via visual inspection of tissue samples images. Our fully-automated techniques streamlines this error-prone and time-consuming process, thereby facilitating analysis and diagnosis. Experimental results for several real-life datasets demonstrate the high quantitative precision of our approach. The joint co-clustering method was tested with the receptor EGFR/erb-B family data on non-small cell lung carcinoma (NSCLC) tissue and identified statistically significant co-clusters of genes, receptor protein expression and clinical traits. The validation of our results with the literature suggest that the proposed method can provide biologically meaningful co-clusters of genes and traits and that it is a very promising approach to analyse large-scale biological data and to study multi-factorial genetic pathologies through their genetic alterations

Multi-learner based recursive supervised training

In this paper, we propose the Multi-Learner Based Recursive Supervised Training (MLRT) algorithm which uses the existing framework of recursive task decomposition, by training the entire dataset, picking out the best learnt patterns, and then repeating the process with the remaining patterns. Instead of having a single learner to classify all datasets during each recursion, an appropriate learner is chosen from a set of three learners, based on the subset of data being trained, thereby avoiding the time overhead associated with the genetic algorithm learner utilized in previous approaches. In this way MLRT seeks to identify the inherent characteristics of the dataset, and utilize it to train the data accurately and efficiently. We observed that empirically, MLRT performs considerably well as compared to RPHP and other systems on benchmark data with 11% improvement in accuracy on the SPAM dataset and comparable performances on the VOWEL and the TWO-SPIRAL problems. In addition, for most datasets, the time taken by MLRT is considerably lower than the other systems with comparable accuracy. Two heuristic versions, MLRT-2 and MLRT-3 are also introduced to improve the efficiency in the system, and to make it more scalable for future updates. The performance in these versions is similar to the original MLRT system

Time series data mining: preprocessing, analysis, segmentation and prediction. Applications

Currently, the amount of data which is produced for any information system is increasing exponentially. This motivates the development of automatic techniques to process and mine these data correctly. Specifically, in this Thesis, we tackled these problems for time series data, that is, temporal data which is collected chronologically. This kind of data can be found in many fields of science, such as palaeoclimatology, hydrology, financial problems, etc. TSDM consists of several tasks which try to achieve different objectives, such as, classification, segmentation, clustering, prediction, analysis, etc. However, in this Thesis, we focus on time series preprocessing, segmentation and prediction. Time series preprocessing is a prerequisite for other posterior tasks: for example, the reconstruction of missing values in incomplete parts of time series can be essential for clustering them. In this Thesis, we tackled the problem of massive missing data reconstruction in SWH time series from the Gulf of Alaska. It is very common that buoys stop working for different periods, what it is usually related to malfunctioning or bad weather conditions. The relation of the time series of each buoy is analysed and exploited to reconstruct the whole missing time series. In this context, EANNs with PUs are trained, showing that the resulting models are simple and able to recover these values with high precision. In the case of time series segmentation, the procedure consists in dividing the time series into different subsequences to achieve different purposes. This segmentation can be done trying to find useful patterns in the time series. In this Thesis, we have developed novel bioinspired algorithms in this context. For instance, for paleoclimate data, an initial genetic algorithm was proposed to discover early warning signals of TPs, whose detection was supported by expert opinions. However, given that the expert had to individually evaluate every solution given by the algorithm, the evaluation of the results was very tedious. This led to an improvement in the body of the GA to evaluate the procedure automatically. For significant wave height time series, the objective was the detection of groups which contains extreme waves, i.e. those which are relatively large with respect other waves close in time. The main motivation is to design alert systems. This was done using an HA, where an LS process was included by using a likelihood-based segmentation, assuming that the points follow a beta distribution. Finally, the analysis of similarities in different periods of European stock markets was also tackled with the aim of evaluating the influence of different markets in Europe. When segmenting time series with the aim of reducing the number of points, different techniques have been proposed. However, it is an open challenge given the difficulty to operate with large amounts of data in different applications. In this work, we propose a novel statistically-driven CRO algorithm (SCRO), which automatically adapts its parameters during the evolution, taking into account the statistical distribution of the population fitness. This algorithm improves the state-of-the-art with respect to accuracy and robustness. Also, this problem has been tackled using an improvement of the BBPSO algorithm, which includes a dynamical update of the cognitive and social components in the evolution, combined with mathematical tricks to obtain the fitness of the solutions, which significantly reduces the computational cost of previously proposed coral reef methods. Also, the optimisation of both objectives (clustering quality and approximation quality), which are in conflict, could be an interesting open challenge, which will be tackled in this Thesis. For that, an MOEA for time series segmentation is developed, improving the clustering quality of the solutions and their approximation. The prediction in time series is the estimation of future values by observing and studying the previous ones. In this context, we solve this task by applying prediction over high-order representations of the elements of the time series, i.e. the segments obtained by time series segmentation. This is applied to two challenging problems, i.e. the prediction of extreme wave height and fog prediction. On the one hand, the number of extreme values in SWH time series is less with respect to the number of standard values. In this way, the prediction of these values cannot be done using standard algorithms without taking into account the imbalanced ratio of the dataset. For that, an algorithm that automatically finds the set of segments and then applies EANNs is developed, showing the high ability of the algorithm to detect and predict these special events. On the other hand, fog prediction is affected by the same problem, that is, the number of fog events is much lower tan that of non-fog events, requiring a special treatment too. A preprocessing of different data coming from sensors situated in different parts of the Valladolid airport are used for making a simple ANN model, which is physically corroborated and discussed. The last challenge which opens new horizons is the estimation of the statistical distribution of time series to guide different methodologies. For this, the estimation of a mixed distribution for SWH time series is then used for fixing the threshold of POT approaches. Also, the determination of the fittest distribution for the time series is used for discretising it and making a prediction which treats the problem as ordinal classification. The work developed in this Thesis is supported by twelve papers in international journals, seven papers in international conferences, and four papers in national conferences