Chronic liver disease staging classification based on ultrasound, clinical and laboratorial data

In this work the identification and diagnosis of various stages of chronic liver disease is addressed. The classification results of a support vector machine, a decision tree and a k-nearest neighbor classifier are compared. Ultrasound image intensity and textural features are jointly used with clinical and laboratorial data in the staging process. The classifiers training is performed by using a population of 97 patients at six different stages of chronic liver disease and a leave-one-out cross-validation strategy. The best results are obtained using the support vector machine with a radial-basis kernel, with 73.20% of overall accuracy. The good performance of the method is a promising indicator that it can be used, in a non invasive way, to provide reliable information about the chronic liver disease staging

Speckle Noise Reduction via Homomorphic Elliptical Threshold Rotations in the Complex Wavelet Domain

Many clinicians regard speckle noise as an undesirable artifact in ultrasound images masking the underlying pathology within a patient. Speckle noise is a random interference pattern formed by coherent radiation in a medium containing many sub-resolution scatterers. Speckle has a negative impact on ultrasound images as the texture does not reflect the local echogenicity of the underlying scatterers. Studies have shown that the presence of speckle noise can reduce a physician's ability to detect lesions by a factor of eight. Without speckle, small high-contrast targets, low contrast objects, and image texture can be deduced quite readily. Speckle filtering of medical ultrasound images represents a critical pre-processing step, providing clinicians with enhanced diagnostic ability. Efficient speckle noise removal algorithms may also find applications in real time surgical guidance assemblies. However, it is vital that regions of interests are not compromised during speckle removal. This research pertains to the reduction of speckle noise in ultrasound images while attempting to retain clinical regions of interest. Recently, the advance of wavelet theory has lead to many applications in noise reduction and compression. Upon investigation of these two divergent fields, it was found that the speckle noise tends to rotate an image's homomorphic complex-wavelet coefficients. This work proposes a new speckle reduction filter involving a counter-rotation of these complex-wavelet coefficients to mitigate the presence of speckle noise. Simulations suggest the proposed denoising technique offers superior visual quality, though its signal-to-mean-square-error ratio (S/MSE) is numerically comparable to adaptive frost and kuan filtering. This research improves the quality of ultrasound medical images, leading to improved diagnosis for one of the most popular and cost effective imaging modalities used in clinical medicine

The usefulness of ultrasound in the classification of chronic liver disease

Chronic Liver Disease is a progressive, most of the time asymptomatic, and potentially fatal disease. In this paper, a semi-automatic procedure to stage this disease is proposed based on ultrasound liver images, clinical and laboratorial data. In the core of the algorithm two classifiers are used: a k nearest neighbor and a Support Vector Machine, with different kernels. The classifiers were trained with the proposed multi-modal feature set and the results obtained were compared with the laboratorial and clinical feature set. The results showed that using ultrasound based features, in association with laboratorial and clinical features, improve the classification accuracy. The support vector machine, polynomial kernel, outperformed the others classifiers in every class studied. For the Normal class we achieved 100% accuracy, for the chronic hepatitis with cirrhosis 73.08%, for compensated cirrhosis 59.26% and for decompensated cirrhosis 91.67%

In situ monitoring of additive manufacturing using digital image correlation: A review

UIDB/00667/2020 POCI-01-0145-FEDER-016414This paper is a critical review of in situ full-field measurements provided by digital image correlation (DIC) for inspecting and enhancing additive manufacturing (AM) processes. The principle of DIC is firstly recalled and its applicability during different AM processes systematically addressed. Relevant customisations of DIC in AM processes are highlighted regarding optical system, lighting and speckled pattern procedures. A perspective is given in view of the impact of in situ monitoring regarding AM processes based on target subjects concerning defect characterisation, evaluation of residual stresses, geometric distortions, strain measurements, numerical modelling validation and material characterisation. Finally, a case study on in situ measurements with DIC for wire and arc additive manufacturing (WAAM) is presented emphasizing opportunities, challenges and solutions.publishersversionpublishe

Echocardiography

The book "Echocardiography - New Techniques" brings worldwide contributions from highly acclaimed clinical and imaging science investigators, and representatives from academic medical centers. Each chapter is designed and written to be accessible to those with a basic knowledge of echocardiography. Additionally, the chapters are meant to be stimulating and educational to the experts and investigators in the field of echocardiography. This book is aimed primarily at cardiology fellows on their basic echocardiography rotation, fellows in general internal medicine, radiology and emergency medicine, and experts in the arena of echocardiography. Over the last few decades, the rate of technological advancements has developed dramatically, resulting in new techniques and improved echocardiographic imaging. The authors of this book focused on presenting the most advanced techniques useful in today's research and in daily clinical practice. These advanced techniques are utilized in the detection of different cardiac pathologies in patients, in contributing to their clinical decision, as well as follow-up and outcome predictions. In addition to the advanced techniques covered, this book expounds upon several special pathologies with respect to the functions of echocardiography

Ultrasound Image Filtering and Reconstruction Using DCT/IDCT Filter Structure

In this paper, a new recursive structure based on the convolution model of discrete cosine transform (DCT) for designing of a finite impulse response (FIR) digital filter is proposed. In our derivation, we start with the convolution model of DCT-II to use its Z-transform for the proposed filter structure perspective. Moreover, using the same algorithm, a filter base implementation of the inverse DCT (IDCT) for image reconstruction is developed. The computational time experiments of the proposed DCT/IDCT filter(s) demonstrate that the proposed filters achieve faster elapsed CPU time compared to the direct recursive structures and recursive algorithms for the DCT/IDCT with Arbitrary Length. Experimental results on clinical ultrasound images and comparisons with classical Wiener filter, non-local mean (NLM) filter and total variation (TV) algorithms are used to validate the improvements of the proposed approaches in both noise reduction and reconstruction performance for ultrasound images

Novel echocardiographic techniques to assess left atrial size, anatomy and function

Three-dimensional echocardiography (3DE) and speckle tracking echocardiography (STE) have recently applied as imaging techniques to accurately evaluate left atrial (LA) size, anatomy and function. 3DE and off-line quantification softwares, have allowed, in comparison to magnetic resonance imaging, the most time-efficient and accurate method of LA volume quantification. STE provides a non-Doppler, angle-independent and objective quantification of LA myocardial deformation. Data regarding feasibility, accuracy and clinical applications of LA analysis by 3DE and STE are rapidly gathering. This review describes the fundamental concepts of LA 3DE and STE, illustrates how to obtain respective measurements and discuss their recognized and emerging clinical applications

Computer-Assisted Algorithms for Ultrasound Imaging Systems

Ultrasound imaging works on the principle of transmitting ultrasound waves into the body and reconstructs the images of internal organs based on the strength of the echoes. Ultrasound imaging is considered to be safer, economical and can image the organs in real-time, which makes it widely used diagnostic imaging modality in health-care. Ultrasound imaging covers the broad spectrum of medical diagnostics; these include diagnosis of kidney, liver, pancreas, fetal monitoring, etc. Currently, the diagnosis through ultrasound scanning is clinic-centered, and the patients who are in need of ultrasound scanning has to visit the hospitals for getting the diagnosis. The services of an ultrasound system are constrained to hospitals and did not translate to its potential in remote health-care and point-of-care diagnostics due to its high form factor, shortage of sonographers, low signal to noise ratio, high diagnostic subjectivity, etc. In this thesis, we address these issues with an objective of making ultrasound imaging more reliable to use in point-of-care and remote health-care applications. To achieve the goal, we propose (i) computer-assisted algorithms to improve diagnostic accuracy and assist semi-skilled persons in scanning, (ii) speckle suppression algorithms to improve the diagnostic quality of ultrasound image, (iii) a reliable telesonography framework to address the shortage of sonographers, and (iv) a programmable portable ultrasound scanner to operate in point-of-care and remote health-care applications

Echocardiographic measurement of cardiac function in breast cancer patients treated with anthracycline chemotherapy

Introduction Anthracyclines are the cornerstone of breast cancer chemotherapy, however anthracyclines can be cardiotoxic. Left ventricular (LV) ejection fraction (LVEF) is the key echocardiographic measurement for monitoring cardiotoxicity, although LVEF has limitations. Myocardial strain imaging is new technology that may improve the measurement of cardiac function. The aim of this research was to study strain imaging for potentially earlier detection of dysfunction than LVEF, in breast cancer patients treated with anthracyclines. Method Anthracycline naïve breast cancer patients were prospectively studied; 78 short-term (over 3 months), and 50 in the intermediate-term (over 12 months). Patients were treated with standard anthracycline regimens. Echocardiograms were performed at 4 time points; 1) 7 days before chemotherapy, 2) 7 days after chemotherapy, 3) 6 months after, and 4) 12 months after chemotherapy. Results Global LV longitudinal systolic strain (GLS) was significantly reduced in the short-term (p<0.001), without a clinically significant reduction in LVEF. In the intermediate-term, strain values remained significantly reduced at 6 months (p<0.01), but normalized 12 months after chemotherapy. GLS at the 4 time points was: -19.0% ± 2.3%, -17.5% ± 2.3%, -18.2% ± 2.2%, -19.1% ± 1.9%. Persistently reduced strain at 12 months (in 16% of participants) was related to significantly higher anthracycline doses. Conclusion Significantly reduced LV systolic strain was detected in the short and intermediate-term after anthracyclines, without discernible changes in LVEF. In the majority, LV systolic dysfunction was transient: persistently reduced systolic strain was associated with higher anthracycline doses. Strain imaging is a more sensitive measure than LVEF in the short and intermediate-term monitoring of cardiac function after anthracycline chemotherapy