Premenopausal endogenous oestrogen levels and breast cancer risk: a meta-analysis.

BACKGROUND: Many of the established risk factors for breast cancer implicate circulating hormone levels in the aetiology of the disease. Increased levels of postmenopausal endogenous oestradiol (E2) have been found to increase the risk of breast cancer, but no such association has been confirmed in premenopausal women. We carried out a meta-analysis to summarise the available evidence in women before the menopause. METHODS: We identified seven prospective studies of premenopausal endogenous E2 and breast cancer risk, including 693 breast cancer cases. From each study we extracted odds ratios of breast cancer between quantiles of endogenous E2, or for unit or s.d. increases in (log transformed) E2, or (where odds ratios were unavailable) summary statistics for the distributions of E2 in breast cancer cases and unaffected controls. Estimates for a doubling of endogenous E2 were obtained from these extracted estimates, and random-effect meta-analysis was used to obtain a pooled estimate across the studies. RESULTS: Overall, we found weak evidence of a positive association between circulating E2 levels and the risk of breast cancer, with a doubling of E2 associated with an odds ratio of 1.10 (95% CI: 0.96, 1.27). CONCLUSION: Our findings are consistent with the hypothesis of a positive association between premenopausal endogenous E2 and breast cancer risk

Palestinian Refugees in Gaza

Events since Arthur Helton\u27s death - including the change in leadership of the Palestinian Authority and the Israeli proposal for disengagement from Gaza make it even timelier to examine some practical solutions. For improving Palestinian lives in the short term, much can be learned from the approaches taken in other refugee situations. This Article begins with background information on Palestinian refugees in Gaza. It then discusses Israeli plans for disengagement from Gaza. In the following section, the Article reviews options for addressing the problems faced by Palestinian refugees in Gaza, utilizing the broader literature devoted to the integration of refugees and displaced persons in post-conflict and post-occupation societies. It concludes with an agenda of action for the international community, Palestinian Authority, and Israel

Effectiveness of blood transfusions and risk factors for mortality in children aged from 1 month to 4 years at the Bon Marche Hospital, Bunia, Democratic Republic of Congo

Objective  To assess the effectiveness of blood transfusions in a hospital of north-eastern Democratic Republic of the Congo. Methods  Prospective study of children admitted for severe anaemia. During admission, data were collected on clinical condition and haemoglobin levels, before and after blood transfusion. A linear regression model was built to explore factors associated with haemoglobin level after transfusion. Risk factors for mortality were explored through multivariate logistic regression. Results  Haemoglobin level (Hb) was below 4 g/dl in 35% (230/657), between 4 and 6 g/dl in 58% (348/657) and at least 6 g/dl in another 6% (43/657) of the transfused children. A transfusion of 15 ml/kg of whole blood increased the Hb from 4.4 to 7.8 g/dl. Haemoglobin level after transfusion was associated with baseline Hb, quantity of delivered blood and history of previous transfusions. Overall case-fatality rate was 5.6% (37/657). Risk factors for deaths were co-morbidities such as chest infection, meningitis or malnutrition, Hb ≥ 6 g/dl, impaired consciousness or jugular venous distention on admission, and provenance. Conclusion  Transfusion was a frequent practice, the use of which could clearly have been rationalised. While indications should be restricted, quantities of transfused blood should be adapted to needs

On the Monotone Upper Bound Problem

The Monotone Upper Bound Problem asks for the maximal number M(d,n) of vertices on a strictly-increasing edge-path on a simple d-polytope with n facets. More specifically, it asks whether the upper bound M(d,n)<=M_{ubt}(d,n) provided by McMullen's (1970) Upper Bound Theorem is tight, where M_{ubt}(d,n) is the number of vertices of a dual-to-cyclic d-polytope with n facets. It was recently shown that the upper bound M(d,n)<=M_{ubt}(d,n) holds with equality for small dimensions (d<=4: Pfeifle, 2003) and for small corank (n<=d+2: G\"artner et al., 2001). Here we prove that it is not tight in general: In dimension d=6 a polytope with n=9 facets can have M_{ubt}(6,9)=30 vertices, but not more than 26 <= M(6,9) <= 29 vertices can lie on a strictly-increasing edge-path. The proof involves classification results about neighborly polytopes, Kalai's (1988) concept of abstract objective functions, the Holt-Klee conditions (1998), explicit enumeration, Welzl's (2001) extended Gale diagrams, randomized generation of instances, as well as non-realizability proofs via a version of the Farkas lemma.Comment: 15 pages; 6 figure

Star formation rate and dynamical mass of 10^8 solar mass black hole host galaxies at redshift 6

We present ALMA observations of two moderate luminosity quasars at redshift 6. These quasars from the Canada-France High-z Quasar Survey (CFHQS) have black hole masses of ~10^8 M_solar. Both quasars are detected in the [CII] line and dust continuum. Combining these data with our previous study of two similar CFHQS quasars we investigate the population properties. We show that z>6 quasars have a significantly lower far-infrared luminosity than bolometric-luminosity-matched samples at lower redshift, inferring a lower star formation rate, possibly correlated with the lower black hole masses at z=6. The ratios of [CII] to far-infrared luminosities in the CFHQS quasars are comparable with those of starbursts of similar star formation rate in the local universe. We determine values of velocity dispersion and dynamical mass for the quasar host galaxies based on the [CII] data. We find that there is no significant offset from the relations defined by nearby galaxies with similar black hole masses. There is however a marked increase in the scatter at z=6, beyond the large observational uncertainties.Comment: 10 pages, 7 figures, accepted for publication in Ap

Massive star formation in Wolf-Rayet galaxies: II. Optical spectroscopy results

(Abridged) We have performed a comprehensive multiwavelength analysis of a sample of 20 starburst galaxies that show the presence of a substantial population of very young massive stars. In this paper, the second of the series, we present the results of the analysis of long-slit intermediate-resolution spectroscopy of star-formation bursts for 16 galaxies of our sample. We study the spatial localization of the WR stars in each galaxy. We analyze the excitation mechanism and derive the reddening coefficient, physical conditions and chemical abundances of the ionized gas. We study the kinematics of the ionized gas to check the rotation/turbulence pattern of each system. When possible, tentative estimates of the Keplerian mass of the galaxies have been calculated. Our analysis has revealed that a substantial fraction of the galaxies show evidences of perturbed kinematics. With respect to the results found in individual galaxies, we remark the detection of objects with different metallicity and decoupled kinematics in Haro 15 and Mkn 1199, the finding of evidences of tidal streams in IRAS 08208+2816, Tol 9 and perhaps in SBS 1319+579, and the development of a merging process in SBS 0926+606 A and in Tol 1457-262. All these results reinforce the hypothesis that interactions with or between dwarf objects is a very important mechanism in the triggering of massive star formation in starburst galaxies, specially in dwarf ones. It must be highlighted that only deep and very detailed observationscan provide clear evidences that these subtle interaction processes are taking place.Comment: Accepted in A&A. 51 pages, 40 Figures, 19 Tables. Full Version: http://www.atnf.csiro.au/people/Angel.Lopez-Sanchez/papers/MSFinWRG_II_main_ACCEPTED_26sep09.pd

HI Observations of the Ca II absorbing galaxies Mrk 1456 and SDSS J211701.26-002633.7

In an effort to study Damped Lyman Alpha galaxies at low redshift, we have been using the Sloan Digital Sky Survey to identify galaxies projected onto QSO sightlines and to characterize their optical properties. For low redshift galaxies, the HI 21cm emission line can be used as an alternate tool for identifying possible DLA galaxies, since HI emitting galaxies typically exhibit HI columns that are larger than the classical DLA limit. Here we report on follow-up HI 21 cm emission line observations of two DLA candidates that are both low-redshift spiral galaxies, Mrk 1456 and SDSS J211701.26-002633.7. The observations were made using the Green Bank and Arecibo Telescopes, respectively. Analysis of their HI properties reveal the galaxies to be about one and two M_HI* galaxies, respectively, and to have average HI mass, gas-richness, and gas mass fraction for their morphological types. We consider Mrk 1456 and SDSS J211701.26-002633.7 to be candidate DLA systems based upon the strength of the CaII absorption lines they cause in their QSO's spectra, and impact parameters to the QSO that are smaller than the stellar disk. Compared to the small numbers of other HI-detected DLA and candidate DLA galaxies, Mrk 1456 and SDSS J211701.26-002633.7 have high HI masses. When compared with the expected properties of low-z DLAs from an HI-detected sample of galaxies, Mrk 1456 and SDSS J211701.26-002633.7 fall within the ranges for impact parameter and B-band absolute magnitude; and the HI mass distribution for the HI-detected DLAs agrees with that of the expected HI mass distribution for low-z DLAs. Our observations support galaxy-evolution models in which high mass galaxies make up an increasing contribution to the DLA cross-section at lower redshifts. [abridged]Comment: 12 pages, 5 figures, 5 tables; to be published in The Astronomical Journa

Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord blood in vitro

Background: There is a need to prevent and treat infection in newborns. One approach is administration of antimicrobial proteins and peptides (APPs) such as LL-37, a membrane-active cathelicidin antimicrobial peptide, and mannose-binding lectin (MBL), a pattern-recognition protein that binds to microbial surface polysaccharides resulting in opsonization and complement activation. Low plasma/serum levels of LL-37 and of MBL have been correlated with infection and exogenous administration of these agents may enhance host defense. Methods: The antimicrobial activity of LL-37 (15 µg/ml) or rMBL (0.5, 2 and 10 µg/ml) was tested in hirudin-anticoagulated preterm and term human cord blood (N = 12-14) against Staphylococcus aureus (SA) USA 300 (2x10 4 CFU/ml), Staphylococcus epidermis (SE) 1457 (2x10 4 CFU/ml) and Candida albicans (CA) SC5314 (1x10 4 CFU/ml). After incubation (1, 45, or 180 min), CFUs were enumerated by plating blood onto agar plates. Supernatants were collected for measurement of MBL via ELISA. Results: Preterm cord blood demonstrated impaired endogenous killing capacity against SA and SE compared to term blood. Addition of LL-37 strongly enhanced antimicrobial/antifungal activity vs SA, SE and CA in term blood and SE and CA in preterm blood. By contrast, rMBL showed modest fungistatic activity vs CA in a sub-analysis of term newborns with high basal MBL levels. Baseline MBL levels varied within preterm and term cohorts with no correlation to gestational age. In summary, exogenous LL-37 demonstrated significant antimicrobial activity against SA, SE and CA in term and SE and CA in preterm human blood tested in vitro. rMBL demonstrated modest antifungal activity in term cord blood of individuals with high baseline MBL levels. Conclusions: To the extent that our in vitro results predict the effects of APPs in vivo, development of APPs for prevention and treatment of infection should take into account host age as well as the target pathogen

Renegotiating father’s identity following stillbirth: what and who am I?

This study examines the experiences of men following stillbirth in particular the challenges they face in claiming their identity as a father of an absent child. Fathers felt diminished when concerns about how they were coping were directed only to the women. Contrary to the notion that father’s experience suggests men suffer less distress, this research shows that men also deal with loss at an emotional level. This investigation into men’s accounts of loss forms part of a larger study in which 28 men and women participated in interviews and focus groups about their experiences of perinatal death. By listening to narrative accounts of loss, the passage to parenthood for bereaved men represents a disruption and re-evaluation of who they are, what they knew about the world as they negotiate the incomprehensibility of the death itself. Narratives by bereaved men also reveal how their sense of self and identity is mediated by the social and cultural milieu to which they belong and are largely disenfranchising experiences when friends, family and others, at times, fail to acknowledge the enormity of their loss. The findings suggest that recognition of the death of baby who is stillborn as well as the impact of the death for father’s is intertwined with personal identity. Men in this study needed to receive recognition as fathers, both at the time of their loss and after. In examining the reproductive and bereavement journey of men, several domains occurred to illuminate the experience of men including; men as support partners; the impact of the death; parenting an absent child [advocate, protector]. The findings from this study will offer insight into the experiences of men that will resonate for others including practitioners who support individuals going through similar experiences. Ethical approval for the study was granted by the University of Bristol Ethics Committee as part of doctoral research. Written informed consent was obtained by all study participants. No formal recruitment was obtained through the National Health Service or Government Institution and was entirely voluntary