Prospects and limitations of full-text index structures in genome analysis

The combination of incessant advances in sequencing technology producing large amounts of data and innovative bioinformatics approaches, designed to cope with this data flood, has led to new interesting results in the life sciences. Given the magnitude of sequence data to be processed, many bioinformatics tools rely on efficient solutions to a variety of complex string problems. These solutions include fast heuristic algorithms and advanced data structures, generally referred to as index structures. Although the importance of index structures is generally known to the bioinformatics community, the design and potency of these data structures, as well as their properties and limitations, are less understood. Moreover, the last decade has seen a boom in the number of variant index structures featuring complex and diverse memory-time trade-offs. This article brings a comprehensive state-of-the-art overview of the most popular index structures and their recently developed variants. Their features, interrelationships, the trade-offs they impose, but also their practical limitations, are explained and compared

Efficient Parallel and Distributed Algorithms for GIS Polygon Overlay Processing

Polygon clipping is one of the complex operations in computational geometry. It is used in Geographic Information Systems (GIS), Computer Graphics, and VLSI CAD. For two polygons with n and m vertices, the number of intersections can be O(nm). In this dissertation, we present the first output-sensitive CREW PRAM algorithm, which can perform polygon clipping in O(log n) time using O(n + k + k\u27) processors, where n is the number of vertices, k is the number of intersections, and k\u27 is the additional temporary vertices introduced due to the partitioning of polygons. The current best algorithm by Karinthi, Srinivas, and Almasi does not handle self-intersecting polygons, is not output-sensitive and must employ O(n^2) processors to achieve O(log n) time. The second parallel algorithm is an output-sensitive PRAM algorithm based on Greiner-Hormann algorithm with O(log n) time complexity using O(n + k) processors. This is cost-optimal when compared to the time complexity of the best-known sequential plane-sweep based algorithm for polygon clipping. For self-intersecting polygons, the time complexity is O(((n + k) log n log log n)/p) using p In addition to these parallel algorithms, the other main contributions in this dissertation are 1) multi-core and many-core implementation for clipping a pair of polygons and 2) MPI-GIS and Hadoop Topology Suite for distributed polygon overlay using a cluster of nodes. Nvidia GPU and CUDA are used for the many-core implementation. The MPI based system achieves 44X speedup while processing about 600K polygons in two real-world GIS shapefiles 1) USA Detailed Water Bodies and 2) USA Block Group Boundaries) within 20 seconds on a 32-node (8 cores each) IBM iDataPlex cluster interconnected by InfiniBand technology

Approximation and Relaxation Approaches for Parallel and Distributed Machine Learning

Large scale machine learning requires tradeoffs. Commonly this tradeoff has led practitioners to choose simpler, less powerful models, e.g. linear models, in order to process more training examples in a limited time. In this work, we introduce parallelism to the training of non-linear models by leveraging a different tradeoff--approximation. We demonstrate various techniques by which non-linear models can be made amenable to larger data sets and significantly more training parallelism by strategically introducing approximation in certain optimization steps. For gradient boosted regression tree ensembles, we replace precise selection of tree splits with a coarse-grained, approximate split selection, yielding both faster sequential training and a significant increase in parallelism, in the distributed setting in particular. For metric learning with nearest neighbor classification, rather than explicitly train a neighborhood structure we leverage the implicit neighborhood structure induced by task-specific random forest classifiers, yielding a highly parallel method for metric learning. For support vector machines, we follow existing work to learn a reduced basis set with extremely high parallelism, particularly on GPUs, via existing linear algebra libraries. We believe these optimization tradeoffs are widely applicable wherever machine learning is put in practice in large scale settings. By carefully introducing approximation, we also introduce significantly higher parallelism and consequently can process more training examples for more iterations than competing exact methods. While seemingly learning the model with less precision, this tradeoff often yields noticeably higher accuracy under a restricted training time budget

Doctor of Philosophy

dissertationWe are living in an age where data are being generated faster than anyone has previously imagined across a broad application domain, including customer studies, social media, sensor networks, and the sciences, among many others. In some cases, data are generated in massive quantities as terabytes or petabytes. There have been numerous emerging challenges when dealing with massive data, including: (1) the explosion in size of data; (2) data have increasingly more complex structures and rich semantics, such as representing temporal data as a piecewise linear representation; (3) uncertain data are becoming a common occurrence for numerous applications, e.g., scientific measurements or observations such as meteorological measurements; (4) and data are becoming increasingly distributed, e.g., distributed data collected and integrated from distributed locations as well as data stored in a distributed file system within a cluster. Due to the massive nature of modern data, it is oftentimes infeasible for computers to efficiently manage and query them exactly. An attractive alternative is to use data summarization techniques to construct data summaries, where even efficiently constructing data summaries is a challenging task given the enormous size of data. The data summaries we focus on in this thesis include the histogram and ranking operator. Both data summaries enable us to summarize a massive dataset to a more succinct representation which can then be used to make queries orders of magnitude more efficient while still allowing approximation guarantees on query answers. Our study has focused on the critical task of designing efficient algorithms to summarize, query, and manage massive data

High-Performance Computing Algorithms for Constructing Inverted Files on Emerging Multicore Processors

Current trends in processor architectures increasingly include more cores on a single chip and more complex memory hierarchies, and such a trend is likely to continue in the foreseeable future. These processors offer unprecedented opportunities for speeding up demanding computations if the available resources can be effectively utilized. Simultaneously, parallel programming languages such as OpenMP and MPI have been commonly used on clusters of multicore CPUs while newer programming languages such as OpenCL and CUDA have been widely adopted on recent heterogeneous systems and GPUs respectively. The main goal of this dissertation is to develop techniques and methodologies for exploiting these emerging parallel architectures and parallel programming languages to solve large scale irregular applications such as the construction of inverted files. The extraction of inverted files from large collections of documents forms a critical component of all information retrieval systems including web search engines. In this problem, the disk I/O throughput is the major performance bottleneck especially when intermediate results are written onto disks. In addition to the I/O bottleneck, a number of synchronization and consistency issues must be resolved in order to build the dictionary and postings lists efficiently. To address these issues, we introduce a dictionary data structure using a hybrid of trie and B-trees and a high-throughput pipeline strategy that completely avoids the use of disks as temporary storage for intermediate results, while ensuring the consumption of the input data at a high rate. The high-throughput pipelined strategy produces parallel parsed streams that are consumed at the same rate by parallel indexers. The pipelined strategy is implemented on a single multicore CPU as well as on a cluster of such nodes. We were able to achieve a throughput of more than 262MB/s on the ClueWeb09 dataset on a single node. On a cluster of 32 nodes, our experimental results show scalable performance using different metrics, significantly improving on prior published results. On the other hand, we develop a new approach for handling time-evolving documents using additional small temporal indexing structures. The lifetime of the collection is partitioned into multiple time windows, which guarantees a very fast temporal query response time at a small space overhead relative to the non-temporal case. Extensive experimental results indicate that the overhead in both indexing and querying is small in this more complicated case, and the query performance can indeed be improved using finer temporal partitioning of the collection. Finally, we employ GPUs to accelerate the indexing process for building inverted files and to develop a very fast algorithm for the highly irregular list ranking problem. For the indexing problem, the workload is split between CPUs and GPUs in such a way that the strengths of both architectures are exploited. For the list ranking problem involved in the decompression of inverted files, an optimized GPU algorithm is introduced by reducing the problem to a large number of fine grain computations in such a way that the processing cost per element is shown to be close to the best possible

Time Series Similarity Search in Distributed Key-Value Data Stores Using R-Trees

Time series data are sequences of data points collected at certain time intervals. The advance in mobile and sensor technologies has led to rapid growth in the available amount of time series data. The ability to search large time series data sets can be extremely useful in many applications. In healthcare, a system monitoring vital signals can perform a search against the past data and identify possible health threatening conditions. In engineering, a system can analyze performances of complicated equipment and identify possible failure situations or needs of maintenance based on historical data. Existing search methods for time series data are limited in many ways. Systems utilizing memory-bound or disk-bound indexes are restricted by the resources of a single machine or hard drive. Systems that do not use indexes must search through the entire database whenever a search is requested. The proposed system uses multidimensional index in the distributed storage environment to break the bound of one physical machine and allow for high data scalability. Utilizing an index allows the system to locate the patterns similar to the query without having to examine the entire dataset, which can significantly reduce the amount of computing resources required. The system uses an Apache HBase distributed key-value database to store the index and time series data across a cluster of machines. Evaluations were conducted to examine the system’s performance using synthesized data up to 30 million data points. The evaluation results showed that, despite some drawbacks inherited from an R-tree data structure, the system can efficiently search and retrieve patterns in large time series datasets

Engineering Parallel String Sorting

We discuss how string sorting algorithms can be parallelized on modern multi-core shared memory machines. As a synthesis of the best sequential string sorting algorithms and successful parallel sorting algorithms for atomic objects, we first propose string sample sort. The algorithm makes effective use of the memory hierarchy, uses additional word level parallelism, and largely avoids branch mispredictions. Then we focus on NUMA architectures, and develop parallel multiway LCP-merge and -mergesort to reduce the number of random memory accesses to remote nodes. Additionally, we parallelize variants of multikey quicksort and radix sort that are also useful in certain situations. Comprehensive experiments on five current multi-core platforms are then reported and discussed. The experiments show that our implementations scale very well on real-world inputs and modern machines.Comment: 46 pages, extension of "Parallel String Sample Sort" arXiv:1305.115