Retinal Blood Vessel Segmentation Algorithm for Diabetic Retinopathy using Wavelet: A Survey

Blood vessel structure in retinal images have an important role in diagnosis of diabetic retinopathy. There are several method present for automatic retinal vessel segmentation. For developing retinal screening systems blood vessel segmentation is the basic foundation since vessels serve as one of the main retinal landmark features. The most common signs of diabetic retinopathy include hemorrhages, cotton wool spots, dilated retinal veins, and hard exudates. A patient with diabetic retinopathy disease has to undergo periodic screening of eye. For the diagnosis, doctors use color retinal images of a patient required from digital fundus camera. We present a method that uses Gabor wavelet for vessel enhancement due to their ability to enhance directional structures and euclidean distance technique for accurate vessel segmentation. Retinal angiography images are mainly used in the diagnosis of diseases such as diabetic retinopathy and hypertension etc. In diabetic retinopathy structure of retinal blood vessels change that leads to adult blindness. To overcome this problem automatic biomedical diagnosis system is required.The main stage of diabetic retinopathy are Non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). Eye care specialist can screen vessel abnormalities using an efficient and effective computer based approach to the automated segmentation of blood vessels in retinal images. Automated segmentation reduces the time required by a physician or a skilled technician for manual labeling. Thus a reliable method of vessel segmentation would be valuable for the early detection and characterization of changes due to such diseases. This article presents the automated vessel enhancement and segmentation technique for colored retinal images. Segmentation of blood vessels from image is a difficult task due to thin vessels and low contrast between vessel edges and background. The proposed method enhances the vascular pattern using Gabor wavelet and then it uses euclidean distance technique to generate gray level segmented image. DOI: 10.17762/ijritcc2321-8169.15030

The Impact of Different Image Thresholding based Mammogram Image Segmentation- A Review

Images are examined and discretized numerical capacities. The goal of computerized image processing is to enhance the nature of pictorial data and to encourage programmed machine elucidation. A computerized imaging framework ought to have fundamental segments for picture procurement, exceptional equipment for encouraging picture applications, and a tremendous measure of memory for capacity and info/yield gadgets. Picture segmentation is the field broadly scrutinized particularly in numerous restorative applications and still offers different difficulties for the specialists. Segmentation is a critical errand to recognize districts suspicious of tumor in computerized mammograms. Every last picture have distinctive sorts of edges and diverse levels of limits. In picture transforming, the most regularly utilized strategy as a part of extricating articles from a picture is "thresholding". Thresholding is a prevalent device for picture segmentation for its straightforwardness, particularly in the fields where ongoing handling is required

The Impact of Different Image Thresholding based Mammogram Image Segmentation- A Review

Images are examined and discretized numerical capacities. The goal of computerized image processing is to enhance the nature of pictorial data and to encourage programmed machine elucidation. A computerized imaging framework ought to have fundamental segments for picture procurement, exceptional equipment for encouraging picture applications, and a tremendous measure of memory for capacity and info/yield gadgets. Picture segmentation is the field broadly scrutinized particularly in numerous restorative applications and still offers different difficulties for the specialists. Segmentation is a critical errand to recognize districts suspicious of tumor in computerized mammograms. Every last picture have distinctive sorts of edges and diverse levels of limits. In picture transforming, the most regularly utilized strategy as a part of extricating articles from a picture is "thresholding". Thresholding is a prevalent device for picture segmentation for its straightforwardness, particularly in the fields where ongoing handling is required

Automated image analysis for petrographic image assessments

In this thesis, the algorithms developed for an automated image analysis toolkit called PetrograFX for petrographic image assessments, particularly thin section images, are presented. These algorithms perform two main functions, porosity determination and quartz grain measurements. For porosity determination, the pore space is segmented using a seeded region growing scheme in color space where the seeds are generated automatically based on the absolute R - B differential image. The porosity is then derived by pixel-counting to identify the pore space regions. For quartz grain measurements, adaptive thresholding is applied to make the system robust to the color variations in the entire image for the segmentation of the quartz grains. Median filtering and blob analysis are used to remove lines of fluid inclusions, which appear as black speckles and spots, on the quartz grains before the subsequent measurement operations are performed. The distance transformation and watershed transformation are then performed to separate connected objects. A modified watershed transformation is developed to eliminate false watersheds based on the physical nature of quartz grains. Finally, the grain are characterized in terms of NSD, which is the nominal sectional diameter, NSD distribution and sorting

Retinal vessel segmentation using textons

Segmenting vessels from retinal images, like segmentation in many other medical image domains, is a challenging task, as there is no unified way that can be adopted to extract the vessels accurately. However, it is the most critical stage in automatic assessment of various forms of diseases (e.g. Glaucoma, Age-related macular degeneration, diabetic retinopathy and cardiovascular diseases etc.). Our research aims to investigate retinal image segmentation approaches based on textons as they provide a compact description of texture that can be learnt from a training set. This thesis presents a brief review of those diseases and also includes their current situations, future trends and techniques used for their automatic diagnosis in routine clinical applications. The importance of retinal vessel segmentation is particularly emphasized in such applications. An extensive review of previous work on retinal vessel segmentation and salient texture analysis methods is presented. Five automatic retinal vessel segmentation methods are proposed in this thesis. The first method focuses on addressing the problem of removing pathological anomalies (Drusen, exudates) for retinal vessel segmentation, which have been identified by other researchers as a problem and a common source of error. The results show that the modified method shows some improvement compared to a previously published method. The second novel supervised segmentation method employs textons. We propose a new filter bank (MR11) that includes bar detectors for vascular feature extraction and other kernels to detect edges and photometric variations in the image. The k-means clustering algorithm is adopted for texton generation based on the vessel and non-vessel elements which are identified by ground truth. The third improved supervised method is developed based on the second one, in which textons are generated by k-means clustering and texton maps representing vessels are derived by back projecting pixel clusters onto hand labelled ground truth. A further step is implemented to ensure that the best combinations of textons are represented in the map and subsequently used to identify vessels in the test set. The experimental results on two benchmark datasets show that our proposed method performs well compared to other published work and the results of human experts. A further test of our system on an independent set of optical fundus images verified its consistent performance. The statistical analysis on experimental results also reveals that it is possible to train unified textons for retinal vessel segmentation. In the fourth method a novel scheme using Gabor filter bank for vessel feature extraction is proposed. The ii method is inspired by the human visual system. Machine learning is used to optimize the Gabor filter parameters. The experimental results demonstrate that our method significantly enhances the true positive rate while maintaining a level of specificity that is comparable with other approaches. Finally, we proposed a new unsupervised texton based retinal vessel segmentation method using derivative of SIFT and multi-scale Gabor filers. The lack of sufficient quantities of hand labelled ground truth and the high level of variability in ground truth labels amongst experts provides the motivation for this approach. The evaluation results reveal that our unsupervised segmentation method is comparable with the best other supervised methods and other best state of the art methods

Image Processing Algorithms for Diagnostic Analysis of Microcirculation

Microcirculation has become a key factor for the study and assessment of tissue perfusion and oxygenation. Detection and assessment of the microvasculature using videomicroscopy from the oral mucosa provides a metric on the density of blood vessels in each single frame. Information pertaining to the density of these microvessels within a field of view can be used to quantitatively monitor and assess the changes occurring in tissue oxygenation and perfusion over time. Automated analysis of this information can be used for real-time diagnostic and therapeutic planning of a number of clinical applications including resuscitation. The objective of this study is to design an automated image processing system to segment microvessels, estimate the density of blood vessels in video recordings, and identify the distribution of blood flow. The proposed algorithm consists of two main stages: video processing and image segmentation. The first step of video processing is stabilization. In the video stabilization step, block matching is applied to the video frames. Similarity is measured by cross-correlation coefficients. The main technique used in the segmentation step is multi-thresholding and pixel verification based on calculated geometric and contrast parameters. Segmentation results and differences of video frames are then used to identify the capillaries with blood flow. After categorizing blood vessels as active or passive, according to the amount of blood flow, quantitative measures identifying microcirculation are calculated. The algorithm is applied to the videos obtained using Microscan Side-stream Dark Field (SDF) imaging technique captured from healthy and critically ill humans/animals. Segmentation results were compared and validated using a blind detailed inspection by experts who used a commercial semi-automated image analysis software program, AVA (Automated Vascular Analysis). The algorithm was found to extract approximately 97% of functionally active capillaries and blood vessels in every frame. The aim of this study is to eliminate the human interaction, increase accuracy and reduce the computation time. The proposed method is an entirely automated process that can perform stabilization, pre-processing, segmentation, and microvessel identification without human intervention. The method may allow for assessment of microcirculatory abnormalities occurring in critically ill and injured patients including close to real-time determination of the adequacy of resuscitation

A Survey on Evolutionary Computation for Computer Vision and Image Analysis: Past, Present, and Future Trends

Computer vision (CV) is a big and important field in artificial intelligence covering a wide range of applications. Image analysis is a major task in CV aiming to extract, analyse and understand the visual content of images. However, imagerelated tasks are very challenging due to many factors, e.g., high variations across images, high dimensionality, domain expertise requirement, and image distortions. Evolutionary computation (EC) approaches have been widely used for image analysis with significant achievement. However, there is no comprehensive survey of existing EC approaches to image analysis. To fill this gap, this paper provides a comprehensive survey covering all essential EC approaches to important image analysis tasks including edge detection, image segmentation, image feature analysis, image classification, object detection, and others. This survey aims to provide a better understanding of evolutionary computer vision (ECV) by discussing the contributions of different approaches and exploring how and why EC is used for CV and image analysis. The applications, challenges, issues, and trends associated to this research field are also discussed and summarised to provide further guidelines and opportunities for future research

Data mining based learning algorithms for semi-supervised object identification and tracking

Sensor exploitation (SE) is the crucial step in surveillance applications such as airport security and search and rescue operations. It allows localization and identification of movement in urban settings and can significantly boost knowledge gathering, interpretation and action. Data mining techniques offer the promise of precise and accurate knowledge acquisition techniques in high-dimensional data domains (and diminishing the “curse of dimensionality” prevalent in such datasets), coupled by algorithmic design in feature extraction, discriminative ranking, feature fusion and supervised learning (classification). Consequently, data mining techniques and algorithms can be used to refine and process captured data and to detect, recognize, classify, and track objects with predictable high degrees of specificity and sensitivity. Automatic object detection and tracking algorithms face several obstacles, such as large and incomplete datasets, ill-defined regions of interest (ROIs), variable scalability, lack of compactness, angular regions, partial occlusions, environmental variables, and unknown potential object classes, which work against their ability to achieve accurate real-time results. Methods must produce fast and accurate results by streamlining image processing, data compression and reduction, feature extraction, classification, and tracking algorithms. Data mining techniques can sufficiently address these challenges by implementing efficient and accurate dimensionality reduction with feature extraction to refine incomplete (ill-partitioning) data-space and addressing challenges related to object classification, intra-class variability, and inter-class dependencies. A series of methods have been developed to combat many of the challenges for the purpose of creating a sensor exploitation and tracking framework for real time image sensor inputs. The framework has been broken down into a series of sub-routines, which work in both series and parallel to accomplish tasks such as image pre-processing, data reduction, segmentation, object detection, tracking, and classification. These methods can be implemented either independently or together to form a synergistic solution to object detection and tracking. The main contributions to the SE field include novel feature extraction methods for highly discriminative object detection, classification, and tracking. Also, a new supervised classification scheme is presented for detecting objects in urban environments. This scheme incorporates both novel features and non-maximal suppression to reduce false alarms, which can be abundant in cluttered environments such as cities. Lastly, a performance evaluation of Graphical Processing Unit (GPU) implementations of the subtask algorithms is presented, which provides insight into speed-up gains throughout the SE framework to improve design for real time applications. The overall framework provides a comprehensive SE system, which can be tailored for integration into a layered sensing scheme to provide the war fighter with automated assistance and support. As more sensor technology and integration continues to advance, this SE framework can provide faster and more accurate decision support for both intelligence and civilian applications

Detection and Classification of Diabetic Retinopathy Pathologies in Fundus Images

Diabetic Retinopathy (DR) is a disease that affects up to 80% of diabetics around the world. It is the second greatest cause of blindness in the Western world, and one of the leading causes of blindness in the U.S. Many studies have demonstrated that early treatment can reduce the number of sight-threatening DR cases, mitigating the medical and economic impact of the disease. Accurate, early detection of eye disease is important because of its potential to reduce rates of blindness worldwide. Retinal photography for DR has been promoted for decades for its utility in both disease screening and clinical research studies. In recent years, several research centers have presented systems to detect pathology in retinal images. However, these approaches apply specialized algorithms to detect specific types of lesion in the retina. In order to detect multiple lesions, these systems generally implement multiple algorithms. Furthermore, some of these studies evaluate their algorithms on a single dataset, thus avoiding potential problems associated with the differences in fundus imaging devices, such as camera resolution. These methodologies primarily employ bottom-up approaches, in which the accurate segmentation of all the lesions in the retina is the basis for correct determination. A disadvantage of bottom-up approaches is that they rely on the accurate segmentation of all lesions in order to measure performance. On the other hand, top-down approaches do not depend on the segmentation of specific lesions. Thus, top-down methods can potentially detect abnormalities not explicitly used in their training phase. A disadvantage of these methods is that they cannot identify specific pathologies and require large datasets to build their training models. In this dissertation, I merged the advantages of the top-down and bottom-up approaches to detect DR with high accuracy. First, I developed an algorithm based on a top-down approach to detect abnormalities in the retina due to DR. By doing so, I was able to evaluate DR pathologies other than microaneurysms and exudates, which are the main focus of most current approaches. In addition, I demonstrated good generalization capacity of this algorithm by applying it to other eye diseases, such as age-related macular degeneration. Due to the fact that high accuracy is required for sight-threatening conditions, I developed two bottom-up approaches, since it has been proven that bottom-up approaches produce more accurate results than top-down approaches for particular structures. Consequently, I developed an algorithm to detect exudates in the macula. The presence of this pathology is considered to be a surrogate for clinical significant macular edema (CSME), a sight-threatening condition of DR. The analysis of the optic disc is usually not taken into account in DR screening systems. However, there is a pathology called neovascularization that is present in advanced stages of DR, making its detection of crucial clinical importance. In order to address this problem, I developed an algorithm to detect neovascularization in the optic disc. These algorithms are based on amplitude-modulation and frequency-modulation (AM-FM) representations, morphological image processing methods, and classification algorithms. The methods were tested on a diverse set of large databases and are considered to be the state-of the art in this field