567 research outputs found

    The image biomarker standardization initiative: Standardized convolutional filters for reproducible radiomics and enhanced clinical insights

    Get PDF
    Standardizing convolutional filters that enhance specific structures and patterns in medical imaging enables reproducible radiomics analyses, improving consistency and reliability for enhanced clinical insights. Filters are commonly used to enhance specific structures and patterns in images, such as vessels or peritumoral regions, to enable clinical insights beyond the visible image using radiomics. However, their lack of standardization restricts reproducibility and clinical translation of radiomics decision support tools. In this special report, teams of researchers who developed radiomics software participated in a three-phase study (September 2020 to December 2022) to establish a standardized set of filters. The first two phases focused on finding reference filtered images and reference feature values for commonly used convolutional filters: mean, Laplacian of Gaussian, Laws and Gabor kernels, separable and nonseparable wavelets (including decomposed forms), and Riesz transformations. In the first phase, 15 teams used digital phantoms to establish 33 reference filtered images of 36 filter configurations. In phase 2, 11 teams used a chest CT image to derive reference values for 323 of 396 features computed from filtered images using 22 filter and image processing configurations. Reference filtered images and feature values for Riesz transformations were not established. Reproducibility of standardized convolutional filters was validated on a public data set of multimodal imaging (CT, fluorodeoxyglucose PET, and T1-weighted MRI) in 51 patients with soft-tissue sarcoma. At validation, reproducibility of 486 features computed from filtered images using nine configurations × three imaging modalities was assessed using the lower bounds of 95% CIs of intraclass correlation coefficients. Out of 486 features, 458 were found to be reproducible across nine teams with lower bounds of 95% CIs of intraclass correlation coefficients greater than 0.75. In conclusion, eight filter types were standardized with reference filtered images and reference feature values for verifying and calibrating radiomics software packages. A web-based tool is available for compliance checking

    Towards addressing training data scarcity challenge in emerging radio access networks: a survey and framework

    Get PDF
    The future of cellular networks is contingent on artificial intelligence (AI) based automation, particularly for radio access network (RAN) operation, optimization, and troubleshooting. To achieve such zero-touch automation, a myriad of AI-based solutions are being proposed in literature to leverage AI for modeling and optimizing network behavior to achieve the zero-touch automation goal. However, to work reliably, AI based automation, requires a deluge of training data. Consequently, the success of the proposed AI solutions is limited by a fundamental challenge faced by cellular network research community: scarcity of the training data. In this paper, we present an extensive review of classic and emerging techniques to address this challenge. We first identify the common data types in RAN and their known use-cases. We then present a taxonomized survey of techniques used in literature to address training data scarcity for various data types. This is followed by a framework to address the training data scarcity. The proposed framework builds on available information and combination of techniques including interpolation, domain-knowledge based, generative adversarial neural networks, transfer learning, autoencoders, fewshot learning, simulators and testbeds. Potential new techniques to enrich scarce data in cellular networks are also proposed, such as by matrix completion theory, and domain knowledge-based techniques leveraging different types of network geometries and network parameters. In addition, an overview of state-of-the art simulators and testbeds is also presented to make readers aware of current and emerging platforms to access real data in order to overcome the data scarcity challenge. The extensive survey of training data scarcity addressing techniques combined with proposed framework to select a suitable technique for given type of data, can assist researchers and network operators in choosing the appropriate methods to overcome the data scarcity challenge in leveraging AI to radio access network automation

    QoS-aware architectures, technologies, and middleware for the cloud continuum

    Get PDF
    The recent trend of moving Cloud Computing capabilities to the Edge of the network is reshaping how applications and their middleware supports are designed, deployed, and operated. This new model envisions a continuum of virtual resources between the traditional cloud and the network edge, which is potentially more suitable to meet the heterogeneous Quality of Service (QoS) requirements of diverse application domains and next-generation applications. Several classes of advanced Internet of Things (IoT) applications, e.g., in the industrial manufacturing domain, are expected to serve a wide range of applications with heterogeneous QoS requirements and call for QoS management systems to guarantee/control performance indicators, even in the presence of real-world factors such as limited bandwidth and concurrent virtual resource utilization. The present dissertation proposes a comprehensive QoS-aware architecture that addresses the challenges of integrating cloud infrastructure with edge nodes in IoT applications. The architecture provides end-to-end QoS support by incorporating several components for managing physical and virtual resources. The proposed architecture features: i) a multilevel middleware for resolving the convergence between Operational Technology (OT) and Information Technology (IT), ii) an end-to-end QoS management approach compliant with the Time-Sensitive Networking (TSN) standard, iii) new approaches for virtualized network environments, such as running TSN-based applications under Ultra-low Latency (ULL) constraints in virtual and 5G environments, and iv) an accelerated and deterministic container overlay network architecture. Additionally, the QoS-aware architecture includes two novel middlewares: i) a middleware that transparently integrates multiple acceleration technologies in heterogeneous Edge contexts and ii) a QoS-aware middleware for Serverless platforms that leverages coordination of various QoS mechanisms and virtualized Function-as-a-Service (FaaS) invocation stack to manage end-to-end QoS metrics. Finally, all architecture components were tested and evaluated by leveraging realistic testbeds, demonstrating the efficacy of the proposed solutions

    Time-sensitive autonomous architectures

    Get PDF
    Autonomous and software-defined vehicles (ASDVs) feature highly complex systems, coupling safety-critical and non-critical components such as infotainment. These systems require the highest connectivity, both inside the vehicle and with the outside world. An effective solution for network communication lies in Time-Sensitive Networking (TSN) which enables high-bandwidth and low-latency communications in a mixed-criticality environment. In this work, we present Time-Sensitive Autonomous Architectures (TSAA) to enable TSN in ASDVs. The software architecture is based on a hypervisor providing strong isolation and virtual access to TSN for virtual machines (VMs). TSAA latest iteration includes an autonomous car controlled by two Xilinx accelerators and a multiport TSN switch. We discuss the engineering challenges and the performance evaluation of the project demonstrator. In addition, we propose a Proof-of-Concept design of virtualized TSN to enable multiple VMs executing on a single board taking advantage of the inherent guarantees offered by TSN

    Resilient and Scalable Forwarding for Software-Defined Networks with P4-Programmable Switches

    Get PDF
    Traditional networking devices support only fixed features and limited configurability. Network softwarization leverages programmable software and hardware platforms to remove those limitations. In this context the concept of programmable data planes allows directly to program the packet processing pipeline of networking devices and create custom control plane algorithms. This flexibility enables the design of novel networking mechanisms where the status quo struggles to meet high demands of next-generation networks like 5G, Internet of Things, cloud computing, and industry 4.0. P4 is the most popular technology to implement programmable data planes. However, programmable data planes, and in particular, the P4 technology, emerged only recently. Thus, P4 support for some well-established networking concepts is still lacking and several issues remain unsolved due to the different characteristics of programmable data planes in comparison to traditional networking. The research of this thesis focuses on two open issues of programmable data planes. First, it develops resilient and efficient forwarding mechanisms for the P4 data plane as there are no satisfying state of the art best practices yet. Second, it enables BIER in high-performance P4 data planes. BIER is a novel, scalable, and efficient transport mechanism for IP multicast traffic which has only very limited support of high-performance forwarding platforms yet. The main results of this thesis are published as 8 peer-reviewed and one post-publication peer-reviewed publication. The results cover the development of suitable resilience mechanisms for P4 data planes, the development and implementation of resilient BIER forwarding in P4, and the extensive evaluations of all developed and implemented mechanisms. Furthermore, the results contain a comprehensive P4 literature study. Two more peer-reviewed papers contain additional content that is not directly related to the main results. They implement congestion avoidance mechanisms in P4 and develop a scheduling concept to find cost-optimized load schedules based on day-ahead forecasts

    Security and Privacy for Modern Wireless Communication Systems

    Get PDF
    The aim of this reprint focuses on the latest protocol research, software/hardware development and implementation, and system architecture design in addressing emerging security and privacy issues for modern wireless communication networks. Relevant topics include, but are not limited to, the following: deep-learning-based security and privacy design; covert communications; information-theoretical foundations for advanced security and privacy techniques; lightweight cryptography for power constrained networks; physical layer key generation; prototypes and testbeds for security and privacy solutions; encryption and decryption algorithm for low-latency constrained networks; security protocols for modern wireless communication networks; network intrusion detection; physical layer design with security consideration; anonymity in data transmission; vulnerabilities in security and privacy in modern wireless communication networks; challenges of security and privacy in node–edge–cloud computation; security and privacy design for low-power wide-area IoT networks; security and privacy design for vehicle networks; security and privacy design for underwater communications networks

    Flexible Global Aggregation and Dynamic Client Selection for Federated Learning in Internet of Vehicles

    Get PDF
    Federated Learning (FL) enables collaborative and privacy-preserving training of machine learning models within the Internet of Vehicles (IoV) realm. While FL effectively tackles privacy concerns, it also imposes significant resource requirements. In traditional FL, trained models are transmitted to a central server for global aggregation, typically in the cloud. This approach often leads to network congestion and bandwidth limitations when numerous devices communicate with the same server. The need for Flexible Global Aggregation and Dynamic Client Selection in FL for the IoV arises from the inherent characteristics of IoV environments. These include diverse and distributed data sources, varying data quality, and limited communication resources. By employing dynamic client selection, we can prioritize relevant and high-quality data sources, enhancing model accuracy. To address this issue, we propose an FL framework that selects global aggregation nodes dynamically rather than a single fixed aggregator. Flexible global aggregation ensures efficient utilization of limited network resources while accommodating the dynamic nature of IoV data sources. This approach optimizes both model performance and resource allocation, making FL in IoV more effective and adaptable. The selection of the global aggregation node is based on workload and communication speed considerations. Additionally, our framework overcomes the constraints associated with network, computational, and energy resources in the IoV environment by implementing a client selection algorithm that dynamically adjusts participants according to predefined parameters. Our approach surpasses Federated Averaging (FedAvg) and Hierarchical FL (HFL) regarding energy consumption, delay, and accuracy, yielding superior results

    Multiparametric Magnetic Resonance Imaging Artificial Intelligence Pipeline for Oropharyngeal Cancer Radiotherapy Treatment Guidance

    Get PDF
    Oropharyngeal cancer (OPC) is a widespread disease and one of the few domestic cancers that is rising in incidence. Radiographic images are crucial for assessment of OPC and aid in radiotherapy (RT) treatment. However, RT planning with conventional imaging approaches requires operator-dependent tumor segmentation, which is the primary source of treatment error. Further, OPC expresses differential tumor/node mid-RT response (rapid response) rates, resulting in significant differences between planned and delivered RT dose. Finally, clinical outcomes for OPC patients can also be variable, which warrants the investigation of prognostic models. Multiparametric MRI (mpMRI) techniques that incorporate simultaneous anatomical and functional information coupled to artificial intelligence (AI) approaches could improve clinical decision support for OPC by providing immediately actionable clinical rationale for adaptive RT planning. If tumors could be reproducibly segmented, rapid response could be classified, and prognosis could be reliably determined, overall patient outcomes would be optimized to improve the therapeutic index as a function of more risk-adapted RT volumes. Consequently, there is an unmet need for automated and reproducible imaging which can simultaneously segment tumors and provide predictive value for actionable RT adaptation. This dissertation primarily seeks to explore and optimize image processing, tumor segmentation, and patient outcomes in OPC through a combination of advanced imaging techniques and AI algorithms. In the first specific aim of this dissertation, we develop and evaluate mpMRI pre-processing techniques for use in downstream segmentation, response prediction, and outcome prediction pipelines. Various MRI intensity standardization and registration approaches were systematically compared and benchmarked. Moreover, synthetic image algorithms were developed to decrease MRI scan time in an effort to optimize our AI pipelines. We demonstrated that proper intensity standardization and image registration can improve mpMRI quality for use in AI algorithms, and developed a novel method to decrease mpMRI acquisition time. Subsequently, in the second specific aim of this dissertation, we investigated underlying questions regarding the implementation of RT-related auto-segmentation. Firstly, we quantified interobserver variability for an unprecedented large number of observers for various radiotherapy structures in several disease sites (with a particular emphasis on OPC) using a novel crowdsourcing platform. We then trained an AI algorithm on a series of extant matched mpMRI datasets to segment OPC primary tumors. Moreover, we validated and compared our best model\u27s performance to clinical expert observers. We demonstrated that AI-based mpMRI OPC tumor auto-segmentation offers decreased variability and comparable accuracy to clinical experts, and certain mpMRI input channel combinations could further improve performance. Finally, in the third specific aim of this dissertation, we predicted OPC primary tumor mid-therapy (rapid) treatment response and prognostic outcomes. Using co-registered pre-therapy and mid-therapy primary tumor manual segmentations of OPC patients, we generated and characterized treatment sensitive and treatment resistant pre-RT sub-volumes. These sub-volumes were used to train an AI algorithm to predict individual voxel-wise treatment resistance. Additionally, we developed an AI algorithm to predict OPC patient progression free survival using pre-therapy imaging from an international data science competition (ranking 1st place), and then translated these approaches to mpMRI data. We demonstrated AI models could be used to predict rapid response and prognostic outcomes using pre-therapy imaging, which could help guide treatment adaptation, though further work is needed. In summary, the completion of these aims facilitates the development of an image-guided fully automated OPC clinical decision support tool. The resultant deliverables from this project will positively impact patients by enabling optimized therapeutic interventions in OPC. Future work should consider investigating additional imaging timepoints, imaging modalities, uncertainty quantification, perceptual and ethical considerations, and prospective studies for eventual clinical implementation. A dynamic version of this dissertation is publicly available and assigned a digital object identifier through Figshare (doi: 10.6084/m9.figshare.22141871)
    • …
    corecore