Modeling and Control of a Magnetic Drug Delivery System

Therapeutic operation risk has been reduced by the use of micro-robots, allowing highly invasive surgery to be replaced by low invasive surgery (LIS), which provides an effective tool even in previously inaccessible parts of the human body. LIS techniques help delivering drugs effectively via micro-carriers. The micro-carriers are divided into two groups: tethered devices, which are supported by internally supplied propulsion mechanism, and untethered devices. Remote actuation is the critical issue in micro-device navigation, especially through blood vessels. To achieve remote control within the cardiovascular system, magnetic propulsion offers an advantage over other proposed actuation methods. In the literature, most research has focused on micro-device structural design, while there is a lack of research into design and analysis of combined structure and control. As the main part, integrating the principle of electromagnetic induced force by feedback control design will lead to the desired automatic movement. An actuator configuration should thus first be designed to initiate the desired force. The design is basically defining the type and placement of a set of coils to achieve an operational goal. In this project, the magnetic actuation is initiated by a combination of four electromagnets and two sets of uniform coils. Preliminary studies on 2D navigation of a ferromagnetic particle are used to show the effect of actuator structure on controller performance. Accordingly, the performance of the four electromagnets combination is compared to the proposed augmented structure with uniform coils. The simulation results show the improved efficiency of the augmented structure. In more general cases, the arrangement and number of electromagnets are unknown and should be defined. An optimization method is suggested to find these variables when the working space is maximized. Finally, the problem of robust output regulation of the electromagnetic system driven by a linear exosystem, is also addressed in this project. The exosystem is assumed to be neutrally stable with unknown frequencies. The parallel connection of two controllers, a robust stabilizer and an internal model-based controller, is presented to eliminate the output error. In the latter one, an adaptation is used to tune the internal model frequencies such that a steady-state control is produced to maintain the output-zeroing condition. The robust regulation with a local domain of convergence is achieved for a special class of decomposable MIMO nonlinear minimum-phase system. The simulation results show the effectiveness and robustness of this method for the electromagnetic system when two different paths are considered

Feedback control of three-dimensional bluff body wakes for efficient drag reduction

The wakes of bluff bodies, such as automotive vehicles, exhibit complex behaviour due to three-dimensionality and high Reynolds numbers, and are furthermore responsible for significant aerodynamic drag. There are significant environmental and economic incentives for reducing drag, however practicalities limit the extent to which this can be achieved through changes to the vehicle shape. This motivates the use of active feedback control methods that modify the flow directly, without significant geometric changes. In this thesis we develop feedback control strategies for two generic three-dimensional bluff bodies, a bullet-shaped body and the widely used Ahmed body. After first applying an extremum-seeking controller to a pre-existing open-loop strategy, we then examine the control of specific coherent structures within the wakes. Two such structures understood to be related to the drag are the static symmetry breaking (SB) mode and the quasi-oscillatory vortex shedding. The former of these is observed as a large-scale asymmetry within the recirculating region. We find, through simultaneous surface pressure and wake velocity measurements, that both the SB mode and vortex shedding may be observed in real-time using practical pressure sensors. Through the use of forcing flaps, we further demonstrate that we are able to strongly interact with both these coherent structures. Statically deflected flaps also prove effective at drag reduction under cross-wind conditions. In order to guide feedback controller design, we develop stochastic models for each of the coherent structures, describing their dynamics and response to forcing. Controllers are then implemented, achieving an efficient drag reduction of 2% when suppressing the asymmetry of the SB mode. Vortex shedding control proved ineffective at drag reduction, despite the suppression of measured fluctuations around the frequency at which oscillations are observed.Open Acces

A COLLISION AVOIDANCE SYSTEM FOR AUTONOMOUS UNDERWATER VEHICLES

The work in this thesis is concerned with the development of a novel and practical collision avoidance system for autonomous underwater vehicles (AUVs). Synergistically, advanced stochastic motion planning methods, dynamics quantisation approaches, multivariable tracking controller designs, sonar data processing and workspace representation, are combined to enhance significantly the survivability of modern AUVs. The recent proliferation of autonomous AUV deployments for various missions such as seafloor surveying, scientific data gathering and mine hunting has demanded a substantial increase in vehicle autonomy. One matching requirement of such missions is to allow all the AUV to navigate safely in a dynamic and unstructured environment. Therefore, it is vital that a robust and effective collision avoidance system should be forthcoming in order to preserve the structural integrity of the vehicle whilst simultaneously increasing its autonomy. This thesis not only provides a holistic framework but also an arsenal of computational techniques in the design of a collision avoidance system for AUVs. The design of an obstacle avoidance system is first addressed. The core paradigm is the application of the Rapidly-exploring Random Tree (RRT) algorithm and the newly developed version for use as a motion planning tool. Later, this technique is merged with the Manoeuvre Automaton (MA) representation to address the inherent disadvantages of the RRT. A novel multi-node version which can also address time varying final state is suggested. Clearly, the reference trajectory generated by the aforementioned embedded planner must be tracked. Hence, the feasibility of employing the linear quadratic regulator (LQG) and the nonlinear kinematic based state-dependent Ricatti equation (SDRE) controller as trajectory trackers are explored. The obstacle detection module, which comprises of sonar processing and workspace representation submodules, is developed and tested on actual sonar data acquired in a sea-trial via a prototype forward looking sonar (AT500). The sonar processing techniques applied are fundamentally derived from the image processing perspective. Likewise, a novel occupancy grid using nonlinear function is proposed for the workspace representation of the AUV. Results are presented that demonstrate the ability of an AUV to navigate a complex environment. To the author's knowledge, it is the first time the above newly developed methodologies have been applied to an A UV collision avoidance system, and, therefore, it is considered that the work constitutes a contribution of knowledge in this area of work.J&S MARINE LT

Efficient Real-Time Solutions for Nonlinear Model Predictive Control with Applications

Nonlinear Model Predictive Control is an advanced optimisation methodology widely used for developing optimal Feedback Control Systems that use mathematical models of dynamical systems to predict and optimise their future performance. Its popularity comes from its general ability to handle a wide range of challenges present when developing control systems such as input/output constraints, complex nonlinear dynamics multi-variable systems, dynamic systems with significant delays as well as handling of uncertainty, disturbances and fault-tolerance. One of the main and most important challenges is the computational burden associated with the optimisation, particularly when attempting to implement the underlying methods in fast/real-time systems. To tackle this, recent research has been focused on developing efficient real-time solutions or strategies that could be used to overcome this problem. In this case, efficiency may come in various different ways from mathematical simplifications, to fast optimisation solvers, special algorithms and hardware, as well as tailored auto-generated coding tool-kits which help to make an efficient overall implementation of these type of approaches. This thesis addresses this fundamental problem by proposing a wide variety of methods that could serve as alternatives from which the final user can choose from depending on the requirements specific to the application. The proposed approaches focus specifically of developing efficient real-time NMPC methods which have a significantly reduced computational burden whilst preserving desirable properties of standard NMPC such as nominal stability, recursive feasibility guarantees, good performance, as well as adequate numeric conditioning for their use in platforms with reduced numeric precision such as ``floats'' subject to certain conditions being met. One of the specific aims of this work is to obtain faster solutions than the popular ACADO toolkit, in particular when using condensing-based NMPC solutions under the Real-Time Iteration Scheme, considered for all practical purposes the state-of-the-art standard real-time solution to which all the approaches will be bench-marked against. Moreover, part of the work of this thesis uses the concept of ``auto-generation'' for developing similar tool-kits that apply the proposed approaches. To achieve this, the developed tool-kits were supported by the Eigen 3 library which were observed to result in even better computation times than the ACADO toolkit. Finally, although the work undertaking by this thesis does not look into robust control approaches, the developed methods could be used for improving the performance of the underlying ``online'' optimisation, eg. by being able to perform additional iterations of the underlying SQP optimisation, as well as be used in common robust frameworks where multi-model systems must be simultaneously optimised in real-time. Thus, future work will look into merging the proposed methods with other existing strategies to give an even wider range of alternatives to the final user

Automatic Control with Experiments

Everybody has been a part of a control system at some time. Some examples of this are when driving a car, balancing a broomstick on a hand, walking or standing up without falling, taking a glass to drink water, and so on. These control systems, however,arenotautomaticcontrolsystems,asapersonisrequiredtoperformarole in it. To explain this idea, in this section some more technical examples of control systems are described in which a person performs a rol

Force-Canceling Mixer Algorithm for Vehicles with Fully-Articulated Radially Symmetric Thruster Arrays

A new type of fully-holonomic aerial vehicle is identified and developed that can optionally utilize automatic cancellation of excessive thruster forces to maintain precise control despite little or no throttle authority. After defining the physical attributes of the new vehicle, a flight control mixer algorithm is defined and presented. This mixer is an input/output abstraction that grants a flight control system (or pilot) full authority of the vehicle\u27s position and orientation by means of an input translation vector and input torque vector. The mixer is shown to be general with respect to the number of thrusters in the system provided that they are distributed in a radially symmetric array. As the mixer is designed to operate independently of the chosen flight control system, it is completely agnostic to the type of control methodology implemented. Validation of both the vehicle\u27s holonomic capabilities and efficacy of the flight control mixing algorithm are provided by a custom MATLAB-based rigid body simulation environment

NASA SBIR abstracts of 1992, phase 1 projects

The objectives of 346 projects placed under contract by the Small Business Innovation Research (SBIR) program of the National Aeronautics and Space Administration (NASA) are described. These projects were selected competitively from among proposals submitted to NASA in response to the 1992 SBIR Program Solicitation. The basic document consists of edited, non-proprietary abstracts of the winning proposals submitted by small businesses. The abstracts are presented under the 15 technical topics within which Phase 1 proposals were solicited. Each project was assigned a sequential identifying number from 001 to 346, in order of its appearance in the body of the report. Appendixes to provide additional information about the SBIR program and permit cross-reference of the 1992 Phase 1 projects by company name, location by state, principal investigator, NASA Field Center responsible for management of each project, and NASA contract number are included

Design Development Test and Evaluation (DDT and E) Considerations for Safe and Reliable Human Rated Spacecraft Systems

A team directed by the NASA Engineering and Safety Center (NESC) collected methodologies for how best to develop safe and reliable human rated systems and how to identify the drivers that provide the basis for assessing safety and reliability. The team also identified techniques, methodologies, and best practices to assure that NASA can develop safe and reliable human rated systems. The results are drawn from a wide variety of resources, from experts involved with the space program since its inception to the best-practices espoused in contemporary engineering doctrine. This report focuses on safety and reliability considerations and does not duplicate or update any existing references. Neither does it intend to replace existing standards and policy

Research reports: 1991 NASA/ASEE Summer Faculty Fellowship Program

The basic objectives of the programs, which are in the 28th year of operation nationally, are: (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA Centers. The faculty fellows spent 10 weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA/MSFC colleague. This is a compilation of their research reports for summer 1991

Large space structures and systems in the space station era: A bibliography with indexes (supplement 05)

Bibliographies and abstracts are listed for 1363 reports, articles, and other documents introduced into the NASA scientific and technical information system between January 1, 1991 and July 31, 1992. Topics covered include technology development and mission design according to system, interactive analysis and design, structural and thermal analysis and design, structural concepts and control systems, electronics, advanced materials, assembly concepts, propulsion and solar power satellite systems