Multi-scale cellular engineering: From molecules to organ-on-a-chip.

Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems. Here, we summarize the state of advances at the molecular, cellular, and multi-cellular levels using experimental and computational tools. The areas of focus include intrinsically disordered proteins, synthetic proteins, spatiotemporally dynamic extracellular matrices, organ-on-a-chip approaches, and computational modeling, which all have tremendous potential for advancing fundamental and translational science. Perspectives on the current limitations and future directions are also described, with the goal of stimulating interest to overcome these hurdles using multi-disciplinary approaches

Cost engineering for manufacturing: current and future research

The article aims to identify the scientific challenges and point out future research directions on Cost Engineering. The research areas covered in this article include Design Cost; Manufacturing Cost; Operating Cost; Life Cycle Cost; Risk and Uncertainty management and Affordability Engineering. Collected information at the Academic Forum on Cost Engineering held at Cranfield University in 2008 and further literature review findings are presented. The forum set the scope of the Cost Engineering research, a brainstorming was held on the forum and literatures were further reviewed to understand the current and future practices in cost engineering. The main benefits of the article include coverage of the current research on cost engineering from different perspectives and the future research areas on Cost Engineering

Advanced Techniques for Design and Manufacturing in Marine Engineering

Modern engineering design processes are driven by the extensive use of numerical simulations; naval architecture and ocean engineering are no exception. Computational power has been improved over the last few decades; therefore, the integration of different tools such as CAD, FEM, CFD, and CAM has enabled complex modeling and manufacturing problems to be solved in a more feasible way. Classical naval design methodology can take advantage of this integration, giving rise to more robust designs in terms of shape, structural and hydrodynamic performances, and the manufacturing process.This Special Issue invites researchers and engineers from both academia and the industry to publish the latest progress in design and manufacturing techniques in marine engineering and to debate the current issues and future perspectives in this research area. Suitable topics for this issue include, but are not limited to, the following:CAD-based approaches for designing the hull and appendages of sailing and engine-powered boats and comparisons with traditional techniques;Finite element method applications to predict the structural performance of the whole boat or of a portion of it, with particular attention to the modeling of the material used;Embedded measurement systems for structural health monitoring;Determination of hydrodynamic efficiency using experimental, numerical, or semi-empiric methods for displacement and planning hulls;Topology optimization techniques to overcome traditional scantling criteria based on international standards;Applications of additive manufacturing to derive innovative shapes for internal reinforcements or sandwich hull structures

The 2021 flexible and printed electronics roadmap

This roadmap includes the perspectives and visions of leading researchers in the key areas of flexible and printable electronics. The covered topics are broadly organized by the device technologies (sections 1–9), fabrication techniques (sections 10–12), and design and modeling approaches (sections 13 and 14) essential to the future development of new applications leveraging flexible electronics (FE). The interdisciplinary nature of this field involves everything from fundamental scientific discoveries to engineering challenges; from design and synthesis of new materials via novel device design to modelling and digital manufacturing of integrated systems. As such, this roadmap aims to serve as a resource on the current status and future challenges in the areas covered by the roadmap and to highlight the breadth and wide-ranging opportunities made available by FE technologies

Electrospinning for healthcare: recent advancements

Electrospinning is a simple route to generate polymer-based fibres with diameters on the nano- to micron-scale. It has been very widely explored in biomedical science for applications including drug delivery systems, diagnostic imaging, theranostics, and tissue engineering. This extensive literature reveals that a diverse range of functional components including small molecule drugs, biologics, and nanoparticles can be incorporated into electrospun fibres, and it is possible to prepare materials with complex compartmentalised architectures. This perspective article briefly introduces the electrospinning technique before considering its potential applications in biomedicine. Particular attention is paid to the translation of electrospinning to the clinic, including the need to produce materials at large scale and the requirement to do so under Good Manufacturing Practice conditions. We finish with a summary of the key current challenges and future perspectives

Experimental characterization of a new class of polymeric-wire coiled transducers

The recent discovery of a new kind of thermo-Active coiled polymeric wires has opened new perspectives for the implementation of a novel class of actuators that can be easily and effectively manufactured using low-cost materials such as sewing threads or finishing lines. These new devices feature large displacements in response to temperature variations and show very promising performance in terms of energy and power densities. With the aim of providing information and data useful for the future engineering applications of polymeric coiled actuators, a custom experimental test-bench and procedure have been developed and employed to characterise their thermo-mechanical response. Such a test-bench has been designed to run isothermal and isometric tensile tests on a set of sample actuators that are fabricated with a repeatable process. This paper provides technical details on the manufacturing process of such sample actuators and on the design and operation of the test-bench. Preliminary experimental results are finally reported

IDeS Method Applied to an Innovative Motorbike—Applying Topology Optimization and Augmented Reality

This study is on the conception of the DS700 HYBRID project by the application of the Industrial Design Structure method (IDeS), which applies different tools sourced from engineering and style departments, including QFD and SDE, used to create the concept of a hybrid motorbike that could reach the market in the near future. SDE is an engineering approach for the design and development of industrial design projects, and it finds important applications in the automotive sector. In addition, analysis tools such as QFD, comprising benchmarking and top-flop analysis are carried out to maximize the creative process. The key characteristics of the bike and the degree of innovation are identified and outlined, the market segment is identified, and the stylistic trends that are most suitable for a naked motorbike of the future are analyzed. In the second part the styling of each superstructure and of all the components of the vehicle is carried out. Afterwards the aesthetics and engineering perspectives are accounted for to complete the project. This is achieved with modelling and computing tools such as 3D CAD, visual renderings, and FEM simulations, and virtual prototyping thanks to augmented reality (AR), and finally physical prototyping with the use of additive manufacturing (AM). The result is a product conception able to compete in the present challenging market, with a design that is technically feasible and also reaches new lightness targets for efficiency

Perspectives of Integrated “Next Industrial Revolution” Clusters in Poland and Siberia

Rozdział z: Functioning of the Local Production Systems in Central and Eastern European Countries and Siberia. Case Studies and Comparative Studies, ed. Mariusz E. Sokołowicz.The paper presents the mapping of potential next industrial revolution clusters in Poland and Siberia. Deindustrialization of the cities and struggles with its consequences are one of the fundamental economic problems in current global economy. Some hope to find an answer to that problem is associated with the idea of next industrial revolution and reindustrialization initiatives. In the paper, projects aimed at developing next industrial revolution clusters are analyzed. The objective of the research was to examine new industrial revolution paradigm as a platform for establishing university-based trans-border industry clusters in Poland and Siberia47 and to raise awareness of next industry revolution initiatives.Monograph financed under a contract of execution of the international scientific project within 7th Framework Programme of the European Union, co-financed by Polish Ministry of Science and Higher Education (title: “Functioning of the Local Production Systems in the Conditions of Economic Crisis (Comparative Analysis and Benchmarking for the EU and Beyond”)). Monografia sfinansowana w oparciu o umowę o wykonanie projektu między narodowego w ramach 7. Programu Ramowego UE, współfinansowanego ze środków Ministerstwa Nauki i Szkolnictwa Wyższego (tytuł projektu: „Funkcjonowanie lokalnych systemów produkcyjnych w warunkach kryzysu gospodarczego (analiza porównawcza i benchmarking w wybranych krajach UE oraz krajach trzecich”))