8 research outputs found
Image Based Biomarkers from Magnetic Resonance Modalities: Blending Multiple Modalities, Dimensions and Scales.
The successful analysis and processing of medical
imaging data is a multidisciplinary work that requires the
application and combination of knowledge from diverse fields,
such as medical engineering, medicine, computer science and
pattern classification. Imaging biomarkers are biologic features
detectable by imaging modalities and their use offer the prospect
of more efficient clinical studies and improvement in both
diagnosis and therapy assessment. The use of Dynamic Contrast
Enhanced Magnetic Resonance Imaging (DCE-MRI) and its
application to the diagnosis and therapy has been extensively
validated, nevertheless the issue of an appropriate or optimal
processing of data that helps to extract relevant biomarkers
to highlight the difference between heterogeneous tissue still
remains. Together with DCE-MRI, the data extracted from
Diffusion MRI (DWI-MR and DTI-MR) represents a promising
and complementary tool. This project initially proposes the
exploration of diverse techniques and methodologies for the
characterization of tissue, following an analysis and classification
of voxel-level time-intensity curves from DCE-MRI data mainly
through the exploration of dissimilarity based representations
and models. We will explore metrics and representations to
correlate the multidimensional data acquired through diverse
imaging modalities, a work which starts with the appropriate
elastic registration methodology between DCE-MRI and DWI-
MR on the breast and its corresponding validation.
It has been shown that the combination of multi-modal MRI
images improve the discrimination of diseased tissue. However the fusion
of dissimilar imaging data for classification and segmentation purposes is
not a trivial task, there is an inherent difference in information domains,
dimensionality and scales. This work also proposes a multi-view consensus
clustering methodology for the integration of multi-modal MR images
into a unified segmentation of tumoral lesions for heterogeneity assessment. Using a variety of metrics and distance functions this multi-view
imaging approach calculates multiple vectorial dissimilarity-spaces for
each one of the MRI modalities and makes use of the concepts behind
cluster ensembles to combine a set of base unsupervised segmentations
into an unified partition of the voxel-based data. The methodology is
specially designed for combining DCE-MRI and DTI-MR, for which a
manifold learning step is implemented in order to account for the geometric constrains of the high dimensional diffusion information.The successful analysis and processing of medical
imaging data is a multidisciplinary work that requires the
application and combination of knowledge from diverse fields,
such as medical engineering, medicine, computer science and
pattern classification. Imaging biomarkers are biologic features
detectable by imaging modalities and their use offer the prospect
of more efficient clinical studies and improvement in both
diagnosis and therapy assessment. The use of Dynamic Contrast
Enhanced Magnetic Resonance Imaging (DCE-MRI) and its
application to the diagnosis and therapy has been extensively
validated, nevertheless the issue of an appropriate or optimal
processing of data that helps to extract relevant biomarkers
to highlight the difference between heterogeneous tissue still
remains. Together with DCE-MRI, the data extracted from
Diffusion MRI (DWI-MR and DTI-MR) represents a promising
and complementary tool. This project initially proposes the
exploration of diverse techniques and methodologies for the
characterization of tissue, following an analysis and classification
of voxel-level time-intensity curves from DCE-MRI data mainly
through the exploration of dissimilarity based representations
and models. We will explore metrics and representations to
correlate the multidimensional data acquired through diverse
imaging modalities, a work which starts with the appropriate
elastic registration methodology between DCE-MRI and DWI-
MR on the breast and its corresponding validation.
It has been shown that the combination of multi-modal MRI
images improve the discrimination of diseased tissue. However the fusion
of dissimilar imaging data for classification and segmentation purposes is
not a trivial task, there is an inherent difference in information domains,
dimensionality and scales. This work also proposes a multi-view consensus
clustering methodology for the integration of multi-modal MR images
into a unified segmentation of tumoral lesions for heterogeneity assessment. Using a variety of metrics and distance functions this multi-view
imaging approach calculates multiple vectorial dissimilarity-spaces for
each one of the MRI modalities and makes use of the concepts behind
cluster ensembles to combine a set of base unsupervised segmentations
into an unified partition of the voxel-based data. The methodology is
specially designed for combining DCE-MRI and DTI-MR, for which a
manifold learning step is implemented in order to account for the geometric constrains of the high dimensional diffusion information
Machine Learning for Biomedical Application
Biomedicine is a multidisciplinary branch of medical science that consists of many scientific disciplines, e.g., biology, biotechnology, bioinformatics, and genetics; moreover, it covers various medical specialties. In recent years, this field of science has developed rapidly. This means that a large amount of data has been generated, due to (among other reasons) the processing, analysis, and recognition of a wide range of biomedical signals and images obtained through increasingly advanced medical imaging devices. The analysis of these data requires the use of advanced IT methods, which include those related to the use of artificial intelligence, and in particular machine learning. It is a summary of the Special Issue “Machine Learning for Biomedical Application”, briefly outlining selected applications of machine learning in the processing, analysis, and recognition of biomedical data, mostly regarding biosignals and medical images
Texture analysis of multimodal magnetic resonance images in support of diagnostic classification of childhood brain tumours
Primary brain tumours are recognised as the most common form of solid tumours in children, with pilocytic astrocytoma, medulloblastoma and ependymoma being found most frequently. Despite their high mortality rate, early detection can be facilitated through the use of Magnetic Resonance Imaging (MRI), which is the preferred scanning technique for paediatric patients. MRI offers a variety of imaging sequences through structural and functional imaging, as well as providing complementary tissue information. However visual examination of MR images provides limited ability to characterise distinct histological types of brain tumours. In order to improve diagnostic classification, we explore the use of a computer-aided system based on texture analysis (TA) methods. TA has been applied on conventional MRI but has been less commonly studied on diffusion MRI of brain-related pathology. Furthermore, the combination of textural features derived from both imaging approaches has not yet been widely studied. In this thesis, the aim of the research is to investigate TA based on multi-centre multimodal MRI, in order to provide more comprehensive information and develop an automated processing framework for the classification of childhood brain tumours
XXIV congreso anual de la sociedad española de ingeniería biomédica (CASEIB2016)
En la presente edición, más de 150 trabajos de alto nivel científico van a ser presentados en 18 sesiones paralelas y 3 sesiones de póster, que se centrarán en áreas relevantes de la Ingeniería Biomédica. Entre las sesiones paralelas se pueden destacar la sesión plenaria Premio José María Ferrero Corral y la sesión de Competición de alumnos de Grado en Ingeniería Biomédica, con la participación de 16 alumnos de los Grados en Ingeniería Biomédica a nivel nacional.
El programa científico se complementa con dos ponencias invitadas de científicos reconocidos internacionalmente, dos mesas redondas con una importante participación de sociedades científicas médicas y de profesionales de la industria de tecnología médica, y dos actos sociales que permitirán a los participantes acercarse a la historia y cultura valenciana. Por primera vez, en colaboración con FENIN, seJane Campos, R. (2017). XXIV congreso anual de la sociedad española de ingeniería biomédica (CASEIB2016). Editorial Universitat Politècnica de València. http://hdl.handle.net/10251/79277EDITORIA