The safety case and the lessons learned for the reliability and maintainability case

This paper examine the safety case and the lessons learned for the reliability and maintainability case

Set-based design of mechanical systems with design robustness integrated

This paper presents a method for parameter design of mechanical products based on a set-based approach. Set-based concurrent engineering emphasises on designing in a multi-stakeholder environment with concurrent involvement of the stakeholders in the design process. It also encourages flexibility in design through communication in terms of ranges instead of fixed point values and subsequent alternative solutions resulting from intersection of these ranges. These alternative solutions can then be refined and selected according to the designers’ preferences and clients’ needs. This paper presents a model and tools for integrated flexible design that take into account the manufacturing variations as well as the design objectives for finding inherently robust solutions using QCSP transformation through interval analysis. In order to demonstrate the approach, an example of design of rigid flange coupling with a variable number of bolts and a choice of bolts from ISO M standard has been resolved and demonstrated

Ascent trajectory optimisation for a single-stage-to-orbit vehicle with hybrid propulsion

This paper addresses the design of ascent trajectories for a hybrid-engine, high performance, unmanned, single-stage-to-orbit vehicle for payload deployment into low Earth orbit. A hybrid optimisation technique that couples a population-based, stochastic algorithm with a deterministic, gradient-based technique is used to maximize the nal vehicle mass in low Earth orbit after accounting for operational constraints on the dynamic pressure, Mach number and maximum axial and normal accelerations. The control search space is first explored by the population-based algorithm, which uses a single shooting method to evaluate the performance of candidate solutions. The resultant optimal control law and corresponding trajectory are then further refined by a direct collocation method based on finite elements in time. Two distinct operational phases, one using an air-breathing propulsion mode and the second using rocket propulsion, are considered. The presence of uncertainties in the atmospheric and vehicle aerodynamic models are considered in order to quantify their effect on the performance of the vehicle. Firstly, the deterministic optimal control law is re-integrated after introducing uncertainties into the models. The proximity of the final solutions to the target states are analysed statistically. A second analysis is then performed, aimed at determining the best performance of the vehicle when these uncertainties are included directly in the optimisation. The statistical analysis of the results obtained are summarized by an expectancy curve which represents the probable vehicle performance as a function of the uncertain system parameters. This analysis can be used during the preliminary phase of design to yield valuable insights into the robustness of the performance of the vehicle to uncertainties in the specification of its parameters

Lost in optimisation of water distribution systems? A literature review of system operation

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Optimisation of the operation of water distribution systems has been an active research field for almost half a century. It has focused mainly on optimal pump operation to minimise pumping costs and optimal water quality management to ensure that standards at customer nodes are met. This paper provides a systematic review by bringing together over two hundred publications from the past three decades, which are relevant to operational optimisation of water distribution systems, particularly optimal pump operation, valve control and system operation for water quality purposes of both urban drinking and regional multiquality water distribution systems. Uniquely, it also contains substantial and thorough information for over one hundred publications in a tabular form, which lists optimisation models inclusive of objectives, constraints, decision variables, solution methodologies used and other details. Research challenges in terms of simulation models, optimisation model formulation, selection of optimisation method and postprocessing needs have also been identified

A COVID-19 Recovery Strategy Based on the Health System Capacity Modeling. Implications on Citizen Self-management

Versión preprint depositada sin articulo publicado dada la actualidad del tema. *Solicitud de los autoresConfinement ends, and recovery phase should be accurate planned. Health System (HS) capacity, specially ICUs and plants capacity and availability, will remain the key stone in this new Covid-19 pandemic life cycle phase. Until massive vaccination programs will be a real option (vaccine developed, world wield production capacity and effective and efficient administration process), date that will mark recovery phase end, important decisions should be taken. Not only by authorities. Citizen self-management and organizations self-management will be crucial. This means: citizen and organizations day a day decision in order to control their own risks (infecting others and being infected). This paper proposes a management tool that is based on a ICUs and plants capacity model. Principal outputs of this tool are, by sequential order and by last best data available: (i) ICUs and plants saturation estimation data (according to incoming rate of patients), (ii) with this results new local and temporal confinement measure can be planned and also a dynamic analysis can be done to estimate maximum Ro saturation scenarios, and finally (iii) provide citizen with clear and accurate data allow them adapting their behavior to authorities’ previous recommendations. One common objective: to accelerate as much as possible socioeconomic normalization with a strict control over HS relapses risk

Computational Techniques for Analysis of Genetic Network Dynamics

In this paper we propose modeling and analysis techniques for genetic networks that provide biologists with insight into the dynamics of such systems. Central to our modeling approach is the framework of hybrid systems and our analysis tools are derived from formal analysis of such systems. Given a set of states characterizing a property of biological interest P, we present the Multi-Affine Rectangular Partition (MARP) algorithm for the construction of a set of infeasible states I that will never reach P and the Rapidly Exploring Random Forest of Trees (RRFT) algorithm for the construction of a set of feasible states F that will reach P. These techniques are scalable to high dimensions and can incorporate uncertainty (partial knowledge of kinetic parameters and state uncertainty). We apply these methods to understand the genetic interactions involved in the phenomenon of luminescence production in the marine bacterium V. fischeri

Modelling interdependencies between fish species in the North Atlantic : a Bayesian machine learning approach to predictive biomass and recruitment models

The science of fish stock assessment is one that is very resource and labor intensive, with stock assessment models historically being based on data that causes a model to overestimate the strength of a population, sometimes with drastic consequences. The need of cost-effective assessment models and approaches increases, which is why I looked into using Bayesian modeling and networks as an approach not often used in fisheries science. I wanted to determine if it could be used to predict both recruitment and spawning stock biomass of four fish species in the north Atlantic, cod, haddock, pollock and capelin, based on no other evidence other than the recruitment or biomass data of the other species and if these results could be used to lower the uncertanties of fish stock models. I used data available on the RAM legacy database to produce four different models with the statistical software R, based on four different Bayes algorithms found in the R-package bnlearn, two based on continuous data and two based on discrete data. What I found was that there is much potential in the Bayesian approach to stock prediction and forecasting, as our prediction error percentage ranged between 1 and 40 percent. The best predictions were made when the species used as evidence had a high correlation coefficient with the target species, which was the case with cod and haddock biomass, which had a unusually high correlation of 0.96. As such, this approach could be used to make preliminary models of interactions between a high amount of species in a specific area, where there is data abundantly available and these models could be used to lower the uncertanties of the stock assessments. However, more research into the applicability for this approach to other species and areas needs to be conducted

Multi-objective genetic optimisation for self-organising fuzzy logic control

This is the post-print version of the article. The official published version can be accessed from the link below.A multi-objective genetic algorithm is developed for the purpose of optimizing the rule-base of a Self-Organising Fuzzy Logic Control algorithm (SOFLC). The tuning of the SOFLC optimization is based on selection of the best shaped performance index for modifying the rule-base on-line. A comparative study is conducted between various methods of multi-objective genetic optimisation using the SOFLC algorithm on the muscle relaxant anaesthesia system, which includes a severe non-linearity, varying dynamics and time-delay