Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors

Acoustic wave resonator techniques are widely used in in-liquid biochemical applications. The main challenges remaining are the improvement of sensitivity and limit of detection, as well as multianalysis capabilities and reliability. The sensitivity improvement issue has been addressed by increasing the sensor frequency, using different techniques such as high fundamental frequency quartz crystal microbalances (QCMs), surface generated acoustic waves (SGAWs) and film bulk acoustic resonators (FBARs). However, this sensitivity improvement has not been completely matched in terms of limit of detection. The decrease on frequency stability due to the increase of the phase noise, particularly in oscillators, has made it impossible to increase the resolution. A new concept of sensor characterization at constant frequency has been recently proposed based on the phase/mass sensitivity equation: Δφ/Δm ≈ −1/mL, where mL is the liquid mass perturbed by the resonator. The validation of the new concept is presented in this article. An immunosensor application for the detection of a low molecular weight pollutant, the insecticide carbaryl, has been chosen as a validation model

High frequency surface acoustic wave resonator-based sensor for particulate matter detection

This paper describes the characterization of high frequency Surface Acoustic Wave Resonator-based (SAWR) sensors, for the detection of micron and sub-micron sized particles. The sensor comprises two 262 MHz ST-cut quartz based Rayleigh wave SAWRs where one is used for particle detection and the other as a reference. Electro-acoustic detection of different sized particles shows a strong relationship between mass sensitivity (Δf/Δm) and particle diameter (Dp). This enables frequency-dependent SAWR sensitivity to be tailored to the size of particles, thus making these types of sensors good candidates for PM10, PM2.5 and ultrafine particle (UFP) detection. Our initial characterisation demonstrated a typical SAWR frequency shift of 60 Hz in response to a deposition of ca. 0.21 ng of 0.75 μm-sized gold particles (∼50 particles) on sensor’s surface. Sensor responses to different size particles, such as ∼30 μm diameter silicon, gold (diameters of ∼0.75 μm and ∼20 μm), ∼8 μm fine sugar, PTFE (∼1 μm and ∼15 μm), ∼4 μm talcum powder, and ∼2 μm molybdenum powder were evaluated, and an average mass sensitivity of 275 Hz/ng was obtained. Based on the results obtained in this study we believe that acoustic wave technology has great potential for application in airborne particle detection. Moreover, acoustic resonator devices can be integrated with CMOS interface circuitry to obtain sensitive, robust, low-power and low-cost particle detectors for variety of applications including outdoor environmental monitoring

Use of triple beam resonant gauges in torque measurement transfer standard

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A new torque transfer standard using metallic TBTF resonant sensor was developed to overcome the overload capability problem which occurs with conventional metallic resistance strain gauges. Previous research work, however, has shown that the first prototype of the metallic TBTF resonant sensor was not suitable for use in a torque transfer standard due to its size and subsequent sensitivity to parasitic lateral forces. To maximize the benefits from this sensor, particularly overload capability and long-term stability, in the high accuracy torque measurement application area, there is a need to develop significantly smaller devices. The aim of this thesis is to research through FEA modelling and experimental characterisation the key performance parameters required to produce a miniaturised metallic TBTF resonant sensor that provides better performance when applied in a torque measurement system. For high accuracy any torque transducer using these sensors ought to have low sensitivity to parasitic influences such as bending moments and lateral forces, which can only be achieved with reduced size. The problems with the existing design, key design issues, possible configuration and packaging solutions of the metallic TBTF resonant sensor that could be used for achieving a higher accuracy torque transfer standard are considered. Two designs of miniaturised metallic TBTF resonant sensors, SL20 and SL12, are considered and experimentally investigated. The lateral forces are reduced by 52% for SL20 design and by 80% for SL12 design when compared to the original SL40 design. A torque transducer using the SL20 design was calibrated falling into the Torque Transfer Standard class of accuracy 1 category, uncertainty 0.8%. A torque transducer using the SL12 design was made and calibration showed a class of accuracy 0.5 category, uncertainty 0.2%. The results from this research indicate that the SL12 design is suitable for use in a torque transfer standard. The SL12 design is optimal and the smallest size possible based on the overload capability design criteria requiring the tine cross sectional area to remain constant

Techniques, Circuits and Devices for Noncontact Sensing through Wireless Coupling

Le tecnologie per la misurazione di grandezze fisiche senza contatto sono diventate sempre più centrali in vari settori, che vanno dal monitoraggio industriale alle applicazioni sanitarie. In questo contesto, la tesi si concentra sullo sviluppo e l'implementazione di tecniche innovative, circuiti elettronici e dispositivi per la rilevazione senza contatto. L’analisi presentata all'interno di questa tesi considera lo scenario del rilevamento senza contatto a distanza nel campo elettromagnetico lontano (far-field) e al rilevamento senza contatto di prossimità, sfruttando le interazioni elettromagnetiche in campo vicino (near field). Nell’ambito del rilevamento senza contatto a distanza, la tesi indaga l'uso delle onde elettromagnetiche per il monitoraggio non invasivo del livello di solidi granulari all’interno di silos. Questo sistema, sviluppato impiegando un sensore radar commerciale a onda continua modulata in frequenza, dimostra il potenziale di questa tecnologia nel monitoraggio non invasivo e senza contatto in contesti agricoli e industriali. Considerando invece lo scenario del rilevamento senza contatto di prossimità, la tesi fornisce un'analisi dell'interrogazione senza contatto di sensori passivi e ne presenta diversi approcci e applicazioni. Vengono affrontate le problematiche delle misurazioni senza contatto, proponendo alcune soluzioni per migliorarne l'affidabilità e l'accuratezza, permettendo in particolare di renderle indipendenti dalla distanza di interrogazione. In particolare, la tesi presenta un sistema per la misurazione senza contatto della frequenza di risonanza di risonatori MEMS piezoelettrici. La tecnica proposta sfrutta l'accoppiamento magnetico tra un’unità di interrogazione ed un’unità sensore ed è applicata in modo innovativo per la rilevazione della temperatura, sfruttando le proprietà dei risonatori a disco in nitruro di alluminio (AlN) su silicio sottile piezoelettrico (TPoS) ed una tecnica di interrogazione senza contatto a tempo commutato. Inoltre, la tesi presenta un’etichetta flessibile per la misurazione della temperatura corporea, che combina il rilevamento a contatto della temperatura con una lettura senza contatto dell’unità sensore sfruttandone l'accoppiamento magnetico con un unità di interrogazione. L’etichetta flessibile, che costituisce l'unità sensore, è composta da una bobina induttiva che consente l'accoppiamento magnetico, un condensatore ceramico utilizzato come elemento sensibile alla temperatura, sfruttandone il coefficiente di temperatura della capacità, ed un induttore aggiuntivo utilizzato per rendere la frequenza di risonanza del circuito risonante RLC indipendente dalla flessione dell’etichetta. In modo analogo, le tecniche di interrogazione proposte sono state applicate ad un nuovo metodo per l'interrogazione senza contatto di un sensore induttivo, utilizzato per rilevare target conduttivi. Il sistema proposto presenta una bobina avvolta collegata con un condensatore per formare un circuito LC risonante, la cui frequenza di risonanza cambia quando un target conduttivo viene introdotto nel campo magnetico generato dalla bobina stessa. Attraverso una bobina di interrogazione esterna, accoppiata elettromagneticamente al sensore induttivo, è possibile interrogare senza contatto il sensore induttivo, permettendo quindi la rilevazione a distanza di target conduttivi. Infine, lo studio esposto in questa tesi introduce una tecnica avanzata per l'interrogazione senza contatto di sensori resistivi passivi, sfruttando risonatori a cristallo di quarzo come dispositivo risonante e basandosi sulla stima del fattore di qualità del circuito che costituisce l’unità sensore. Il metodo proposto supera i limiti delle tecniche basate su misure di ampiezza, legati in particolare all'influenza della distanza di interrogazioneNoncontact sensing technologies have become increasingly central in a variety of fields, ranging from industrial monitoring to healthcare applications. In this context, the thesis focuses on the development and implementation of innovative techniques, electronic circuits, and devices for contactless sensing via wireless coupling, responding to the growing interest in noncontact measurement methods. The themes treated in this thesis regard both the scenario of distant noncontact sensing in the electromagnetic far field, and proximate wireless sensing, leveraging on near-field electromagnetic interactions. Each domain is distinctly characterized by its specific technologies, applications, and methodologies, reflecting their operational ranges and fundamental principles. In the domain of distant wireless sensing, the thesis investigates the use of electromagnetic waves for unobtrusive level monitoring of granular solids in silos. This system, developed employing a commercial frequency-modulated continuous-wave radar sensor, demonstrates the potential of this technology in unobtrusive monitoring in agricultural and industrial environments. Considering the proximate wireless sensing domain, the thesis provides an analysis of noncontact interrogation of passive sensors and it presents different approaches and applications. It addresses the challenges and offers solutions for enhancing the reliability and accuracy of contactless measurements, which can be advantageously independent of the interrogation distance. This can path the way to the development of low-cost, disposable and sustainable devices for healthcare and industrial applications. In particular, the thesis presents a system for the noncontact measurement of the resonant frequency of piezoelectric MEMS resonators. The technique exploits magnetic coupling between interrogation and sensor units, and it is innovatively applied for temperature sensing exploiting a thin-film piezoelectric on silicon (TPoS) aluminium nitride (AlN) disk resonators and a contactless interrogation time-gated technique. Furthermore, the thesis presents a flexible patch for body temperature measurement, combining contact sensing with contactless readout, and exploiting magnetic coupling between interrogation and sensor units. The flexible patch, forming the sensor unit, is composed of an inductive coil for magnetic coupling, a ceramic capacitor used as the temperature sensing element exploiting its temperature coefficient of capacitance and an additional inductor to make the resonant frequency of the resulting resonant RLC circuit independent from the bending of the patch. Similarly, interrogation techniques have been applied to a novel method for contactless interrogation of an inductive sensor used for detecting conductive targets. The system features a solenoidal coil connected with a capacitor to form a resonating LC circuit, whose resonant frequency changes when a conductive target is introduced in the generated magnetic field. An external interrogation coil electromagnetically coupled to the inductive sensor enables the wireless measurement for conductive target detection. Lastly, the study introduces an advanced technique for the contactless interrogation of passive resistive sensors. The novel approach exploits the resonant frequency stability and the high quality factor of a quartz crystal resonator, used as a resonant element, with a series-connected resistor acting as the sensing element. This method overcomes the limitations of amplitude measurements techniques typically affected by the interrogation distance

Piezo-electromechanical smart materials with distributed arrays of piezoelectric transducers: Current and upcoming applications

This review paper intends to gather and organize a series of works which discuss the possibility of exploiting the mechanical properties of distributed arrays of piezoelectric transducers. The concept can be described as follows: on every structural member one can uniformly distribute an array of piezoelectric transducers whose electric terminals are to be connected to a suitably optimized electric waveguide. If the aim of such a modification is identified to be the suppression of mechanical vibrations then the optimal electric waveguide is identified to be the 'electric analog' of the considered structural member. The obtained electromechanical systems were called PEM (PiezoElectroMechanical) structures. The authors especially focus on the role played by Lagrange methods in the design of these analog circuits and in the study of PEM structures and we suggest some possible research developments in the conception of new devices, in their study and in their technological application. Other potential uses of PEMs, such as Structural Health Monitoring and Energy Harvesting, are described as well. PEM structures can be regarded as a particular kind of smart materials, i.e. materials especially designed and engineered to show a specific andwell-defined response to external excitations: for this reason, the authors try to find connection between PEM beams and plates and some micromorphic materials whose properties as carriers of waves have been studied recently. Finally, this paper aims to establish some links among some concepts which are used in different cultural groups, as smart structure, metamaterial and functional structural modifications, showing how appropriate would be to avoid the use of different names for similar concepts. © 2015 - IOS Press and the authors

Ultra-Low Power Wake Up Receiver For Medical Implant Communications Service Transceiver

This thesis explores the specific requirements and challenges for the design of a dedicated wake-up receiver for medical implant communication services equipped with a novel “uncertain-IF†architecture combined with a high – Q filtering MEMS resonator and a free running CMOS ring oscillator as the RF LO. The receiver prototype, implements an IBM 0.18μm mixed-signal 7ML RF CMOS technology and achieves a sensitivity of -62 dBm at 404MHz while consuming \u3c100 μW from a 1 V supply

A basic Michelson laser interferometer for the undergraduate teaching laboratory demonstrating picometer sensitivity

We describe a basic Michelson laser interferometer experiment for the undergraduate teaching laboratory that achieves picometer sensitivity in a hands-on, table-top instrument. In addition to providing an introduction to interferometer physics and optical hardware, the experiment also focuses on precision measurement techniques including servo control, signal modulation, phase-sensitive detection, and different types of signal averaging. Students examine these techniques in a series of steps that take them from micron-scale sensitivity using direct fringe counting to picometer sensitivity using a modulated signal and phase-sensitive signal averaging. After students assemble, align, and characterize the interferometer, they then use it to measure nanoscale motions of a simple harmonic oscillator system as a substantive example of how laser interferometry can be used as an effective tool in experimental science

ΔE-Effect Magnetic Field Sensors

Many conceivable biomedical and diagnostic applications require the detection of small-amplitude and low-frequency magnetic fields. Against this background, a magnetometer concept is investigated in this work based on the magnetoelastic ΔE effect. The ΔE effect causes the resonance frequency of a magnetoelastic resonator to detune in the presence of a magnetic field, which can be read-out electrically with an additional piezoelectric phase. Various microelectromechanical resonators are experimentally analyzed in terms of the ΔE effect and signal-and-noise response. This response is highly complex because of the anisotropic and nonlinear coupled magnetic, mechanical, and electrical properties. Models are developed and extended where necessary to gain insights into the potentials and limits accompanying sensor design and operating parameters. Beyond the material and geometry parameters, we analyze the effect of different resonance modes, spatial property variations, and operating frequencies on sensitivity. Although a large ΔE effect is confirmed in the shear modulus, the sensitivity of classical cantilever resonators does not benefit from this effect. An approach utilizing surface acoustic shear-waves provides a solution and can detect small signals over a large bandwidth. Comprehensive analyses of the quality factor and piezoelectric material parameters indicate methods to increase sensitivity and signal-to-noise ratio significantly. First exchange-biased ΔE-effect sensors pave the way for compact setups and arrays with a large number of sensor elements. With an extended signal-and-noise model, specific requirements are identified that could improve the signal-to-noise ratio. The insights gained lead to a new concept that can circumvent previous limitations. With the results and models, important contributions are made to the understanding and development of ΔE-effect sensors with prospects for improvements in the future

Applied Measurement Systems

Measurement is a multidisciplinary experimental science. Measurement systems synergistically blend science, engineering and statistical methods to provide fundamental data for research, design and development, control of processes and operations, and facilitate safe and economic performance of systems. In recent years, measuring techniques have expanded rapidly and gained maturity, through extensive research activities and hardware advancements. With individual chapters authored by eminent professionals in their respective topics, Applied Measurement Systems attempts to provide a comprehensive presentation and in-depth guidance on some of the key applied and advanced topics in measurements for scientists, engineers and educators