Wearable electroencephalography for long-term monitoring and diagnostic purposes

Truly Wearable EEG (WEEG) can be considered as the future of ambulatory EEG units, which are the current standard for long-term EEG monitoring. Replacing these short lifetime, bulky units with long-lasting, miniature and wearable devices that can be easily worn by patients will result in more EEG data being collected for extended monitoring periods. This thesis presents three new fabricated systems, in the form of Application Specific Integrated Circuits (ASICs), to aid the diagnosis of epilepsy and sleep disorders by detecting specific clinically important EEG events on the sensor node, while discarding background activity. The power consumption of the WEEG monitoring device incorporating these systems can be reduced since the transmitter, which is the dominating element in terms of power consumption, will only become active based on the output of these systems. Candidate interictal activity is identified by the developed analog-based interictal spike selection system-on-chip (SoC), using an approximation of the Continuous Wavelet Transform (CWT), as a bandpass filter, and thresholding. The spike selection SoC is fabricated in a 0.35 μm CMOS process and consumes 950 nW. Experimental results reveal that the SoC is able to identify 87% of interictal spikes correctly while only transmitting 45% of the data. Sections of EEG data containing likely ictal activity are detected by an analog seizure selection SoC using the low complexity line length feature. This SoC is fabricated in a 0.18 μm CMOS technology and consumes 1.14 μW. Based on experimental results, the fabricated SoC is able to correctly detect 83% of seizure episodes while transmitting 52% of the overall EEG data. A single-channel analog-based sleep spindle detection SoC is developed to aid the diagnosis of sleep disorders by detecting sleep spindles, which are characteristic events of sleep. The system identifies spindle events by monitoring abrupt changes in the input EEG. An approximation of the median frequency calculation, incorporated as part of the system, allows for non-spindle activity incorrectly identified by the system as sleep spindles to be discarded. The sleep spindle detection SoC is fabricated in a 0.18 μm CMOS technology, consuming only 515 nW. The SoC achieves a sensitivity and specificity of 71.5% and 98% respectively.Open Acces

A Computational Framework for the Structural Change Analysis of 3D Volumes of Microscopic Specimens

Glaucoma, commonly observed with an elevation in the intraocular pressure level (IOP), is one of the leading causes of blindness. The lamina cribrosa is a mesh-like structure that provides axonal support for the optic nerves leaving the eye. The changes in the laminar structure under IOP elevations may result in the deaths of retinal ganglion cells, leading to vision degradation and loss. We have developed a comprehensive computational framework that can assist the study of structural changes in microscopic structures such as lamina cribrosa. The optical sectioning property of a confocal microscope facilitates imaging thick microscopic specimen at various depths without physical sectioning. The confocal microscope images are referred to as optical sections. The computational framework developed includes: 1) a multi-threaded system architecture for tracking a volume-of-interest within a microscopic specimen in a parallel computation environment using a reliable-multicast for collective-communication operations 2) a Karhunen-Loève (KL) expansion based adaptive noise prefilter for the restoration of the optical sections using an inverse restoration method 3) a morphological operator based ringing metric to quantify the ringing artifacts introduced during iterative restoration of optical sections 4) a l2 norm based error metric to evaluate the performance of optical flow algorithms without a priori knowledge of the true motion field and 5) a Compute-and-Propagate (CNP) framework for iterative optical flow algorithms. The realtime tracking architecture can convert a 2D-confocal microscope into a 4D-confocal microscope with tracking. The adaptive KL filter is suitable for realtime restoration of optical sections. The CNP framework significantly improves the speed and convergence of the iterative optical flow algorithms. Also, the CNP framework can reduce the errors in the motion field estimates due to the aperture problem. The performance of the proposed framework is demonstrated on real-life image sequences and on z-Stack datasets of random cotton fibers and lamina cribrosa of a cow retina with an experimentally induced glaucoma. The proposed framework can be used for routine laboratory and clinical investigation of microstructures such as cells and tissues, for the evaluation of complex structures such as cornea and has potential use as a surgical guidance tool

Low-complexity algorithms for automatic detection of sleep stages and events for use in wearable EEG systems

Objective: Diagnosis of sleep disorders is an expensive procedure that requires performing a sleep study, known as polysomnography (PSG), in a controlled environment. This study monitors the neural, eye and muscle activity of a patient using electroencephalogram (EEG), electrooculogram (EOG) and electromyogram (EMG) signals which are then scored in to different sleep stages. Home PSG is often cited as an alternative of clinical PSG to make it more accessible, however it still requires patients to use a cumbersome system with multiple recording channels that need to be precisely placed. This thesis proposes a wearable sleep staging system using a single channel of EEG. For realisation of such a system, this thesis presents novel features for REM sleep detection from EEG (normally detected using EMG/EOG), a low-complexity automatic sleep staging algorithm using a single EEG channel and its complete integrated circuit implementation. Methods: The difference between Spectral Edge Frequencies (SEF) at 95% and 50% in the 8-16 Hz frequency band is shown to have high discriminatory ability for detecting REM sleep stages. This feature, together with other spectral features from single-channel EEG are used with a set of decision trees controlled by a state machine for classification. The hardware for the complete algorithm is designed using low-power techniques and implemented on chip using 0.18μm process node technology. Results: The use of SEF features from one channel of EEG resulted in 83% of REM sleep epochs being correctly detected. The automatic sleep staging algorithm, based on contextually aware decision trees, resulted in an accuracy of up to 79% on a large dataset. Its hardware implementation, which is also the very first complete circuit level implementation of any sleep staging algorithm, resulted in an accuracy of 98.7% with great potential for use in fully wearable sleep systems.Open Acces

Radio frequency interference detection and mitigation techniques for navigation and Earth observation

Radio-Frequency Interference (RFI) signals are undesired signals that degrade or disrupt the performance of a wireless receiver. RFI signals can be troublesome for any receiver, but they are especially threatening for applications that use very low power signals. This is the case of applications that rely on the Global Navigation Satellite Systems (GNSS), or passive microwave remote sensing applications such as Microwave Radiometry (MWR) and GNSS-Reflectometry (GNSS-R). In order to solve the problem of RFI, RFI-countermeasures are under development. This PhD thesis is devoted to the design, implementation and test of innovative RFI-countermeasures in the fields of MWR and GNSS. In the part devoted to RFI-countermeasures for MWR applications, first, this PhD thesis completes the development of the MERITXELL instrument. The MERITXELL is a multi-frequency total-power radiometer conceived to be an outstanding platform to perform detection, characterization, and localization of RFI signals at the most common MWR imaging bands up to 92 GHz. Moreover, a novel RFI mitigation technique is proposed for MWR: the Multiresolution Fourier Transform (MFT). An assessment of the performance of the MFT has been carried out by comparison with other time-frequency mitigation techniques. According to the results, the MFT technique is a good trade-off solution among all other techniques since it can mitigate efficiently all kinds of RFI signals under evaluation. In the part devoted to RFI-countermeasures for GNSS and GNSS-R applications, first, a system for RFI detection and localization at GNSS bands is proposed. This system is able to detect RFI signals at the L1 band with a sensitivity of -108 dBm at full-band, and of -135 dBm for continuous wave and chirp-like signals when using the averaged spectrum technique. Besides, the Generalized Spectral Separation Coefficient (GSSC) is proposed as a figure of merit to evaluate the Signal-to-Noise Ratio (SNR) degradation in the Delay-Doppler Maps (DDMs) due to the external RFI effect. Furthermore, the FENIX system has been conceived as an innovative system for RFI detection and mitigation and anti-jamming for GNSS and GNSS-R applications. FENIX uses the MFT blanking as a pre-correlation excision tool to perform the mitigation. In addition, FENIX has been designed to be cross-GNSS compatible and RFI-independent. The principles of operation of the MFT blanking algorithm are assessed and compared with other techniques for GNSS signals. Its performance as a mitigation tool is proven using GNSS-R data samples from a real airborne campaign. After that, the main building blocks of the patented architecture of FENIX have been described. The FENIX architecture has been implemented in three real-time prototypes. Moreover, a simulator named FENIX-Sim allows for testing its performance under different jamming scenarios. The real-time performance of FENIX prototype has been tested using different setups. First, a customized VNA has been built in order to measure the transfer function of FENIX in the presence of several representative RFI/jamming signals. The results show how the power transfer function adapts itself to mitigate the RFI/jamming signal. Moreover, several real-time tests with GNSS receivers have been performed using GPS L1 C/A, GPS L2C, and Galileo E1OS. The results show that FENIX provides an extra resilience against RFI and jamming signals up to 30 dB. Furthermore, FENIX is tested using a real GNSS timing setup. Under nominal conditions, when no RFI/jamming signal is present, a small additional jitter on the order of 2-4 ns is introduced in the system. Besides, a maximum bias of 45 ns has been measured under strong jamming conditions (-30 dBm), which is acceptable for current timing systems requiring accuracy levels of 100 ns. Finally, the design of a backup system for GNSS in tracking applications that require high reliability against RFI and jamming attacks is proposed.Les interferències de radiofreqüència (RFI) són senyals no desitjades que degraden o interrompen el funcionament dels receptors sense fils. Les RFI poden suposar un problema per qualsevol receptor, però són especialment amenaçadores per les a aplicacions que fan servir senyals de molt baixa potència. Aquest és el cas de les aplicacions que depenen dels sistemes mundials de navegació per satèl·lit (GNSS) o de les aplicacions de teledetecció passiva de microones, com la radiometria de microones (MWR) i la reflectometria GNSS (GNSS-R). Per combatre aquest problema, sistemes anti-RFI s'estan desenvolupament actualment. Aquesta tesi doctoral està dedicada al disseny, la implementació i el test de sistemes anti-RFI innovadors en els camps de MWR i GNSS. A la part dedicada als sistemes anti-RFI en MWR, aquesta tesi doctoral completa el desenvolupament de l'instrument MERITXELL. El MERITXELL és un radiòmetre multifreqüència concebut com una plataforma excepcional per la detecció, caracterització i localització de RFI a les bandes de MWR més utilitzades per sota dels 92 GHz. A més a més, es proposa una nova tècnica de mitigació de RFI per MWR: la Transformada de Fourier amb Multiresolució (MFT). El funcionament de la MFT s'ha comparat amb el d'altres tècniques de mitigació en els dominis del temps i la freqüència. D'acord amb els resultats obtinguts, la MFT és una bona solució de compromís entre les altres tècniques, ja que pot mitigar de manera eficient tots els tipus de senyals RFI considerats. A la part dedicada als sistemes anti-RFI en GNSS i GNSS-R, primer es proposa un sistema per a la detecció i localització de RFI a les bandes GNSS. Aquest sistema és capaç de detectar senyals RFI a la banda L1 amb una sensibilitat de -108 dBm a tota la banda, i de -135 dBm per a senyals d'ona contínua i chirp fen un mitjana de l'espectre. A més a més, el Coeficient de Separació Espectral Generalitzada (GSSC) es proposa com una mesura per avaluar la degradació de la relació senyal a soroll (SNR) en els Mapes de Delay-Doppler (DDM) a causa del impacte de les RFI. La major contribució d'aquesta tesi doctoral és el sistema FENIX. FENIX és un sistema innovador de detecció i mitigació de RFI i inhibidors de freqüència per aplicacions GNSS i GNSS-R. FENIX utilitza la MFT per eliminar la interferència abans del procés de correlació amb el codi GNSS independentment del tipus de RFI. L'algoritme de mitigació de FENIX s'ha avaluat i comparat amb altres tècniques i els principals components de la seva arquitectura patentada es descriuen. Finalment, un simulador anomenat FENIX-Sim permet avaluar el seu rendiment en diferents escenaris d'interferència. El funcionament en temps real del prototip FENIX ha estat provat utilitzant diferents mètodes. En primer lloc, s'ha creat un analitzador de xarxes per a mesurar la funció de transferència del FENIX en presència de diverses RFI representatives. Els resultats mostren com la funció de transferència s'adapta per mitigar el senyal interferent. A més a més, s'han realitzat diferents proves en temps real amb receptors GNSS compatibles amb els senyals GPS L1 C/A, GPS L2C i Galileo E1OS. Els resultats mostren que FENIX proporciona una resistència addicional contra les RFI i els senyals dels inhibidors de freqüència de fins a 30 dB. A més a més, FENIX s'ha provat amb un sistema comercial de temporització basat en GNSS. En condicions nominals, sense RFI, FENIX introdueix un petit error addicional de tan sols 2-4 ns. Per contra, el biaix màxim mesurat en condicions d'alta interferència (-30 dBm) és de 45 ns, el qual és acceptable per als sistemes de temporització actuals que requereixen nivells de precisió d'uns 100 ns. Finalment, es proposa el disseny d'un sistema robust de seguiment, complementari als GNSS, per a aplicacions que requereixen alta fiabilitat contra RFI.Postprint (published version

Development Of A High Performance Mosaicing And Super-Resolution Algorithm

In this dissertation, a high-performance mosaicing and super-resolution algorithm is described. The scale invariant feature transform (SIFT)-based mosaicing algorithm builds an initial mosaic which is iteratively updated by the robust super resolution algorithm to achieve the final high-resolution mosaic. Two different types of datasets are used for testing: high altitude balloon data and unmanned aerial vehicle data. To evaluate our algorithm, five performance metrics are employed: mean square error, peak signal to noise ratio, singular value decomposition, slope of reciprocal singular value curve, and cumulative probability of blur detection. Extensive testing shows that the proposed algorithm is effective in improving the captured aerial data and the performance metrics are accurate in quantifying the evaluation of the algorithm

Computationally efficient algorithms and implementations of adaptive deep brain stimulation systems for Parkinson's disease

Clinical deep brain stimulation (DBS) is a tool used to mitigate pharmacologically intractable neurodegenerative diseases such as Parkinson's disease (PD), tremor and dystonia. Present implementations of DBS use continuous, high frequency voltage or current pulses so as to mitigate PD. This results in some limitations, among which there is stimulation induced side effects and shortening of pacemaker battery life. Adaptive DBS (aDBS) can be used to overcome a number of these limitations. Adaptive DBS is intended to deliver stimulation precisely only when needed. This thesis presents work undertaken to investigate, propose and develop novel algorithms and implementations of systems for adapting DBS. This thesis proposes four system implementations that could facilitate DBS adaptation either in the form of closed-loop DBS or spatial adaptation. The first method involved the use of dynamic detection to track changes in local field potentials (LFP) which can be indicative of PD symptoms. The work on dynamic detection included the synthesis of validation dataset using mainly autoregressive moving average (ARMA) models to enable the evaluation of a subset of PD detection algorithms for accuracy and complexity trade-offs. The subset of algorithms consisted of feature extraction (FE), dimensionality reduction (DR) and dynamic pattern classification stages. The combination with the best trade-off in terms of accuracy and complexity consisted of discrete wavelet transform (DWT) for FE, maximum ratio method (MRM) for DR and k-nearest neighbours (k-NN) for classification. The MRM is a novel DR method inspired by Fisher's separability criterion. The best combination achieved accuracy measures: F1-score of 97.9%, choice probability of 99.86% and classification accuracy of 99.29%. Regarding complexity, it had an estimated microchip area of 0.84 mm² for estimates in 90 nm CMOS process. The second implementation developed the first known PD detection and monitoring processor. This was achieved using complementary detection, which presents a hardware-efficient method of implementing a PD detection processor for monitoring PD progression in Parkinsonian patients. Complementary detection is achieved by using a combination of weak classifiers to produce a classifier with a higher consistency and confidence level than the individual classifiers in the configuration. The PD detection processor using the same processing stages as the first implementation was validated on an FPGA platform. By mapping the implemented design on a 45 nm CMOS process, the most optimal implementation achieved a dynamic power per channel of 2.26 μW and an area per channel of 0.2384 mm². It also achieved mean accuracy measures: Mathews correlation coefficient (MCC) of 0.6162, an F1-score of 91.38%, and mean classification accuracy of 91.91%. The third implementation proposed a framework for adapting DBS based on a critic-actor control approach. This models the relationship between a trained clinician (critic) and a neuro-modulation system (actor) for modulating DBS. The critic was implemented and validated using machine learning models, and the actor was implemented using a fuzzy controller. Therapy is modulated based on state estimates obtained through the machine learning models. PD suppression was achieved in seven out of nine test cases. The final implementation introduces spatial adaptation for aDBS. Spatial adaptation adjusts to variation in lead position and/or stimulation focus, as poor stimulation focus has been reported to affect therapeutic benefits of DBS. The implementation proposes dynamic current steering systems as a power-efficient implementation for multi-polar multisite current steering, with a particular focus on the output stage of the dynamic current steering system. The output stage uses dynamic current sources in implementing push-pull current sources that are interfaced to 16 electrodes so as to enable current steering. The performance of the output stage was demonstrated using a supply of 3.3 V to drive biphasic current pulses of up to 0.5 mA through its electrodes. The preliminary design of the circuit was implemented in 0.18 μm CMOS technology

Systems engineering approaches to safety in transport systems

openDuring driving, driver behavior monitoring may provide useful information to prevent road traffic accidents caused by driver distraction. It has been shown that 90% of road traffic accidents are due to human error and in 75% of these cases human error is the only cause. Car manufacturers have been interested in driver monitoring research for several years, aiming to enhance the general knowledge of driver behavior and to evaluate the functional state as it may drastically influence driving safety by distraction, fatigue, mental workload and attention. Fatigue and sleepiness at the wheel are well known risk factors for traffic accidents. The Human Factor (HF) plays a fundamental role in modern transport systems. Drivers and transport operators control a vehicle towards its destination in according to their own sense, physical condition, experience and ability, and safety strongly relies on the HF which has to take the right decisions. On the other hand, we are experiencing a gradual shift towards increasingly autonomous vehicles where HF still constitutes an important component, but may in fact become the "weakest link of the chain", requiring strong and effective training feedback. The studies that investigate the possibility to use biometrical or biophysical signals as data sources to evaluate the interaction between human brain activity and an electronic machine relate to the Human Machine Interface (HMI) framework. The HMI can acquire human signals to analyse the specific embedded structures and recognize the behavior of the subject during his/her interaction with the machine or with virtual interfaces as PCs or other communication systems. Based on my previous experience related to planning and monitoring of hazardous material transport, this work aims to create control models focused on driver behavior and changes of his/her physiological parameters. Three case studies have been considered using the interaction between an EEG system and external device, such as driving simulators or electronical components. A case study relates to the detection of the driver's behavior during a test driver. Another case study relates to the detection of driver's arm movements according to the data from the EEG during a driver test. The third case is the setting up of a Brain Computer Interface (BCI) model able to detect head movements in human participants by EEG signal and to control an electronic component according to the electrical brain activity due to head turning movements. Some videos showing the experimental results are available at https://www.youtube.com/channel/UCj55jjBwMTptBd2wcQMT2tg.openXXXIV CICLO - INFORMATICA E INGEGNERIA DEI SISTEMI/ COMPUTER SCIENCE AND SYSTEMS ENGINEERING - Ingegneria dei sistemiZero, Enric

The detection of unknown waveforms in ESM receivers: FFT-based real-time solutions

Radars and airborne electronic support measures (ESMs) systems are locked in a tactical battle to detect each other whilst remaining undetected. Traditionally, the ESM system has a range advantage. Low probability of intercept (LPI) waveform designers are, however, more heavily exploiting the matched filter radar advantage and hence degrading the range advantage. There have been literature and internal, SELEX Galileo proposals to regain some ESM processing gain of low probability of intercept (LPI) waveforms. This study, however, has sought digital signal processing (DSP) solutions which are: (1) computationally simple; (2) backward-compatible with existing SELEX Galileo digital receivers (DRxs) and (3) have low resource requirements. The two contributions are complementary and result in a detector which is suitable for detection of most radar waveforms. The first contribution is the application of spatially variant apodization (SVA) in a detection role. Compared to conventional window functions, SVA was found to be beneficial for the detection of sinusoidal radar waveforms as it surpassed the fixed window function detectors in all scenarios tested. The second contribution shows by simulation that simple spectral smoothing techniques improved DRx LPI detection capability to a level similar to more complicated non-parametric spectral estimators and far in excess of the conventional (modified) periodogram. The DSP algorithms were implemented using model-based design (MBD). The implication is that a detector with improved conventional and LPI waveform detection capability can be created from the intellectual property (IP). Estimates of the improvement in SELEX Galileo DRx system detection range are provided in the conclusion

Multibiometric security in wireless communication systems

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 05/08/2010.This thesis has aimed to explore an application of Multibiometrics to secured wireless communications. The medium of study for this purpose included Wi-Fi, 3G, and WiMAX, over which simulations and experimental studies were carried out to assess the performance. In specific, restriction of access to authorized users only is provided by a technique referred to hereafter as multibiometric cryptosystem. In brief, the system is built upon a complete challenge/response methodology in order to obtain a high level of security on the basis of user identification by fingerprint and further confirmation by verification of the user through text-dependent speaker recognition. First is the enrolment phase by which the database of watermarked fingerprints with memorable texts along with the voice features, based on the same texts, is created by sending them to the server through wireless channel. Later is the verification stage at which claimed users, ones who claim are genuine, are verified against the database, and it consists of five steps. Initially faced by the identification level, one is asked to first present one’s fingerprint and a memorable word, former is watermarked into latter, in order for system to authenticate the fingerprint and verify the validity of it by retrieving the challenge for accepted user. The following three steps then involve speaker recognition including the user responding to the challenge by text-dependent voice, server authenticating the response, and finally server accepting/rejecting the user. In order to implement fingerprint watermarking, i.e. incorporating the memorable word as a watermark message into the fingerprint image, an algorithm of five steps has been developed. The first three novel steps having to do with the fingerprint image enhancement (CLAHE with 'Clip Limit', standard deviation analysis and sliding neighborhood) have been followed with further two steps for embedding, and extracting the watermark into the enhanced fingerprint image utilising Discrete Wavelet Transform (DWT). In the speaker recognition stage, the limitations of this technique in wireless communication have been addressed by sending voice feature (cepstral coefficients) instead of raw sample. This scheme is to reap the advantages of reducing the transmission time and dependency of the data on communication channel, together with no loss of packet. Finally, the obtained results have verified the claims