43 research outputs found
Systematic Approaches for Telemedicine and Data Coordination for COVID-19 in Baja California, Mexico
Conference proceedings info:
ICICT 2023: 2023 The 6th International Conference on Information and Computer Technologies
Raleigh, HI, United States, March 24-26, 2023
Pages 529-542We provide a model for systematic implementation of telemedicine within a large evaluation center for COVID-19 in the area of Baja California, Mexico. Our model is based on human-centric design factors and cross disciplinary collaborations for scalable data-driven enablement of smartphone, cellular, and video Teleconsul-tation technologies to link hospitals, clinics, and emergency medical services for point-of-care assessments of COVID testing, and for subsequent treatment and quar-antine decisions. A multidisciplinary team was rapidly created, in cooperation with different institutions, including: the Autonomous University of Baja California, the Ministry of Health, the Command, Communication and Computer Control Center
of the Ministry of the State of Baja California (C4), Colleges of Medicine, and the College of Psychologists. Our objective is to provide information to the public and to evaluate COVID-19 in real time and to track, regional, municipal, and state-wide data in real time that informs supply chains and resource allocation with the anticipation of a surge in COVID-19 cases. RESUMEN Proporcionamos un modelo para la implementación sistemática de la telemedicina dentro de un gran centro de evaluación de COVID-19 en el área de Baja California, México. Nuestro modelo se basa en factores de diseño centrados en el ser humano y colaboraciones interdisciplinarias para la habilitación escalable basada en datos de tecnologías de teleconsulta de teléfonos inteligentes, celulares y video para vincular hospitales, clínicas y servicios médicos de emergencia para evaluaciones de COVID en el punto de atención. pruebas, y para el tratamiento posterior y decisiones de cuarentena. Rápidamente se creó un equipo multidisciplinario, en cooperación con diferentes instituciones, entre ellas: la Universidad Autónoma de Baja California, la Secretaría de Salud, el Centro de Comando, Comunicaciones y Control Informático.
de la Secretaría del Estado de Baja California (C4), Facultades de Medicina y Colegio de Psicólogos. Nuestro objetivo es proporcionar información al público y evaluar COVID-19 en tiempo real y rastrear datos regionales, municipales y estatales en tiempo real que informan las cadenas de suministro y la asignación de recursos con la anticipación de un aumento de COVID-19. 19 casos.ICICT 2023: 2023 The 6th International Conference on Information and Computer Technologieshttps://doi.org/10.1007/978-981-99-3236-
Collected Papers (on various scientific topics), Volume XIII
This thirteenth volume of Collected Papers is an eclectic tome of 88 papers in various fields of sciences, such as astronomy, biology, calculus, economics, education and administration, game theory, geometry, graph theory, information fusion, decision making, instantaneous physics, quantum physics, neutrosophic logic and set, non-Euclidean geometry, number theory, paradoxes, philosophy of science, scientific research methods, statistics, and others, structured in 17 chapters (Neutrosophic Theory and Applications; Neutrosophic Algebra; Fuzzy Soft Sets; Neutrosophic Sets; Hypersoft Sets; Neutrosophic Semigroups; Neutrosophic Graphs; Superhypergraphs; Plithogeny; Information Fusion; Statistics; Decision Making; Extenics; Instantaneous Physics; Paradoxism; Mathematica; Miscellanea), comprising 965 pages, published between 2005-2022 in different scientific journals, by the author alone or in collaboration with the following 110 co-authors (alphabetically ordered) from 26 countries: Abduallah Gamal, Sania Afzal, Firoz Ahmad, Muhammad Akram, Sheriful Alam, Ali Hamza, Ali H. M. Al-Obaidi, Madeleine Al-Tahan, Assia Bakali, Atiqe Ur Rahman, Sukanto Bhattacharya, Bilal Hadjadji, Robert N. Boyd, Willem K.M. Brauers, Umit Cali, Youcef Chibani, Victor Christianto, Chunxin Bo, Shyamal Dalapati, Mario Dalcín, Arup Kumar Das, Elham Davneshvar, Bijan Davvaz, Irfan Deli, Muhammet Deveci, Mamouni Dhar, R. Dhavaseelan, Balasubramanian Elavarasan, Sara Farooq, Haipeng Wang, Ugur Halden, Le Hoang Son, Hongnian Yu, Qays Hatem Imran, Mayas Ismail, Saeid Jafari, Jun Ye, Ilanthenral Kandasamy, W.B. Vasantha Kandasamy, Darjan Karabašević, Abdullah Kargın, Vasilios N. Katsikis, Nour Eldeen M. Khalifa, Madad Khan, M. Khoshnevisan, Tapan Kumar Roy, Pinaki Majumdar, Sreepurna Malakar, Masoud Ghods, Minghao Hu, Mingming Chen, Mohamed Abdel-Basset, Mohamed Talea, Mohammad Hamidi, Mohamed Loey, Mihnea Alexandru Moisescu, Muhammad Ihsan, Muhammad Saeed, Muhammad Shabir, Mumtaz Ali, Muzzamal Sitara, Nassim Abbas, Munazza Naz, Giorgio Nordo, Mani Parimala, Ion Pătrașcu, Gabrijela Popović, K. Porselvi, Surapati Pramanik, D. Preethi, Qiang Guo, Riad K. Al-Hamido, Zahra Rostami, Said Broumi, Saima Anis, Muzafer Saračević, Ganeshsree Selvachandran, Selvaraj Ganesan, Shammya Shananda Saha, Marayanagaraj Shanmugapriya, Songtao Shao, Sori Tjandrah Simbolon, Florentin Smarandache, Predrag S. Stanimirović, Dragiša Stanujkić, Raman Sundareswaran, Mehmet Șahin, Ovidiu-Ilie Șandru, Abdulkadir Șengür, Mohamed Talea, Ferhat Taș, Selçuk Topal, Alptekin Ulutaș, Ramalingam Udhayakumar, Yunita Umniyati, J. Vimala, Luige Vlădăreanu, Ştefan Vlăduţescu, Yaman Akbulut, Yanhui Guo, Yong Deng, You He, Young Bae Jun, Wangtao Yuan, Rong Xia, Xiaohong Zhang, Edmundas Kazimieras Zavadskas, Zayen Azzouz Omar, Xiaohong Zhang, Zhirou Ma.
Colorectal Cancer Biology
Colorectal cancer is a common disease, affecting millions worldwide and represents a global health problem. Effective therapeutic solutions and control measures for the disease will come from the collective research efforts of clinicians and scientists worldwide. This book presents the current status of the strides being made to understand the fundamental scientific basis of colorectal cancer. It provides contributions from scientists, clinicians and investigators from 20 different countries. The four sections of this volume examine the evidence and data in relation to genes and various polymorphisms, tumor microenvironment and infections associated with colorectal cancer. An increasingly better appreciation of the complex inter-connected basic biology of colorectal cancer will translate into effective measures for management and treatment of the disease. Research scientists and investigators as well as clinicians searching for a good understanding of the disease will find this book useful
How digital data are used in the domain of health: A short review of current knowledge
In the era of digitalization, digital data is available about every aspect of our daily lives,
including our physical and mental health. Digital data has been applied in the domain of healthcare
for the detection of an outbreak of infectious diseases, clinical decision support, personalized care, and genomics. This paper will serve as a review of the rapidly evolving field of digital health. More specifically, we will discuss (1) big data and physical health, (2) big data and mental health, (3) digital contact tracing during the COVID-19 pandemic, and finally, (4) ethical issues with using digital data for health-related purposes. With this review, we aim to stimulate a public debate on the appropriate usage of digital data in the health sector
Recent Application in Biometrics
In the recent years, a number of recognition and authentication systems based on biometric measurements have been proposed. Algorithms and sensors have been developed to acquire and process many different biometric traits. Moreover, the biometric technology is being used in novel ways, with potential commercial and practical implications to our daily activities. The key objective of the book is to provide a collection of comprehensive references on some recent theoretical development as well as novel applications in biometrics. The topics covered in this book reflect well both aspects of development. They include biometric sample quality, privacy preserving and cancellable biometrics, contactless biometrics, novel and unconventional biometrics, and the technical challenges in implementing the technology in portable devices. The book consists of 15 chapters. It is divided into four sections, namely, biometric applications on mobile platforms, cancelable biometrics, biometric encryption, and other applications. The book was reviewed by editors Dr. Jucheng Yang and Dr. Norman Poh. We deeply appreciate the efforts of our guest editors: Dr. Girija Chetty, Dr. Loris Nanni, Dr. Jianjiang Feng, Dr. Dongsun Park and Dr. Sook Yoon, as well as a number of anonymous reviewers
Risk Management for the Future
A large part of academic literature, business literature as well as practices in real life are resting on the assumption that uncertainty and risk does not exist. We all know that this is not true, yet, a whole variety of methods, tools and practices are not attuned to the fact that the future is uncertain and that risks are all around us. However, despite risk management entering the agenda some decades ago, it has introduced risks on its own as illustrated by the financial crisis. Here is a book that goes beyond risk management as it is today and tries to discuss what needs to be improved further. The book also offers some cases
Development of Quantum-Crystallographic Methods for Chemical and Biochemical Applications
The field of crystallography is a key branch of natural sciences, important not only for physics, geology, biology or chemistry, but it also provides crucial information for life sciences and materials science. It laid the foundations of our textbook knowledge of matter in general. In this thesis, the field of quantum crystallography – a synergistic approach of crystallography and quantum mechanics – is used as a tool to predict and understand processes of molecules and their interactions. New methods are proposed and used that provide deeper insight into the influence of local molecular environments on molecules and allows advanced predictions of the biochemical effect of drugs. Ultimately, this means that we can now understand interactions between molecules in crystal structures more completely that were long thought to be fully characterized.
As part of this work, new software was developed to handle theoretical simulations as well as experimental data – and also both of them together at the same time. The introduction of non-spherical refinements in standard software for crystallography opens the field of quantum crystallography to a wide audience and will hopefully strengthen the mutual ground between experimentalists and theoreticians. Specifically, we created a new native interface between Olex2 and non-spherical refinement techniques, which we called NoSpherA2. This interface has been designed in such a way that it can be used for any kind of non-spherical atom descriptions. This will allow refinement of modern diffraction data employing modern quantum crystallographic models, leaving behind the century old Independent Atom Model (IAM).
New software was also developed to provide novel models and descriptors for understanding environmental effects on the electron density and electrostatic potential of a molecule. This so-called Quantum Crystallographic Toolbox (QCrT) provides a framework for the fast and easy implementation of various methods and descriptors. File conversion tools allow the interfacing with many existing software packages and might provide useful
information for future method development, experimental setups and data evaluation, as well as chemical insight into intra- and intermolecular interactions. It is fully parallelized and portable to graphic card processors (GPUs), which provide extraordinary amounts of computational power with moderate resource requirements. Especially in the context of ultra-bright X-ray sources like X-ray free electron lasers and electron diffraction these new
models become crucial to have a better description of experimental findings. In applying this new framework of quantum crystallographic methods, we analyze a type of bonding at the edge of conventional organic chemistry: The push-pull systems of ethylenes. We show how X-ray constrained bonding analysis leads to the unambiguous determination of the behavior and type of bonding present in a series of compounds which are contradicting the Lewis-picture of a double-bond.
This new understanding has led to the development of a new potential drug, namely a silicon analogue of ibuprofen; one of the most important drugs known to humankind. We determined its physical properties, investigated its stability and potency as a more soluble and novel alternative of ibuprofen: While retaining the same pharmaceutical activity of ibuprofen, making it a bioisoster for ibuprofen, this material shows a better applicability in aqueous media
The role of pre-receptor steroid metabolism in the therapeutic application of glucocorticoids
Glucocorticoids (GCs) are widely used in the treatment of chronic inflammatory diseases such as rheumatoid arthritis (RA). Unfortunately, their application is limited by side effects including GC-induced osteoporosis (GIO). The GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been shown to mediate side effects associated with therapeutic GCs, suggesting that 11β-HSD1 inhibition may be effective in managing their deleterious side effect profile. In this thesis, I have examined the contribution of 11β-HSD1 to therapeutic actions and off target bone side effects of therapeutic GCs in the TNF-transgenic (TNF-tg) murine model of chronic polyarthritis. TNF-tg animals receiving the GC corticosterone in drinking water (100 mg/L) demonstrated a significant reduction in markers of inflammation, disease activity, synovitis and inflammatory bone loss. In contrast, TNF-tg animals with transgenic deletion of 11β-HSD1 (TNF11βKO) showed a marked resistance to GC-induced changes showing more severe, persistent inflammation and inflammatory bone loss, despite being protected from GIO driven by suppression of anabolic bone formation. Local and systemic bone loss in TNF11βKO animals receiving GCs, was underpinned by increased inflammatory activation of osteoclasts. This study demonstrates a fundamental role for 11β-HSD1 in mediating the anti-inflammatory and bone protective actions of therapeutic GCs in murine models of chronic polyarthritis
Mass Spectrometry-Based Characterization, Quantitation, And Repair Investigations Of Complex DNA Lesions
University of Minnesota Ph.D. dissertation. March 2018. Major: Medicinal Chemistry. Advisor: Natalia Tretyakova. 1 computer file (PDF); xxv, 359 pages.DNA is constantly under the threat of damage by various endogenous and exogenous agents, leading to the structural modification of nucleobases (DNA adducts). These DNA adducts can range from smaller nucleoside monoadducts and exocyclic adducts, to the helix distorting and super-bulky DNA-DNA cross-links and DNA-protein cross-links. If not repaired, DNA adducts can inhibit crucial biological processes such as DNA replication, leading to adverse consequences such as mutagenesis and carcinogenesis. Therefore, understanding the atomic connectivity, extent of formation, and repair of DNA adducts is crucial to fully elucidating the biological consequences of the adduct. DNA-protein cross-links (DPCs) are ubiquitous, super-bulky DNA lesions that form when proteins become irreversibly trapped on chromosomal DNA. The structural complexity of cross-linking and the diversity of proteins susceptible to DPC formation represents significant challenges to studying the biological consequence of these adducts. In the first part of the thesis, we identified the protein constituents, structural characterized and quantified, and investigated the repair mechanism of bis-electrophile (Chapter 2) and reactive oxygen species (ROS, Chapters 3 and 4)-induced DPCs. In Chapter 2, we investigated DPC formation after exposure to N,N-bis-(2-chloroethyl)-phosphorodiamidic acid (phosphoramide mustard, PM) and N,N-bis-(2-chloroethyl)-ethylamine (nornitrogen mustard, NOR), the two biologically active metabolites of the antitumor agent cyclophosphamide. A mass spectrometry-based proteomics approach was employed to characterize the protein constituents of PM- and NOR-mediated DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. HPLC-ESI+-MS/MS analysis of proteolytic digests of DPC-containing DNA from NOR-treated cells revealed a concentration-dependent formation of N-[2-[cysteinyl]ethyl]-N-[2-(guan-7-yl)ethyl]amine (Cys-NOR-N7G) conjugates, confirming that it cross-links cysteine thiols of proteins to the N-7 position of guanines in DNA. A sensitive and accurate Cys-NOR-N7G isotope dilution tandem mass spectrometry assay was developed to quantify PM-induced DPC formation and repair in mammalian cells proficient or deficient in a DNA repair pathway. In Chapters 3, we employed the model of left anterior descending artery ligation/reperfusion surgery in rat to show that ischemia/reperfusion injury is associated with the formation of hydroxyl radical-induced DNA-protein cross-links (DPCs) in cardiomyocytes. Mass spectrometry based experiments revealed that these conjugates were formed by a free radical mechanism and involved thymidine residues of DNA and tyrosine side chains of proteins (dT-Tyr). Quantitative proteomics experiments utilizing Tandem mass tags (TMT) revealed that radical-induced DPC formation increase after LAD-ligation/reperfusion compared to the control sham surgery. Using the developed dT-Tyr nanoLC-ESI+-MS/MS assay, we investigated the role of the metalloprotease Spartan (SPRTN) in the repair of radical-induced DPCs (Chapter 4). Analysis of the brain, liver, heart, and kidneys of wild type (SPRTN+/+) and hypomorphic (SPRTN f/-) mice revealed a 1.5 – 2-fold increase in dT-Tyr in the hypomorphic mice, providing direct evidence that Spartan plays a role in the repair of radical-induced DPCs. Finally, we investigated the formation of formamidopyrimidine (FAPy) adducts after exposure to 3,4-epoxybutene, an epoxide metabolite of the known carcinogen 1,3-butadiene (Chapter 5). We successfully synthesized and structurally characterized a novel BD-induced DNA adduct EB-FAPy-dG, and developed a sensitive isotope dilution tandem mass spectrometry assay for its detection in vitro and in cells. To our knowledge, this is the first report of a BD-induced FAPy adduct, and future studies will examine whether BD-induced FAPy adducts In summary, during the course of this Thesis, we utilized mass spectrometry-based proteomics techniques to identify the proteins susceptible to PM- and ROS-induced DPC formation. After structurally characterizing the atomic connectivity of these adduces, we developed sensitive and accurate isotope dilution tandem mass spectrometry assays to perform absolute quantitation of PM- and ROS-induced DPC formation in cells and tissues. These assays were further utilized to begin investigating the repair mechanism of DPCs in cells and tissues, including providing direct evidence that the metalloprotease Spartan is involved in the repair of radical-induced DPCs. Finally, we detected EB-FAPy-dG formation in vitro and in vivo, the first evidence of 1,3-butadiene induced formamidopyrimidine formation