User-centered visual analysis using a hybrid reasoning architecture for intensive care units

One problem pertaining to Intensive Care Unit information systems is that, in some cases, a very dense display of data can result. To ensure the overview and readability of the increasing volumes of data, some special features are required (e.g., data prioritization, clustering, and selection mechanisms) with the application of analytical methods (e.g., temporal data abstraction, principal component analysis, and detection of events). This paper addresses the problem of improving the integration of the visual and analytical methods applied to medical monitoring systems. We present a knowledge- and machine learning-based approach to support the knowledge discovery process with appropriate analytical and visual methods. Its potential benefit to the development of user interfaces for intelligent monitors that can assist with the detection and explanation of new, potentially threatening medical events. The proposed hybrid reasoning architecture provides an interactive graphical user interface to adjust the parameters of the analytical methods based on the users' task at hand. The action sequences performed on the graphical user interface by the user are consolidated in a dynamic knowledge base with specific hybrid reasoning that integrates symbolic and connectionist approaches. These sequences of expert knowledge acquisition can be very efficient for making easier knowledge emergence during a similar experience and positively impact the monitoring of critical situations. The provided graphical user interface incorporating a user-centered visual analysis is exploited to facilitate the natural and effective representation of clinical information for patient care

Holistic System Design for Distributed National eHealth Services

publishedVersio

Wearable feedback systems for rehabilitation

In this paper we describe LiveNet, a flexible wearable platform intended for long-term ambulatory health monitoring with real-time data streaming and context classification. Based on the MIT Wearable Computing Group's distributed mobile system architecture, LiveNet is a stable, accessible system that combines inexpensive, commodity hardware; a flexible sensor/peripheral interconnection bus; and a powerful, light-weight distributed sensing, classification, and inter-process communications software architecture to facilitate the development of distributed real-time multi-modal and context-aware applications. LiveNet is able to continuously monitor a wide range of physiological signals together with the user's activity and context, to develop a personalized, data-rich health profile of a user over time. We demonstrate the power and functionality of this platform by describing a number of health monitoring applications using the LiveNet system in a variety of clinical studies that are underway. Initial evaluations of these pilot experiments demonstrate the potential of using the LiveNet system for real-world applications in rehabilitation medicine

Distributed Knowledge Modeling and Integration of Model-Based Beliefs into the Clinical Decision-Making Process

Das Treffen komplexer medizinischer Entscheidungen wird durch die stetig steigende Menge an zu berücksichtigenden Informationen zunehmend komplexer. Dieser Umstand ist vor allem auf die Verfügbarkeit von immer präziseren diagnostischen Methoden zur Charakterisierung der Patienten zurückzuführen (z.B. genetische oder molekulare Faktoren). Hiermit einher geht die Entwicklung neuartiger Behandlungsstrategien und Wirkstoffe sowie die damit verbundenen Evidenzen aus klinischen Studien und Leitlinien. Dieser Umstand stellt die behandelnden Ärztinnen und Ärzte vor neuartige Herausforderungen im Hinblick auf die Berücksichtigung aller relevanten Faktoren im Kontext der klinischen Entscheidungsfindung. Moderne IT-Systeme können einen wesentlichen Beitrag leisten, um die klinischen Experten weitreichend zu unterstützen. Diese Assistenz reicht dabei von Anwendungen zur Vorverarbeitung von Daten für eine Reduktion der damit verbundenen Komplexität bis hin zur systemgestützten Evaluation aller notwendigen Patientendaten für eine therapeutischen Entscheidungsunterstützung. Möglich werden diese Funktionen durch die formale Abbildung von medizinischem Fachwissen in Form einer komplexen Wissensbasis, welche die kognitiven Prozesse im Entscheidungsprozess adaptiert. Entsprechend werden an den Prozess der IT-konformen Wissensabbildung erhöhte Anforderungen bezüglich der Validität und Signifikanz der enthaltenen Informationen gestellt. In den ersten beiden Kapiteln dieser Arbeit wurden zunächst wichtige methodische Grundlagen im Kontext der strukturierten Abbildung von Wissen sowie dessen Nutzung für die klinische Entscheidungsunterstützung erläutert. Hierbei wurden die inhaltlichen Kernthemen weiterhin im Rahmen eines State of the Art mit bestehenden Ansätzen abgeglichen, um den neuartigen Charakter der vorgestellten Lösungen herauszustellen. Als innovativer Kern wurde zunächst die Konzeption und Umsetzung eines neuartigen Ansatzes zur Fusion von fragmentierten Wissensbausteinen auf der formalen Grundlage von Bayes-Netzen vorgestellt. Hierfür wurde eine neuartige Datenstruktur unter Verwendung des JSON Graph Formats erarbeitet. Durch die Entwicklung von qualifizierten Methoden zum Umgang mit den formalen Kriterien eines Bayes-Netz wurden weiterhin Lösungen aufgezeigt, welche einen automatischen Fusionsprozess durch einen eigens hierfür entwickelten Algorithmus ermöglichen. Eine prototypische und funktionale Plattform zur strukturierten und assistierten Integration von Wissen sowie zur Erzeugung valider Bayes-Netze als Resultat der Fusion wurde unter Verwendung eines Blockchain Datenspeichers implementiert und in einer Nutzerstudie gemäß ISONORM 9241/110-S evaluiert. Aufbauend auf dieser technologischen Plattform wurden im Anschluss zwei eigenständige Entscheidungsunterstützungssysteme vorgestellt, welche relevante Anwendungsfälle im Kontext der HNO-Onkologie adressieren. Dies ist zum einen ein System zur personalisierten Bewertung von klinischen Laborwerten im Kontext einer Radiochemotherapie und zum anderen ein in Form eines Dashboard implementiertes Systems zur effektiveren Informationskommunikation innerhalb des Tumor Board. Beide Konzepte wurden hierbei zunächst im Rahmen einer initialen Nutzerstudie auf Relevanz geprüft, um eine nutzerzentrische Umsetzung zu gewährleisten. Aufgrund des zentralen Fokus dieser Arbeit auf den Bereich der klinischen Entscheidungsunterstützung, werden an zahlreichen Stellen sowohl kritische als auch optimistische Aspekte der damit verbundenen praktischen Lösungen diskutiert.:1 Introduction 1.1 Motivation and Clinical Setting 1.2 Objectives 1.3 Thesis Outline 2 State of the Art 2.1 Medical Knowledge Modeling 2.2 Knowledge Fusion 2.3 Clinical Decision Support Systems 2.4 Clinical Information Access 3 Fundamentals 3.1 Evidence-Based Medicine 3.1.1 Literature-Based Evidence 3.1.2 Practice-Based Evidence 3.1.3 Patient-Directed Evidence 3.2 Knowledge Representation Formats 3.2.1 Logic-Based Representation 3.2.2 Procedural Representation 3.2.3 Network or Graph-Based Representation 3.3 Knowledge-Based Clinical Decision Support 3.4 Conditional Probability and Bayesian Networks 3.5 Clinical Reasoning 3.5.1 Deterministic Reasoning 3.5.2 Probabilistic Reasoning 3.6 Knowledge Fusion of Bayesian Networks 4 Block-Based Collaborative Knowledge Modeling 4.1 Data Model 4.1.1 Belief Structure 4.1.2 Conditional Probabilities 4.1.3 Metadata 4.2 Constraint-Based Automatic Knowledge Fusion 4.2.1 Fusion of the Bayesian Network Structures 4.2.2 Fusion of the Conditional Probability Tables 4.3 Blockchain-Based Belief Storage and Retrieval 4.3.1 Blockchain Characteristics 4.3.2 Relevance for Belief Management 5 Selected CDS Applications for Clinical Practice 5.1 Distributed Knowledge Modeling Platform 5.1.1 Requirement Analysis 5.1.2 System Architecture 5.1.3 System Evaluation 5.1.4 Limitations of the Proposed Solution 5.2 Personalization of Laboratory Findings 5.2.1 Requirement Analysis 5.2.2 System Architecture 5.2.3 Limitations of the Proposed Solution 5.3 Dashboard for Collaborative Decision-Making in the Tumor Board 5.3.1 Requirement Analysis 5.3.2 System Architecture 5.3.3 Limitations of the Proposed Solution 6 Discussion 6.1 Goal Achievements 6.2 Contributions and Conclusion 7 Bibliograph

Semantically-enhanced recommendations in cultural heritage

In the Web 2.0 environment, institutes and organizations are starting to open up their previously isolated and heterogeneous collections in order to provide visitors with maximal access. Semantic Web technologies act as instrumental in integrating these rich collections of metadata by defining ontologies which accommodate different representation schemata and inconsistent naming conventions over the various vocabularies. Facing the large amount of metadata with complex semantic structures, it is becoming more and more important to support visitors with a proper selection and presentation of information. In this context, the Dutch Science Foundation (NWO) funded the Cultural Heritage Information Personalization (CHIP) project in early 2005, as part of the Continuous Access to Cultural Heritage (CATCH) program in the Netherlands. It is a collaborative project between the Rijksmuseum Amsterdam, the Eindhoven University of Technology and the Telematica Instituut. The problem statement that guides the research of this thesis is as follows: Can we support visitors with personalized access to semantically-enriched collections? To study this question, we chose cultural heritage (museums) as an application domain, and the semantically rich background knowledge about the museum collection provides a basis to our research. On top of it, we deployed user modeling and recommendation technologies in order to provide personalized services for museum visitors. Our main contributions are: (i) we developed an interactive rating dialog of artworks and art concepts for a quick instantiation of the CHIP user model, which is built as a specialization of FOAF and mapped to an existing event model ontology SEM; (ii) we proposed a hybrid recommendation algorithm, combining both explicit and implicit relations from the semantic structure of the collection. On the presentation level, we developed three tools for end-users: Art Recommender, Tour Wizard and Mobile Tour Guide. Following a user-centered design cycle, we performed a series of evaluations with museum visitors to test the effectiveness of recommendations using the rating dialog, different ways to build an optimal user model and the prediction accuracy of the hybrid algorithm. Chapter 1 introduces the research questions, our approaches and the outline of this thesis. Chapter 2 gives an overview of our work at the first stage. It includes (i) the semantic enrichment of the Rijksmuseum collection, which is mapped to three Getty vocabularies (ULAN, AAT, TGN) and the Iconclass thesaurus; (ii) the minimal user model ontology defined as a specialization of FOAF, which only stores user ratings at that time, (iii) the first implementation of the content-based recommendation algorithm in our first tool, the CHIP Art Recommender. Chapter 3 presents two other tools: Tour Wizard and Mobile Tour Guide. Based on the user's ratings, the Web-based Tour Wizard recommends museum tours consisting of recommended artworks that are currently available for museum exhibitions. The Mobile Tour Guide converts recommended tours to mobile devices (e.g. PDA) that can be used in the physical museum space. To connect users' various interactions with these tools, we made a conversion of the online user model stored in RDF into XML format which the mobile guide can parse, and in this way we keep the online and on-site user models dynamically synchronized. Chapter 4 presents the second generation of the Mobile Tour Guide with a real time routing system on different mobile devices (e.g. iPod). Compared with the first generation, it can adapt museum tours based on the user's ratings artworks and concepts, her/his current location in the physical museum and the coordinates of the artworks and rooms in the museum. In addition, we mapped the CHIP user model to an existing event model ontology SEM. Besides ratings, it can store additional user activities, such as following a tour and viewing artworks. Chapter 5 identifies a number of semantic relations within one vocabulary (e.g. a concept has a broader/narrower concept) and across multiple vocabularies (e.g. an artist is associated to an art style). We applied all these relations as well as the basic artwork features in content-based recommendations and compared all of them in terms of usefulness. This investigation also enables us to look at the combined use of artwork features and semantic relations in sequence and derive user navigation patterns. Chapter 6 defines the task of personalized recommendations and decomposes the task into a number of inference steps for ontology-based recommender systems, from a perspective of knowledge engineering. We proposed a hybrid approach combining both explicit and implicit recommendations. The explicit relations include artworks features and semantic relations with preliminary weights which are derived from the evaluation in Chapter 5. The implicit relations are built between art concepts based on instance-based ontology matching. Chapter 7 gives an example of reusing user interaction data generated by one application into another one for providing cross-application recommendations. In this example, user tagging about cultural events, gathered by iCITY, is used to enrich the user model for generating content-based recommendations in the CHIP Art Recommender. To realize full tagging interoperability, we investigated the problems that arise in mapping user tags to domain ontologies, and proposed additional mechanisms, such as the use of SKOS matching operators to deal with the possible mis-alignment of tags and domain-specific ontologies. We summarized to what extent the problem statement and each of the research questions are answered in Chapter 8. We also discussed a number of limitations in our research and looked ahead at what may follow as future work

Adaptive hypertext and hypermedia : workshop : proceedings, 3rd, Sonthofen, Germany, July 14, 2001 and Aarhus, Denmark, August 15, 2001

This paper presents two empirical usability studies based on techniques from Human-Computer Interaction (HeI) and software engineering, which were used to elicit requirements for the design of a hypertext generation system. Here we will discuss the findings of these studies, which were used to motivate the choice of adaptivity techniques. The results showed dependencies between different ways to adapt the explanation content and the document length and formatting. Therefore, the system's architecture had to be modified to cope with this requirement. In addition, the system had to be made adaptable, in addition to being adaptive, in order to satisfy the elicited users' preferences

Adaptive hypertext and hypermedia : workshop : proceedings, 3rd, Sonthofen, Germany, July 14, 2001 and Aarhus, Denmark, August 15, 2001

This paper presents two empirical usability studies based on techniques from Human-Computer Interaction (HeI) and software engineering, which were used to elicit requirements for the design of a hypertext generation system. Here we will discuss the findings of these studies, which were used to motivate the choice of adaptivity techniques. The results showed dependencies between different ways to adapt the explanation content and the document length and formatting. Therefore, the system's architecture had to be modified to cope with this requirement. In addition, the system had to be made adaptable, in addition to being adaptive, in order to satisfy the elicited users' preferences

A survey of deep learning models in medical therapeutic areas.

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Internet of Things Strategic Research Roadmap

Internet of Things (IoT) is an integrated part of Future Internet including existing and evolving Internet and network developments and could be conceptually defined as a dynamic global network infrastructure with self configuring capabilities based on standard and interoperable communication protocols where physical and virtual “things” have identities, physical attributes, and virtual personalities, use intelligent interfaces, and are seamlessly integrated into the information network