Stability Analysis of Delayed Genetic Regulatory Networks via a Relaxed Double Integral Inequality

Time delay arising in a genetic regulatory network may cause the instability. This paper is concerned with the stability analysis of genetic regulatory networks with interval time-varying delays. Firstly, a relaxed double integral inequality, named as Wirtinger-type double integral inequality (WTDII), is established to estimate the double integral term appearing in the derivative of Lyapunov-Krasovskii functional with a triple integral term. And it is proved theoretically that the proposed WTDII is tighter than the widely used Jensen-based double inequality and the recently developed Wiringter-based double inequality. Then, by applying the WTDII to the stability analysis of a delayed genetic regulatory network, together with the usage of useful information of regulatory functions, several delay-range- and delay-rate-dependent (or delay-rate-independent) criteria are derived in terms of linear matrix inequalities. Finally, an example is carried out to verify the effectiveness of the proposed method and also to show the advantages of the established stability criteria through the comparison with some literature

Synchronization of stochastic genetic oscillator networks with time delays and Markovian jumping parameters

The official published version of the article can be found at the link below.Genetic oscillator networks (GONs) are inherently coupled complex systems where the nodes indicate the biochemicals and the couplings represent the biochemical interactions. This paper is concerned with the synchronization problem of a general class of stochastic GONs with time delays and Markovian jumping parameters, where the GONs are subject to both the stochastic disturbances and the Markovian parameter switching. The regulatory functions of the addressed GONs are described by the sector-like nonlinear functions. By applying up-to-date ‘delay-fractioning’ approach for achieving delay-dependent conditions, we construct novel matrix functional to derive the synchronization criteria for the GONs that are formulated in terms of linear matrix inequalities (LMIs). Note that LMIs are easily solvable by the Matlab toolbox. A simulation example is used to demonstrate the synchronization phenomena within biological organisms of a given GON and therefore shows the applicability of the obtained results.This work was supported in part by the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK under Grants BB/C506264/1 and 100/EGM17735, the Royal Society of the UK, the National Natural Science Foundation of China under Grant 60804028, the Teaching and Research Fund for Excellent Young Teachers at Southeast University of China, the International Science and Technology Cooperation Project of China under Grant 2009DFA32050, and the Alexander von Humboldt Foundation of Germany

Parameters identification of unknown delayed genetic regulatory networks by a switching particle swarm optimization algorithm

The official published version can be found at the link below.This paper presents a novel particle swarm optimization (PSO) algorithm based on Markov chains and competitive penalized method. Such an algorithm is developed to solve global optimization problems with applications in identifying unknown parameters of a class of genetic regulatory networks (GRNs). By using an evolutionary factor, a new switching PSO (SPSO) algorithm is first proposed and analyzed, where the velocity updating equation jumps from one mode to another according to a Markov chain, and acceleration coefficients are dependent on mode switching. Furthermore, a leader competitive penalized multi-learning approach (LCPMLA) is introduced to improve the global search ability and refine the convergent solutions. The LCPMLA can automatically choose search strategy using a learning and penalizing mechanism. The presented SPSO algorithm is compared with some well-known PSO algorithms in the experiments. It is shown that the SPSO algorithm has faster local convergence speed, higher accuracy and algorithm reliability, resulting in better balance between the global and local searching of the algorithm, and thus generating good performance. Finally, we utilize the presented SPSO algorithm to identify not only the unknown parameters but also the coupling topology and time-delay of a class of GRNs.This research was partially supported by the National Natural Science Foundation of PR China (Grant No. 60874113), the Research Fund for the Doctoral Program of Higher Education (Grant No. 200802550007), the Key Creative Project of Shanghai Education Community (Grant No. 09ZZ66), the Key Foundation Project of Shanghai (Grant No. 09JC1400700), the Engineering and Physical Sciences Research Council EPSRC of the UK under Grant No. GR/S27658/01, the International Science and Technology Cooperation Project of China under Grant No. 2009DFA32050, an International Joint Project sponsored by the Royal Society of the UK, and the Alexander von Humboldt Foundation of Germany

Fault Detection for Wireless Network Control Systems with Stochastic Uncertainties and Time Delays

The fault detection problem is investigated for a class of wireless network control systems which has stochastic uncertainties in the state-space matrices, combined with time delays and nonlinear disturbance. First, the system error observer is proposed. Then, by constructing proper Lyapunov-Krasovskii functional, we acquire sufficient conditions to guarantee the stability of the fault detection observer for the discrete system, and observer gain is also derived by solving linear matrix inequalities. Finally, a simulation example shows that when a fault happens, the observer residual rises rapidly and fault can be quickly detected, which demonstrates the effectiveness of the proposed method

State Estimation for Time-Delay Systems with Markov Jump Parameters and Missing Measurements

This paper is concerned with the state estimation problem for a class of time-delay systems with Markovian jump parameters and missing measurements, considering the fact that data missing may occur in the process of transmission and its failure rates are governed by random variables satisfying certain probabilistic distribution. By employing a new Lyapunov function and using the convexity property of the matrix inequality, a sufficient condition for the existence of the desired state estimator for Markovian jump systems with missing measurements can be achieved by solving some linear matrix inequalities, which can be easily facilitated by using the standard numerical software. Furthermore, the gain of state estimator can also be derived based on the known conditions. Finally, a numerical example is exploited to demonstrate the effectiveness of the proposed method

H

This paper is concerned with the H∞ filtering for a class of networked Markovian jump systems with multiple communication delays. Due to the existence of communication constraints, the measurement signal cannot arrive at the filter completely on time, and the stochastic communication delays are considered in the filter design. Firstly, a set of stochastic variables is introduced to model the occurrence probabilities of the delays. Then based on the stochastic system approach, a sufficient condition is obtained such that the filtering error system is stable in the mean-square sense and with a prescribed H∞ disturbance attenuation level. The optimal filter gain parameters can be determined by solving a convex optimization problem. Finally, a simulation example is given to show the effectiveness of the proposed filter design method

Robust Controller for Delays and Packet Dropout Avoidance in Solar-Power Wireless Network

Solar Wireless Networked Control Systems (SWNCS) are a style of distributed control systems where sensors, actuators, and controllers are interconnected via a wireless communication network. This system setup has the benefit of low cost, flexibility, low weight, no wiring and simplicity of system diagnoses and maintenance. However, it also unavoidably calls some wireless network time delays and packet dropout into the design procedure. Solar lighting system offers a clean environment, therefore able to continue for a long period. SWNCS also offers multi Service infrastructure solution for both developed and undeveloped countries. The system provides wireless controller lighting, wireless communications network (WI-FI/WIMAX), CCTV surveillance, and wireless sensor for weather measurement which are all powered by solar energy

ℓ<inf>2</inf>–ℓ<inf>∞</inf> proportional–integral observer design for systems with mixed time-delays under round–robin protocol

The Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia, FP-21-42; National Natural Science Foundation of China, 61873148; 61873169; 61933007; Alexander von Humboldt Foundation of Germany