Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease

Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evidence suggests that brain maturation can be delayed and pre- and postoperative brain injury may occur, and there is limited information on the long-term effect of congenital heart disease on brain development and function in adolescent patients. At a mean age of 13.8 years, 39 adolescent survivors of childhood cardiopulmonary bypass surgery with no structural brain lesions evident through conventional cerebral magnetic resonance imaging and 32 healthy control subjects underwent extensive neurodevelopmental assessment and cerebral magnetic resonance imaging. Cerebral scans were analysed quantitatively using surface-based and voxel-based morphometry. Compared with control subjects, patients had lower total brain (P = 0.003), white matter (P = 0.004) and cortical grey matter (P = 0.005) volumes, whereas cerebrospinal fluid volumes were not different. Regional brain volume reduction ranged from 5.3% (cortical grey matter) to 11% (corpus callosum). Adolescents with cyanotic heart disease showed more brain volume loss than those with acyanotic heart disease, particularly in the white matter, thalami, hippocampi and corpus callosum (all P-values < 0.05). Brain volume reduction correlated significantly with cognitive, motor and executive functions (grey matter: P < 0.05, white matter: P < 0.01). Our findings suggest that there are long-lasting cerebral changes in adolescent survivors of cardiopulmonary bypass surgery for congenital heart disease and that these changes are associated with functional outcom

Living Liquid Crystals

Collective motion of self-propelled organisms or synthetic particles often termed active fluid has attracted enormous attention in broad scientific community because of it fundamentally non-equilibrium nature. Energy input and interactions among the moving units and the medium lead to complex dynamics. Here we introduce a new class of active matter, living liquid crystals (LLCs) that combine living swimming bacteria with a lyotropic liquid crystal. The physical properties of LLCs can be controlled by the amount of oxygen available to bacteria, by concentration of ingredients, or by temperature. Our studies reveal a wealth of new intriguing dynamic phenomena, caused by the coupling between the activity-triggered flow and long-range orientational order of the medium. Among these are (a) non-linear trajectories of bacterial motion guided by non-uniform director, (b) local melting of the liquid crystal caused by the bacteria-produced shear flows, (c) activity-triggered transition from a non-flowing uniform state into a flowing one-dimensional periodic pattern and its evolution into a turbulent array of topological defects, (d) birefringence-enabled visualization of microflow generated by the nanometers-thick bacterial flagella. Unlike their isotropic counterpart, the LLCs show collective dynamic effects at very low volume fraction of bacteria, on the order of 0.2%. Our work suggests an unorthodox design concept to control and manipulate the dynamic behavior of soft active matter and opens the door for potential biosensing and biomedical applications.Comment: 32 pages, 8 figures, Supporting Information include

Iot-Based Smart Trash Monitoring Using Blynk Application

Poor waste management and lack of public awareness of environmental hygiene, especially if waste is disposed of in the local trash can, causes garbage to accumulate and emit bad odors which can be a source of disease transmission. The lack of information technology for waste management by janitors can cause slow waste disposal. Based on these problems, it is necessary to equip an automatic trash can with a monitoring function in real time. Added the IOT (Internet of Things) function, which can provide initial information indicating that the trash can is full and can be quickly picked up by the garbage collector. The smart trash can prototype uses an ESP 32 microcontroller as a system control. Servo to control the trash can cover. The output of DF Player is in the form of thanks to people who throw garbage in its place. Ultrasonic sensors can detect human presence and waste volume and send monitoring results in real time as well as notifications to the blynk application as a notification if the trash can is full

Can malignant and inflammatory pleural effusions in dogs be distinguished using computed tomography

Computed tomography (CT) is the primary imaging modality used to investigate human patients with suspected malignant or inflammatory pleural effusion, but there is a lack of information about the clinical use of this test in dogs. To identify CT signs that could be used to distinguish pleural malignant neoplasia from pleuritis, a retrospective case‐control study was done based on dogs that had pleural effusion, pre‐ and postcontrast thoracic CT images, and cytological or histopathological diagnosis of malignant or inflammatory pleural effusion. There were 20 dogs with malignant pleural effusion (13 mesothelioma, 6 carcinoma; 1 lymphoma), and 32 dogs with pleuritis (18 pyothorax; 14 chylothorax). Compared to dogs with pleuritis, dogs with malignant pleural effusions were significantly older (median 8.5 years vs. 4.9 years, P = 0.001), more frequently had CT signs of pleural thickening (65% vs.34%, P = 0.05), tended to have thickening of the parietal pleura only (45% vs. 3%, P = 0.002) and had more marked pleural thickening (median 3 mm vs. 0 mm, P = 0.03). Computed tomography signs of thoracic wall invasion were observed only in dogs with malignant pleural effusions (P = 0.05). There were no significant differences in pleural fluid volume, distribution or attenuation, degree of pleural contrast accumulation, amount of pannus, or prevalence of mediastinal adenopathy. Although there was considerable overlap in findings in dogs with malignant pleural effusion and pleuritis, marked thickening affecting the parietal pleural alone and signs of thoracic wall invasion on CT support diagnosis of pleural malignant neoplasia, and may help prioritize further diagnostic testing

Motion corrected fetal body magnetic resonance imaging provides reliable 3D lung volumes in normal and abnormal fetuses

Objectives: To calculate 3D-segmented total lung volume (TLV) in fetuses with thoracic anomalies using deformable slice-to-volume registration (DSVR) with comparison to 2D-manual segmentation. To establish a normogram of TLV calculated by DSVR in healthy control fetuses. Methods: A pilot study at a single regional fetal medicine referral centre included 16 magnetic resonance imaging (MRI) datasets of fetuses (22–32 weeks gestational age). Diagnosis was CDH (n = 6), CPAM (n = 2), and healthy controls (n = 8). Deformable slice-to-volume registration was used for reconstruction of 3D isotropic (0.85 mm) volumes of the fetal body followed by semi-automated lung segmentation. 3D TLV were compared to traditional 2D-based volumetry. Abnormal cases referenced to a normogram produced from 100 normal fetuses whose TLV was calculated by DSVR only. Results: Deformable slice-to-volume registration-derived TLV values have high correlation with the 2D-based measurements but with a consistently lower volume; bias −1.44 cm3 [95% limits: −2.6 to −0.3] with improved resolution to exclude hilar structures even in cases of motion corruption or very low lung volumes. Conclusions: Deformable slice-to-volume registration for fetal lung MRI aids analysis of motion corrupted scans and does not suffer from the interpolation error inherent to 2D-segmentation. It increases information content of acquired data in terms of visualising organs in 3D space and quantification of volumes, which may improve counselling and surgical planning

The effect of orally consumed Lactuca sativa syrup on human milk volume and weight gain in the preterm infant:a randomized controlled clinical trial

Abstract Human milk feeding can support premature infants to thrive. Yet those with premature infants can be challenged in human milk production. Considering this, and the use of potentially harmful human milk enhancers, the present study was conducted with the aim of determining the effect of orally consumed Lactuca sativa (L. sativa) syrup (lettuce extract) on human milk volume and subsequent weight gain in the preterm infant. Extracts from lettuce and other plants such as silymarin are already evidenced to be safe for use during lactation and have other therapeutic effects in humans. Yet this is the first study of its kind. This parallel randomized clinical trial included lactating participants with their preterm infants who were born at < 32 weeks' gestation and admitted to an intensive care unit. Convenience sampling was used to recruit participants. Eligible participants were allocated to groups randomly: intervention (n = 47), placebo (n = 46), and control (n = 47). The intervention group received one tablespoon of Lactuca sativa (L. sativa) syrup, and the placebo group received one tablespoon of placebo syrup 3 times a day for 1 week. Those in the control group did not receive any herbal or chemical milk-enhancing compounds. Routine care was provided to all three groups. Participants recorded their milk volume for 7 days in a daily information recorder form. Infant weight was measured prior to the intervention, and on the third, fifth and seventh days of the intervention period. There was a statistically significant difference observed in the adjusted mean volume of milk on the fourth and fifth days between the intervention, placebo, and control groups (P < 0.05). The adjusted mean milk volume of those in the intervention group on the first day was significantly higher than those in the control group and those in the placebo group. On the second day, the adjusted mean milk volume of those in the intervention group was higher than in those from the control group; and on the fourth day it was higher than in those from both the control and placebo groups; on the fifth day it was higher than in those in the placebo group; on the sixth day it was higher than in those in the control group and on the seventh day it was higher than in those in the control group (P < 0.05). There was no statistically significant difference in terms of the mean changes (with or without adjustment) in the weight of preterm infants between any of the groups. Lactuca sativa (L. sativa) syrup increases the volume of human milk production and no specific side effects have been reported in its use. Therefore, Lactuca sativa syrup can be recommended for use as one of the compounds that increase human milk volume

Atrial Remodeling in Pregnant Hypertensive Women: Comparison between Chronic and Gestational Hypertension

Objectives: Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is available on LA changes during pregnancy. The present study evaluated LA size and function in pregnant women with hypertension.Methods: Patients population included 30 women with chronic hypertension and 30 patients with gestational hypertension.A control group of 16 normotensive pregnant women was selected. Serial echocardiography was performed at 12 and 24 week of gestation in chronic hypertension and at 24 week in gestational hypertension and after delivery. LA diameters andvolumes were measured and compared. LA conduit volume, passive and active emptying volumes were calculated.Patients were divided in 2 groups according to max LAV Index > 32 ml/m2 at 24 week of gestation.Results: Patients with chronic hypertension showed higher LA diameters (42 \ub1 2.0 vs. 36.5 \ub1 1.8; p 32 ml/m2 had more clinical complications evaluated as increase of therapy, fluid retention that need diuretic and hospitalization.Conclusion: Patients with chronic hypertension showed a more marked increased of LA volumes compared to gestationalhypertension due to a remodeling of atrial shape as effect of chronic overload. Patients with more dilated LA volumes developed a greater number of clinical complications suggesting that a dilated LA could be a parameter of hemodynamic instability

A modified Camel and Cactus Test detects presymptomatic semantic impairment in genetic frontotemporal dementia within the GENFI cohort

Impaired semantic knowledge is a characteristic feature of some forms of frontotemporal dementia (FTD), particularly the sporadic disorder semantic dementia. Less is known about semantic cognition in the genetic forms of FTD caused by mutations in the genes MAPT, C9orf72, and GRN. We developed a modified version of the Camel and Cactus Test (mCCT) to investigate the presence of semantic difficulties in a large genetic FTD cohort from the Genetic FTD Initiative (GENFI) study. Six-hundred-forty-four participants were tested with the mCCT including 67 MAPT mutation carriers (15 symptomatic, and 52 in the presymptomatic period), 165 GRN mutation carriers (33 symptomatic, 132 presymptomatic), and 164 C9orf72 mutation carriers (56 symptomatic, 108 presymptomatic) and 248 mutation-negative members of FTD families who acted as a control group. The presymptomatic mutation carriers were further split into those early and late in the presymptomatic period (more than vs. within 10 years of expected symptom onset). Groups were compared using a linear regression model, adjusting for age and education, with bootstrapping. Performance on the mCCT had a weak negative correlation with age (rho = −0.20) and a weak positive correlation with education (rho = 0.13), with an overall abnormal score (below the 5th percentile of the control population) being below 27 out of a total of 32. All three of the symptomatic mutation groups scored significantly lower than controls: MAPT mean 22.3 (standard deviation 8.0), GRN 24.4 (7.2), C9orf72 23.6 (6.5) and controls 30.2 (1.6). However, in the presymptomatic groups, only the late MAPT and late C9orf72 mutation groups scored lower than controls (28.8 (2.2) and 28.9 (2.5) respectively). Performance on the mCCT correlated strongly with temporal lobe volume in the symptomatic MAPT mutation group (rho > 0.80). In the C9orf72 group, mCCT score correlated with both bilateral temporal lobe volume (rho > 0.31) and bilateral frontal lobe volume (rho > 0.29), whilst in the GRN group mCCT score correlated only with left frontal lobe volume (rho = 0.48). This study provides evidence for presymptomatic impaired semantic knowledge in genetic FTD. The different neuroanatomical associations of the mCCT score may represent distinct cognitive processes causing deficits in different groups: loss of core semantic knowledge associated with temporal lobe atrophy (particularly in the MAPT group), and impaired executive control of semantic information associated with frontal lobe atrophy. Further studies will be helpful to address the longitudinal change in mCCT performance and the exact time at which presymptomatic impairment occurs

How does the status “trending” attributed by Twitter to a corporation influence trading of its stock? The case study of the top 25 companies in the S&P500 Index

Master’s degree in Management Control and Performance EvaluationWith some news sources mentioning that young individual investors are massively manipulating the market, while others mention that there is nothing to worry about, it is hard to understand what is truly going on. One of the factors mentioned of this uncertainty is the communication and sharing of information via social media, like Reddit and Twitter. Hence, the objective of this investigation is to analyse if there is a correlation between going trending on Twitter and certain stock market events like a trading volume peak and/or a daily price peak or drop. This investigation used the case study of the top 25 S&P500 companies to investigate whether this is true. The observation of this sample occurred in the period of September 2020 - September 2021 analysing the quantitative data available in this empirical field. Given the nature of the problem, the case study is markedly exploratory and descriptive, following a deductive approach, via a pre-existing theoretical model. It was found that worldwide in 46% of the cases there did exist a correlation between going trending on Twitter and a peak or drop on the stock daily stock prices. Only in 29% of the cases this was true for the trading volume. Yet for the USA, in 41% of the cases there was a correlation between going trending on Twitter and a daily price peak or drop, compared to 32% in case of the trading volume. As this is a recent and complex phenomenon, where knowledge is scarce, the present work also discusses the practical implications of the conclusions, offering clues for future investigations.info:eu-repo/semantics/publishedVersio

Platelet count and platelets indices of mortuary workers exposed to formaldehyde: a study in Calabar, Nigeria

Background: Embalming chemicals such as formaldehyde has been shown to be toxic to human system. It’s carcinogenicity effect and ability to cause adverse health conditions has been reported. Formalin is the aqueous solution of formaldehyde and it is converted to H2C (OH)2 when dissolved in water. This study was done to provide information on the effect of formaldehyde on the platelet count and platelet indices of mortuary workers.Methods: Total of 64 subjects were recruited for the study based on convenience sampling method in Calabar, Cross River State. The test group comprised of 32 mortuary workers with age ranging from 18-60 years from University of Calabar Teaching Hospital, General Hospital, Navy Hospital, Anatomy Department-University of Calabar and Infectious Disease Hospital, all in Calabar Meteropolis and 32 non-mortuary workers of the same age bracket from Calabar municipality served as control. Sample collection was by venipuncture and method of analysis was by the use of automated haematology analyzer.Results: This study shows that mean platelet volume (MPV) and platelet distribution width were significantly increased p<0.01) in mortuary workers. The platelet count of mortuary workers were also significantly decreased (p=0.918) when compared to non-mortuary workers. Three out of thirty two mortuary workers had giant forms of platelet. The result also shows that long term exposure to formaldehyde can cause a reduction in the platelet count and platelet indices of mortuary workers.Conclusions: This study has shown that exposure to formaldehyde has a negative alteration on the platelet count and platelet indices of mortuary workers