Distributed control of reconfigurable mobile network agents for resource coordination

Includes abstract.Includes bibliographical references.Considering the tremendous growth of internet applications and network resource federation proposed towards future open access network (FOAN), the need to analyze the robustness of the classical signalling mechanisms across multiple network operators cannot be over-emphasized. It is envisaged, there will be additional challenges in meeting the bandwidth requirements and network management...The first objective of this project is to describe the networking environment based on the support for heterogeneity of network components..

2018 - The Twenty-third Annual Symposium of Student Scholars

The full program book from the Twenty-third Annual Symposium of Student Scholars, held on April 19, 2018. Includes abstracts from the presentations and posters.https://digitalcommons.kennesaw.edu/sssprograms/1020/thumbnail.jp

Estudo metabolómico da reprogramação metabólica induzida por flavonoides em macrófagos humanos

The ability of macrophages to change between pro-inflammatory (M1-like) and anti-inflammatory (M2-like) phenotypes makes their modulation an attractive therapeutic strategy to mitigate excessive and/or chronic inflammation. Bioflavonoids are natural compounds with well documented anti-inflammatory activity. However, little is known about their molecular and metabolic effects on human macrophages. In this thesis, NMR metabolomics has been used to assess how different bioflavonoids (Quercetin, Naringenin and Naringin) modulate the metabolism of human macrophages, with a view to better understand their modes of action. In vitro-cultured macrophages differentiated from human THP-1 monocytes were treated with each flavonoid, both in the uncommitted state (M0) or after pre-polarization with LPS/IFN-γ (M1). Treatment with IL-4/IL-13 (M2) was also carried out for comparison. Cells were solvent-extracted to obtain the polar fractions and subsequently analysed by 1H NMR spectroscopy. Near 50 intracellular metabolites were detected (endometabolome), whereas analysis of cells-conditioned culture medium (exometabolome) was useful to assess consumption and excretion patterns. Multivariate analysis and discrete quantitative assessments of metabolic profiles revealed consistent variations upon macrophage exposure to the different stimuli. The three flavonoids produced pronounced metabolic alterations, with the strongest impact being observed for Quercetin and the mildest for Naringin. The main effects shared by all flavonoids, especially in M1 pre-polarized macrophages, comprised downregulation of glucose uptake and decreased energetic pools (ATP, UTP, phosphocreatine). Other effects were highly flavonoid-specific, namely TCA cycle modulation and amino acid metabolism, antioxidant response and variations in membrane-related metabolites. Overall, this work has shown that, although sharing similar ability to attenuate pro-inflammatory activity of macrophages, the three flavonoids affect macrophage metabolism in distinct ways. Future studies should entail assessment of key metabolic enzymes to further advance current understanding on flavonoid-mediated modulation of macrophage metabolism. This knowledge is expected to support the development of flavonoids as immunomodulatory drugs, especially aimed at attenuating and/or resolving inflammation, for instance, in the context of chronic inflammatory diseases or the rejection of biomaterial implants.A capacidade dos macrófagos alterarem o seu fenótipo entre estados pro-inflamatórios (tipo-M1) e anti-inflamatórios (tipo-M2), faz com que a sua modulação seja uma estratégia promissora para mitigar a inflamação excessiva e/ou crónica. Os bioflavonóides são compostos naturais com atividade anti-inflamatória bem documentada. No entanto, pouco se sabe acerca dos seus efeitos metabólicos em macrófagos humanos. Nesta tese, utilizou-se a metabolómica baseada em RMN para averiguar de que forma diferentes bioflavonóides (Quercetina, Naringenina e Naringina) modulam o metabolismo de macrófagos humanos, com vista a compreender melhor os seus mecanismos de ação. Macrófagos derivados de monócitos humanos THP-1 foram cultivados in vitro e tratados com cada flavonóide, tanto no estado não-polarizado (M0) como após uma pré-polarização com LPS/IFN-γ (M1). A estimulação com IL-4/IL-13 (M2) foi também empregue para comparação. As frações polares das células foram obtidas por extração com solventes orgânicos e subsequentemente analisadas por espetroscopia de RMN-1H. Perto de 50 metabolitos intracelulares foram identificados (endometaboloma), sendo que a análise dos meios de cultura (exometaboloma) foi útil para estudar padrões de consumo e excreção. O estudo dos perfis metabólicos através de análise multivariada e quantitativa revelou variações consistentes perante os diferentes estímulos fornecidos aos macrófagos. Os três flavonóides causaram diferentes alterações metabólicas, sendo que o maior impacto foi observado para a Quercetina e o menor para a Naringina. Os principais efeitos partilhados por todos os flavonóides, especialmente em macrófagos pré-polarizados para M1, incluíram diminuição do consumo de glucose e das reservas energéticas (ATP, UTP, fosfocreatina). Outros efeitos foram muito específicos dependendo do flavonóide, nomeadamente a modulação do ciclo TCA e do metabolismo de aminoácidos, a resposta anti-oxidante e variações em metabolitos associados às membranas. De forma geral, este estudo demonstrou que, apesar de apresentarem capacidade semelhante de atenuar a atividade pró-inflamatória de macrófagos, os três flavonóides afetaram o metabolismo celular de formas distintas. Em estudos futuros, será importante avaliar a expressão/atividade de enzimas metabólicas chave, de modo a incrementar o conhecimento atual sobre a modulação do metabolismo de macrófagos mediada por flavonóides. Este conhecimento deverá pois suportar o desenvolvimento de flavonóides como fármacos imunomodulatórios, especialmente direcionados para a atenuação e/ou resolução da inflamação, por exemplo, no contexto de doenças associadas a inflamação crónica ou da rejeição de biomateriais implantados.Mestrado em Bioquímic

Evaluating Commonwealth Coordinated Care: The Experiences of Individuals Dually Eligible for Medicare and Medicaid

Objectives 1. To understand Virginia’s rationale for implementing the Commonwealth Coordinated Care Program and its approach to evaluating it. 2. To provide a framework for examining the health care experiences of individuals with behavioral health and/or long-term service and support needs who are enrolled in the Commonwealth Coordinated Care Program. 3. To inform policy on future options for improving the quality and health care experiences of similar groups of individuals in Virginia and other states

Réseaux de capteurs ubiquitous dans l'environnement NGN

Ubiquités Sensor Network (USN) is a conceptual network built over existing physical networks. It makes use of sensed data and provides knowledge services to anyone, anywhere and at anytime, and where the information is generated by using context awareness. Smart wearable devices and USNs are emerging rapidly providing many reliable services facilitating people life. Those very useful small end terminals and devices require a global communication substrate to provide a comprehensive global end user service. In 2010, the ITU-T provided the requirements to support USN applications and services in the Next Génération Network (NGN) environment to exploit the advantages of the core network. One of the main promising markets for the USN application and services is the e-Health. It provides continuous patients’ monitoring and enables a great improvement in medical services. On the other hand, Vehicular Ad-Hoc NETwork (VANET) is an emerging technology, which provides intelligent communication between mobile vehicles. Integrating VANET with USN has a great potential to improve road safety and traffic efficiency. Most VANET applications are applied in real time and they are sensitive to delay, especially those related to safety and health. In this work, we propose to use IP Multimedia Subsystem (IMS) as a service controller sub-layer in the USN environment providing a global substrate for a comprehensive end-to-end service. Moreover, we propose to integrate VANETs with USN for more rich applications and facilities, which will ease the life of humans. We started studying the challenges on the road to achieve this goalUbiquitous Sensor Network (USN) est un réseau conceptuel construit sur des réseaux physiques existantes. Il se sert des données détectées et fournit des services de connaissances à quiconque, n'importe où et à tout moment, et où l'information est générée en utilisant la sensibilité au contexte. Dispositifs et USN portables intelligents émergent rapidement en offrant de nombreux services fiables facilitant la vie des gens. Ces petits terminaux et terminaux très utiles besoin d'un substrat de communication globale pour fournir un service complet de l'utilisateur final global. En 2010, ITU -T a fourni les exigences pour supporter des applications et services USN dans le Next Generation Network (NGN) de l'environnement d'exploiter les avantages du réseau de base. L'un des principaux marchés prometteurs pour l'application et les services USN est la e- santé. Il fournit le suivi des patients en continu et permet une grande amélioration dans les services médicaux. D'autre part, des Véhicules Ad-hoc NETwork (VANET) est une technologie émergente qui permet une communication intelligente entre les véhicules mobiles. Intégrer VANET avec USN a un grand potentiel pour améliorer la sécurité routière et la fluidité du trafic. La plupart des applications VANET sont appliqués en temps réel et ils sont sensibles à retarder, en particulier ceux liés à la sécurité et à la santé. Dans ce travail, nous proposons d'utiliser l'IP Multimédia Subsystem (IMS) comme une sous- couche de contrôle de service dans l'environnement USN fournir un substrat mondiale pour un service complet de bout en bout. De plus, nous vous proposons d'intégrer VANETs avec USN pour des applications et des installations riches plus, ce qui facilitera la vie des humains. Nous avons commencé à étudier les défis sur la route pour atteindre cet objecti

Brain-Targeted Drug Delivery

Brain diseases currently affect one in six people worldwide; they include a wide range of neurological diseases, from Alzheimer’s and Parkinson’s diseases to epilepsy, brain injuries, brain cancer, neuroinfections, and strokes. The treatment of these diseases is complex and limited due to the presence of the blood–brain barrier (BBB), which covers the entirety of the brain. The BBB not only has the function of protecting the brain from harmful substances; it is also a metabolic barrier and a transport regulator of nutrients/serum factors/neurotoxins. Knowing these characteristics when it comes to the treatment of brain diseases makes it easier to understand the lack of efficacy of therapeutic drugs, resulting from the innate resistance of the BBB to permeation. To overcome this limitation, drug delivery systems based on nanotechnology/microtechnology have been developed. Brain-targeted drug delivery enables targeted therapy with a higher therapeutic efficacy and fewer side effects because it targets moieties present in the drug delivery systems

Analysis of QoS Requirements for e-Health Services and Mapping to Evolved Packet System QoS Classes

E-Health services comprise a broad range of healthcare services delivered by using information and communication technology. In order to support existing as well as emerging e-Health services over converged next generation network (NGN) architectures, there is a need for network QoS control mechanisms that meet the often stringent requirements of such services. In this paper, we evaluate the QoS support for e-Health services in the context of the Evolved Packet System (EPS), specified by the Third Generation Partnership Project (3GPP) as a multi-access all-IP NGN. We classify heterogeneous e-Health services based on context and network QoS requirements and propose a mapping to existing 3GPP QoS Class Identifiers (QCIs) that serve as a basis for the class-based QoS concept of the EPS. The proposed mapping aims to provide network operators with guidelines for meeting heterogeneous e-Health service requirements. As an example, we present the QoS requirements for a prototype e-Health service supporting tele-consultation between a patient and a doctor and illustrate the use of the proposed mapping to QCIs in standardized QoS control procedures

Naringenin-functionalized multi-walled carbon nanotubes: a potential approach for site-specific remote-controlled anticancer delivery for the treatment of lung cancer cells

Multi-walled carbon nanotubes functionalized with naringenin have been developed as new drug carriers to improve the performance of lung cancer treatment. The nanocarrier was characterized by Transmission Electron Microscopy (TEM), Fourier-Transform Infrared Spectroscopy (FTIR), X-ray photoelectron spectroscopy, Raman Spectroscopy, and Differential Scanning Calorimetry (DSC). Drug release rates were determined in vitro by the dialysis method. The cytotoxic profile was evaluated using the MTT assay, against a human skin cell line (hFB) as a model for normal cells, and against an adenocarcinomic human alveolar basal epithelial (A569) cell line as a lung cancer in vitro model. The results demonstrated that the functionalization of carbon nanotubes with naringenin occurred by non-covalent interactions. The release profiles demonstrated a pH-responsive behavior, showing a prolonged release in the tumor pH environment. The naringenin-functionalized carbon nanotubes showed lower cytotoxicity on non-malignant cells (hFB) than free naringenin, with an improved anticancer effect on malignant lung cells (A549) as an in vitro model of lung cancer.This work was supported by the Banco do Nordeste (grant FUNDECI/2016.0015), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe (Fapitec) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Eliana B. Souto would like to acknowledge the contributions from the Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) for the projects M-ERA-NET/0004/2015-PAIRED and UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersio

Future Trends and Challenges for Mobile and Convergent Networks

Some traffic characteristics like real-time, location-based, and community-inspired, as well as the exponential increase on the data traffic in mobile networks, are challenging the academia and standardization communities to manage these networks in completely novel and intelligent ways, otherwise, current network infrastructures can not offer a connection service with an acceptable quality for both emergent traffic demand and application requisites. In this way, a very relevant research problem that needs to be addressed is how a heterogeneous wireless access infrastructure should be controlled to offer a network access with a proper level of quality for diverse flows ending at multi-mode devices in mobile scenarios. The current chapter reviews recent research and standardization work developed under the most used wireless access technologies and mobile access proposals. It comprehensively outlines the impact on the deployment of those technologies in future networking environments, not only on the network performance but also in how the most important requirements of several relevant players, such as, content providers, network operators, and users/terminals can be addressed. Finally, the chapter concludes referring the most notable aspects in how the environment of future networks are expected to evolve like technology convergence, service convergence, terminal convergence, market convergence, environmental awareness, energy-efficiency, self-organized and intelligent infrastructure, as well as the most important functional requisites to be addressed through that infrastructure such as flow mobility, data offloading, load balancing and vertical multihoming.Comment: In book 4G & Beyond: The Convergence of Networks, Devices and Services, Nova Science Publishers, 201