Artificial neural network-statistical approach for PET volume analysis and classification

Copyright © 2012 The Authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.The increasing number of imaging studies and the prevailing application of positron emission tomography (PET) in clinical oncology have led to a real need for efficient PET volume handling and the development of new volume analysis approaches to aid the clinicians in the clinical diagnosis, planning of treatment, and assessment of response to therapy. A novel automated system for oncological PET volume analysis is proposed in this work. The proposed intelligent system deploys two types of artificial neural networks (ANNs) for classifying PET volumes. The first methodology is a competitive neural network (CNN), whereas the second one is based on learning vector quantisation neural network (LVQNN). Furthermore, Bayesian information criterion (BIC) is used in this system to assess the optimal number of classes for each PET data set and assist the ANN blocks to achieve accurate analysis by providing the best number of classes. The system evaluation was carried out using experimental phantom studies (NEMA IEC image quality body phantom), simulated PET studies using the Zubal phantom, and clinical studies representative of nonsmall cell lung cancer and pharyngolaryngeal squamous cell carcinoma. The proposed analysis methodology of clinical oncological PET data has shown promising results and can successfully classify and quantify malignant lesions.This study was supported by the Swiss National Science Foundation under Grant SNSF 31003A-125246, Geneva Cancer League, and the Indo Swiss Joint Research Programme ISJRP 138866. This article is made available through the Brunel Open Access Publishing Fund

Machine Learning for Robust Understanding of Scene Materials in Hyperspectral Images

The major challenges in hyperspectral (HS) imaging and data analysis are expensive sensors, high dimensionality of the signal, limited ground truth, and spectral variability. This dissertation develops and analyzes machine learning based methods to address these problems. In the first part, we examine one of the most important HS data analysis tasks-vegetation parameter estimation. We present two Gaussian processes based approaches for improving the accuracy of vegetation parameter retrieval when ground truth is limited and/or spectral variability is high. The first is the adoption of covariance functions based on well-established metrics, such as, spectral angle and spectral correlation, which are known to be better measures of similarity for spectral data. The second is the joint modeling of related vegetation parameters by multitask Gaussian processes so that the prediction accuracy of the vegetation parameter of interest can be improved with the aid of related vegetation parameters for which a larger set of ground truth is available. The efficacy of the proposed methods is demonstrated by comparing them against state-of-the art approaches on three real-world HS datasets and one synthetic dataset. In the second part, we demonstrate how Bayesian optimization can be applied to jointly tune the different components of hyperspectral data analysis frameworks for better performance. Experimental validation on the spatial-spectral classification framework consisting of a classifier and a Markov random field is provided. In the third part, we investigate whether high dimensional HS spectra can be reconstructed from low dimensional multispectral (MS) signals, that can be obtained from much cheaper, lower spectral resolution sensors. A novel end-to-end convolutional residual neural network architecture is proposed that can simultaneously optimize both the MS bands and the transformation to reconstruct HS spectra from MS signals by analyzing a large quantity of HS data. The learned band can be implemented in sensor hardware and the learned transformation can be incorporated in the data processing pipeline to build a low-cost hyperspectral data collection system. Using a diverse set of real-world datasets, we show how the proposed approach of optimizing MS bands along with the transformation rather than just optimizing the transformation with fixed bands, as proposed by previous studies, can drastically increase the reconstruction accuracy. Additionally, we also investigate the prospects of using reconstructed HS spectra for land cover classification

Design of an Adaptive Classification Procedure for the Analysis of High-Dimensional Data with Limited Training Samples

In a typical supervised classification procedure the availability of training samples has a fundamental effect on classifier performance. For a fixed number of training samples classifier performance is degraded as the number of dimensions (features) is increased. This phenomenon has a significant influence on the analysis of hyperspectral data sets where the ratio of training samples to dimensionality is small. Objectives of this research are to develop novel methods for mitigating the detrimental effects arising from this small ratio and to reduce the effort required by an analyst in terms of training sample selection. An iterative method is developed where semi-labeled samples (classification outputs) are used with the original training samples to estimate parameters and establish a positive feedback procedure wherein parameter estimation and classification enhance each other in an iterative fashion. This work is comprised of four discrete phases. First, the role of semi-labeled samples on parameter estimates is investigated. In this phase it is demonstrated that an iterative procedure based on positive feedback is achievable. Second, a maximum likelihood pixel-wise adaptive classifier is designed. Third, a family of adaptive covariance estimators is developed that combines the adaptive classifiers and covariance estimators to deal with cases where the training sample set is extremely small. Finally, to fully utilize the rich spectral and spatial information contained in hyperspectral data and enhance the performance and robustness of the proposed adaptive classifier, an adaptive Bayesian contextual classifier based on the Markov random field is developed

Novel pattern recognition methods for classification and detection in remote sensing and power generation applications

Novel pattern recognition methods for classification and detection in remote sensing and power generation application

A multiple-point spatially weighted k-NN classifier for remote sensing

A novel classification method based on multiple-point statistics (MPS) is proposed in this article. The method is a modified version of the spatially weighted k-nearest neighbour (k-NN) classifier, which accounts for spatial correlation through weights applied to neighbouring pixels. The MPS characterizes the spatial correlation between multiple points of land-cover classes by learning local patterns in a training image. This rich spatial information is then converted to multiple-point probabilities and incorporated into the k-NN classifier. Experiments were conducted in two study areas, in which the proposed method for classification was tested on a WorldView-2 sub-scene of the Sichuan mountainous area and an IKONOS image of the Beijing urban area. The multiple-point weighted k-NN method (MPk-NN) was compared to several alternatives; including the traditional k-NN and two previously published spatially weighted k-NN schemes; the inverse distance weighted k-NN, and the geostatistically weighted k-NN. The classifiers using the Bayesian and Support Vector Machine (SVM) methods, and these classifiers weighted with spatial context using the Markov random field (MRF) model, were also introduced to provide a benchmark comparison with the MPk-NN method. The proposed approach increased classification accuracy significantly relative to the alternatives, and it is, thus, recommended for the identification of land-cover types with complex and diverse spatial distributions

Two and three dimensional segmentation of multimodal imagery

The role of segmentation in the realms of image understanding/analysis, computer vision, pattern recognition, remote sensing and medical imaging in recent years has been significantly augmented due to accelerated scientific advances made in the acquisition of image data. This low-level analysis protocol is critical to numerous applications, with the primary goal of expediting and improving the effectiveness of subsequent high-level operations by providing a condensed and pertinent representation of image information. In this research, we propose a novel unsupervised segmentation framework for facilitating meaningful segregation of 2-D/3-D image data across multiple modalities (color, remote-sensing and biomedical imaging) into non-overlapping partitions using several spatial-spectral attributes. Initially, our framework exploits the information obtained from detecting edges inherent in the data. To this effect, by using a vector gradient detection technique, pixels without edges are grouped and individually labeled to partition some initial portion of the input image content. Pixels that contain higher gradient densities are included by the dynamic generation of segments as the algorithm progresses to generate an initial region map. Subsequently, texture modeling is performed and the obtained gradient, texture and intensity information along with the aforementioned initial partition map are used to perform a multivariate refinement procedure, to fuse groups with similar characteristics yielding the final output segmentation. Experimental results obtained in comparison to published/state-of the-art segmentation techniques for color as well as multi/hyperspectral imagery, demonstrate the advantages of the proposed method. Furthermore, for the purpose of achieving improved computational efficiency we propose an extension of the aforestated methodology in a multi-resolution framework, demonstrated on color images. Finally, this research also encompasses a 3-D extension of the aforementioned algorithm demonstrated on medical (Magnetic Resonance Imaging / Computed Tomography) volumes