Smart Sensors for Healthcare and Medical Applications

This book focuses on new sensing technologies, measurement techniques, and their applications in medicine and healthcare. Specifically, the book briefly describes the potential of smart sensors in the aforementioned applications, collecting 24 articles selected and published in the Special Issue “Smart Sensors for Healthcare and Medical Applications”. We proposed this topic, being aware of the pivotal role that smart sensors can play in the improvement of healthcare services in both acute and chronic conditions as well as in prevention for a healthy life and active aging. The articles selected in this book cover a variety of topics related to the design, validation, and application of smart sensors to healthcare

Motor overflow during reaching in infancy: Quantification of limb movement using inertial motion units

Early in life, infants exhibit motor overflow, which can be defined as the generation of involuntary movements accompanying purposeful actions. We present the results of a quantitative study exploring motor overflow in 4-month-old infants. This is the first study quantifying motor overflow with high accuracy and precision provided by Inertial Motion Units. The study aimed to investigate the motor activity across the non-acting limbs during goal-directed action. To this end, we used wearable motion trackers to measure infant motor activity during a baby-gym task designed to capture overflow during reaching movements. The analysis was conducted on the subsample of participants (n = 20), who performed at least four reaches during the task. A series of Granger causality tests revealed that the activity differed depending on the non-acting limb and the type of the reaching movement. Importantly, on average, the non-acting arm preceded the activation of the acting arm. In contrast, the activity of the acting arm was followed by the activation of the legs. This may be caused by their distinct purposes in supporting postural stability and efficiency of movement execution. Finally, our findings demonstrate the utility of wearable motion trackers for precise measurement of infant movement dynamics

The whole-body motor skills of children with autism spectrum disorder taking goal-directed actions in virtual reality

Many symptoms of the autism spectrum disorder (ASD) are evident in early infancy, but ASD is usually diagnosed much later by procedures lacking objective measurements. It is necessary to anticipate the identification of ASD by improving the objectivity of the procedure and the use of ecological settings. In this context, atypical motor skills are reaching consensus as a promising ASD biomarker, regardless of the level of symptom severity. This study aimed to assess differences in the whole-body motor skills between 20 children with ASD and 20 children with typical development during the execution of three tasks resembling regular activities presented in virtual reality. The virtual tasks asked to perform precise and goal-directed actions with different limbs vary in their degree of freedom of movement. Parametric and non-parametric statistical methods were applied to analyze differences in children's motor skills. The findings endorsed the hypothesis that when particular goal-directed movements are required, the type of action could modulate the presence of motor abnormalities in ASD. In particular, the ASD motor abnormalities emerged in the task requiring to take with the upper limbs goal-directed actions with low degree of freedom. The motor abnormalities covered (1) the body part mainly involved in the action, and (2) further body parts not directly involved in the movement. Findings were discussed against the background of atypical prospective control of movements and visuomotor discoordination in ASD. These findings contribute to advance the understanding of motor skills in ASD while deepening ecological and objective assessment procedures based on VR

Event Structure In Vision And Language

Our visual experience is surprisingly rich: We do not only see low-level properties such as colors or contours; we also see events, or what is happening. Within linguistics, the examination of how we talk about events suggests that relatively abstract elements exist in the mind which pertain to the relational structure of events, including general thematic roles (e.g., Agent), Causation, Motion, and Transfer. For example, “Alex gave Jesse flowers” and “Jesse gave Alex flowers” both refer to an event of transfer, with the directionality of the transfer having different social consequences. The goal of the present research is to examine the extent to which abstract event information of this sort (event structure) is generated in visual perceptual processing. Do we perceive this information, just as we do with more ‘traditional’ visual properties like color and shape? In the first study (Chapter 2), I used a novel behavioral paradigm to show that event roles – who is acting on whom – are rapidly and automatically extracted from visual scenes, even when participants are engaged in an orthogonal task, such as color or gender identification. In the second study (Chapter 3), I provided functional magnetic resonance (fMRI) evidence for commonality in content between neural representations elicited by static snapshots of actions and by full, dynamic action sequences. These two studies suggest that relatively abstract representations of events are spontaneously extracted from sparse visual information. In the final study (Chapter 4), I return to language, the initial inspiration for my investigations of events in vision. Here I test the hypothesis that the human brain represents verbs in part via their associated event structures. Using a model of verbs based on event-structure semantic features (e.g., Cause, Motion, Transfer), it was possible to successfully predict fMRI responses in language-selective brain regions as people engaged in real-time comprehension of naturalistic speech. Taken together, my research reveals that in both perception and language, the mind rapidly constructs a representation of the world that includes events with relational structure

Markerless Human Motion Analysis

Measuring and understanding human motion is crucial in several domains, ranging from neuroscience, to rehabilitation and sports biomechanics. Quantitative information about human motion is fundamental to study how our Central Nervous System controls and organizes movements to functionally evaluate motor performance and deficits. In the last decades, the research in this field has made considerable progress. State-of-the-art technologies that provide useful and accurate quantitative measures rely on marker-based systems. Unfortunately, markers are intrusive and their number and location must be determined a priori. Also, marker-based systems require expensive laboratory settings with several infrared cameras. This could modify the naturalness of a subject\u2019s movements and induce discomfort. Last, but not less important, they are computationally expensive in time and space. Recent advances on markerless pose estimation based on computer vision and deep neural networks are opening the possibility of adopting efficient video-based methods for extracting movement information from RGB video data. In this contest, this thesis presents original contributions to the following objectives: (i) the implementation of a video-based markerless pipeline to quantitatively characterize human motion; (ii) the assessment of its accuracy if compared with a gold standard marker-based system; (iii) the application of the pipeline to different domains in order to verify its versatility, with a special focus on the characterization of the motion of preterm infants and on gait analysis. With the proposed approach we highlight that, starting only from RGB videos and leveraging computer vision and machine learning techniques, it is possible to extract reliable information characterizing human motion comparable to that obtained with gold standard marker-based systems

Children’s Fitness and Quality of Movement

Introduction: Movement is essential to life and plays a key role in development throughout childhood. Movement can be assessed by its quantity and quality. Movement is important to measure as it can aid early intervention. Current research suggests that global levels of fitness are declining, with a lack of research surrounding children’s natural fitness levels as they get older. Quantity of movement is commonly studied, however quality is becoming increasingly popular. A clear understanding of the methods of technology used to measure quality of movement is important as understanding this area will aid in designing appropriate interventions.Methods: This thesis comprises of two experimental studies. Study one is a repeated measures design using previously collected Swanlinx data to investigate how components of children’s fitness change over a one-year period. Study two is a scoping review investigating the measurement of quality of movement with technology in the form of MEM’s devices, while aiming to gain clarity on the definition of quality.Results: Study one revealed that children’s fitness levels increase across a one-year period, in all components of fitness, except sit and reach. Boys performed significantly better in all fitness components, apart from sit and reach. Study two demonstrated the broad field that is included under the term of quality, showing clarity is needed in this area. A large number of devices, movements and populations are being observed, with multiple definitions of quality which is dependent on the metrics collected.Conclusion: Study one concludes that children’s fitness levels increase over one-year, with boys performing better than girls. This can be used to understand children’s natural fitness levels and aid future interventions in participation. Study two concludes that there are multiple ways to assess quality of movement however a clear definition of the quality should be stated, aiding comparison of quality

Human Movement Disorders Analysis with Graph Neural Networks

Human movement disorders encompass a group of neurological conditions that cause abnormal movements. These disorders, even when subtle, may be symptomatic of a broad spectrum of medical issues, from neurological to musculoskeletal. Clinicians and researchers still encounter challenges in understanding the underlying pathologies. In light of this, medical professionals and associated researchers are increasingly looking towards the fast-evolving domain of computer vision in pursuit of precise and dependable automated diagnostic tools to support clinical diagnosis. To this end, this thesis explores the feasibility of the interpretable and accurate human movement disorders analysis system using graph neural networks. Cerebral Palsy (CP) and Parkinson’s Disease (PD) are two common neurological diseases associated with movement disorders that seriously affect patients’ quality of life. Specifically, CP is estimated to affect 2 in 1000 babies born in the UK each year, while PD affects an estimated 10 million people globally. Considering their clinical significance and properties, we develop and examine the state-of-the-art attention-informed Graph Neural Networks (GNN) for robust and interpretable CP prediction and PD diagnosis. We highlight the significant differences between the human body movement frequency of CP infants and healthy groups, and propose frequency attention-informed convolutional networks (GCNs) and spatial frequency attention based GCNs to predict CP with strong interpretability. To support the early diagnosis of PD, we propose novel video-based deep learning system, SPA-PTA, with a spatial pyramidal attention design based on clinical observations and mathematical theories. Our systems provide undiagnosed PD patients with low-cost, non-intrusive PT classification and tremor severity rating results as a PD warning sign with interpretable attention visualizations