12,815 research outputs found

    Improved Answer-Set Programming Encodings for Abstract Argumentation

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    The design of efficient solutions for abstract argumentation problems is a crucial step towards advanced argumentation systems. One of the most prominent approaches in the literature is to use Answer-Set Programming (ASP) for this endeavor. In this paper, we present new encodings for three prominent argumentation semantics using the concept of conditional literals in disjunctions as provided by the ASP-system clingo. Our new encodings are not only more succinct than previous versions, but also outperform them on standard benchmarks.Comment: To appear in Theory and Practice of Logic Programming (TPLP), Proceedings of ICLP 201

    Defeasible Logic Programming: An Argumentative Approach

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    The work reported here introduces Defeasible Logic Programming (DeLP), a formalism that combines results of Logic Programming and Defeasible Argumentation. DeLP provides the possibility of representing information in the form of weak rules in a declarative manner, and a defeasible argumentation inference mechanism for warranting the entailed conclusions. In DeLP an argumentation formalism will be used for deciding between contradictory goals. Queries will be supported by arguments that could be defeated by other arguments. A query q will succeed when there is an argument A for q that is warranted, ie, the argument A that supports q is found undefeated by a warrant procedure that implements a dialectical analysis. The defeasible argumentation basis of DeLP allows to build applications that deal with incomplete and contradictory information in dynamic domains. Thus, the resulting approach is suitable for representing agent's knowledge and for providing an argumentation based reasoning mechanism to agents.Comment: 43 pages, to appear in the journal "Theory and Practice of Logic Programming

    Exploiting Parallelism for Hard Problems in Abstract Argumentation

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    Abstract argumentation framework (AF) is a unifying framework able to encompass a variety of nonmonotonic reasoning approaches, logic programming and computational argumentation. Yet, efficient approaches for most of the decision and enumeration problems associated to AF s are missing, thus potentially limiting the efficacy of argumentation-based approaches in real domains. In this paper, we present an algorithm for enumerating the preferred extensions of abstract argumentation frameworks which exploits parallel computation. To this purpose, the SCC-recursive semantics definition schema is adopted, where extensions are defined at the level of specific sub-frameworks. The algorithm shows significant performance improvements in large frameworks, in terms of number of solutions found and speedup

    Engineering simulations for cancer systems biology

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    Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses. In this way, in silico models become a scientific instrument for investigation, and so should be developed to high standards, be carefully calibrated and their findings presented in such that they may be reproduced. Here, we outline a framework that supports developing simulations as scientific instruments, and we select cancer systems biology as an exemplar domain, with a particular focus on cellular signalling models. We consider the challenges of lack of data, incomplete knowledge and modelling in the context of a rapidly changing knowledge base. Our framework comprises a process to clearly separate scientific and engineering concerns in model and simulation development, and an argumentation approach to documenting models for rigorous way of recording assumptions and knowledge gaps. We propose interactive, dynamic visualisation tools to enable the biological community to interact with cellular signalling models directly for experimental design. There is a mismatch in scale between these cellular models and tissue structures that are affected by tumours, and bridging this gap requires substantial computational resource. We present concurrent programming as a technology to link scales without losing important details through model simplification. We discuss the value of combining this technology, interactive visualisation, argumentation and model separation to support development of multi-scale models that represent biologically plausible cells arranged in biologically plausible structures that model cell behaviour, interactions and response to therapeutic interventions
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