17,017 research outputs found
Performance specifications for a meteorological satellite lidar Final report
Cirrus cloud cover observation capability and performance specifications for meteorological satellite lida
Laser diagnostics and minor species detection in combustion using resonant four-wave mixing
Peer reviewedPostprin
Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging
Multiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological studies. However, MPM application to human tissues is limited by weak endogenous fluorescence in tissue and cytotoxicity of exogenous probes. Herein, we describe the applications of moxifloxacin, an FDA-approved antibiotic, as a cell-labeling agent for MPM. Moxifloxacin has bright intrinsic multiphoton fluorescence, good tissue penetration and high intracellular concentration. MPM with moxifloxacin was demonstrated in various cell lines, and animal tissues of cornea, skin, small intestine and bladder. Clinical application is promising since imaging based on moxifloxacin labeling could be 10 times faster than imaging based on endogenous fluorescence.1152sciescopu
Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization:a solution for practical application
Mechanical properties are important parameters that can be used to assess the physiologic conditions of biologic tissue. Measurements and mapping of tissue mechanical properties can aid in the diagnosis, characterisation and treatment of diseases. As a non-invasive, non-destructive and non-contact method, laser induced surface acoustic waves (SAWs) have potential to accurately characterise tissue elastic properties. However, challenge still exists when the laser is directly applied to the tissue because of potential heat generation due to laser energy deposition. This paper focuses on the thermal effect of the laser induced SAW on the tissue target and provides an alternate solution to facilitate its application in clinic environment. The solution proposed is to apply a thin agar membrane as surface shield to protect the tissue. Transient thermal analysis is developed and verified by experiments to study the effects of the high energy Nd:YAG laser pulse on the surface shield. The approach is then verified by measuring the mechanical property of skin in a Thiel mouse model. The results demonstrate a useful step toward the practical application of laser induced SAW method for measuring real elasticity of normal and diseased tissues in dermatology and other surface epithelia
Optics and Quantum Electronics
Contains table of contents for Section 3, reports on twenty-one research projects and a list of publications and meeting papers.Joint Services Electronics Program Contract DAAL03-92-C-0001U.S. Air Force - Office of Scientific Research Contract F49620-91-C-0091Charles S. Draper Laboratories Contract DL-H-441692MIT Lincoln LaboratoryNational Science Foundation Grant ECS 90-12787Fujitsu LaboratoriesU.S. Navy - Office of Naval Research Grant N00014-92-J-1302National Center for Integrated Photonic TechnologyNational Science Foundation Grant ECS 85-52701U.S. Navy - Office of Naval Research (MFEL) Grant N00014-91-C-0084U.S. Navy - Office of Naval Research (MFEL) Grant N00014-91-J-1956National Institutes of Health Grant R01-GM35459-08U.S. Air Force - Office of Scientific Research Grant F49620-93-1-0301MIT Lincoln Laboratory Contract BX-5098Electric Power Research Institute Contract RP3170-2
Benchmarking Cerebellar Control
Cerebellar models have long been advocated as viable models
for robot dynamics control. Building on an increasing insight
in and knowledge of the biological cerebellum, many models have been
greatly refined, of which some computational models have emerged
with useful properties with respect to robot dynamics control.
Looking at the application side, however, there is a totally different
picture. Not only is there not one robot on the market which uses
anything remotely connected with cerebellar control, but even in
research labs most testbeds for cerebellar models are restricted to
toy problems. Such applications hardly ever exceed the complexity of
a 2 DoF simulated robot arm; a task which is hardly representative for
the field of robotics, or relates to realistic applications.
In order to bring the amalgamation of the two fields forwards, we
advocate the use of a set of robotics benchmarks, on which existing
and new computational cerebellar models can be comparatively tested.
It is clear that the traditional approach to solve robotics dynamics
loses ground with the advancing complexity of robotic structures;
there is a desire for adaptive methods which can compete as traditional
control methods do for traditional robots.
In this paper we try to lay down the successes and problems in the
fields of cerebellar modelling as well as robot dynamics control.
By analyzing the common ground, a set of benchmarks is suggested
which may serve as typical robot applications for cerebellar models
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