The context-dependence of mutations: a linkage of formalisms

Defining the extent of epistasis - the non-independence of the effects of mutations - is essential for understanding the relationship of genotype, phenotype, and fitness in biological systems. The applications cover many areas of biological research, including biochemistry, genomics, protein and systems engineering, medicine, and evolutionary biology. However, the quantitative definitions of epistasis vary among fields, and its analysis beyond just pairwise effects remains obscure in general. Here, we show that different definitions of epistasis are versions of a single mathematical formalism - the weighted Walsh-Hadamard transform. We discuss that one of the definitions, the backgound-averaged epistasis, is the most informative when the goal is to uncover the general epistatic structure of a biological system, a description that can be rather different from the local epistatic structure of specific model systems. Key issues are the choice of effective ensembles for averaging and to practically contend with the vast combinatorial complexity of mutations. In this regard, we discuss possible approaches for optimally learning the epistatic structure of biological systems.Comment: 6 pages, 3 figures, supplementary informatio

Data-driven Soft Sensors in the Process Industry

In the last two decades Soft Sensors established themselves as a valuable alternative to the traditional means for the acquisition of critical process variables, process monitoring and other tasks which are related to process control. This paper discusses characteristics of the process industry data which are critical for the development of data-driven Soft Sensors. These characteristics are common to a large number of process industry fields, like the chemical industry, bioprocess industry, steel industry, etc. The focus of this work is put on the data-driven Soft Sensors because of their growing popularity, already demonstrated usefulness and huge, though yet not completely realised, potential. A comprehensive selection of case studies covering the three most important Soft Sensor application fields, a general introduction to the most popular Soft Sensor modelling techniques as well as a discussion of some open issues in the Soft Sensor development and maintenance and their possible solutions are the main contributions of this work

Intelligent Learning Algorithms for Active Vibration Control

YesThis correspondence presents an investigation into the comparative performance of an active vibration control (AVC) system using a number of intelligent learning algorithms. Recursive least square (RLS), evolutionary genetic algorithms (GAs), general regression neural network (GRNN), and adaptive neuro-fuzzy inference system (ANFIS) algorithms are proposed to develop the mechanisms of an AVC system. The controller is designed on the basis of optimal vibration suppression using a plant model. A simulation platform of a flexible beam system in transverse vibration using a finite difference method is considered to demonstrate the capabilities of the AVC system using RLS, GAs, GRNN, and ANFIS. The simulation model of the AVC system is implemented, tested, and its performance is assessed for the system identification models using the proposed algorithms. Finally, a comparative performance of the algorithms in implementing the model of the AVC system is presented and discussed through a set of experiments