Evaluating Future Dangerousness and Need for Treatment: The Roles of Expert Testimony, Attributional Complexity, and Victim Type

In the current study, we explored the effect of risk-assessment testimony, attributional complexity, and victim type on participants’ perceptions of the dangerousness of a sexually violent person and his need for treatment. Participants read details of a hypothetical sexual assault of a female minor and of an adult. Expert testimony of his risk assessment consisted of clinical opinion versus structured-clinical judgment (SCJ) versus actuarial assessment. Participants perceived clinical-opinion and SCJ testimony as equally influential when forming judgments of future dangerousness. In the context of treatment, however, participants relied on actuarial testimony when judging potential for risk. In addition, attributional complexity (AC) moderated perceptions of sexual risk. Overall, results point to the need for continued refinement of assessment techniques when determining dangerousness and need for treatment

Contributions of natural and human factors to increases in vegetation productivity in China

Increasing trends in vegetation productivity have been identified for the last three decades for many regions in the northern hemisphere including China. Multiple natural and human factors are possibly responsible for the increases in vegetation productivity, while their relative contributions remain unclear. Here we analyzed the long-term trends in vegetation productivity in China using the satellite-derived normalized difference vegetation index (NDVI) and assessed the relationships of NDVI with a suite of natural (air temperature, precipitation, photosynthetically active radiation (PAR), atmospheric carbon dioxide (CO2) concentrations, and nitrogen (N) deposition) and human (afforestation and improved agricultural management practices) factors. Overall, China exhibited an increasing trend in vegetation productivity with an increase of 2.7%. At the provincial scale, eleven provinces exhibited significant increases in vegetation productivity, and the majority of these provinces are located within the northern half of the country. At the national scale, annual air temperature was most closely related to NDVI and explained 36.8% of the variance in NDVI, followed by afforestation (25.5%) and crop yield (15.8%). Altogether, temperature, total forest plantation area, and crop yield explained 78.1% of the variance in vegetation productivity at the national scale, while precipitation, PAR, atmospheric CO2 concentrations, and N deposition made no significant contribution to the increases in vegetation productivity. At the provincial scale, each factor explained a part of the variance in NDVI for some provinces, and the increases in NDVI for many provinces could be attributed to the combined effects of multiple factors. Crop yield and PAR were correlated with NDVI for more provinces than were other factors, indicating that both elevated crop yield resulting from improved agricultural management practices and increasing diffuse radiation were more important than other factors in increasing vegetation productivity at the provincial scale. The relative effects of the natural and human factors on vegetation productivity varied with spatial scale. The true contributions of multiple factors can be obscured by the correlation among these variables, and it is essential to examine the contribution of each factor while controlling for other factors. Future changes in climate and human activities will likely have larger influences on vegetation productivity in China

The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions

The focal adhesion protein testin is a modular scaffold and tumour suppressor that consists of an N-terminal cysteine rich (CR) domain, a PET domain of unknown function and three C-terminal LIM domains. Testin has been proposed to have an open and a closed conformation based on the observation that its N-terminal half and C-terminal half directly interact. Here we extend the testin conformational model by demonstrating that testin can also form an antiparallel homodimer. In support of this extended model we determined that the testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains in vitro and in cells, and assign a critical role to tyrosine 288 in this interaction

Acidosis slows electrical conduction through the atrio-ventricular node

Acidosis affects the mechanical and electrical activity of mammalian hearts but comparatively little is known about its effects on the function of the atrio-ventricular node (AVN). In this study, the electrical activity of the epicardial surface of the left ventricle of isolated Langendorff-perfused rabbit hearts was examined using optical methods. Perfusion with hypercapnic Tyrode's solution (20% CO2, pH 6.7) increased the time of earliest activation (Tact) from 100.5 ± 7.9 to 166.1 ± 7.2 ms (n = 8) at a pacing cycle length (PCL) of 300 ms (37°C). Tact increased at shorter PCL, and the hypercapnic solution prolonged Tact further: at 150 ms PCL, Tact was prolonged from 131.0 ± 5.2 to 174.9 ± 16.3 ms. 2:1 AVN block was common at shorter cycle lengths. Atrial and ventricular conduction times were not significantly affected by the hypercapnic solution suggesting that the increased delay originated in the AVN. Isolated right atrial preparations were superfused with Tyrode's solutions at pH 7.4 (control), 6.8 and 6.3. Low pH prolonged the atrial-Hisian (AH) interval, the AVN effective and functional refractory periods and Wenckebach cycle length significantly. Complete AVN block occurred in 6 out of 9 preparations. Optical imaging of conduction at the AV junction revealed increased conduction delay in the region of the AVN, with less marked effects in atrial and ventricular tissue. Thus acidosis can dramatically prolong the AVN delay, and in combination with short cycle lengths, this can cause partial or complete AVN block and is therefore implicated in the development of brady-arrhythmias in conditions of local or systemic acidosis

An Introduction to Volume 8 of \u3ci\u3eThe New Age\u3c/i\u3e

Dr. Lee Garver\u27s introduction to The New Age, Volume 8 (November 3, 1910 to April 27, 1911)

The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies.

Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats. Recent studies of diseases caused by several RNA viruses in people and other species indicate that antiviral therapy may be effective against FIP in cats. The small molecule nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. We determined that GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. We determined the pharmacokinetics of GS-441524 in cats in vivo and established a dosage that would sustain effective blood levels for 24 h. In an experimental FIPV infection of cats, GS-441524 treatment caused a rapid reversal of disease signs and return to normality with as little as two weeks of treatment in 10/10 cats and with no apparent toxicity

Quantifying Wikipedia usage patterns before stock market moves

Financial crises result from a catastrophic combination of actions. Vast stock market datasets offer us a window into some of the actions that have led to these crises. Here, we investigate whether data generated through Internet usage contain traces of attempts to gather information before trading decisions were taken. We present evidence in line with the intriguing suggestion that data on changes in how often financially related Wikipedia pages were viewed may have contained early signs of stock market moves. Our results suggest that online data may allow us to gain new insight into early information gathering stages of decision making

Geophysical investigation of the Pb-Zn deposit of Lontzen-Poppelsberg, Belgium

The drillhole information from the Lontzen-Poppelsberg site has demonstrated three orebodies and has allowed the estimation of the extension of the lodes, their dip, and the location at the ground surface. The localisation of the lodes makes them excellent targets for further exploration with geophysics. This deposit is classified as a Mississippi Valley Type (MVT) deposit. It consists mainly of Pb-Zn-Fe sulphides that display contrasting values in resistivity, chargeability, density, and magnetic susceptibility, with regards to the sedimentary host rocks. The dipole-dipole direct current (DC) resistivity and induce polarization (IP) profiles have been collected and inverted to successfully delineate the Pb-Zn mineralization and the geological structures. Short-spacing EM34 electromagnetic conductivity data were collected mainly on the top of Poppelsberg East lode and have revealed a conductive body matching with the geologically modelled mineralization. Gravity profiles have been carried out perpendicularly to the lode orientation; they show a strong structural anomaly. High resolution ground magnetic data were collected over the study area, but they showed no anomaly over the ore deposits. The geophysical inversion results are complementary to the model based on drill information, and allow us to refine the delineation of the mineralization. The identification of the geophysical signatures of this deposit permits targeting new possible mineralization in the area