Non Invasive Foetal Monitoring with a Combined ECG - PCG System

Although modern ultrasound provides remarkable images and biophysical measures, the technology is expensive and the observations are only available over a short time. Longer term monitoring is achieved in a clinical setting using ultrasonic Doppler cardiotocography (CTG) but this has a number of limitations. Some pathologies and some anomalies of cardiac functioning are not detectable with CTG. Moreover, although frequent and/or long-term foetal heart rate (FHR) monitoring is recommended, mainly in high risk pregnancies, there is a lack of established evidence for safe ultrasound irradiation exposure to the foetus for extended periods (Ang et al., 2006). Finally, high quality ultrasound devices are too expensive and not approved for home care use. In fact, there is a remarkable mismatch between ability to examine a foetus in a clinical setting, and the almost complete absence of technology that permits longer term monitoring of a foetus at home. Therefore, in the last years, many efforts (Hany et al., 1989; Jimenez et al., 1999; Kovacs et al., 2000; Mittra et al., 2008; Moghavvemi et al., 2003; Nagal, 1986; Ruffo et al., 2010; Talbert et al., 1986; Varady et al., 2003) have been attempted by the scientific community to find a suitable alternative

Validation of two types of textile electrodes for electrocardiography and electromyography measurement applications

Tese de mestrado. Engenharia Biomédica. Faculdade de Engenharia. Universidade do Porto. 201

Automatic signal and image-based assessments of spinal cord injury and treatments.

Spinal cord injury (SCI) is one of the most common sources of motor disabilities in humans that often deeply impact the quality of life in individuals with severe and chronic SCI. In this dissertation, we have developed advanced engineering tools to address three distinct problems that researchers, clinicians and patients are facing in SCI research. Particularly, we have proposed a fully automated stochastic framework to quantify the effects of SCI on muscle size and adipose tissue distribution in skeletal muscles by volumetric segmentation of 3-D MRI scans in individuals with chronic SCI as well as non-disabled individuals. We also developed a novel framework for robust and automatic activation detection, feature extraction and visualization of the spinal cord epidural stimulation (scES) effects across a high number of scES parameters to build individualized-maps of muscle recruitment patterns of scES. Finally, in the last part of this dissertation, we introduced an EMG time-frequency analysis framework that implements EMG spectral analysis and machine learning tools to characterize EMG patterns resulting in independent or assisted standing enabled by scES, and identify the stimulation parameters that promote muscle activation patterns more effective for standing. The neurotechnological advancements proposed in this dissertation have greatly benefited SCI research by accelerating the efforts to quantify the effects of SCI on muscle size and functionality, expanding the knowledge regarding the neurophysiological mechanisms involved in re-enabling motor function with epidural stimulation and the selection of stimulation parameters and helping the patients with complete paralysis to achieve faster motor recovery

Effects of Functional Electrical Stimulation Cycling of Different Duration on Viscoelastic and Electromyographic Properties of the Knee in Patients with Spinal Cord Injury

The benefits of functional electrical stimulation during cycling (FES-cycling) have been ascertained following spinal cord injury. The instrumented pendulum test was applied to chronic paraplegic patients to investigate the effects of FES-cycling of different duration (20-min vs. 40-min) on biomechanical and electromyographic characterization of knee mobility. Seven adults with post-traumatic paraplegia attended two FES-cycling sessions, a 20-min and a 40-min one, in a random order. Knee angular excursion, stiffness and viscosity were measured using the pendulum test before and after each session. Surface electromyographic activity was recorded from the rectus femoris (RF) and biceps femoris (BF) muscles. FES-cycling led to reduced excursion (p < 0.001) and increased stiffness (p = 0.005) of the knee, which was more evident after the 20-min than 40-min session. Noteworthy, biomechanical changes were associated with an increase of muscle activity and changes in latency of muscle activity only for 20-min, with anticipated response times for RF (p < 0.001) and delayed responses for BF (p = 0.033). These results indicate that significant functional changes in knee mobility can be achieved by FES-cycling for 20 min, as evaluated by the pendulum test in patients with chronic paraplegia. The observed muscle behaviour suggests modulatory effects of exercise on spinal network aimed to partially restore automatic neuronal processes

脳波信号解析に注目したノイズ除去、特徴抽出、実験観測応用を最適化する数理基盤に関する研究

Electroencephalography (EEG) data inevitably contains a large amount of noise particularly from ocular potentials in tasks with eye-movements and eye-blink, known as electrooculography (EOG) artifact, which has been a crucial issue in the braincomputer- interface (BCI) study. The eye-movements and eye-blinks have different time-frequency properties mixing together in EEGs of interest. This time-frequency characteristic has been substantially dealt with past proposed denoising algorithms relying on the consistent assumption based on the single noise component model. However, the traditional model is not simply applicable for biomedical signals consist of multiple signal components, such as weak EEG signals easily recognized as a noise because of the signal amplitude with respect to the EOG signal. In consideration of the realistic signal contamination, we newly designed the EEG-EOG signal contamination model for quantitative validations of the artifact removal from EEGs, and then proposed the two-stage wavelet shrinkage method with the undecimated wavelet decomposition (UDWT), which is suitable for the signal structure. The features of EEG-EOG signal has been extracted with existing decomposition methods known as Principal Component Analysis (PCA), Independent Component Analysis (ICA) based on a consistent assumption of the orthogonality of signal vectors or statistical independence of signal components. In the viewpoint of the signal morphology such as spiking, waves and signal pattern transitions, A systematic decomposition method is proposed to identify the type of signal components or morphology on the basis of sparsity in time-frequency domain. Morphological Component Analysis (MCA) is extended the traditional concept of signal decomposition including Fourier and wavelet transforms and provided a way of reconstruction that guarantees accuracy in reconstruction by using multiple bases being independent of each other and uniqueness representation, called the concept of “dictionary”. MCA is applied to decompose the real EEG signal and clarified the best combination of dictionaries for the purpose. In this proposed semi-realistic biological signal analysis, target EEG data was prepared as mixture signals of artificial eye movements and blinks and iEEG recorded from electrodes embedded into the brain intracranially and then those signals were successfully decomposed into original types by a linear expansion of waveforms such as redundant transforms: UDWT, DCT,LDCT, DST and DIRAC. The result demonstrated that the most suitable combination for EEG data analysis was UDWT, DST and DIRAC to represent the baseline envelop, multi frequency wave forms and spiking activities individually as representative types of EEG morphologies. MCA proposed method is used in negative-going Bereitschaftspotential (BP). It is associated with the preparation and execution of voluntary movement. Thus far, the BP for simple movements involving either the upper or lower body segment has been studied. However, the BP has not yet been recorded during sit-to-stand movements, which use the upper and lower body segments. Electroencephalograms were recorded during movement. To detect the movement of the upper body segment, a gyro sensor was placed on the back, and to detect the movement of the lower body segment, an electromyogram (EMG) electrode was placed on the surface of the hamstrings and quadriceps. Our study revealed that a negative-going BP was evoked around -3 to -2 seconds before the onset of the upper body movement in the sit-to-stand movement in response to the start cue. The BP had a negative peak before the onset of the movement. The potential was followed by premotor positivity, a motor-related potential, and a reafferent potential. The BP for the sit-to-stand movement had a steeper negative slope (-0.8 to -0.001 seconds) just before the onset of the upper body movement. The slope correlated with the gyro peak and the max amplitude of hamstrings EMG. A BP negative peak value was correlated with the max amplitude of the hamstring EMG. These results suggested that the observed BP is involved in the preparation/execution for a sit-to-stand movement using the upper and lower body. In summary, this thesis is help to pave the practical approach of real time analysis of desired EEG signal of interest toward the implementation of rehabilitation device which may be used for motor disabled people. We also pointed out the EEG-EOG contamination model that helps in removal of the artifacts and explicit dictionaries are representing the EEG morphologies.九州工業大学博士学位論文 学位記番号:生工博甲第290号 学位授与年月日:平成29年3月24日1 Introduction|2 Research Background and Preliminaries|3 Introduction of Morphological Component Analysis|4 Two-Stage Undecimated Wavelet Shrinkage Method|5 Morphologically Decomposition of EEG Signals|6 Bereitschaftspotential for Rise to Stand-Up Behavior九州工業大学平成28年

Vibro-acoustic Analysis of Reciprocating Compressor in the Context of Fault Diagnosis

This project assessed the behaviour of a positive displacement type of compressor utilising airborne acoustic signatures. The study concentrated on finding an improved method based on airborne sound that can be suitable for diagnosing some common faults in reciprocating compressor (RC). Being a critical component of the industry, the condition monitoring of reciprocating compressor is very much needed to avoid any failure of its machine parts that can cause a sudden breakdown of RC. The compressor acoustic signal is a result of various mechanical forces related to the varied cylinder pressure, valve movement, turbulence air flow which in terms contribute to the periodic excitation along with the non-linearity caused by the valve fluttering, hence making the airborne signal complex and non-stationary in nature. The transient response due to the periodic impact of the valves, modulation effect due to the fluid-mechanical interaction and low signal to noise ratio (SNR) are the challenging aspects of this study. To demonstrate the vibro-acoustic property of the reciprocating compressor, first a model was developed. The leakages in valve and intercooler are very common in RC. The second most common fault which is often neglected is a clogged filter. Hence, taking into consideration, filter blockage fault is introduced for the first time in the existing test set up. Three faults (discharge valve leakage, intercooler leakage and filter blockage) are simulated, and corresponding acoustic responses are recorded for further study of the signal-nature. The model is then validated by the actual data from RC test bed. Along with the modelling of compressor acoustics, various signal processing techniques like Minimum Entropy Deconvolution (MED), Teager Energy Operator (TEO) are used on the test data to detect abnormalities present. MED in this case, is proved to be effective in finding the transient responses whereas, TEO serves as an energy detection tool for tracking the total mechanical energy. Still both methods find it difficult to come up with the best possible diagnosis results as they fail to take all the major characteristics of the RC acoustics into consideration. To overcome this challenge, higher order spectral analysis as a form of Modulation Signal Bi-Spectrum (MSB) is used to find out the most effective modulating components by enhancing the modulating characteristics and suppressing the noise. Moreover, the quadratic phase coupling allows MSB to handle the non-linearity that might be present in RC due to the valve fluttering. The proposed MSB based method not only provides a more consistent and accurate diagnosis of compressor faults but also shows that airborne acoustics has a good aspect in fault identification of RC by validating both model and test results. Recognizing that there is perpetual room for improvement, the performance of the proposed RC fault diagnosis method can be enhanced by incorporating a denoising technique developed using the Variational Mode Decomposition (VMD) associated with Kalman filtering method. The future study must also consider several other individual and compound faults that can be incorporated in the study for understanding vibro-acoustic phenomena of RC

Wearable electroencephalography for long-term monitoring and diagnostic purposes

Truly Wearable EEG (WEEG) can be considered as the future of ambulatory EEG units, which are the current standard for long-term EEG monitoring. Replacing these short lifetime, bulky units with long-lasting, miniature and wearable devices that can be easily worn by patients will result in more EEG data being collected for extended monitoring periods. This thesis presents three new fabricated systems, in the form of Application Specific Integrated Circuits (ASICs), to aid the diagnosis of epilepsy and sleep disorders by detecting specific clinically important EEG events on the sensor node, while discarding background activity. The power consumption of the WEEG monitoring device incorporating these systems can be reduced since the transmitter, which is the dominating element in terms of power consumption, will only become active based on the output of these systems. Candidate interictal activity is identified by the developed analog-based interictal spike selection system-on-chip (SoC), using an approximation of the Continuous Wavelet Transform (CWT), as a bandpass filter, and thresholding. The spike selection SoC is fabricated in a 0.35 μm CMOS process and consumes 950 nW. Experimental results reveal that the SoC is able to identify 87% of interictal spikes correctly while only transmitting 45% of the data. Sections of EEG data containing likely ictal activity are detected by an analog seizure selection SoC using the low complexity line length feature. This SoC is fabricated in a 0.18 μm CMOS technology and consumes 1.14 μW. Based on experimental results, the fabricated SoC is able to correctly detect 83% of seizure episodes while transmitting 52% of the overall EEG data. A single-channel analog-based sleep spindle detection SoC is developed to aid the diagnosis of sleep disorders by detecting sleep spindles, which are characteristic events of sleep. The system identifies spindle events by monitoring abrupt changes in the input EEG. An approximation of the median frequency calculation, incorporated as part of the system, allows for non-spindle activity incorrectly identified by the system as sleep spindles to be discarded. The sleep spindle detection SoC is fabricated in a 0.18 μm CMOS technology, consuming only 515 nW. The SoC achieves a sensitivity and specificity of 71.5% and 98% respectively.Open Acces

Study and development of sensorimotor interfaces for robotic human augmentation

This thesis presents my research contribution to robotics and haptics in the context of human augmentation. In particular, in this document, we are interested in bodily or sensorimotor augmentation, thus the augmentation of humans by supernumerary robotic limbs (SRL). The field of sensorimotor augmentation is new in robotics and thanks to the combination with neuroscience, great leaps forward have already been made in the past 10 years. All of the research work I produced during my Ph.D. focused on the development and study of fundamental technology for human augmentation by robotics: the sensorimotor interface. This new concept is born to indicate a wearable device which has two main purposes, the first is to extract the input generated by the movement of the user's body, and the second to provide the somatosensory system of the user with an haptic feedback. This thesis starts with an exploratory study of integration between robotic and haptic devices, intending to combine state-of-the-art devices. This allowed us to realize that we still need to understand how to improve the interface that will allow us to feel the agency when using an augmentative robot. At this point, the path of this thesis forks into two alternative ways that have been adopted to improve the interaction between the human and the robot. In this regard, the first path we presented tackles two aspects conerning the haptic feedback of sensorimotor interfaces, which are the choice of the positioning and the effectiveness of the discrete haptic feedback. In the second way we attempted to lighten a supernumerary finger, focusing on the agility of use and the lightness of the device. One of the main findings of this thesis is that haptic feedback is considered to be helpful by stroke patients, but this does not mitigate the fact that the cumbersomeness of the devices is a deterrent to their use. Preliminary results here presented show that both the path we chose to improve sensorimotor augmentation worked: the presence of the haptic feedback improves the performance of sensorimotor interfaces, the co-positioning of haptic feedback and the input taken from the human body can improve the effectiveness of these interfaces, and creating a lightweight version of a SRL is a viable solution for recovering the grasping function