100 research outputs found
DilatedFormer: dilated granularity transformer network for placental maturity grading in ultrasound
Placental maturity grading (PMG) is often utilized for evaluating fetal growth and maternal health. Currently, PMG often relied on the subjective judgment of the clinician, which is time-consuming and tends to incur a wrong estimation due to redundancy and repeatability of the process. The existing methods often focus on designing diverse hand-crafted features or combining deep features and hand-crafted features to learn a hybrid feature with an SVM for grading the placental maturity of ultrasound images. Motivated by the dominated performance of end-to-end convolutional neural networks (CNNs) at diverse medical imaging tasks, we devise a dilated granularity transformer network for learning multi-scale global transformer features for boosting PMG. Our network first devises dilated transformer blocks to learn multi-scale transformer features at each convolutional layer and then integrates these obtained multi-scale transformer features for predicting the final result of PMG. We collect 500 ultrasound images to verify our network, and experimental results show that our network clearly outperforms state-of-the-art methods on PMG. In the future, we will strive to improve the computational complexity and generalization ability of deep neural networks for PMG
Alternative methods for regulatory toxicology – a state-of-the-art review
This state-of-the art review is based on the final report of a project carried out by the European Commission’s Joint Research Centre (JRC) for the European Chemicals Agency (ECHA). The aim of the project was to review the state of the science of non-standard methods that are available for assessing the toxicological and ecotoxicological properties of chemicals. Non-standard methods refer to alternatives to animal experiments, such as in vitro tests and computational models, as well as animal methods that are not covered by current regulatory guidelines.
This report therefore reviews the current scientific status of non-standard methods for a range of human health and ecotoxicological endpoints, and provides a commentary on the mechanistic basis and regulatory applicability of these methods. For completeness, and to provide context, currently accepted (standard) methods are also summarised. In particular, the following human health endpoints are covered: a) skin irritation and corrosion; b) serious eye damage and eye irritation; c) skin sensitisation; d) acute systemic toxicity; e) repeat dose toxicity; f) genotoxicity and mutagenicity; g) carcinogenicity; h) reproductive toxicity (including effects on development and fertility); i) endocrine disruption relevant to human health; and j) toxicokinetics. In relation to ecotoxicological endpoints, the report focuses on non-standard methods for acute and chronic fish toxicity.
While specific reference is made to the information needs of REACH, the Biocidal Products Regulation and the Classification, Labelling and Packaging Regulation, this review is also expected to be informative in relation to the possible use of alternative and non-standard methods in other sectors, such as cosmetics and plant protection products.JRC.I.5-Systems Toxicolog
Biomedical applications of belief networks
Biomedicine is an area in which computers have long been expected to play a significant
role. Although many of the early claims have proved unrealistic, computers are gradually
becoming accepted in the biomedical, clinical and research environment. Within these
application areas, expert systems appear to have met with the most resistance, especially
when applied to image interpretation.In order to improve the acceptance of computerised decision support systems it is
necessary to provide the information needed to make rational judgements concerning
the inferences the system has made. This entails an explanation of what inferences
were made, how the inferences were made and how the results of the inference are to
be interpreted. Furthermore there must be a consistent approach to the combining of
information from low level computational processes through to high level expert analyses.nformation from low level computational processes through to high level expert analyses.
Until recently ad hoc formalisms were seen as the only tractable approach to reasoning
under uncertainty. A review of some of these formalisms suggests that they are less
than ideal for the purposes of decision making. Belief networks provide a tractable way
of utilising probability theory as an inference formalism by combining the theoretical
consistency of probability for inference and decision making, with the ability to use the
knowledge of domain experts.nowledge of domain experts.
The potential of belief networks in biomedical applications has already been recog¬
nised and there has been substantial research into the use of belief networks for medical
diagnosis and methods for handling large, interconnected networks. In this thesis the use
of belief networks is extended to include detailed image model matching to show how,
in principle, feature measurement can be undertaken in a fully probabilistic way. The
belief networks employed are usually cyclic and have strong influences between adjacent
nodes, so new techniques for probabilistic updating based on a model of the matching
process have been developed.An object-orientated inference shell called FLAPNet has been implemented and used
to apply the belief network formalism to two application domains. The first application is
model-based matching in fetal ultrasound images. The imaging modality and biological
variation in the subject make model matching a highly uncertain process. A dynamic,
deformable model, similar to active contour models, is used. A belief network combines
constraints derived from local evidence in the image, with global constraints derived from
trained models, to control the iterative refinement of an initial model cue.In the second application a belief network is used for the incremental aggregation of
evidence occurring during the classification of objects on a cervical smear slide as part of
an automated pre-screening system. A belief network provides both an explicit domain
model and a mechanism for the incremental aggregation of evidence, two attributes
important in pre-screening systems.Overall it is argued that belief networks combine the necessary quantitative features
required of a decision support system with desirable qualitative features that will lead
to improved acceptability of expert systems in the biomedical domain
Novel Therapeutic Concepts in Targeting Glioma
Novel Therapeutic Concepts for Targeting Glioma offers a comprehensive collection of current information and the upcoming possibilities for designing new therapies for Glioma by an array of experts ranging from Cell Biologists to Oncologists and Neurosurgeons. A variety of topics cover therapeutic strategies based on Cell Signaling, Gene Therapy, Drug Therapy and Surgical methods providing the reader with a unique opportunity to expand and advance his knowledge of the field
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