Continuous Melody Generation via Disentangled Short-Term Representations and Structural Conditions

Automatic music generation is an interdisciplinary research topic that combines computational creativity and semantic analysis of music to create automatic machine improvisations. An important property of such a system is allowing the user to specify conditions and desired properties of the generated music. In this paper we designed a model for composing melodies given a user specified symbolic scenario combined with a previous music context. We add manual labeled vectors denoting external music quality in terms of chord function that provides a low dimensional representation of the harmonic tension and resolution. Our model is capable of generating long melodies by regarding 8-beat note sequences as basic units, and shares consistent rhythm pattern structure with another specific song. The model contains two stages and requires separate training where the first stage adopts a Conditional Variational Autoencoder (C-VAE) to build a bijection between note sequences and their latent representations, and the second stage adopts long short-term memory networks (LSTM) with structural conditions to continue writing future melodies. We further exploit the disentanglement technique via C-VAE to allow melody generation based on pitch contour information separately from conditioning on rhythm patterns. Finally, we evaluate the proposed model using quantitative analysis of rhythm and the subjective listening study. Results show that the music generated by our model tends to have salient repetition structures, rich motives, and stable rhythm patterns. The ability to generate longer and more structural phrases from disentangled representations combined with semantic scenario specification conditions shows a broad application of our model.Comment: 9 pages, 12 figures, 4 tables. in 14th international conference on semantic computing, ICSC 202

Development of Integrated Machine Learning and Data Science Approaches for the Prediction of Cancer Mutation and Autonomous Drug Discovery of Anti-Cancer Therapeutic Agents

Few technological ideas have captivated the minds of biochemical researchers to the degree that machine learning (ML) and artificial intelligence (AI) have. Over the last few years, advances in the ML field have driven the design of new computational systems that improve with experience and are able to model increasingly complex chemical and biological phenomena. In this dissertation, we capitalize on these achievements and use machine learning to study drug receptor sites and design drugs to target these sites. First, we analyze the significance of various single nucleotide variations and assess their rate of contribution to cancer. Following that, we used a portfolio of machine learning and data science approaches to design new drugs to target protein kinase inhibitors. We show that these techniques exhibit strong promise in aiding cancer research and drug discovery

Automatic characterization and generation of music loops and instrument samples for electronic music production

Repurposing audio material to create new music - also known as sampling - was a foundation of electronic music and is a fundamental component of this practice. Currently, large-scale databases of audio offer vast collections of audio material for users to work with. The navigation on these databases is heavily focused on hierarchical tree directories. Consequently, sound retrieval is tiresome and often identified as an undesired interruption in the creative process. We address two fundamental methods for navigating sounds: characterization and generation. Characterizing loops and one-shots in terms of instruments or instrumentation allows for organizing unstructured collections and a faster retrieval for music-making. The generation of loops and one-shot sounds enables the creation of new sounds not present in an audio collection through interpolation or modification of the existing material. To achieve this, we employ deep-learning-based data-driven methodologies for classification and generation.Repurposing audio material to create new music - also known as sampling - was a foundation of electronic music and is a fundamental component of this practice. Currently, large-scale databases of audio offer vast collections of audio material for users to work with. The navigation on these databases is heavily focused on hierarchical tree directories. Consequently, sound retrieval is tiresome and often identified as an undesired interruption in the creative process. We address two fundamental methods for navigating sounds: characterization and generation. Characterizing loops and one-shots in terms of instruments or instrumentation allows for organizing unstructured collections and a faster retrieval for music-making. The generation of loops and one-shot sounds enables the creation of new sounds not present in an audio collection through interpolation or modification of the existing material. To achieve this, we employ deep-learning-based data-driven methodologies for classification and generation

A deep generative model framework for creating high quality synthetic transaction sequences

Synthetic data are artificially generated data that closely model real-world measurements, and can be a valuable substitute for real data in domains where it is costly to obtain real data, or privacy concerns exist. Synthetic data has traditionally been generated using computational simulations, but deep generative models (DGMs) are increasingly used to generate high-quality synthetic data. In this thesis, we create a framework which employs DGMs for generating highquality synthetic transaction sequences. Transaction sequences, such as we may see in an online banking platform, or credit card statement, are important type of financial data for gaining insight into financial systems. However, research involving this type of data is typically limited to large financial institutions, as privacy concerns often prevent academic researchers from accessing this kind of data. Our work represents a step towards creating shareable synthetic transaction sequence datasets, containing data not connected to any actual humans. To achieve this goal, we begin by developing Banksformer, a DGM based on the transformer architecture, which is able to generate high-quality synthetic transaction sequences. Throughout the remainder of the thesis, we develop extensions to Banksformer that further improve the quality of data we generate. Additionally, we perform extensively examination of the quality synthetic data produced by our method, both with qualitative visualizations and quantitative metrics

Learning disentangled speech representations

A variety of informational factors are contained within the speech signal and a single short recording of speech reveals much more than the spoken words. The best method to extract and represent informational factors from the speech signal ultimately depends on which informational factors are desired and how they will be used. In addition, sometimes methods will capture more than one informational factor at the same time such as speaker identity, spoken content, and speaker prosody. The goal of this dissertation is to explore different ways to deconstruct the speech signal into abstract representations that can be learned and later reused in various speech technology tasks. This task of deconstructing, also known as disentanglement, is a form of distributed representation learning. As a general approach to disentanglement, there are some guiding principles that elaborate what a learned representation should contain as well as how it should function. In particular, learned representations should contain all of the requisite information in a more compact manner, be interpretable, remove nuisance factors of irrelevant information, be useful in downstream tasks, and independent of the task at hand. The learned representations should also be able to answer counter-factual questions. In some cases, learned speech representations can be re-assembled in different ways according to the requirements of downstream applications. For example, in a voice conversion task, the speech content is retained while the speaker identity is changed. And in a content-privacy task, some targeted content may be concealed without affecting how surrounding words sound. While there is no single-best method to disentangle all types of factors, some end-to-end approaches demonstrate a promising degree of generalization to diverse speech tasks. This thesis explores a variety of use-cases for disentangled representations including phone recognition, speaker diarization, linguistic code-switching, voice conversion, and content-based privacy masking. Speech representations can also be utilised for automatically assessing the quality and authenticity of speech, such as automatic MOS ratings or detecting deep fakes. The meaning of the term "disentanglement" is not well defined in previous work, and it has acquired several meanings depending on the domain (e.g. image vs. speech). Sometimes the term "disentanglement" is used interchangeably with the term "factorization". This thesis proposes that disentanglement of speech is distinct, and offers a viewpoint of disentanglement that can be considered both theoretically and practically