Neural primacy of the salience processing system in schizophrenia

For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed “frontal inefficiency,” the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia

Dynamic performance of a low voltage microgrid with droop controlled distributed generation

Microgrids are small-scale highly controlled networks designed to supply electrical energy. From the operational point of view, microgrids are active distribution networks, facilitating the integration of distributed generation units. Major technical issues in this concept include system stability and protection coordination which are significantly influenced by the high penetration of inverter-interfaced distributed energy sources. These units often adopt the frequency-active power and voltage-reactive power droop control strategy to participate in the load sharing of an islanded microgrid. The scope of the paper is to investigate the dynamic performance of a low voltage laboratory-scale microgrid system, using experimental results and introduce the concept of Prony analysis for understanding the connected components. Several small disturbance test cases are conducted and the investigations focus on the influence of the droop controlled distributed generation sources

Flexible Transmission Network Planning Considering the Impacts of Distributed Generation

The restructuring of global power industries has introduced a number of challenges, such as conflicting planning objectives and increasing uncertainties,to transmission network planners. During the recent past, a number of distributed generation technologies also reached a stage allowing large scale implementation, which will profoundly influence the power industry, as well as the practice of transmission network expansion. In the new market environment, new approaches are needed to meet the above challenges. In this paper, a market simulation based method is employed to assess the economical attractiveness of different generation technologies, based on which future scenarios of generation expansion can be formed. A multi-objective optimization model for transmission expansion planning is then presented. A novel approach is proposed to select transmission expansion plans that are flexible given the uncertainties of generation expansion, system load and other market variables. Comprehensive case studies will be conducted to investigate the performance of our approach. In addition, the proposed method will be employed to study the impacts of distributed generation, especially on transmission expansion planning.

The IPR System, Venture Capital and Capital Markets – Contributions and Distortions of Small Firm Innovation?

This study explores how capital markets, exemplified by venture capital, and recent trends in the patent system may influence innovation activity and the financing of small businesses. Specifically it is evaluated if there are costs and distortions of incentives related hereto. Additionally, the positive contribution of venture capital in the patenting process is investigated. It is found that trends at a macro economic level is nowadays of major importance for the patenting and innovation behaviour and financing of firms. Patenting has increased in scale, scope and trade volume, patents have become a strategic asset to an extent that may de-link it from innovation activities. The IPR-system may render distortions of innovation activities facilitated by these trends. These distortions may impose costs on the overall function of the innovation system, costs that are unequally distributed among firms as small firms are bearing most of the burdens. The results points to new perspectives on strategy that are important to management of firms and investment funds.Small firms; venture capital; IPR

Simulation of fluid flow in hydrophobic rough microchannels

Surface effects become important in microfluidic setups because the surface to volume ratio becomes large. In such setups the surface roughness is not any longer small compared to the length scale of the system and the wetting properties of the wall have an important influence on the flow. However, the knowledge about the interplay of surface roughness and hydrophobic fluid-surface interaction is still very limited because these properties cannot be decoupled easily in experiments. We investigate the problem by means of lattice Boltzmann (LB) simulations of rough microchannels with a tunable fluid-wall interaction. We introduce an ``effective no-slip plane'' at an intermediate position between peaks and valleys of the surface and observe how the position of the wall may change due to surface roughness and hydrophobic interactions. We find that the position of the effective wall, in the case of a Gaussian distributed roughness depends linearly on the width of the distribution. Further we are able to show that roughness creates a non-linear effect on the slip length for hydrophobic boundaries.Comment: 10 pages, 5 figure

Real-Time Monitoring System for a Utility-Scale Photovoltaic Power Plant

There is, at present, considerable interest in the storage and dispatchability of photovoltaic (PV) energy, together with the need to manage power flows in real-time. This paper presents a new system, PV-on time, which has been developed to supervise the operating mode of a Grid-Connected Utility-Scale PV Power Plant in order to ensure the reliability and continuity of its supply. This system presents an architecture of acquisition devices, including wireless sensors distributed around the plant, which measure the required information. It is also equipped with a high-precision protocol for synchronizing all data acquisition equipment, something that is necessary for correctly establishing relationships among events in the plant. Moreover, a system for monitoring and supervising all of the distributed devices, as well as for the real-time treatment of all the registered information, is presented. Performances were analyzed in a 400 kW transformation center belonging to a 6.1 MW Utility-Scale PV Power Plant. In addition to monitoring the performance of all of the PV plant’s components and detecting any failures or deviations in production, this system enables users to control the power quality of the signal injected and the influence of the installation on the distribution grid

Chlorine concentration modelling and supervision in water distribution systems

The quality of the drinking water distributed through the networks has become the main concern of most operators. This work focuses on one of the most important variables of the drinking water distribution networks (WDN) that use disinfection, chlorine. This powerful disinfectant must be dosed carefully in order to reduce disinfection byproducts (DBPs). The literature demonstrates researchers’ interest in modelling chlorine decay and using several different approaches. Nevertheless, the full-scale application of these models is far from being a reality in the supervision of water distribution networks. This paper combines the use of validated chlorine prediction models with an intensive study of a large amount of data and its influence on the model’s parameters. These parameters are estimated and validated using data coming from the Supervisory Control and Data Acquisition (SCADA) software, a full-scale water distribution system, and using off-line analytics. The result is a powerful methodology for calibrating a chlorine decay model on-line which coherently evolves over time along with the significant variables that influence it.Peer ReviewedPostprint (author's final draft

Effects of component-subscription network topology on large-scale data centre performance scaling

Modern large-scale date centres, such as those used for cloud computing service provision, are becoming ever-larger as the operators of those data centres seek to maximise the benefits from economies of scale. With these increases in size comes a growth in system complexity, which is usually problematic. There is an increased desire for automated "self-star" configuration, management, and failure-recovery of the data-centre infrastructure, but many traditional techniques scale much worse than linearly as the number of nodes to be managed increases. As the number of nodes in a median-sized data-centre looks set to increase by two or three orders of magnitude in coming decades, it seems reasonable to attempt to explore and understand the scaling properties of the data-centre middleware before such data-centres are constructed. In [1] we presented SPECI, a simulator that predicts aspects of large-scale data-centre middleware performance, concentrating on the influence of status changes such as policy updates or routine node failures. [...]. In [1] we used a first-approximation assumption that such subscriptions are distributed wholly at random across the data centre. In this present paper, we explore the effects of introducing more realistic constraints to the structure of the internal network of subscriptions. We contrast the original results [...] exploring the effects of making the data-centre's subscription network have a regular lattice-like structure, and also semi-random network structures resulting from parameterised network generation functions that create "small-world" and "scale-free" networks. We show that for distributed middleware topologies, the structure and distribution of tasks carried out in the data centre can significantly influence the performance overhead imposed by the middleware