MoKCa database - mutations of kinases in cancer

Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer therapies The MoKCa database (Mutations of Kinases in Cancer, http://strubiol.icr.ac.uk/extra/mokca) has been developed to structurally and functionally annotate, and where possible predict, the phenotypic consequences of mutations in protein kinases implicated in cancer. Somatic mutation data from tumours and tumour cell lines have been mapped onto the crystal structures of the affected protein domains. Positions of the mutated amino-acids are highlighted on a sequence-based domain pictogram, as well as a 3D-image of the protein structure, and in a molecular graphics package, integrated for interactive viewing. The data associated with each mutation is presented in the Web interface, along with expert annotation of the detailed molecular functional implications of the mutation. Proteins are linked to functional annotation resources and are annotated with structural and functional features such as domains and phosphorylation sites. MoKCa aims to provide assessments available from multiple sources and algorithms for each potential cancer-associated mutation, and present these together in a consistent and coherent fashion to facilitate authoritative annotation by cancer biologists and structural biologists, directly involved in the generation and analysis of new mutational data

Network support for integrated design

A framework of network support for utilization of integrated design over the Internet has been developed. The techniques presented also applicable for Intranet/Extranet. The integrated design system was initially developed for local application in a single site. With the network support, geographically dispersed designers can collaborate a design task through out the total design process, quickly respond to clients’ requests and enhance the design argilty. In this paper, after a brief introduction of the integrated design system, the network support framework is presented, followed by description of two key techniques involved: Java Saverlet approach for remotely executing a large program and online CAD collaboration

Webpage design optimization using genetic algorithm driven CSS

In the rapid emergence of globalization, e-commerce, and internet accessibility in remote parts of the world, ongoing feedback and participation from site visitors are essential for attaining clear and effective communication on a web site. This thesis presents a computational experiment for optimizing design of a webpage in an evolutionary manner. Webpage personalization is viewed as a configuration problem whose goal is to determine the optimal presentation of a webpage while taking into account the preference of the web author (designer), layout constraints (web design/editing language: HTML, CSS), and viewer interaction with the browser. The study proposes use of genetic algorithm-driven Cascading Style Sheets (CSS) to assist the process of webpage design optimization. This method will engage visitors to remotely modify and enhance the style (type, layout and color) of web site to fit their aesthetic and functional representation of well-received design. The preference feedback from user will be stored in an application server for automated evolutionary selection process and reinitialized for the next generation of users. Through the experimentation of web prototype and user evaluation test, the implementation of this method is examined and the derived design solutions are analyzed based on web aesthetics, standards, and accessibility

Web Mining Functions in an Academic Search Application

This paper deals with Web mining and the different categories of Web mining like content, structure and usage mining. The application of Web mining in an academic search application has been discussed. The paper concludes with open problems related to Web mining. The present work can be a useful input to Web users, Web Administrators in a university environment.Database, HITS, IR, NLP, Web mining

Sketching space

In this paper, we present a sketch modelling system which we call Stilton. The program resembles a desktop VRML browser, allowing a user to navigate a three-dimensional model in a perspective projection, or panoramic photographs, which the program maps onto the scene as a `floor' and `walls'. We place an imaginary two-dimensional drawing plane in front of the user, and any geometric information that user sketches onto this plane may be reconstructed to form solid objects through an optimization process. We show how the system can be used to reconstruct geometry from panoramic images, or to add new objects to an existing model. While panoramic imaging can greatly assist with some aspects of site familiarization and qualitative assessment of a site, without the addition of some foreground geometry they offer only limited utility in a design context. Therefore, we suggest that the system may be of use in `just-in-time' CAD recovery of complex environments, such as shop floors, or construction sites, by recovering objects through sketched overlays, where other methods such as automatic line-retrieval may be impossible. The result of using the system in this manner is the `sketching of space' - sketching out a volume around the user - and once the geometry has been recovered, the designer is free to quickly sketch design ideas into the newly constructed context, or analyze the space around them. Although end-user trials have not, as yet, been undertaken we believe that this implementation may afford a user-interface that is both accessible and robust, and that the rapid growth of pen-computing devices will further stimulate activity in this area

RTS2 - the Remote Telescope System

RTS2 is an open source observatory manager. It was written from scratch in the C++ language, with portability and modularity in mind. Its driving requirements originated from quick follow-ups of Gamma Ray Bursts. After some years of development it is now used to carry tasks it was originally not intended to carry. This article presents the current development status of the RTS2 code. It focuses on describing strategies which worked as well as things which failed to deliver expected results.Comment: 9 pages, 3 figures, Workshop on Robotic Autonomous Observatories, M\'alaga, Spain, 18-21 May 200