Disease spread over randomly switched large-scale networks

In this paper we study disease spread over a randomly switched network, which is modeled by a stochastic switched differential equation based on the so called $N$-intertwined model for disease spread over static networks. Assuming that all the edges of the network are independently switched, we present sufficient conditions for the convergence of infection probability to zero. Though the stability theory for switched linear systems can naively derive a necessary and sufficient condition for the convergence, the condition cannot be used for large-scale networks because, for a network with $n$ agents, it requires computing the maximum real eigenvalue of a matrix of size exponential in $n$. On the other hand, our conditions that are based also on the spectral theory of random matrices can be checked by computing the maximum real eigenvalue of a matrix of size exactly $n$

Epidemic Threshold in Continuous-Time Evolving Networks

Current understanding of the critical outbreak condition on temporal networks relies on approximations (time scale separation, discretization) that may bias the results. We propose a theoretical framework to compute the epidemic threshold in continuous time through the infection propagator approach. We introduce the {\em weak commutation} condition allowing the interpretation of annealed networks, activity-driven networks, and time scale separation into one formalism. Our work provides a coherent connection between discrete and continuous time representations applicable to realistic scenarios.Comment: 13 pages, 2 figure

Immunization strategies for epidemic processes in time-varying contact networks

Spreading processes represent a very efficient tool to investigate the structural properties of networks and the relative importance of their constituents, and have been widely used to this aim in static networks. Here we consider simple disease spreading processes on empirical time-varying networks of contacts between individuals, and compare the effect of several immunization strategies on these processes. An immunization strategy is defined as the choice of a set of nodes (individuals) who cannot catch nor transmit the disease. This choice is performed according to a certain ranking of the nodes of the contact network. We consider various ranking strategies, focusing in particular on the role of the training window during which the nodes' properties are measured in the time-varying network: longer training windows correspond to a larger amount of information collected and could be expected to result in better performances of the immunization strategies. We find instead an unexpected saturation in the efficiency of strategies based on nodes' characteristics when the length of the training window is increased, showing that a limited amount of information on the contact patterns is sufficient to design efficient immunization strategies. This finding is balanced by the large variations of the contact patterns, which strongly alter the importance of nodes from one period to the next and therefore significantly limit the efficiency of any strategy based on an importance ranking of nodes. We also observe that the efficiency of strategies that include an element of randomness and are based on temporally local information do not perform as well but are largely independent on the amount of information available

Cost-efficient vaccination protocols for network epidemiology

We investigate methods to vaccinate contact networks -- i.e. removing nodes in such a way that disease spreading is hindered as much as possible -- with respect to their cost-efficiency. Any real implementation of such protocols would come with costs related both to the vaccination itself, and gathering of information about the network. Disregarding this, we argue, would lead to erroneous evaluation of vaccination protocols. We use the susceptible-infected-recovered model -- the generic model for diseases making patients immune upon recovery -- as our disease-spreading scenario, and analyze outbreaks on both empirical and model networks. For different relative costs, different protocols dominate. For high vaccination costs and low costs of gathering information, the so-called acquaintance vaccination is the most cost efficient. For other parameter values, protocols designed for query-efficient identification of the network's largest degrees are most efficient

From temporal network data to the dynamics of social relationships

Networks are well-established representations of social systems, and temporal networks are widely used to study their dynamics. Temporal network data often consist in a succession of static networks over consecutive time windows whose length, however, is arbitrary, not necessarily corresponding to any intrinsic timescale of the system. Moreover, the resulting view of social network evolution is unsatisfactory: short time windows contain little information, whereas aggregating over large time windows blurs the dynamics. Going from a temporal network to a meaningful evolving representation of a social network therefore remains a challenge. Here we introduce a framework to that purpose: transforming temporal network data into an evolving weighted network where the weights of the links between individuals are updated at every interaction. Most importantly, this transformation takes into account the interdependence of social relationships due to the finite attention capacities of individuals: each interaction between two individuals not only reinforces their mutual relationship but also weakens their relationships with others. We study a concrete example of such a transformation and apply it to several data sets of social interactions. Using temporal contact data collected in schools, we show how our framework highlights specificities in their structure and temporal organization. We then introduce a synthetic perturbation into a data set of interactions in a group of baboons to show that it is possible to detect a perturbation in a social group on a wide range of timescales and parameters. Our framework brings new perspectives to the analysis of temporal social networks

Networks and the epidemiology of infectious disease

The science of networks has revolutionised research into the dynamics of interacting elements. It could be argued that epidemiology in particular has embraced the potential of network theory more than any other discipline. Here we review the growing body of research concerning the spread of infectious diseases on networks, focusing on the interplay between network theory and epidemiology. The review is split into four main sections, which examine: the types of network relevant to epidemiology; the multitude of ways these networks can be characterised; the statistical methods that can be applied to infer the epidemiological parameters on a realised network; and finally simulation and analytical methods to determine epidemic dynamics on a given network. Given the breadth of areas covered and the ever-expanding number of publications, a comprehensive review of all work is impossible. Instead, we provide a personalised overview into the areas of network epidemiology that have seen the greatest progress in recent years or have the greatest potential to provide novel insights. As such, considerable importance is placed on analytical approaches and statistical methods which are both rapidly expanding fields. Throughout this review we restrict our attention to epidemiological issues

Quantifying the effect of temporal resolution on time-varying networks

Time-varying networks describe a wide array of systems whose constituents and interactions evolve over time. They are defined by an ordered stream of interactions between nodes, yet they are often represented in terms of a sequence of static networks, each aggregating all edges and nodes present in a time interval of size Δt. In this work we quantify the impact of an arbitrary Δt on the description of a dynamical process taking place upon a time-varying network. We focus on the elementary random walk, and put forth a simple mathematical framework that well describes the behavior observed on real datasets. The analytical description of the bias introduced by time integrating techniques represents a step forward in the correct characterization of dynamical processes on time-varying graphs