Defect Perturbations in Landau-Ginzburg Models

Perturbations of B-type defects in Landau-Ginzburg models are considered. In particular, the effect of perturbations of defects on their fusion is analyzed in the framework of matrix factorizations. As an application, it is discussed how fusion with perturbed defects induces perturbations on boundary conditions. It is shown that in some classes of models all boundary perturbations can be obtained in this way. Moreover, a universal class of perturbed defects is constructed, whose fusion under certain conditions obey braid relations. The functors obtained by fusing these defects with boundary conditions are twist functors as introduced in the work of Seidel and Thomas.Comment: 46 page

The Tensor Networks Anthology: Simulation techniques for many-body quantum lattice systems

We present a compendium of numerical simulation techniques, based on tensor network methods, aiming to address problems of many-body quantum mechanics on a classical computer. The core setting of this anthology are lattice problems in low spatial dimension at finite size, a physical scenario where tensor network methods, both Density Matrix Renormalization Group and beyond, have long proven to be winning strategies. Here we explore in detail the numerical frameworks and methods employed to deal with low-dimension physical setups, from a computational physics perspective. We focus on symmetries and closed-system simulations in arbitrary boundary conditions, while discussing the numerical data structures and linear algebra manipulation routines involved, which form the core libraries of any tensor network code. At a higher level, we put the spotlight on loop-free network geometries, discussing their advantages, and presenting in detail algorithms to simulate low-energy equilibrium states. Accompanied by discussions of data structures, numerical techniques and performance, this anthology serves as a programmer's companion, as well as a self-contained introduction and review of the basic and selected advanced concepts in tensor networks, including examples of their applications.Comment: 115 pages, 56 figure

TBA for non-perturbative moduli spaces

Recently, an exact description of instanton corrections to the moduli spaces of 4d N=2 supersymmetric gauge theories compactified on a circle and Calabi-Yau compactifications of Type II superstring theories was found. The equations determining the instanton contributions turn out to have the form of Thermodynamic Bethe Ansatz. We explore further this relation and, in particular, we identify the contact potential of quaternionic string moduli space with the free energy of the integrable system and the Kahler potential of the gauge theory moduli space with the Yang-Yang functional. We also show that the corresponding S-matrix satisfies all usual constraints of 2d integrable models, including crossing and bootstrap, and derive the associated Y-system. Surprisingly, in the simplest case the Y-system is described by the MacMahon function relevant for crystal melting and topological strings.Comment: 25 pages, 1 figur

Universal amplitude ratios and Coxeter geometry in the dilute A model

The leading excitations of the dilute $A_L$ model in regime 2 are considered using analytic arguments. The model can be identified with the integrable $\phi_{1,2}$ perturbation of the unitary minimal series $M_{L,L+1}$. It is demonstrated that the excitation spectrum of the transfer matrix satisfies the same functional equations in terms of elliptic functions as the exact S-matrices of the $\phi_{1,2}$ perturbation do in terms of trigonometric functions. In particular, the bootstrap equation corresponding to a self-fusing process is recovered. For the special cases $L=3,4,6$ corresponding to the Ising model in a magnetic field, and the leading thermal perturbations of the tricritical Ising and three-state Potts model, as well as for the unrestricted model, $L=\infty$, we relate the structure of the Bethe roots to the Lie algebras $E_{8,7,6}$ and $D_4$ using Coxeter geometry. In these cases Coxeter geometry also allows for a single formula in generic Lie algebraic terms describing all four cases. For general $L$ we calculate the spectral gaps associated with the leading excitation which allows us to compute universal amplitude ratios characteristic of the universality class. The ratios are of field theoretic importance as they enter the bulk vacuum expectation value of the energy momentum tensor associated with the corresponding integrable quantum field theories.Comment: 32 pages (tcilatex

Boundary Conditions in Rational Conformal Field Theories

We develop further the theory of Rational Conformal Field Theories (RCFTs) on a cylinder with specified boundary conditions emphasizing the role of a triplet of algebras: the Verlinde, graph fusion and Pasquier algebras. We show that solving Cardy's equation, expressing consistency of a RCFT on a cylinder, is equivalent to finding integer valued matrix representations of the Verlinde algebra. These matrices allow us to naturally associate a graph $G$ to each RCFT such that the conformal boundary conditions are labelled by the nodes of $G$. This approach is carried to completion for $sl(2)$ theories leading to complete sets of conformal boundary conditions, their associated cylinder partition functions and the $A$-$D$-$E$ classification. We also review the current status for WZW $sl(3)$ theories. Finally, a systematic generalization of the formalism of Cardy-Lewellen is developed to allow for multiplicities arising from more general representations of the Verlinde algebra. We obtain information on the bulk-boundary coefficients and reproduce the relevant algebraic structures from the sewing constraints.Comment: 71 pages. Minor changes with respect to 2nd version. Recently published in Nucl.Phys.B but mistakenly as 1st version. Will be republished in Nucl.Phys.B as this (3rd) versio

Pseudotyping exosomes for enhanced protein delivery in mammalian cells.

Exosomes are cell-derived nanovesicles that hold promise as living vehicles for intracellular delivery of therapeutics to mammalian cells. This potential, however, is undermined by the lack of effective methods to load exosomes with therapeutic proteins and to facilitate their uptake by target cells. Here, we demonstrate how a vesicular stomatitis virus glycoprotein (VSVG) can both load protein cargo onto exosomes and increase their delivery ability via a pseudotyping mechanism. By fusing a set of fluorescent and luminescent reporters with VSVG, we show the successful targeting and incorporation of VSVG fusions into exosomes by gene transfection and fluorescence tracking. We subsequently validate our system by live cell imaging of VSVG and its participation in endosomes/exosomes that are ultimately released from transfected HEK293 cells. We show that VSVG pseudotyping of exosomes does not affect the size or distributions of the exosomes, and both the full-length VSVG and the VSVG without the ectodomain are shown to integrate into the exosomal membrane, suggesting that the ectodomain is not required for protein loading. Finally, exosomes pseudotyped with full-length VSVG are internalized by multiple-recipient cell types to a greater degree compared to exosomes loaded with VSVG without the ectodomain, confirming a role of the ectodomain in cell tropism. In summary, our work introduces a new genetically encoded pseudotyping platform to load and enhance the intracellular delivery of therapeutic proteins via exosome-based vehicles to target cells