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Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial.
ObjectiveNo evidence of progression or active disease (NEPAD) is a novel combined endpoint defined by the absence of both progression and inflammatory disease activity in primary progressive multiple sclerosis (PPMS). In the placebo-controlled phase III ORATORIO study (NCT01194570), we investigated the effect of ocrelizumab on this comprehensive outcome and its components in a post-hoc analysis.MethodsThe proportion of patients with NEPAD (no evidence of progression [NEP; no 12-week confirmed progression of ≥1/≥0.5 points on the Expanded Disability Status Scale if the baseline score was ≤5.5/>5.5 points, respectively; no 12-week confirmed progression of ≥20% on the Timed 25-Foot Walk test and 9-Hole Peg Test], no brain magnetic resonance imaging activity [no new/enlarging T2 lesions and no T1 gadolinium-enhancing lesions], and no protocol-defined relapse) from baseline to week 120 was determined in ocrelizumab- (600 mg; n = 465) and placebo-treated (n = 234) patients.ResultsThe majority of ORATORIO study patients with PPMS experienced clinical progression or evidence of disease activity. From baseline to week 120, 29.9% and 42.7% ocrelizumab-treated compared to 9.4% and 29.1% placebo-treated patients maintained NEPAD (relative risk [95% confidence interval {CI}], 3.15 [2.07-4.79]; p < 0.001) and NEP (relative risk [95% CI], 1.47 [1.17-1.84]; p < 0.001), respectively. Effects on the individual components of both measures were consistent with the compound outcomes.InterpretationCompared to placebo, ocrelizumab enhanced 3-fold the proportion of PPMS patients with no evidence of either progression or inflammatory disease activity. NEPAD may represent a sensitive and meaningful comprehensive measure of disease control in patients with PPMS. Ann Neurol 2018;84:527-536
SEMA4A: An ontology for emergency notification systems accessibility
This is the post-print version of the final paper published in Expert Systems with Applications. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2009 Elsevier B.V.Providing alert communication in emergency situations is vital to reduce the number of victims. Reaching this goal is challenging due to users’ diversity: people with disabilities, elderly and children, and other vulnerable groups. Notifications are critical when an emergency scenario is going to happen (e.g. a typhoon approaching) so the ability to transmit notifications to different kind of users is a crucial feature for such systems. In this work an ontology was developed by investigating different sources: accessibility guidelines, emergency response systems, communication devices and technologies, taking into account the different abilities of people to react to different alarms (e.g. mobile phone vibration as an alarm for deafblind people). We think that the proposed ontology addresses the information needs for sharing and integrating emergency notification messages over distinct emergency response information systems providing accessibility under different conditions and for different kind of users.Ministerio de Educación y Cienci
"If You Can't Beat them, Join them": A Usability Approach to Interdependent Privacy in Cloud Apps
Cloud storage services, like Dropbox and Google Drive, have growing
ecosystems of 3rd party apps that are designed to work with users' cloud files.
Such apps often request full access to users' files, including files shared
with collaborators. Hence, whenever a user grants access to a new vendor, she
is inflicting a privacy loss on herself and on her collaborators too. Based on
analyzing a real dataset of 183 Google Drive users and 131 third party apps, we
discover that collaborators inflict a privacy loss which is at least 39% higher
than what users themselves cause. We take a step toward minimizing this loss by
introducing the concept of History-based decisions. Simply put, users are
informed at decision time about the vendors which have been previously granted
access to their data. Thus, they can reduce their privacy loss by not
installing apps from new vendors whenever possible. Next, we realize this
concept by introducing a new privacy indicator, which can be integrated within
the cloud apps' authorization interface. Via a web experiment with 141
participants recruited from CrowdFlower, we show that our privacy indicator can
significantly increase the user's likelihood of choosing the app that minimizes
her privacy loss. Finally, we explore the network effect of History-based
decisions via a simulation on top of large collaboration networks. We
demonstrate that adopting such a decision-making process is capable of reducing
the growth of users' privacy loss by 70% in a Google Drive-based network and by
40% in an author collaboration network. This is despite the fact that we
neither assume that users cooperate nor that they exhibit altruistic behavior.
To our knowledge, our work is the first to provide quantifiable evidence of the
privacy risk that collaborators pose in cloud apps. We are also the first to
mitigate this problem via a usable privacy approach.Comment: Authors' extended version of the paper published at CODASPY 201
Event-Cloud Platform to Support Decision- Making in Emergency Management
The challenge of this paper is to underline the capability of an Event-Cloud
Platform to support efficiently an emergency situation. We chose to focus on a
nuclear crisis use case. The proposed approach consists in modeling the
business processes of crisis response on the one hand, and in supporting the
orchestration and execution of these processes by using an Event-Cloud Platform
on the other hand. This paper shows how the use of Event-Cloud techniques can
support crisis management stakeholders by automatizing non-value added tasks
and by directing decision- makers on what really requires their capabilities of
choice. If Event-Cloud technology is a very interesting and topical subject,
very few research works have considered this to improve emergency management.
This paper tries to fill this gap by considering and applying these
technologies on a nuclear crisis use-case
Online Personal Data Processing and EU Data Protection Reform. CEPS Task Force Report, April 2013
This report sheds light on the fundamental questions and underlying tensions between current policy objectives, compliance strategies and global trends in online personal data processing, assessing the existing and future framework in terms of effective regulation and public policy. Based on the discussions among the members of the CEPS Digital Forum and independent research carried out by the rapporteurs, policy conclusions are derived with the aim of making EU data protection policy more fit for purpose in today’s online technological context. This report constructively engages with the EU data protection framework, but does not provide a textual analysis of the EU data protection reform proposal as such
Program Learning Event on Violence against Children in and around Schools in East Africa
Sponsored by the Elevate Children Funders Group (ECFG), a three-day Program Learning Event (PLE) on Violence against Children in and around Schools (VACiS) held in Kampala, Uganda from 14-16 July 2015, attracted 77 practitioners, donors, advocates, researchers and government representatives in the field of violence against children from Uganda, Tanzania, Kenya, South Africa, Germany, the United Kingdom and United States of America. The theme of the event was developing a common learning agenda on preventing and responding to VACiS
Quantify resilience enhancement of UTS through exploiting connect community and internet of everything emerging technologies
This work aims at investigating and quantifying the Urban Transport System
(UTS) resilience enhancement enabled by the adoption of emerging technology
such as Internet of Everything (IoE) and the new trend of the Connected
Community (CC). A conceptual extension of Functional Resonance Analysis Method
(FRAM) and its formalization have been proposed and used to model UTS
complexity. The scope is to identify the system functions and their
interdependencies with a particular focus on those that have a relation and
impact on people and communities. Network analysis techniques have been applied
to the FRAM model to identify and estimate the most critical community-related
functions. The notion of Variability Rate (VR) has been defined as the amount
of output variability generated by an upstream function that can be
tolerated/absorbed by a downstream function, without significantly increasing
of its subsequent output variability. A fuzzy based quantification of the VR on
expert judgment has been developed when quantitative data are not available.
Our approach has been applied to a critical scenario (water bomb/flash
flooding) considering two cases: when UTS has CC and IoE implemented or not.
The results show a remarkable VR enhancement if CC and IoE are deploye
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