Welcome to EICS 2015

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Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment

Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation. To complement classical CQA, bevacizumab and infliximab were subjected to oxidative stress by H2O2 for 24, 48, or 72 h to probe their oxidation susceptibility. For investigation, a middle-up approach was used utilizing liquid chromatography hyphenated with mass spectrometry (LC-QTOF-MS). In both mAbs, the Fc/2 subunit was completely oxidized. Additional oxidations were found in the light chain (LC) and in the Fd’ subunit of infliximab, but not in bevacizumab. By direct comparison of methionine positions, the oxidized residues in infliximab were assigned to M55 in LC and M18 in Fd’. The forced oxidation approach was further exploited for comparison of respective biosimilar products. Both for bevacizumab and infliximab, comparison of posttranslational modification profiles demonstrated high similarity of the unstressed reference product (RP) and the biosimilar (BS). However, for bevacizumab, comparison after forced oxidation revealed a higher susceptibility of the BS compared to the RP. It may thus be considered a useful tool for biopharmaceutical engineering, biosimilarity assessment, as well as for quality control of protein drugs

Responsive task modelling

In this paper we present a new tool for specifying task models (Responsive CTT), which can be accessed through touch-based mobile devices such as smartphones and tablets as well. The tool is Web-based and responsive in order to provide adapted user interfaces to better support the most common activities in task modelling through various types of devices. We describe the relevant aspects to take into account for this purpose and how we have addressed them in designing the tool. We also report on first user tests

Guest editorial preface: special issue on Evolving security and privacy requirements engineering (ESPRE'14) 2014, Sweden.

At the Evolving Security and Privacy Requirements Engineering (ESPRE) workshop, practitioners and researchers interested in security and privacy requirements gather to discuss significant issues in the field. In particular, ESPRE participants probe the interfaces between requirements engineering, security and privacy. At ESPRE workshops, participants also take the first step in evolving security and privacy requirements engineering to meet the needs of stakeholders, ranging from business analysts and security engineers to technology entrepreneurs and privacy advocates. The most recent ESPRE workshop was held in Karlskrona, Sweden in August 2014, and was co-located with the RE 2014 conference

HCI-E 2 : HCI Engineering Education

This workshop aims at identifying, examining, structuring and sharing educational resources and approaches to support the process of teaching/learning Human-Computer Interaction (HCI) Engineering. The broadening of the range of available interaction technologies and their applications, many times in safety and mission critical areas, to novel and less understood application domains, brings the question of how to address this ever-changing nature in university curricula usually static. Beyond, as these technologies are taught in diverse curricula (ranging from Human Factors and psychology to hardcore computer science), we are interested in what the best approaches and best practices are to integrate HCI Engineering topics in the curricula of programs in software engineering, computer science, human-computer interaction, psychology, design, etc. The workshop is proposed on behalf of the IFIP Working Groups 2.7/13.4 on User Interface Engineering and 13.1 on Education in HCI and HCI Curricula

A case study into the accessibility of text-parser based interaction.

The academic issues surrounding the accessibility of video games are reasonably well understood although compensations and inclusive design have not yet been comprehensively adopted by professional game developers. Several sets of guidelines have been produced to support developers wishing to ensure a greater degree of accessibility in their titles, and while the recommendations are broadly harmonious they only address the issues in isolation without being mindful of context or the subtle relationships between interaction choices and verisimilitude within game interfaces. That is not to denigrate the value of these resources, which is considerable -- instead it is to highlight a deficiency in the literature which can be addressed with reflective case studies. This paper represents one such case study, aimed at addressing accessibility concerns within interactive text interfaces. While the specifics of this paper are aimed at multiplayer text game accessibility improvements, it is anticipated that many of the lessons learned would be appropriate for any environment, such as command line interfaces, where the accessibility of written and read text is currently suboptimal

A User-Centered View on Formal Methods: Interactive Support for Validation and Verification

International audienceDuring early phases of the development of an interactive system, future system properties are identified (through interaction with end users e.g. in the brainstorming and prototyping phases of the development process, or by re-quirements provided by other stakeholders) imposing re-quirements on the final system. Some of these properties rely on informal aspects of the system (e.g. satisfaction of users) and can be checked by questionnaires, while other ones require the use of formal methods. Whether these properties are specific to the application under development or generic to a class of applications, the verification of the presence of these properties in the system under construc-tion usually involve verification tools to process the formal description of the system. The usability [26] of these tools has a significant impact on the V&V phases which usually remains perceived as very resource consuming. This posi-tion paper proposes the application of action theory to iden-tify complex aspects of verification and exploits it for iden-tifying areas of improvement

HiReD: a high-resolution multi-window visualisation environment for cluster-driven displays

High-resolution, wall-size displays often rely on bespoke software for performing interactive data visualisation, leading to interface designs with little or no consistency between displays. This makes adoption for novice users difficult when migrating from desktop environments. However, desktop interface techniques (such as task- and menu- bars) do not scale well and so cannot be relied on to drive the design of large display interfaces. In this paper we present HiReD, a multi-window environment for cluster-driven displays. As well as describing the technical details of the system, we also describe a suite of low-precision interface techniques that aim to provide a familiar desktop environment to the user while overcoming the scalability issues of high-resolution displays. We hope that these techniques, as well as the implementation of HiReD itself, can encourage good practice in the design and development of future interfaces for high-resolution, wall-size displays