Signal processing methodologies for an acoustic fetal heart rate monitor

Research and development is presented of real time signal processing methodologies for the detection of fetal heart tones within a noise-contaminated signal from a passive acoustic sensor. A linear predictor algorithm is utilized for detection of the heart tone event and additional processing derives heart rate. The linear predictor is adaptively 'trained' in a least mean square error sense on generic fetal heart tones recorded from patients. A real time monitor system is described which outputs to a strip chart recorder for plotting the time history of the fetal heart rate. The system is validated in the context of the fetal nonstress test. Comparisons are made with ultrasonic nonstress tests on a series of patients. Comparative data provides favorable indications of the feasibility of the acoustic monitor for clinical use

Artifact Rejection Methodology Enables Continuous, Noninvasive Measurement of Gastric Myoelectric Activity in Ambulatory Subjects.

The increasing prevalence of functional and motility gastrointestinal (GI) disorders is at odds with bottlenecks in their diagnosis, treatment, and follow-up. Lack of noninvasive approaches means that only specialized centers can perform objective assessment procedures. Abnormal GI muscular activity, which is coordinated by electrical slow-waves, may play a key role in symptoms. As such, the electrogastrogram (EGG), a noninvasive means to continuously monitor gastric electrical activity, can be used to inform diagnoses over broader populations. However, it is seldom used due to technical issues: inconsistent results from single-channel measurements and signal artifacts that make interpretation difficult and limit prolonged monitoring. Here, we overcome these limitations with a wearable multi-channel system and artifact removal signal processing methods. Our approach yields an increase of 0.56 in the mean correlation coefficient between EGG and the clinical "gold standard", gastric manometry, across 11 subjects (p < 0.001). We also demonstrate this system's usage for ambulatory monitoring, which reveals myoelectric dynamics in response to meals akin to gastric emptying patterns and circadian-related oscillations. Our approach is noninvasive, easy to administer, and has promise to widen the scope of populations with GI disorders for which clinicians can screen patients, diagnose disorders, and refine treatments objectively

A clinical patient vital signs parameter measurement, processing and predictive algorithm using ECG

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In the modern clinical and healthcare setting, the electronic collection and analysis of patient related vital signs and parameters are a fundamental part of the relevant treatment plan and positive patient response. Modern analytical techniques combined with readily available computer software today allow for the near real time analysis of digitally acquired measurements. In the clinical context, this can directly relate to patient survival rates and treatment success. The processing of clinical parameters, especially the Electrocardiogram (ECG) in the critical care setting has changed little in recent years and the analytical processes have mostly been managed by highly trained and experienced cardiac specialists. Warning, detection and measurement techniques are focused on the post processing of events relying heavily on averaging and analogue filtering to accurately capture waveform morphologies and deviations. This Ph.D. research investigates an alternative and the possibility to analyse, in the digital domain, bio signals with a focus on the ECG to determine if the feasibility of bit by bit or near real time analysis is indeed possible but more so if the data captured has any significance in the analysis and presentation of the wave patterns in a patient monitoring environment. The research and experiments have shown the potential for the development of logical models that address both the detection and short term predication of possible follow-on events with a focus on Myocardial Ischemic (MI) and Infraction based deviations. The research has shown that real time waveform processing compared to traditional graph based analysis, is both accurate and has the potential to be of benefit to the clinician by detecting deviations and morphologies in a real time domain. This is a significant step forward and has the potential to embed years of clinical experience into the measurement processes of clinical devices, in real terms. Also, providing expert analytical and identification input electronically at the patient bedside. The global human population is testing the healthcare systems and care capabilities with the shortage of clinical and healthcare providers in ever decreasing coverage of treatment that can be provided. The research is a moderate step in further realizing this and aiding the caregiver by providing true and relevant information and data, which assists in the clinical decision process and ultimately improving the required standard of patient care

Design techniques for smart and energy-efficient wireless body sensor networks

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Informática, Departamento de Arquitectura de Computadores y Automática, leída el 26/10/2012Las redes inalámbricas de sensores corporales (en inglés: "wireless body sensor networks" o WBSNs) para monitorización, diagnóstico y detección de emergencias, están ganando popularidad y están llamadas a cambiar profundamente la asistencia sanitaria en los próximos años. El uso de estas redes permite una supervisión continua, contribuyendo a la prevención y el diagnóstico precoz de enfermedades, al tiempo que mejora la autonomía del paciente con respecto a otros sistemas de monitorización actuales. Valiéndose de esta tecnología, esta tesis propone el desarrollo de un sistema de monitorización de electrocardiograma (ECG), que no sólo muestre continuamente el ECG del paciente, sino que además lo analice en tiempo real y sea capaz de dar información sobre el estado del corazón a través de un dispositivo móvil. Esta información también puede ser enviada al personal médico en tiempo real. Si ocurre un evento peligroso, el sistema lo detectará automáticamente e informará de inmediato al paciente y al personal médico, posibilitando una rápida reacción en caso de emergencia. Para conseguir la implementación de dicho sistema, se desarrollan y optimizan distintos algoritmos de procesamiento de ECG en tiempo real, que incluyen filtrado, detección de puntos característicos y clasificación de arritmias. Esta tesis también aborda la mejora de la eficiencia energética de la red de sensores, cumpliendo con los requisitos de fidelidad y rendimiento de la aplicación. Para ello se proponen técnicas de diseño para reducir el consumo de energía, que permitan buscar un compromiso óptimo entre el tamaño de la batería y su tiempo de vida. Si el consumo de energía puede reducirse lo suficiente, sería posible desarrollar una red que funcione permanentemente. Por lo tanto, el muestreo, procesamiento, almacenamiento y transmisión inalámbrica tienen que hacerse de manera que se suministren todos los datos relevantes, pero con el menor consumo posible de energía, minimizando así el tamaño de la batería (que condiciona el tamaño total del nodo) y la frecuencia de recarga de la batería (otro factor clave para su usabilidad). Por lo tanto, para lograr una mejora en la eficiencia energética del sistema de monitorización y análisis de ECG propuesto en esta tesis, se estudian varias soluciones a nivel de control de acceso al medio y sistema operativo.Depto. de Arquitectura de Computadores y AutomáticaFac. de InformáticaTRUEunpu

Advanced sensors technology survey

This project assesses the state-of-the-art in advanced or 'smart' sensors technology for NASA Life Sciences research applications with an emphasis on those sensors with potential applications on the space station freedom (SSF). The objectives are: (1) to conduct literature reviews on relevant advanced sensor technology; (2) to interview various scientists and engineers in industry, academia, and government who are knowledgeable on this topic; (3) to provide viewpoints and opinions regarding the potential applications of this technology on the SSF; and (4) to provide summary charts of relevant technologies and centers where these technologies are being developed

Error Prevention in Sensors and Sensor Systems

Achievements in all fields of engineering and fabrication methods have led towards optimization and integration of multiple sensing devices into a concise system. These advances have caused significant innovation in various commercial, industrial, and research efforts. Integrations of subsystems have important applications for sensor systems in particular. The need for reporting and real time awareness of a device’s condition and surroundings have led to sensor systems being implemented in a wide variety of fields. From environmental sensors for agriculture, to object characterization and biomedical sensing, the application for sensor systems has impacted all modern facets of innovation. With these innovations, however, additional sources of errors can occur, that can cause new but exciting challenges for such integrated devices. Such challenges range from error correction and accuracy to power optimization. Researchers have invested significant time and effort to improve the applicability and accuracy of sensors and sensor systems. Efforts to reduce inherent and external noise of sensors can range from hardware to software solutions, focusing on signal processing and exploiting the integration of multiple signals and/or sensor types. My research work throughout my career has been focused on deployable and integrated sensor systems. Their integration not only in hardware and components but also in software, machine learning, pattern recognition, and overall signal processing algorithms to aid in error correction and noise tailoring in all their hardware and software components