Intelligent Systems

This book is dedicated to intelligent systems of broad-spectrum application, such as personal and social biosafety or use of intelligent sensory micro-nanosystems such as "e-nose", "e-tongue" and "e-eye". In addition to that, effective acquiring information, knowledge management and improved knowledge transfer in any media, as well as modeling its information content using meta-and hyper heuristics and semantic reasoning all benefit from the systems covered in this book. Intelligent systems can also be applied in education and generating the intelligent distributed eLearning architecture, as well as in a large number of technical fields, such as industrial design, manufacturing and utilization, e.g., in precision agriculture, cartography, electric power distribution systems, intelligent building management systems, drilling operations etc. Furthermore, decision making using fuzzy logic models, computational recognition of comprehension uncertainty and the joint synthesis of goals and means of intelligent behavior biosystems, as well as diagnostic and human support in the healthcare environment have also been made easier

Gene Regulatory Network Reconstruction Using Dynamic Bayesian Networks

High-content technologies such as DNA microarrays can provide a system-scale overview of how genes interact with each other in a network context. Various mathematical methods and computational approaches have been proposed to reconstruct GRNs, including Boolean networks, information theory, differential equations and Bayesian networks. GRN reconstruction faces huge intrinsic challenges on both experimental and theoretical fronts, because the inputs and outputs of the molecular processes are unclear and the underlying principles are unknown or too complex. In this work, we focused on improving the accuracy and speed of GRN reconstruction with Dynamic Bayesian based method. A commonly used structure-learning algorithm is based on REVEAL (Reverse Engineering Algorithm). However, this method has some limitations when it is used for reconstructing GRNs. For instance, the two-stage temporal Bayes network (2TBN) cannot be well recovered by application of REVEAL; it has low accuracy and speed for high dimensionality networks that has above a hundred nodes; and it even cannot accomplish the task of reconstructing a network with 400 nodes. We implemented an algorithm for DBN structure learning with Friedman\u27s score function to replace REVEAL, and tested it on reconstruction of both synthetic networks and real yeast networks and compared it with REVEAL in the absence or presence of preprocessed network generated by Zou and Conzen\u27s algorithm. The new score metric improved the precision and recall of GRN reconstruction. Networks of gene interactions were reconstructed using a Dynamic Bayesian Network (DBN) approach and were analyzed to identify the mechanism of chemical-induced reversible neurotoxicity through reconstruction of gene regulatory networks in earthworms with tools curating relevant genes from non-model organism\u27s pathway to model organism pathway

Efficient Decision Support Systems

This series is directed to diverse managerial professionals who are leading the transformation of individual domains by using expert information and domain knowledge to drive decision support systems (DSSs). The series offers a broad range of subjects addressed in specific areas such as health care, business management, banking, agriculture, environmental improvement, natural resource and spatial management, aviation administration, and hybrid applications of information technology aimed to interdisciplinary issues. This book series is composed of three volumes: Volume 1 consists of general concepts and methodology of DSSs; Volume 2 consists of applications of DSSs in the biomedical domain; Volume 3 consists of hybrid applications of DSSs in multidisciplinary domains. The book is shaped upon decision support strategies in the new infrastructure that assists the readers in full use of the creative technology to manipulate input data and to transform information into useful decisions for decision makers

A Comprehensive Survey on Particle Swarm Optimization Algorithm and Its Applications

Particle swarm optimization (PSO) is a heuristic global optimization method, proposed originally by Kennedy and Eberhart in 1995. It is now one of the most commonly used optimization techniques. This survey presented a comprehensive investigation of PSO. On one hand, we provided advances with PSO, including its modifications (including quantum-behaved PSO, bare-bones PSO, chaotic PSO, and fuzzy PSO), population topology (as fully connected, von Neumann, ring, star, random, etc.), hybridization (with genetic algorithm, simulated annealing, Tabu search, artificial immune system, ant colony algorithm, artificial bee colony, differential evolution, harmonic search, and biogeography-based optimization), extensions (to multiobjective, constrained, discrete, and binary optimization), theoretical analysis (parameter selection and tuning, and convergence analysis), and parallel implementation (in multicore, multiprocessor, GPU, and cloud computing forms). On the other hand, we offered a survey on applications of PSO to the following eight fields: electrical and electronic engineering, automation control systems, communication theory, operations research, mechanical engineering, fuel and energy, medicine, chemistry, and biology. It is hoped that this survey would be beneficial for the researchers studying PSO algorithms

Multi-agent system for flood forecasting in Tropical River Basin

It is well known, the problems related to the generation of floods, their control, and management, have been treated with traditional hydrologic modeling tools focused on the study and the analysis of the precipitation-runoff relationship, a physical process which is driven by the hydrological cycle and the climate regime and that is directly proportional to the generation of floodwaters. Within the hydrological discipline, they classify these traditional modeling tools according to three principal groups, being the first group defined as trial-and-error models (e.g., "black-models"), the second group are the conceptual models, which are categorized in three main sub-groups as "lumped", "semi-lumped" and "semi-distributed", according to the special distribution, and finally, models that are based on physical processes, known as "white-box models" are the so-called "distributed-models". On the other hand, in engineering applications, there are two types of models used in streamflow forecasting, and which are classified concerning the type of measurements and variables required as "physically based models", as well as "data-driven models". The Physically oriented prototypes present an in-depth account of the dynamics related to the physical aspects that occur internally among the different systems of a given hydrographic basin. However, aside from being laborious to implement, they rely thoroughly on mathematical algorithms, and an understanding of these interactions requires the abstraction of mathematical concepts and the conceptualization of the physical processes that are intertwined among these systems. Besides, models determined by data necessitates an a-priori understanding of the physical laws controlling the process within the system, and they are bound to mathematical formulations, which require a lot of numeric information for field adjustments. Therefore, these models are remarkably different from each other because of their needs for data, and their interpretation of physical phenomena. Although there is considerable progress in hydrologic modeling for flood forecasting, several significant setbacks remain unresolved, given the stochastic nature of the hydrological phenomena, is the challenge to implement user-friendly, re-usable, robust, and reliable forecasting systems, the amount of uncertainty they must deal with when trying to solve the flood forecasting problem. However, in the past decades, with the growing environment and development of the artificial intelligence (AI) field, some researchers have seldomly attempted to deal with the stochastic nature of hydrologic events with the application of some of these techniques. Given the setbacks to hydrologic flood forecasting previously described this thesis research aims to integrate the physics-based hydrologic, hydraulic, and data-driven models under the paradigm of Multi-agent Systems for flood forecasting by designing and developing a multi-agent system (MAS) framework for flood forecasting events within the scope of tropical watersheds. With the emergence of the agent technologies, the "agent-based modeling" and "multiagent systems" simulation methods have provided applications for some areas of hydro base management like flood protection, planning, control, management, mitigation, and forecasting to combat the shocks produced by floods on society; however, all these focused on evacuation drills, and the latter not aimed at the tropical river basin, whose hydrological regime is extremely unique. In this catchment modeling environment approach, it was applied the multi-agent systems approach as a surrogate of the conventional hydrologic model to build a system that operates at the catchment level displayed with hydrometric stations, that use the data from hydrometric sensors networks (e.g., rainfall, river stage, river flow) captured, stored and administered by an organization of interacting agents whose main aim is to perform flow forecasting and awareness, and in so doing enhance the policy-making process at the watershed level. Section one of this document surveys the status of the current research in hydrologic modeling for the flood forecasting task. It is a journey through the background of related concerns to the hydrological process, flood ontologies, management, and forecasting. The section covers, to a certain extent, the techniques, methods, and theoretical aspects and methods of hydrological modeling and their types, from the conventional models to the present-day artificial intelligence prototypes, making special emphasis on the multi-agent systems, as most recent modeling methodology in the hydrological sciences. However, it is also underlined here that the section does not contribute to an all-inclusive revision, rather its purpose is to serve as a framework for this sort of work and a path to underline the significant aspects of the works. In section two of the document, it is detailed the conceptual framework for the suggested Multiagent system in support of flood forecasting. To accomplish this task, several works need to be carried out such as the sketching and implementation of the system’s framework with the (Belief-Desire-Intention model) architecture for flood forecasting events within the concept of the tropical river basin. Contributions of this proposed architecture are the replacement of the conventional hydrologic modeling with the use of multi-agent systems, which makes it quick for hydrometric time-series data administration and modeling of the precipitation-runoff process which conveys to flood in a river course. Another advantage is the user-friendly environment provided by the proposed multi-agent system platform graphical interface, the real-time generation of graphs, charts, and monitors with the information on the immediate event taking place in the catchment, which makes it easy for the viewer with some or no background in data analysis and their interpretation to get a visual idea of the information at hand regarding the flood awareness. The required agents developed in this multi-agent system modeling framework for flood forecasting have been trained, tested, and validated under a series of experimental tasks, using the hydrometric series information of rainfall, river stage, and streamflow data collected by the hydrometric sensor agents from the hydrometric sensors.Como se sabe, los problemas relacionados con la generación de inundaciones, su control y manejo, han sido tratados con herramientas tradicionales de modelado hidrológico enfocados al estudio y análisis de la relación precipitación-escorrentía, proceso físico que es impulsado por el ciclo hidrológico y el régimen climático y este esta directamente proporcional a la generación de crecidas. Dentro de la disciplina hidrológica, clasifican estas herramientas de modelado tradicionales en tres grupos principales, siendo el primer grupo el de modelos empíricos (modelos de caja negra), modelos conceptuales (o agrupados, semi-agrupados o semi-distribuidos) dependiendo de la distribución espacial y, por último, los basados en la física, modelos de proceso (o "modelos de caja blanca", y/o distribuidos). En este sentido, clasifican las aplicaciones de predicción de caudal fluvial en la ingeniería de recursos hídricos en dos tipos con respecto a los valores y parámetros que requieren en: modelos de procesos basados en la física y la categoría de modelos impulsados por datos. Los modelos basados en la física proporcionan una descripción detallada de la dinámica relacionada con los aspectos físicos que ocurren internamente entre los diferentes sistemas de una cuenca hidrográfica determinada. Sin embargo, aparte de ser complejos de implementar, se basan completamente en algoritmos matemáticos, y la comprensión de estas interacciones requiere la abstracción de conceptos matemáticos y la conceptualización de los procesos físicos que se entrelazan entre estos sistemas. Además, los modelos impulsados por datos no requieren conocimiento de los procesos físicos que gobiernan, sino que se basan únicamente en ecuaciones empíricas que necesitan una gran cantidad de datos y requieren calibración de los datos en el sitio. Los dos modelos difieren significativamente debido a sus requisitos de datos y de cómo expresan los fenómenos físicos. La elaboración de modelos hidrológicos para el pronóstico de inundaciones ha dado grandes pasos, pero siguen sin resolverse algunos contratiempos importantes, dada la naturaleza estocástica de los fenómenos hidrológicos, es el desafío de implementar sistemas de pronóstico fáciles de usar, reutilizables, robustos y confiables, la cantidad de incertidumbre que deben afrontar al intentar resolver el problema de la predicción de inundaciones. Sin embargo, en las últimas décadas, con el entorno creciente y el desarrollo del campo de la inteligencia artificial (IA), algunos investigadores rara vez han intentado abordar la naturaleza estocástica de los eventos hidrológicos con la aplicación de algunas de estas técnicas. Dados los contratiempos en el pronóstico de inundaciones hidrológicas descritos anteriormente, esta investigación de tesis tiene como objetivo integrar los modelos hidrológicos, basados en la física, hidráulicos e impulsados por datos bajo el paradigma de Sistemas de múltiples agentes para el pronóstico de inundaciones por medio del bosquejo y desarrollo del marco de trabajo del sistema multi-agente (MAS) para los eventos de predicción de inundaciones en el contexto de cuenca hidrográfica tropical. Con la aparición de las tecnologías de agentes, se han emprendido algunos enfoques de simulación recientes en la investigación hidrológica con modelos basados en agentes y sistema multi-agente, principalmente en alerta por inundaciones, seguridad y planificación de inundaciones, control y gestión de inundaciones y pronóstico de inundaciones, todos estos enfocado a simulacros de evacuación, y este último no dirigido a la cuenca tropical, cuyo régimen hidrológico es extremadamente único. En este enfoque de entorno de modelado de cuencas, se aplican los enfoques de sistemas multi-agente como un sustituto del modelado hidrológico convencional para construir un sistema que opera a nivel de cuenca con estaciones hidrométricas desplegadas, que utilizan los datos de redes de sensores hidrométricos (por ejemplo, lluvia , nivel del río, caudal del río) capturado, almacenado y administrado por una organización de agentes interactuantes cuyo objetivo principal es realizar pronósticos de caudal y concientización para mejorar las capacidades de soporte en la formulación de políticas a nivel de cuenca hidrográfica. La primera sección de este documento analiza el estado del arte sobre la investigación actual en modelos hidrológicos para la tarea de pronóstico de inundaciones. Es un viaje a través de los antecedentes preocupantes relacionadas con el proceso hidrológico, las ontologías de inundaciones, la gestión y la predicción. El apartado abarca, en cierta medida, las técnicas, métodos y aspectos teóricos y métodos del modelado hidrológico y sus tipologías, desde los modelos convencionales hasta los prototipos de inteligencia artificial actuales, haciendo hincapié en los sistemas multi-agente, como un enfoque de simulación reciente en la investigación hidrológica. Sin embargo, se destaca que esta sección no contribuye a una revisión integral, sino que su propósito es servir de marco para este tipo de trabajos y una guía para subrayar los aspectos significativos de los trabajos. En la sección dos del documento, se detalla el marco de trabajo propuesto para el sistema multi-agente para el pronóstico de inundaciones. Los trabajos realizados comprendieron el diseño y desarrollo del marco de trabajo del sistema multi-agente con la arquitectura (modelo Creencia-Deseo-Intención) para la predicción de eventos de crecidas dentro del concepto de cuenca hidrográfica tropical. Las contribuciones de esta arquitectura propuesta son el reemplazo del modelado hidrológico convencional con el uso de sistemas multi-agente, lo que agiliza la administración de las series de tiempo de datos hidrométricos y el modelado del proceso de precipitación-escorrentía que conduce a la inundación en el curso de un río. Otra ventaja es el entorno amigable proporcionado por la interfaz gráfica de la plataforma del sistema multi-agente propuesto, la generación en tiempo real de gráficos, cuadros y monitores con la información sobre el evento inmediato que tiene lugar en la cuenca, lo que lo hace fácil para el espectador con algo o sin experiencia en análisis de datos y su interpretación para tener una idea visual de la información disponible con respecto a la cognición de las inundaciones. Los agentes necesarios desarrollados en este marco de modelado de sistemas multi-agente para el pronóstico de inundaciones han sido entrenados, probados y validados en una serie de tareas experimentales, utilizando la información de la serie hidrométrica de datos de lluvia, nivel del río y flujo del curso de agua recolectados por los agentes sensores hidrométricos de los sensores hidrométricos de campo.Programa de Doctorado en Ciencia y Tecnología Informática por la Universidad Carlos III de MadridPresidente: María Araceli Sanchis de Miguel.- Secretario: Juan Gómez Romero.- Vocal: Juan Carlos Corrale

An assessment on potential long-term health effects caused by antibiotic resistance marker genes in genetically modified organisms based on antibiotic usage and resistance patterns in Norway.

Source at https://vkm.no/Usage of antibiotics selects for resistant bacteria, resulting in reduced treatment options, and increased morbidity and mortality from microbial infections. Development of resistance in susceptible bacteria can occur through spontaneous mutation or horizontal gene transfer (HGT). Our current understanding of resistance development in bacterial pathogens is more descriptive than predictive in nature. That is, whereas the acquisition or development of new resistance determinants in bacteria can be retrospectively described relatively easily at the molecular, species and geographical distribution levels, the initial horizontal transfer events, the resistance gene donor, and the environmental location and conditions that produced the first generation of the resistant bacteria remain largely unknown. Without this latter knowledge and without a clear understanding of directional selection and genetic drift in natural bacterial populations, it is impossible to predict accurately further resistance development occurring through HGT. Some of the antibiotic resistance marker (ARM) genes used in the production of genetically modified organisms (GMO) encode resistance to antibiotics in clinical and veterinary use. Thus, concerns have been raised that the large-scale release of such genes in commercialized GMOs may increase the rate of, and broaden the locations where, bacteria horizontally acquire resistance genes

Environmental, health, and safety assessment of chemical alternatives during early process design: The role of predictive modeling and streamlined techniques

Industrial chemicals are important for many aspects of modern life, though they can be harmful to the environment and human health. Environmental or safety concerns identified during the early design and selection of chemicals could motivate choices as to safer alternatives and process setups. There is a growing interest in developing more rapid, and streamlined assessment methods to obtain a first indication of the potential impacts linked to the nature and use of industrial chemicals. This work applies predictive modeling and streamlined techniques to estimate the potential environmental, health, and safety hazards associated with specific chemical structures. The assessment is performed during the design and selection of promising candidates for a particular process as part of the computer-aided molecular design (CAMD) and process setup. The case of phase-change solvents used for post-combustion carbon capture is examined. Furthermore, the refinement of predictive models through the incorporation of knowledge already existing in the field (prior knowledge) is investigated. A procedure for knowledge extraction from scientific articles that applies text mining is proposed. The results show that incorporating impact assessment criteria into the CAMD facilitates the molecular design by enriching the Pareto front of candidates. The use of predictive models that estimate molecular properties, such as acute aquatic toxicity, bioconcentration, and persistency are found to support the identification of the optimal solvents for CO2 capture. Given the role of sustainability-related properties in tasks such as CAMD, the improved performance and the interpretability of the aquatic toxicity predictive models developed here and using prior knowledge are important. The process level assessment of the phase-change solvent systems indicated that phase-change solvent alternatives could provide benefits, not only in terms of reduced energy consumption but also lower impacts on human health and the environment. \ua0However, the degradation behaviors of these compounds should be properly assessed and controlled to ensure beneficial performances compared to conventional carbon capture solvents. Overall, predictive modeling and streamlined life-cycle assessments (LCAs), as well as environmental, health, and safety evaluation methods were revealed to be valuable for defining the critical aspects that influence the potential impacts of chemicals and in supporting decisions concerning the molecular and process designs

Sugar beet

Sugar beet has entered the age of liberalism with the abolition of production quotas in Europe. It finds itself on the world market and on an equal footing with sugar cane. France has benefited from the “AKER - Sugar beet 2020, a competitive innovation” Investments for the Future Programme, which aims to double the annual growth rate of the sugar yield per hectare of beet. It has made a scientific breakthrough by researching all of the genetic diversity available worldwide, and by carrying out genotyping before phenotyping. It is developing new genetic material, available for introduction into future sugar beet varieties. It also offers innovative tools and methods in the fields of genotyping and phenotyping, supporting players in the sector - beet growers and sugar manufacturers - in their imperative improvement in competitiveness. This book is mainly intended for scientists and professionals, and all those interested in research, development and training in the plant sector. It has just completed eight years of multidisciplinary work bringing together a hundred scientists. The AKER programme puts for a long time sugar beet in the top tier of cultivated species and helps to provide the consumer with quality sugar produced locally and under environmentally friendly conditions

Towards the improvement of machine learning peak runoff forecasting by exploiting ground- and satellite-based precipitation data: A feature engineering approach

La predicción de picos de caudal en sistemas montañosos complejos presenta desafíos en hidrología debido a la falta de datos y las limitaciones de los modelos físicos. El aprendizaje automático (ML) ofrece una solución al permitir la integración de técnicas y productos satelitales de precipitación (SPPs). Sin embargo, se ha debatido sobre la efectividad del ML debido a su naturaleza de "caja negra" que dificulta la mejora del rendimiento y la reproducibilidad de los resultados. Para abordar estas preocupaciones, se han propuesto estrategias de ingeniería de características (FE) para incorporar conocimiento físico en los modelos de ML, mejorando la comprensión y precisión de las predicciones. Esta investigación doctoral tiene como objetivo mejorar la predicción de picos de caudal mediante la integración de conceptos hidrológicos a través de técnicas de FE y el uso de datos de precipitación in-situ y SPPs. Se exploran técnicas y estrategias de ML para mejorar la precisión en sistemas hidrológicos macro y mesoescala. Además, se propone una estrategia de FE para aprovechar la información de SPPs y superar la escasez de datos espaciales y temporales. La integración de técnicas avanzadas de ML y FE representa un avance en hidrología, especialmente para sistemas montañosos complejos con limitada o nula red de monitoreo. Los hallazgos de este estudio serán valiosos para tomadores de decisiones e hidrólogos, facilitando la mitigación de los impactos de los picos de caudal. Además, las metodologías desarrolladas se pueden adaptar a otros sistemas de macro y mesoescala, beneficiando a la comunidad científica en general.Peak runoff forecasting in complex mountain systems poses significant challenges in hydrology due to limitations in traditional physically-based models and data scarcity. However, the integration of machine learning (ML) techniques offers a promising solution by balancing computational efficiency and enabling the incorporation of satellite precipitation products (SPPs). However, debates have emerged regarding the effectiveness of ML in hydrology, as its black-box nature lacks explicit representation of hydrological processes, hindering performance improvement and result reproducibility. To address these concerns, recent studies emphasize the inclusion of FE strategies to incorporate physical knowledge into ML models, enabling a better understanding of the system and improved forecasting accuracy. This doctoral research aims to enhance the effectiveness of ML in peak runoff forecasting by integrating hydrological concepts through FE techniques, utilizing both ground-based and satellite-based precipitation data. For this, we explore ML techniques and strategies to enhance accuracy in complex macro- and mesoscale hydrological systems. Additionally, we propose a FE strategy for a proper utilization of SPP information which is crucial for overcoming spatial and temporal data scarcity. The integration of advanced ML techniques and FE represents a significant advancement in hydrology, particularly for complex mountain systems with limited or inexistent monitoring networks. The findings of this study will provide valuable insights for decision-makers and hydrologists, facilitating effective mitigation of the impacts of peak runoffs. Moreover, the developed methodologies can be adapted to other macro- and meso-scale systems, with necessary adjustments based on available data and system-specific characteristics, thus benefiting the broader scientific community.0000-0002-7683-37680000-0002-6206-075XDoctor (PhD) en Recursos HídricosCuenc