Aspects of multiscale modelling in a process algebra for biological systems

We propose a variant of the CCS process algebra with new features aiming at allowing multiscale modelling of biological systems. In the usual semantics of process algebras for modelling biological systems actions are instantaneous. When different scale levels of biological systems are considered in a single model, one should take into account that actions at a level may take much more time than actions at a lower level. Moreover, it might happen that while a component is involved in one long lasting high level action, it is involved also in several faster lower level actions. Hence, we propose a process algebra with operations and with a semantics aimed at dealing with these aspects of multiscale modelling. We study behavioural equivalences for such an algebra and give some examples

Language-based Abstractions for Dynamical Systems

Ordinary differential equations (ODEs) are the primary means to modelling dynamical systems in many natural and engineering sciences. The number of equations required to describe a system with high heterogeneity limits our capability of effectively performing analyses. This has motivated a large body of research, across many disciplines, into abstraction techniques that provide smaller ODE systems while preserving the original dynamics in some appropriate sense. In this paper we give an overview of a recently proposed computer-science perspective to this problem, where ODE reduction is recast to finding an appropriate equivalence relation over ODE variables, akin to classical models of computation based on labelled transition systems.Comment: In Proceedings QAPL 2017, arXiv:1707.0366

Forward and Backward Bisimulations for Chemical Reaction Networks

We present two quantitative behavioral equivalences over species of a chemical reaction network (CRN) with semantics based on ordinary differential equations. Forward CRN bisimulation identifies a partition where each equivalence class represents the exact sum of the concentrations of the species belonging to that class. Backward CRN bisimulation relates species that have the identical solutions at all time points when starting from the same initial conditions. Both notions can be checked using only CRN syntactical information, i.e., by inspection of the set of reactions. We provide a unified algorithm that computes the coarsest refinement up to our bisimulations in polynomial time. Further, we give algorithms to compute quotient CRNs induced by a bisimulation. As an application, we find significant reductions in a number of models of biological processes from the literature. In two cases we allow the analysis of benchmark models which would be otherwise intractable due to their memory requirements.Comment: Extended version of the CONCUR 2015 pape

Process Algebras

Process Algebras are mathematically rigorous languages with well defined semantics that permit describing and verifying properties of concurrent communicating systems. They can be seen as models of processes, regarded as agents that act and interact continuously with other similar agents and with their common environment. The agents may be real-world objects (even people), or they may be artifacts, embodied perhaps in computer hardware or software systems. Many different approaches (operational, denotational, algebraic) are taken for describing the meaning of processes. However, the operational approach is the reference one. By relying on the so called Structural Operational Semantics (SOS), labelled transition systems are built and composed by using the different operators of the many different process algebras. Behavioral equivalences are used to abstract from unwanted details and identify those systems that react similarly to external experiments

COMPUTER SIMULATION AND COMPUTABILITY OF BIOLOGICAL SYSTEMS

The ability to simulate a biological organism by employing a computer is related to the ability of the computer to calculate the behavior of such a dynamical system, or the "computability" of the system.* However, the two questions of computability and simulation are not equivalent. Since the question of computability can be given a precise answer in terms of recursive functions, automata theory and dynamical systems, it will be appropriate to consider it first. The more elusive question of adequate simulation of biological systems by a computer will be then addressed and a possible connection between the two answers given will be considered. A conjecture is formulated that suggests the possibility of employing an algebraic-topological, "quantum" computer (Baianu, 1971b) for analogous and symbolic simulations of biological systems that may include chaotic processes that are not, in genral, either recursively or digitally computable. Depending on the biological network being modelled, such as the Human Genome/Cell Interactome or a trillion-cell Cognitive Neural Network system, the appropriate logical structure for such simulations might be either the Quantum MV-Logic (QMV) discussed in recent publications (Chiara, 2004, and references cited therein)or Lukasiewicz Logic Algebras that were shown to be isomorphic to MV-logic algebras (Georgescu et al, 2001)

Extended Differential Aggregations in Process Algebra for Performance and Biology

We study aggregations for ordinary differential equations induced by fluid semantics for Markovian process algebra which can capture the dynamics of performance models and chemical reaction networks. Whilst previous work has required perfect symmetry for exact aggregation, we present approximate fluid lumpability, which makes nearby processes perfectly symmetric after a perturbation of their parameters. We prove that small perturbations yield nearby differential trajectories. Numerically, we show that many heterogeneous processes can be aggregated with negligible errors.Comment: In Proceedings QAPL 2014, arXiv:1406.156

GSOS for non-deterministic processes with quantitative aspects

Recently, some general frameworks have been proposed as unifying theories for processes combining non-determinism with quantitative aspects (such as probabilistic or stochastically timed executions), aiming to provide general results and tools. This paper provides two contributions in this respect. First, we present a general GSOS specification format (and a corresponding notion of bisimulation) for non-deterministic processes with quantitative aspects. These specifications define labelled transition systems according to the ULTraS model, an extension of the usual LTSs where the transition relation associates any source state and transition label with state reachability weight functions (like, e.g., probability distributions). This format, hence called Weight Function SOS (WFSOS), covers many known systems and their bisimulations (e.g. PEPA, TIPP, PCSP) and GSOS formats (e.g. GSOS, Weighted GSOS, Segala-GSOS, among others). The second contribution is a characterization of these systems as coalgebras of a class of functors, parametric on the weight structure. This result allows us to prove soundness of the WFSOS specification format, and that bisimilarities induced by these specifications are always congruences.Comment: In Proceedings QAPL 2014, arXiv:1406.156

Enhanced Operational Semantics in Systems Biology

We are faced with a great challenge: the cross-fertilization between the fields of formal methods for concurrency, in the computer science domain, and systems biology in the biological realm

Mathematical Models of Abstract Systems: Knowing abstract geometric forms

Scientists use models to know the world. It i susually assumed that mathematicians doing pure mathematics do not. Mathematicians doing pure mathematics prove theorems about mathematical entities like sets, numbers, geometric figures, spaces, etc., they compute various functions and solve equations. In this paper, I want to exhibit models build by mathematicians to study the fundamental components of spaces and, more generally, of mathematical forms. I focus on one area of mathematics where models occupy a central role, namely homotopy theory. I argue that mathematicians introduce genuine models and I offer a rough classification of these models