Changes in sulfhydryl groups of honeybee glyceraldehyde phosphate dehydrogenase associated with generation of the intermediate plateau in its saturation kinetics

Honeybee and rabbit muscle GPDH were studied to obtain information at the chemical level regarding anomolous saturation kinetics of the honeybee enzyme. Results demonstrate that the enzyme's sulfhydryl groups are implicated in the process. Measured by DTNB titration, native honeybee GPDH has one less active SH than the native rabbit muscle enzyme and displays changes in overall sulfhydryl reactivity after preincubation with G-3-P or G-3-P plus NAD+. The total DTNB reactive sulfhydryls of rabbit muscle GPDH are not changed by preincubation with NAD+ or G-3-P; honeybee GPDH, under certain conductions of preincubation with these ligands, shows a decrease of two total DTNB reactive SH groups. This difference has been confirmed by an independent experiment in which the two enzymes were carboxymethylated with C-14 bromoacetic acid

Interactions with Projected Augmented Relief Models (PARM)

Techniques for enhancing physical landscape models with dynamic maps and imagery, termed Projected Augmented Relief Models (PARM), are part of a revival of interest in the power of relief models as tools for geographic visualization. This method enables the creation of dynamic and engaging public displays, which appear attractive but also promote discussion and interaction as revealed through direct observation and video. This paper explores the capabilities of physical relief models as tangible displays for geographic information, and considers the role of interaction using the Kinect sensor for finger detection. The focus of interaction is on making solid landscape models of real geographic areas reactive to touch

Autonomic care platform for optimizing query performance

Background: As the amount of information in electronic health care systems increases, data operations get more complicated and time-consuming. Intensive Care platforms require a timely processing of data retrievals to guarantee the continuous display of recent data of patients. Physicians and nurses rely on this data for their decision making. Manual optimization of query executions has become difficult to handle due to the increased amount of queries across multiple sources. Hence, a more automated management is necessary to increase the performance of database queries. The autonomic computing paradigm promises an approach in which the system adapts itself and acts as self-managing entity, thereby limiting human interventions and taking actions. Despite the usage of autonomic control loops in network and software systems, this approach has not been applied so far for health information systems. Methods: We extend the COSARA architecture, an infection surveillance and antibiotic management service platform for the Intensive Care Unit (ICU), with self-managed components to increase the performance of data retrievals. We used real-life ICU COSARA queries to analyse slow performance and measure the impact of optimizations. Each day more than 2 million COSARA queries are executed. Three control loops, which monitor the executions and take action, have been proposed: reactive, deliberative and reflective control loops. We focus on improvements of the execution time of microbiology queries directly related to the visual displays of patients' data on the bedside screens. Results: The results show that autonomic control loops are beneficial for the optimizations in the data executions in the ICU. The application of reactive control loop results in a reduction of 8.61% of the average execution time of microbiology results. The combined application of the reactive and deliberative control loop results in an average query time reduction of 10.92% and the combination of reactive, deliberative and reflective control loops provides a reduction of 13.04%. Conclusions: We found that by controlled reduction of queries' executions the performance for the end-user can be improved. The implementation of autonomic control loops in an existing health platform, COSARA, has a positive effect on the timely data visualization for the physician and nurse

Hop and HipHop : Multitier Web Orchestration

Rich applications merge classical computing, client-server concurrency, web-based interfaces, and the complex time- and event-based reactive programming found in embedded systems. To handle them, we extend the Hop web programming platform by HipHop, a domain-specific language dedicated to event-based process orchestration. Borrowing the synchronous reactive model of Esterel, HipHop is based on synchronous concurrency and preemption primitives that are known to be key components for the modular design of complex reactive behaviors. HipHop departs from Esterel by its ability to handle the dynamicity of Web applications, thanks to the reflexivity of Hop. Using a music player example, we show how to modularly build a non-trivial Hop application using HipHop orchestration code.Comment: International Conference on Distributed Computing and Internet Technology (2014

Smart grid architecture for rural distribution networks: application to a Spanish pilot network

This paper presents a novel architecture for rural distribution grids. This architecture is designed to modernize traditional rural networks into new Smart Grid ones. The architecture tackles innovation actions on both the power plane and the management plane of the system. In the power plane, the architecture focuses on exploiting the synergies between telecommunications and innovative technologies based on power electronics managing low scale electrical storage. In the management plane, a decentralized management system is proposed based on the addition of two new agents assisting the typical Supervisory Control And Data Acquisition (SCADA) system of distribution system operators. Altogether, the proposed architecture enables operators to use more effectively—in an automated and decentralized way—weak rural distribution systems, increasing the capability to integrate new distributed energy resources. This architecture is being implemented in a real Pilot Network located in Spain, in the frame of the European Smart Rural Grid project. The paper also includes a study case showing one of the potentialities of one of the principal technologies developed in the project and underpinning the realization of the new architecture: the so-called Intelligent Distribution Power Router.Postprint (published version

Mixing the reactive with the personal: Opportunities for end-user programming in personal information management

The transition of personal information management (PIM) tools off the desktop to the Web presents an opportunity to augment these tools with capabilities provided by the wealth of real-time information readily available. In this chapter, we describe a personal information assistance engine that lets end-users delegate to it various simple context- and activity-reactive tasks and reminders. Our system, Atomate, treats RSS/ATOM feeds from social networking and life-tracking sites as sensor streams, integrating information from such feeds into a simple unified RDF world model representing people, places and things and their time-varying states and activities. Combined with other information sources on the web, including the user's online calendar, web-based e-mail client, news feeds and messaging services, Atomate can be made to automatically carry out a variety of simple tasks for the user, ranging from context-aware filtering and messaging, to sharing and social coordination actions. Atomate's open architecture and world model easily accommodate new information sources and actions via the addition of feeds and web services. To make routine use of the system easy for non-programmers, Atomate provides a constrained-input natural language interface (CNLI) for behavior specification, and a direct-manipulation interface for inspecting and updating its world model

The detection of intentional contingencies in simple animations in patients with delusions of persecution

Background. It has been proposed that delusions of persecution are caused by the tendency to over-attribute malevolent intentions to other people's actions. One aspect of intention attribution is detecting contingencies between an agent's actions and intentions. Here, we used simplified stimuli to test the hypothesis that patients with persecutory delusions over-attribute contingency to agents' movements. Method. Short animations were presented to three groups of subjects: (1) schizophrenic patients; (2) patients with affective disorders; and (3) normal control subjects. Patients were divided on the basis of the presence or absence of delusions of persecution. Participants watched four types of film featuring two shapes. In half the films one shape's movement was contingent on the other shape. Contingency was either ‘intentional’: one shape moved when it ‘saw’ another shape; or ‘mechanical’: one shape was launched by the other shape. Subjects were asked to rate the strength of the relationship between the movement of the shapes. Results. Normal control subjects and patients without delusions of persecution rated the relationship between the movement of the shapes as stronger in both mechanical and intentional contingent conditions than in non-contingent conditions. In contrast, there was no significant difference between the ratings of patients with delusions of persecution for the conditions in which movement was animate. Patients with delusions of persecution perceived contingency when there was none in the animate non-contingent condition. Conclusions. The results suggest that delusions of persecution may be associated with the over-attribution of contingency to the actions of agents

Design Concept for a Failover Mechanism in Distributed SDN Controllers

Software defined networking allows the separation of the control plane and data plane in networking. It provides scalability, programmability, and centralized control. It will use these traits to reach ubiquitous connectivity. Like all concepts software defined networking does not offer these advantages without a cost. By utilizing a centralized controller, a single point of failure is created. To address this issue, this paper proposes a distributed controller failover. This failover will provide a mechanism for recovery when controllers are not located in the same location. This failover mechanism is based on number of hops from orphan nodes to the controller in addition to the link connection. This mechanism was simulated in Long Term Evolution telecommunications architecture

Development of a Semi-Autonomous Robotic System to Assist Children with Autism in Developing Visual Perspective Taking Skills

Robot-assisted therapy has been successfully used to help children with Autism Spectrum Condition (ASC) develop their social skills, but very often with the robot being fully controlled remotely by an adult operator. Although this method is reliable and allows the operator to conduct a therapy session in a customised child-centred manner, it increases the cognitive workload on the human operator since it requires them to divide their attention between the robot and the child to ensure that the robot is responding appropriately to the child's behaviour. In addition, a remote-controlled robot is not aware of the information regarding the interaction with children (e.g., body gesture and head pose, proximity etc) and consequently it does not have the ability to shape live HRIs. Further to this, a remote-controlled robot typically does not have the capacity to record this information and additional effort is required to analyse the interaction data. For these reasons, using a remote-controlled robot in robot-assisted therapy may be unsustainable for long-term interactions. To lighten the cognitive burden on the human operator and to provide a consistent therapeutic experience, it is essential to create some degrees of autonomy and enable the robot to perform some autonomous behaviours during interactions with children. Our previous research with the Kaspar robot either implemented a fully autonomous scenario involving pairs of children, which then lacked the often important input of the supervising adult, or, in most of our research, has used a remote control in the hand of the adult or the children to operate the robot. Alternatively, this paper provides an overview of the design and implementation of a robotic system called Sense- Think-Act which converts the remote-controlled scenarios of our humanoid robot into a semi-autonomous social agent with the capacity to play games autonomously (under human supervision) with children in the real-world school settings. The developed system has been implemented on the humanoid robot Kaspar and evaluated in a trial with four children with ASC at a local specialist secondary school in the UK where the data of 11 Child-Robot Interactions (CRIs) was collected. The results from this trial demonstrated that the system was successful in providing the robot with appropriate control signals to operate in a semi-autonomous manner without any latency, which supports autonomous CRIs, suggesting that the proposed architecture appears to have promising potential in supporting CRIs for real-world applications.Peer reviewe