In situ characterization of two wireless transmission schemes for ingestible capsules

We report the experimental in situ characterization of 30-40 MHz and 868 MHz wireless transmission schemes for ingestible capsules, in porcine carcasses. This includes a detailed study of the performance of a magnetically coupled near-field very high-frequency (VHF) transmission scheme that requires only one eighth of the volume and one quarter of the power consumption of existing 868-MHz solutions. Our in situ measurements tested the performance of four different capsules specially constructed for this study (two variants of each transmission scheme), in two scenarios. One mimicked the performance of a body-worn receiving coil, while the other allowed the characterization of the direction-dependent signal attenuation due to losses in the surrounding tissue. We found that the magnetically coupled near-field VHF telemetry scheme presents an attractive option for future, miniturized ingestible capsules for medical applications

Communication system for a tooth-mounted RF sensor used for continuous monitoring of nutrient intake

In this Thesis, the communication system of a wearable device that monitors the user’s diet is studied. Based in a novel RF metamaterial-based mouth sensor, different decisions have to be made concerning the system’s technologies, such as the power source options for the device, the wireless technology used for communications and the method to obtain data from the sensor. These issues, along with other safety rules and regulations, are reviewed, as the first stage of development of the Food-Intake Monitoring projectOutgoin

Experimental Path Loss Models for In-Body Communications Within 2.36-2.5 GHz

"(c) 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works."Biomedical implantable sensors transmitting a variety of physiological signals have been proven very useful in the management of chronic diseases. Currently, the vast majority of these in-body wireless sensors communicate in frequencies below 1 GHz. Although the radio propagation losses through biological tissues may be lower in such frequencies, e.g., the medical implant communication services band of 402 to 405 MHz, the maximal channel bandwidths allowed therein constrain the implantable devices to low data rate transmissions. Novel and more sophisticated wireless in-body sensors and actuators may require higher data rate communication interfaces. Therefore, the radio spectrum above 1 GHz for the use of wearable medical sensing applications should be considered for in-body applications too. Wider channel bandwidths and smaller antenna sizes may be obtained in frequency bands above 1 GHz at the expense of larger propagation losses. Therefore, in this paper, we present a phantom-based radio propagation study for the frequency bands of 2360 to 2400 MHz, which has been set aside for wearable body area network nodes, and the industrial, scientific, medical band of 2400 to 2483.5 MHz. Three different channel scenarios were considered for the propagation measurements: in-body to in-body, in-body to on-body, and in-body to off-body.We provide for the first time path loss formulas for all these cases.Chavez-Santiago, R.; García Pardo, C.; Fornés Leal, A.; Vallés Lluch, A.; Vermeeren, G.; Joseph, W.; Balasingham, I.... (2015). Experimental Path Loss Models for In-Body Communications Within 2.36-2.5 GHz. IEEE Journal of Biomedical and Health Informatics. 19(3):930-937. doi:10.1109/JBHI.2015.2418757S93093719

Design of a Customized multipurpose nano-enabled implantable system for in-vivo theranostics

The first part of this paper reviews the current development and key issues on implantable multi-sensor devices for in vivo theranostics. Afterwards, the authors propose an innovative biomedical multisensory system for in vivo biomarker monitoring that could be suitable for customized theranostics applications. At this point, findings suggest that cross-cutting Key Enabling Technologies (KETs) could improve the overall performance of the system given that the convergence of technologies in nanotechnology, biotechnology, micro&nanoelectronics and advanced materials permit the development of new medical devices of small dimensions, using biocompatible materials, and embedding reliable and targeted biosensors, high speed data communication, and even energy autonomy. Therefore, this article deals with new research and market challenges of implantable sensor devices, from the point of view of the pervasive system, and time-to-market. The remote clinical monitoring approach introduced in this paper could be based on an array of biosensors to extract information from the patient. A key contribution of the authors is that the general architecture introduced in this paper would require minor modifications for the final customized bio-implantable medical device

Insole Antenna for On-Body Telemetry

A 433 MHz antenna is proposed for integration with the insole of footwear for a body area network. The folded dipole design with an asymmetric groundplane radiates from its edges and considers the close proximity of the human foot and ground surfaces. It functions for different ground conductivity conditions and an on-body communication link with an Inverted F Antenna in the upper body area was evaluated on a static and dynamic human subject. The antenna solution was compliant with Specific Absorption Rate requirements, remains matched and links with upper-body nodes regardless of the body posture and node location

Design and development of novel radio frequency identification (RFID) tag structures

The objective of the proposed research is to design and develop a series of radio frequency identification (RFID) tag structures that exhibit good performance characteristics with cost optimization and can be realized on flexible substrates such as liquid crystal polymer (LCP), paper-based substrate and magnetic composite material for conformal applications. The demand for flexible RFID tags has recently increased tremendously due to the requirements of automatic identification in various areas. Several major challenges existing in today's RFID technologies need to be addressed before RFID can eventually march into everyone's daily life, such as how to design high performance tag antennas with effective impedance matching for passive RFID IC chips to optimize the power performance, how to fabricate ultra-low-cost RFID tags in order to facilitate mass production, how to integrate sensors with passive RFID tags for pervasive sensing applications, and how to realize battery-free active RFID tags in which changing battery is not longer needed. In this research, different RFID tag designs are realized on flexible substrates. The design techniques presented set the framework for answering these technical challenges for which, the focus will be on RFID tag structure design, characterization and optimization from the perspectives of both costs involved and technical constraints.Ph.D.Committee Chair: Tentzeris, Manos; Committee Member: DeJean, Gerald; Committee Member: Ingram, Mary; Committee Member: Kavadias, Stylianos; Committee Member: Laskar, Jo

Analysis and Design of Footwear Antennas

Wearable technologies are found in an increasing number of applications including sport and medical monitoring, gaming and consumer electronics. Sensors are used to monitor vital signs and are located on various parts of the body. Footwear sensors permit the collection of data relating to gait, running style, physiotherapy and research. The data is sent from sensors to on-body hubs, often using wired technology, which can impact gait characteristics. This thesis describes the design of footwear antennas for wireless sensor telemetry. The work addresses the challenges of placing antennas close to the foot as well as the proximity to the ground. Guidelines for polarization are presented. The channel link between footwear and wrist is investigated for both narrowband and wideband channels across different frequencies. The effects of the body proximity and movement were gauged for walking subjects and are described in terms of the Rician Distribution K-factor. Different antenna solutions are presented including UWB antennas on various footwear locations as well as 433 MHz integrated antennas in the insole. Both directional and omnidirectional antennas were considered for UWB and the evaluation was for both time-domain and frequencydomain. The research established new ideas that challenge the old paradigm of the waist as the best hub position, demonstrating that a hub on the footwear using directional antennas outperforms a hub on the waist using an omnidirectional antenna. The cumulative distribution functions of measured path gains are evaluated and the results are described in terms of the achievable minimum data rate considering the Body Area Network standard

Development and Experimental Analysis of Wireless High Accuracy Ultra-Wideband Localization Systems for Indoor Medical Applications

This dissertation addresses several interesting and relevant problems in the field of wireless technologies applied to medical applications and specifically problems related to ultra-wideband high accuracy localization for use in the operating room. This research is cross disciplinary in nature and fundamentally builds upon microwave engineering, software engineering, systems engineering, and biomedical engineering. A good portion of this work has been published in peer reviewed microwave engineering and biomedical engineering conferences and journals. Wireless technologies in medicine are discussed with focus on ultra-wideband positioning in orthopedic surgical navigation. Characterization of the operating room as a medium for ultra-wideband signal transmission helps define system design requirements. A discussion of the first generation positioning system provides a context for understanding the overall system architecture of the second generation ultra-wideband positioning system outlined in this dissertation. A system-level simulation framework provides a method for rapid prototyping of ultra-wideband positioning systems which takes into account all facets of the system (analog, digital, channel, experimental setup). This provides a robust framework for optimizing overall system design in realistic propagation environments. A practical approach is taken to outline the development of the second generation ultra-wideband positioning system which includes an integrated tag design and real-time dynamic tracking of multiple tags. The tag and receiver designs are outlined as well as receiver-side digital signal processing, system-level design support for multi-tag tracking, and potential error sources observed in dynamic experiments including phase center error, clock jitter and drift, and geometric position dilution of precision. An experimental analysis of the multi-tag positioning system provides insight into overall system performance including the main sources of error. A five base station experiment shows the potential of redundant base stations in improving overall dynamic accuracy. Finally, the system performance in low signal-to-noise ratio and non-line-of-sight environments is analyzed by focusing on receiver-side digitally-implemented ranging algorithms including leading-edge detection and peak detection. These technologies are aimed at use in next-generation medical systems with many applications including surgical navigation, wireless telemetry, medical asset tracking, and in vivo wireless sensors

In Vivo Characterization of a Wireless Telemetry Module for a Capsule Endoscopy System Utilizing a Conformal Antenna

This paper describes the design, fabrication, packaging, and performance characterization of a conformal helix antenna created on the outside of a 10 mm ×30 mm capsule endoscope designed to operate at a carrier frequency of 433 MHz within human tissue. Wireless data transfer was established between the integrated capsule system and an external receiver. The telemetry system was tested within a tissue phantom and in vivo porcine models. Two different types of transmission modes were tested. The first mode, replicating normal operating conditions, used data packets at a steady power level of 0 dBm, while the capsule was being withdrawn at a steady rate from the small intestine. The second mode, replicating the worst-case clinical scenario of capsule retention within the small bowel, sent data with stepwise increasing power levels of –10, 0, 6, and 10 dBm, with the capsule fixed in position. The temperature of the tissue surrounding the external antenna was monitored at all times using thermistors embedded within the capsule shell to observe potential safety issues. The recorded data showed, for both modes of operation, a low error transmission of 10−3 packet error rate and 10−5 bit error rate and no temperature increase of the tissue according to IEEE standards