Produstion of middle wheel, by solid forming

Pavel Fic: Výroba středního kola objemovým tvářením. Bakalářská práce. Kombinované studium bakalářského studijního programu Strojírenství, Obor Strojírenské technologie. 3.ročník, letní semestr, akademický rok 2009/2010. FSI VUT v Brně, ÚST - odbor technologie tváření kovů a plastů, květen 2010, str. 57, obr. 49, tab. 11, 8 příloh. V této bakalářské práci je provedena detailní literární studie k tématu výroby středního kola objemovým tvářením za tepla - kováním. Dále je zpracován návrh technologie zápustkového kování řetězového kola č.v.: BP - 2010 - 01. K předpokládané sérii 30 tis. kusů za rok je volena technologie zápustkového kování na Svislém kovacím lisu. Ke zpracování technologického postupu byly provedeny nutné výpočty a navazující výkresová dokumentace a technicko ekonomické zhodnocení.Pavel Fic: Volume forming production from middlewheell. Bachelor thesis. Bachelors study.Combined study from bachelors study program – Engineering, specialization on manufacturing technology. 3.grade, summer semester , academical year 2009/2010. FME Brno UT in Brno, IMT – Department of Metal Forming, May 2010, 57 pages, 49 pictures, 11 table, 8 side orders. In this bachelors thesis is processed detail literary studies on thema volume hot-forming production of middlewheell – with drop forging technology. Next is made proposal from drop forging technology of stringwheell – drawing number BP – 2010 – 01. For presumption series 30 thousand pieces per year is choose drop forging technology in the vertical forging press. From technical procedure were made necessary calculations. These calculations are followed by drawing documentation and technical-economic evaluation.

The impact of wettability and fluid saturations on multiphase representative elementary volume estimations of micro-porous media

The occurrence of multi-phase flows in porous media is a complex phenomenon that involves multiple scales, ranging from individual pores to larger continuum scales. Upscaling frameworks have emerged as a response to the need for addressing the disparity between micro-scale processes and macroscopic modelling. Determination of the representative elementary volume is important for understanding fluid dynamics in micro-porous materials. The size of the representative elementary volume for multiphase flow in porous media is significantly affected by wettability and fluid saturations. Previous studies have overlooked this aspect by conducting simulations under conditions of constant medium wettability and fluid saturations. This study uses finite volume simulations with a volume of fluid approach for two distinct asymptotic homogenization methods, namely hydrodynamic bounds of relative permeability and thermodynamic bounds of entropy production. Strong wetting conditions with high wetting phase saturation were found to require a smaller sample size to establish representative elementary volume, while mixed-wettability scenarios necessitate the largest sample sizes. These findings improve our understanding of multiphase fluid flow behaviour in micro-porous materials and aid in enhancing techniques for scaling up observations and predictive modelling in engineering and environmental fields.Document Type: Short communicationCited as: Hussain, S. T., Regenauer-Lieb, K., Zhuravljov, A., Hussain, F., Rahman, S. S. The impact of wettability and fluid saturations on multiphase representative elementary volume estimations of micro-porous media. Capillarity, 2023, 9(1): 1-8. https://doi.org/10.46690/capi.2023.10.0

The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors

Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely efficient for economic viability given a relatively low value product and high 2E12 cell dose. Therefore, the aim of these studies was to define the productivity of an industry standard stirred-tank bioreactor and determine engineering limitations of commercial RBC production. Cord blood derived CD34+ cells were cultured under erythroid differentiation conditions in a stirred micro-bioreactor (ambr™). Enucleated cells of 80% purity could be created under optimal physical conditions: pH 7.5, 50% oxygen, without gas-sparging (which damaged cells) and with mechanical agitation (which directly increased enucleation). O2 consumption was low (~5x10(-8) µg/cell.hr) theoretically enabling erythroblast densities in excess of 5x10(8) /ml in commercial bioreactors and sub-10 L/unit production volumes. The bioreactor process achieved a 24% and 42% reduction in media volume and culture time respectively relative to unoptimized flask processing. However, media exchange limited productivity to 1 unit of erythroblasts per 500 L of media. Systematic replacement of media constituents, as well as screening for inhibitory levels of ammonia, lactate and key cytokines did not identify a reason for this limitation. We conclude that the properties of erythroblasts are such that the conventional constraints on cell manufacturing efficiency, such as mass transfer and metabolic demand, should not prevent high intensity production; furthermore this could be achieved in industry standard equipment. However, identification and removal of an inhibitory mediator is required to enable these economies to be realized

Ecodesign of Batch Processes: Optimal Design Strategies for Economic and Ecological Bioprocesses

This work deals with the multicriteria cost-environment design of multiproduct batch plants, where the design variables are the equipment item sizes as well as the operating conditions. The case study is a multiproduct batch plant for the production of four recombinant proteins. Given the important combinatorial aspect of the problem, the approach used consists in coupling a stochastic algorithm, indeed a Genetic Algorithm (GA) with a Discrete Event Simulator (DES). To take into account the conflicting situations that may be encountered at the earliest stage of batch plant design, i.e. compromise situations between cost and environmental consideration, a Multicriteria Genetic Algorithm (MUGA) was developed with a Pareto optimal ranking method. The results show how the methodology can be used to find a range of trade-off solutions for optimizing batch plant design

IT integration, operations flexibility and performance: an empirical study

Purpose: This study examines the relationship between IT implementation and performance with manufacturing flexibility based on a sample drawn from a set of manufacturing firms. Design/methodology/approach: The relationships were analyzed using structural equations modelling (SEM) using EQS 6.2 software. Previously, an explanatory factor analysis confirmed one-dimensionality of the scales, Cronbach’s alpha was calculated to evaluate its internal consistency and a confirmatory factor analysis was run to observe scales’ validity. Findings: This research proves a significant positive and direct effect of IT implementation on operations performance with 4 out of 6 flexibility dimensions (Machine, Labour, Material handling and Volume). Mix and Routing flexibility dimensions show no significant impact on firm performance. Research limitations/implications: It is necessary to be cautious when generalizing this findings these findings, as service firms were not part of the sample even when statistical results prove robustness suggesting that the findings are quite reliable. Some flexibility dimensions show no significant impact in performance (Routing and Mix flexibility). This is consistent with the fact that these flexibility dimensions act as variability absorbers within the manufacturing process. Future research lines: Future studies can focus on determining further internal and environmental factors that affect operations flexibility according to specific sector characteristics. Originality/value: This research proves a significant positive and direct effect of IT implementation on operations performance. Results show not only the links between IT implementation and operations performance, but also the magnitude of every impact. The model considers IT integration as the degree of alignment that existing technology resources in a firm have with the business strategy, in terms of importance and support for this strategyPeer Reviewe

Automated Additive Construction (AAC) for Earth and Space Using In-situ Resources

Using Automated Additive Construction (AAC), low-fidelity large-scale compressive structures can be produced out of a wide variety of materials found in the environment. Compressionintensive structures need not utilize materials that have tight specifications for internal force management, meaning that the production of the building materials do not require costly methods for their preparation. Where a certain degree of surface roughness can be tolerated, lower-fidelity numerical control of deposited materials can provide a low-cost means for automating building processes, which can be utilized in remote or extreme environments on Earth or in Space. For space missions where every kilogram of mass must be lifted out of Earth’s gravity well, the promise of using in-situ materials for the construction of outposts, facilities, and installations could prove to be enabling if significant reduction of payload mass can be achieved. In a 2015 workshop sponsored by the Keck nstitute for Space Studies, on the topic of Three Dimensional (3D) Additive Construction For Space Using In-situ Resources, was conducted with additive construction experts from around the globe in attendance. The workshop explored disparate efforts, methods, and technologies and established a proposed framework for the field of Additive Construction Using In-situ Resources. This paper defines the field of Automated Additive Construction Using In-situ Resources, describes the state-of-the-art for various methods, establishes a vision for future efforts, identifies gaps in current technologies, explores investment opportunities, and proposes potential technology demonstration missions for terrestrial, International Space Station (ISS), lunar, deep space zero-gravity, and Mars environments

Challenges in the industrialization process of low-volume production systems

A critical part of new product development projects is the industrialization process of new products which affects both time and the cost. The industrialization of new products or variants in low-volume production systems has some specific challenges which are caused by characteristics of low-volume products and production systems. Therefore, an exploratory case study is made within two Swedish manufacturing companies to understand these challenges and compare the industrialization process in high and low volume production systems. The results of the multiple case studies indicate four challenges including knowledge transfer from the projects into production, development of the work instructions, the need for a higher level of training of the operators and production system design and the obligatory tailoring of the new products to the existing production systems

The biologic digestion of garbage with sewage sludge

Bibliography: p. 105-109