Comparative study on the detection of early dental caries using thermo-photonic lock-in imaging and optical coherence tomography

Early detection of dental caries is known to be the key to the effectiveness of therapeutic and preventive approaches in dentistry. However, existing clinical detection techniques, such as radiographs, are not sufficiently sensitive to detect and monitor the progression of caries at early stages. As such, in recent years, several optics-based imaging modalities have been proposed for the early detection of caries. The majority of these techniques rely on the enhancement of light scattering in early carious lesions, while a few of them are based on the enhancement of light absorption at early caries sites. In this paper, we report on a systemic comparative study on the detection performances of optical coherence tomography (OCT) and thermophotonic lock-in imaging (TPLI) as representative early caries detection modalities based on light scattering and absorption, respectively. Through controlled demineralization studies on extracted human teeth and µCT validation experiments, several detection performance parameters of the two modalities such as detection threshold, sensitivity and specificity have been qualitatively analyzed and discussed. Our experiment results suggests that both modalities have sufficient sensitivity for the detection of well-developed early caries on occlusal and smooth surfaces; however, TPLI provides better sensitivity and detection threshold for detecting very early stages of caries formation, which is deemed to be critical for the effectiveness of therapeutic and preventive approaches in dentistry. Moreover, due to the more specific nature of the light absorption contrast mechanism over light scattering, TPLI exhibits better detection specificity, which results in less false positive readings and thus allows for the proper differentiation of early caries regions from the surrounding intact areas. The major shortcoming of TPLI is its inherent depth-integrated nature, prohibiting the production of depth-resolved/B-mode like images. The outcomes of this research justify the need for a light-absorption based imaging modality with the ability to produce tomographic and depth-resolved images, combining the key advantages of OCT and TPLI.York University Librarie

Optical enhancement of sensitivity in laser Doppler velocity systems

Utilization of optical enhancement techniques prevents loss of light by reflections at the photocathode of a photomultiplier and increases signal detection sensitivity

Coherent and Squeezed Vacuum Light Interferometry: Parity detection hits the Heisenberg limit

The interference between coherent and squeezed vacuum light can produce path entangled states with very high fidelities. We show that the phase sensitivity of the above interferometric scheme with parity detection saturates the quantum Cramer-Rao bound, which reaches the Heisenberg-limit when the coherent and squeezed vacuum light are mixed in roughly equal proportions. For the same interferometric scheme, we draw a detailed comparison between parity detection and a symmetric-logarithmic-derivative-based detection scheme suggested by Ono and Hofmann.Comment: Change in the format from aps to iop since we decided to submit it to NJP; Minor changes in tex

Rapid adaptive evolution of colour vision in the threespine stickleback radiation.

Vision is a sensory modality of fundamental importance for many animals, aiding in foraging, detection of predators and mate choice. Adaptation to local ambient light conditions is thought to be commonplace, and a match between spectral sensitivity and light spectrum is predicted. We use opsin gene expression to test for local adaptation and matching of spectral sensitivity in multiple independent lake populations of threespine stickleback populations derived since the last ice age from an ancestral marine form. We show that sensitivity across the visual spectrum is shifted repeatedly towards longer wavelengths in freshwater compared with the ancestral marine form. Laboratory rearing suggests that this shift is largely genetically based. Using a new metric, we found that the magnitude of shift in spectral sensitivity in each population corresponds strongly to the transition in the availability of different wavelengths of light between the marine and lake environments. We also found evidence of local adaptation by sympatric benthic and limnetic ecotypes to different light environments within lakes. Our findings indicate rapid parallel evolution of the visual system to altered light conditions. The changes have not, however, yielded a close matching of spectrum-wide sensitivity to wavelength availability, for reasons we discuss

High-sensitivity detection of narrowband light in a more intense broadband background using coherence interferogram phase

This paper describes an optical interferometric detection technique,. known as the interferogram phase step shift, which detects narrowband, coherent, and partially coherent light in more intense broadband incoherent background light using changes in the phase gradient with the optical path difference of the coherence interferograin to distinguish the bandwidth or coherence of the signal from that of the background. The detection sensitivity is assessed experimentally by measuring the smallest signal-to-background ratio or signal-to-clutter ratio (SCR), which causes a detectable change in the self-coherence interferograin phase. This minimum detectable SCR (MDSCR) is measured for the multimode He-Ne laser, resonant-cavity light-emitting diode (LED), narrowband-filtered white light, and LED signal sources in a more intense tungsten-halogen-lamp white-light background. The highest MDSCRs to date, to the authors' knowledge, are -46.42 dB for coherent light and -31.96 dB for partially coherent light, which exceed those of existing automatic single-domain techniques by 18.97 and 4.51 dB with system input dynamic ranges of 19.24 and 11.39 dB, respectively. The sensitivity dependence on the signal-to-system bandwidth ratio and on the relative offset of their central wavelengths is also assessed, and optimum values are identified

Large area Si low-temperature light detectors with Neganov-Luke effect

Next generation calorimetric experiments for the search of rare events rely on the detection of tiny amounts of light (of the order of 20 optical photons) to discriminate and reduce background sources and improve sensitivity. Calorimetric detectors are the simplest solution for photon detection at cryogenic (mK) temperatures. The development of silicon based light detectors with enhanced performance thanks to the use of the Neganov-Luke effect is described. The aim of this research line is the production of high performance detectors with industrial-grade reproducibility and reliability.Comment: 4 pages, 2 figure

Paired emitter-detector diode detection with dual wavelength monitoring for enhanced sensitivity to transition metals in ion chromatography with post-column reaction

The combination of post-column derivatisation and visible detection are regularly employed in ion chromatography (IC) to detect poorly absorbing species. Although this mode is often highly sensitive, one disadvantage is the increase in repeating baseline artifacts associated with out-of-sync pumping systems. The work presented here will demonstrate the use of a second generation design paired emitter-detector diode (PEDD-II) detection mode offering enhanced sensitivity to transition metals in IC by markedly reducing this problem and also by improving signal noise. First generation designs demonstrated the use of a single integrated PEDD detector cell as a simple, small (15 x 5 mm), highly sensitive, low cost photometric detector for the detection of metals in ion chromatography (IC). The basic principle of this detection mode lies in the employment of two linear light emitting diodes (LEDs), one operating in normal mode as a light source and the other in reverse bias serving as a light detector. The second generation PEDD-II design showed increased sensitivity for Mn(II)- and Co(II)-2-(pyridylazo) resorcinol (PAR) complexes as a result of two simultaneously acquiring detection cells - one analytical PEDD cell and one reference PEDD cell. Therefore, the PEDD-II employs two wavelengths whereby one monitors the analyte reaction product and the second monitors a wavelength close to the isosbestic point. The optimum LED wavelength to be used for the analytical cell was investigated to maximise peak response. The fabrication process for both the analytical and reference PEDD cells was validated by determining the reproducibility of detectors within a batch. The reproducibility and sensitivity of the PEDD-II detector was then investigated using signals obtained from both intra- and inter-day chromatograms

Possible approach to improve sensitivity of a Michelson interferometer

We propose a possible approach to achieve an 1/N sensitivity of Michelson interferometer by using a properly designed random phase modulation. Different from other approaches, the sensitivity improvement does not depend on increasing optical powers or utilizing the quantum properties of light. Moreover the requirements for optical losses and the quantum efficiencies of photodetection systems might be lower than the quantum approaches and the sensitivity improvement is frequency independent in all detection band.Comment: 8 pages, 3 figures, new versio