Root Shoot Coordination Optimization: Conceptualizing Ascent of Sap and Translocation of Solute in Plant

A new nature inspired evolutionary technique called Root Shoot Coordination Optimization (RSCO) has been proposed here. This optimization method has been developed on the basis of conduction procedure of plant. Water and solute i.e. food circulation phenomena maximizes on the fruitful coordination between root and leaves/shoot. This circulation procedure in plant incorporates two vital processes which are ascent of sap and translocation of food. Ascent of sap occurs due to the combined effect of adhesion and cohesion tension of water molecules and transpiration pull for the evaporation of water through stomata of shoot. Translocation of food takes place due to the pressure difference of solute in the shoot and root. This thought has been mathematically modeled as a new soft computing tool. This method has been tested for some benchmark problems. This method showed its effectiveness with encouraging results

MIL primitives for querying a fragmented world

In query-intensive database application areas, like decision support and data mining, systems that use vertical fragmentation have a significant performance advantage. In order to support relational or object oriented applications on top of such a fragmented data model, a flexible yet powerful intermediate language is needed. This problem has been successfully tackled in Monet, a modern extensible database kernel developed by our group. We focus on the design choices made in the Monet Interpreter Language (MIL), its algebraic query language, and outline how its concept of tactical optimization enhances and simplifies the optimization of complex queries. Finally, we summarize the experience gained in Monet by creating a highly efficient implementation of MIL

A self-parametrization framework for meta-heuristics

Even while the scientific community has shown great interest in the analysis of meta-heuristics, the analysis of their parameterization has received little attention. It is the parameterization that will adapt a meta-heuristic to a problem, but it is still performed, mostly, empirically. There are multiple parameterization techniques; however, they are time-consuming, requiring considerable computational effort and they do not take advantage of the meta-heuristics that they parameterize. In order to approach the parameterization of meta-heuristics, in this paper, a self-parameterization framework is proposed. It will automatize the parameterization as an optimization problem, precluding the user from spending too much time on parameterization. The model will automate the parameterization through two meta-heuristics: A meta-heuristic of the solution space and one of the parameter space. To analyze the performance of the framework, a self-parameterization prototype was implemented. The prototype was compared and analyzed in a SP (scheduling problem) and in the TSP (traveling salesman problem). In the SP, the prototype found better solutions than those of the manually parameterized meta-heuristics, although the differences were not statistically significant. In the TSP, the self-parameterization prototype was more effective than the manually parameterized meta-heuristics, this time with statistically significant differences.This work was supported by national funds through the FCT - Fundação para a Ciência e Tecnologia through the R&D Units Project Scopes: UIDB/00319/2020, and EXPL/EME-SIS/1224/2021

Battery-aware contact plan design for LEO satellite constellations: The ulloriaq case study

Power demands of communication technologies between LEO small-satellites are difficult to counterbalance by solar infeed and on-board battery storage, due to size and weight limitations. This makes the problem of battery-powered intersatellite communication a very difficult one. Its management requires a profound understanding as well as techniques for a proper extrapolation of the electric power budget as part of the inter-satellite and satellite-to-ground communication design. We discuss how the construction of contact plans in delay tolerant networking can profit from a sophisticated model of the on-board battery behavior. This model accounts for both nonlinearities in battery behavior as well as stochastic fluctuations in charge, so as to control the risk of battery depletion. We take an hypothetical Ulloriaq constellation based on the GOMX–4 satellites from GomSpace as a reference for our studies.Fil: Fraire, Juan Andres. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universitat Saarland; AlemaniaFil: Nies, Gilles. Universitat Saarland; AlemaniaFil: Gerstacker, Carsten. Universitat Saarland; AlemaniaFil: Hermanns, Holger. Universitat Saarland; Alemania. Institute of Intelligent Software; ChinaFil: Bay, Kristian. GomSpace A/S; DinamarcaFil: Bisgaard, Morten. GomSpace A/S; Dinamarc

A general solution framework for component commonality problems

Component commonality, the use of the same version of a component across multiple products, is increasingly considered as a promising way to offer high external variety while retaining low internal variety in operations. However, increasing commonality has both positive and negative cost effects, so that optimization approaches are required to identify an optimal commonality level. As a more or less of components influences nearly every process step along the supply chain, it is not astounding that a multitude of diverging commonality problems is investigated in literature, each of which developing a specific algorithm designed for the respective commonality problem considered. The paper on hand aims at a general framework, flexible and effcient enough to be applied to a wide range of commonality problems. Such a procedure basing on a two-stage graph approach is presented and tested. Finally, flexibility of the procedure is shown by customizing the framework to account for different types of commonality problems.Product variety, Component commonality, Optimization, Graph approach

Enumeration, conformation sampling and population of libraries of peptide macrocycles for the search of chemotherapeutic cardioprotection agents

Peptides are uniquely endowed with features that allow them to perturb previously difficult to drug biomolecular targets. Peptide macrocycles in particular have seen a flurry of recent interest due to their enhanced bioavailability, tunability and specificity. Although these properties make them attractive hit-candidates in early stage drug discovery, knowing which peptides to pursue is non‐trivial due to the magnitude of the peptide sequence space. Computational screening approaches show promise in their ability to address the size of this search space but suffer from their inability to accurately interrogate the conformational landscape of peptide macrocycles. We developed an in‐silico compound enumerator that was tasked with populating a conformationally laden peptide virtual library. This library was then used in the search for cardio‐protective agents (that may be administered, reducing tissue damage during reperfusion after ischemia (heart attacks)). Our enumerator successfully generated a library of 15.2 billion compounds, requiring the use of compression algorithms, conformational sampling protocols and management of aggregated compute resources in the context of a local cluster. In the absence of experimental biophysical data, we performed biased sampling during alchemical molecular dynamics simulations in order to observe cyclophilin‐D perturbation by cyclosporine A and its mitochondrial targeted analogue. Reliable intermediate state averaging through a WHAM analysis of the biased dynamic pulling simulations confirmed that the cardio‐protective activity of cyclosporine A was due to its mitochondrial targeting. Paralleltempered solution molecular dynamics in combination with efficient clustering isolated the essential dynamics of a cyclic peptide scaffold. The rapid enumeration of skeletons from these essential dynamics gave rise to a conformation laden virtual library of all the 15.2 Billion unique cyclic peptides (given the limits on peptide sequence imposed). Analysis of this library showed the exact extent of physicochemical properties covered, relative to the bare scaffold precursor. Molecular docking of a subset of the virtual library against cyclophilin‐D showed significant improvements in affinity to the target (relative to cyclosporine A). The conformation laden virtual library, accessed by our methodology, provided derivatives that were able to make many interactions per peptide with the cyclophilin‐D target. Machine learning methods showed promise in the training of Support Vector Machines for synthetic feasibility prediction for this library. The synergy between enumeration and conformational sampling greatly improves the performance of this library during virtual screening, even when only a subset is used

10381 Summary and Abstracts Collection -- Robust Query Processing

Dagstuhl seminar 10381 on robust query processing (held 19.09.10 - 24.09.10) brought together a diverse set of researchers and practitioners with a broad range of expertise for the purpose of fostering discussion and collaboration regarding causes, opportunities, and solutions for achieving robust query processing. The seminar strove to build a unified view across the loosely-coupled system components responsible for the various stages of database query processing. Participants were chosen for their experience with database query processing and, where possible, their prior work in academic research or in product development towards robustness in database query processing. In order to pave the way to motivate, measure, and protect future advances in robust query processing, seminar 10381 focused on developing tests for measuring the robustness of query processing. In these proceedings, we first review the seminar topics, goals, and results, then present abstracts or notes of some of the seminar break-out sessions. We also include, as an appendix, the robust query processing reading list that was collected and distributed to participants before the seminar began, as well as summaries of a few of those papers that were contributed by some participants

Algorithms and Methods for Designing and Scheduling Smart Manufacturing Systems

This book, as a Special Issue, is a collection of some of the latest advancements in designing and scheduling smart manufacturing systems. The smart manufacturing concept is undoubtedly considered a paradigm shift in manufacturing technology. This conception is part of the Industry 4.0 strategy, or equivalent national policies, and brings new challenges and opportunities for the companies that are facing tough global competition. Industry 4.0 should not only be perceived as one of many possible strategies for manufacturing companies, but also as an important practice within organizations. The main focus of Industry 4.0 implementation is to combine production, information technology, and the internet. The presented Special Issue consists of ten research papers presenting the latest works in the field. The papers include various topics, which can be divided into three categories—(i) designing and scheduling manufacturing systems (seven articles), (ii) machining process optimization (two articles), (iii) digital insurance platforms (one article). Most of the mentioned research problems are solved in these articles by using genetic algorithms, the harmony search algorithm, the hybrid bat algorithm, the combined whale optimization algorithm, and other optimization and decision-making methods. The above-mentioned groups of articles are briefly described in this order in this book

Evolutionary Computation 2020

Intelligent optimization is based on the mechanism of computational intelligence to refine a suitable feature model, design an effective optimization algorithm, and then to obtain an optimal or satisfactory solution to a complex problem. Intelligent algorithms are key tools to ensure global optimization quality, fast optimization efficiency and robust optimization performance. Intelligent optimization algorithms have been studied by many researchers, leading to improvements in the performance of algorithms such as the evolutionary algorithm, whale optimization algorithm, differential evolution algorithm, and particle swarm optimization. Studies in this arena have also resulted in breakthroughs in solving complex problems including the green shop scheduling problem, the severe nonlinear problem in one-dimensional geodesic electromagnetic inversion, error and bug finding problem in software, the 0-1 backpack problem, traveler problem, and logistics distribution center siting problem. The editors are confident that this book can open a new avenue for further improvement and discoveries in the area of intelligent algorithms. The book is a valuable resource for researchers interested in understanding the principles and design of intelligent algorithms