Kernel methods for the incorporation of prior-knowledge into support vector machines

Ph.DDOCTOR OF PHILOSOPH

New Advancements in Pure and Applied Mathematics via Fractals and Fractional Calculus

This reprint focuses on exploring new developments in both pure and applied mathematics as a result of fractional behaviour. It covers the range of ongoing activities in the context of fractional calculus by offering alternate viewpoints, workable solutions, new derivatives, and methods to solve real-world problems. It is impossible to deny that fractional behaviour exists in nature. Any phenomenon that has a pulse, rhythm, or pattern appears to be a fractal. The 17 papers that were published and are part of this volume provide credence to that claim. A variety of topics illustrate the use of fractional calculus in a range of disciplines and offer sufficient coverage to pique every reader's attention

On the intelligent management of sepsis in the intensive care unit

The management of the Intensive Care Unit (ICU) in a hospital has its own, very specific requirements that involve, amongst others, issues of risk-adjusted mortality and average length of stay; nurse turnover and communication with physicians; technical quality of care; the ability to meet patient's family needs; and avoid medical error due rapidly changing circumstances and work overload. In the end, good ICU management should lead to an improvement in patient outcomes. Decision making at the ICU environment is a real-time challenge that works according to very tight guidelines, which relate to often complex and sensitive research ethics issues. Clinicians in this context must act upon as much available information as possible, and could therefore, in general, benefit from at least partially automated computer-based decision support based on qualitative and quantitative information. Those taking executive decisions at ICUs will require methods that are not only reliable, but also, and this is a key issue, readily interpretable. Otherwise, any decision tool, regardless its sophistication and accuracy, risks being rendered useless. This thesis addresses this through the design and development of computer based decision making tools to assist clinicians at the ICU. It focuses on one of the main problems that they must face: the management of the Sepsis pathology. Sepsis is one of the main causes of death for non-coronary ICU patients. Its mortality rate can reach almost up to one out of two patients for septic shock, its most acute manifestation. It is a transversal condition affecting people of all ages. Surprisingly, its definition has only been standardized two decades ago as a systemic inflammatory response syndrome with confirmed infection. The research reported in this document deals with the problem of Sepsis data analysis in general and, more specifically, with the problem of survival prediction for patients affected with Severe Sepsis. The tools at the core of the investigated data analysis procedures stem from the fields of multivariate and algebraic statistics, algebraic geometry, machine learning and computational intelligence. Beyond data analysis itself, the current thesis makes contributions from a clinical point of view, as it provides substantial evidence to the debate about the impact of the preadmission use of statin drugs in the ICU outcome. It also sheds light into the dependence between Septic Shock and Multi Organic Dysfunction Syndrome. Moreover, it defines a latent set of Sepsis descriptors to be used as prognostic factors for the prediction of mortality and achieves an improvement on predictive capability over indicators currently in use.La gestió d'una Unitat de Cures Intensives (UCI) hospitalària presenta uns requisits força específics incloent, entre altres, la disminució de la taxa de mortalitat, la durada de l'ingrès, la rotació d'infermeres i la comunicació entre metges amb al finalitad de donar una atenció de qualitat atenent als requisits tant dels malalts com dels familiars. També és força important controlar i minimitzar els error mèdics deguts a canvis sobtats i a la presa ràpida de deicisions assistencials. Al cap i a la fi, la bona gestió de la UCI hauria de resultar en una reducció de la mortalitat i durada d'estada. La presa de decisions en un entorn de crítics suposa un repte de presa de decisions en temps real d'acord a unes guies clíniques molt restrictives i que, pel que fa a la recerca, poden resultar en problemes ètics força sensibles i complexos. Per tant, el personal sanitari que ha de prendre decisions sobre la gestió de malalts crítics no només requereix eines de suport a la decisió que siguin fiables sinó que, a més a més, han de ser interpretables. Altrament qualsevol eina de decisió que no presenti aquests trets no és considerarà d'utilitat clínica. Aquesta tesi doctoral adreça aquests requisits mitjançant el desenvolupament d'eines de suport a la decisió per als intensivistes i es focalitza en un dels principals problemes als que s'han denfrontar: el maneig del malalt sèptic. La Sèpsia és una de les principals causes de mortalitats a les UCIS no-coronàries i la seva taxa de mortalitat pot arribar fins a la meitat dels malalts amb xoc sèptic, la seva manifestació més severa. La Sèpsia és un síndrome transversal, que afecta a persones de totes les edats. Sorprenentment, la seva definició ha estat estandaritzada, fa només vint anys, com a la resposta inflamatòria sistèmica a una infecció corfimada. La recerca presentada en aquest document fa referència a l'anàlisi de dades de la Sèpsia en general i, de forma més específica, al problema de la predicció de la supervivència de malalts afectats amb Sèpsia Greu. Les eines i mètodes que formen la clau de bòveda d'aquest treball provenen de diversos camps com l'estadística multivariant i algebràica, geometria algebraica, aprenentatge automàtic i inteligència computacional. Més enllà de l'anàlisi per-se, aquesta tesi també presenta una contribució des de el punt de vista clínic atès que presenta evidència substancial en el debat sobre l'impacte de l'administració d'estatines previ a l'ingrès a la UCI en els malalts sèptics. També s'aclareix la forta dependència entre el xoc sèptic i el Síndrome de Disfunció Multiorgànica. Finalment, també es defineix un conjunt de descriptors latents de la Sèpsia com a factors de pronòstic per a la predicció de la mortalitat, que millora sobre els mètodes actualment més utilitzats en la UCI

Algebraic Topology for Data Scientists

This book gives a thorough introduction to topological data analysis (TDA), the application of algebraic topology to data science. Algebraic topology is traditionally a very specialized field of math, and most mathematicians have never been exposed to it, let alone data scientists, computer scientists, and analysts. I have three goals in writing this book. The first is to bring people up to speed who are missing a lot of the necessary background. I will describe the topics in point-set topology, abstract algebra, and homology theory needed for a good understanding of TDA. The second is to explain TDA and some current applications and techniques. Finally, I would like to answer some questions about more advanced topics such as cohomology, homotopy, obstruction theory, and Steenrod squares, and what they can tell us about data. It is hoped that readers will acquire the tools to start to think about these topics and where they might fit in.Comment: 322 pages, 69 figures, 5 table

Special Functions: Fractional Calculus and the Pathway for Entropy

Historically, the notion of entropy emerged in conceptually very distinct contexts. This book deals with the connection between entropy, probability, and fractional dynamics as they appeared, for example, in solar neutrino astrophysics since the 1970's (Mathai and Rathie 1975, Mathai and Pederzoli 1977, Mathai and Saxena 1978, Mathai, Saxena, and Haubold 2010). The original solar neutrino problem, experimentally and theoretically, was resolved through the discovery of neutrino oscillations and was recently enriched by neutrino entanglement entropy. To reconsider possible new physics of solar neutrinos, diffusion entropy analysis, utilizing Boltzmann entropy, and standard deviation analysis was undertaken with Super-Kamiokande solar neutrino data. This analysis revealed a non-Gaussian signal with harmonic content. The Hurst exponent is different from the scaling exponent of the probability density function and both Hurst exponent and scaling exponent of the Super-Kamiokande data deviate considerably from the value of ½, which indicates that the statistics of the underlying phenomenon is anomalous. Here experiment may provide guidance about the generalization of theory of Boltzmann statistical mechanics. Arguments in the so-called Boltzmann-Planck-Einstein discussion related to Planck's discovery of the black-body radiation law are recapitulated mathematically and statistically and emphasize from this discussion is pursued that a meaningful implementation of the complex ‘entropy-probability-dynamics’ may offer two ways for explaining the results of diffusion entropy analysis and standard deviation analysis. One way is to consider an anomalous diffusion process that needs to use the fractional space-time diffusion equation (Gorenflo and Mainardi) and the other way is to consider a generalized Boltzmann entropy by assuming a power law probability density function. Here new mathematical framework, invented by sheer thought, may provide guidance for the generalization of Boltzmann statistical mechanics. In this book Boltzmann entropy, generalized by Tsallis and Mathai, is considered. The second one contains a varying parameter that is used to construct an entropic pathway covering generalized type-1 beta, type-2 beta, and gamma families of densities. Similarly, pathways for respective distributions and differential equations can be developed. Mathai's entropy is optimized under various conditions reproducing the well-known Boltzmann distribution, Raleigh distribution, and other distributions used in physics. Properties of the entropy measure for the generalized entropy are examined. In this process the role of special functions of mathematical physics, particularly the H-function, is highlighted