8,699 research outputs found
Classical and all-floating FETI methods for the simulation of arterial tissues
High-resolution and anatomically realistic computer models of biological soft
tissues play a significant role in the understanding of the function of
cardiovascular components in health and disease. However, the computational
effort to handle fine grids to resolve the geometries as well as sophisticated
tissue models is very challenging. One possibility to derive a strongly
scalable parallel solution algorithm is to consider finite element tearing and
interconnecting (FETI) methods. In this study we propose and investigate the
application of FETI methods to simulate the elastic behavior of biological soft
tissues. As one particular example we choose the artery which is - as most
other biological tissues - characterized by anisotropic and nonlinear material
properties. We compare two specific approaches of FETI methods, classical and
all-floating, and investigate the numerical behavior of different
preconditioning techniques. In comparison to classical FETI, the all-floating
approach has not only advantages concerning the implementation but in many
cases also concerning the convergence of the global iterative solution method.
This behavior is illustrated with numerical examples. We present results of
linear elastic simulations to show convergence rates, as expected from the
theory, and results from the more sophisticated nonlinear case where we apply a
well-known anisotropic model to the realistic geometry of an artery. Although
the FETI methods have a great applicability on artery simulations we will also
discuss some limitations concerning the dependence on material parameters.Comment: 29 page
Wrinkling, creasing, and folding in fiber-reinforced soft tissues
Many biological tissues develop elaborate folds during growth and development. The onset of this folding is often understood in relation to the creasing and wrinkling of a thin elastic layer that grows whilst attached to a large elastic foundation. In reality, many biological tissues are reinforced by fibres and so are intrinsically anisotropic. However, the correlation between the fiber directions and the pattern formed during growth is not well understood. Here, we consider the stability of a two-layer tissue composed of a thin hyperelastic strip adhered to an elastic half-space in which are embedded elastic fibers. The combined object is subject to a uniform compression and, at a critical value of this compression, buckles out of the plane — it wrinkles. We characterize the wrinkle wavelength at onset as a function of the fiber orientation both computationally and analytically and show that the onset of surface instability can be either promoted or inhibited as the fiber stiffness increases, depending on the fibre angle. However, we find that the structure of the resulting folds is approximately independent of the fiber orientation. We also explore numerically the formation of large creases in fiber-reinforced tissue in the post-buckling regime
Anisotropic behaviour of human gallbladder walls
Inverse estimation of biomechanical parameters of soft tissues from non-invasive measurements has clinical significance in patient-specific modelling and disease diagnosis. In this paper, we propose a fully nonlinear approach to estimate the mechanical properties of the human gallbladder wall muscles from in vivo ultrasound images. The iteration method consists of a forward approach, in which the constitutive equation is based on a modified Hozapfel–Gasser–Ogden law initially developed for arteries. Five constitutive parameters describing the two orthogonal families of fibres and the matrix material are determined by comparing the computed displacements with medical images. The optimisation process is carried out using the MATLAB toolbox, a Python code, and the ABAQUS solver. The proposed method is validated with published artery data and subsequently applied to ten human gallbladder samples. Results show that the human gallbladder wall is anisotropic during the passive refilling phase, and that the peak stress is 1.6 times greater than that calculated using linear mechanics. This discrepancy arises because the wall thickness reduces by 1.6 times during the deformation, which is not predicted by conventional linear elasticity. If the change of wall thickness is accounted for, then the linear model can used to predict the gallbladder stress and its correlation with pain. This work provides further understanding of the nonlinear characteristics of human gallbladder
Possible role of differential growth in airway wall remodeling in asthma
Airway remodeling in patients with chronic asthma is characterized by a thickening of the airway walls. It has been demonstrated in previous theoretical models that this change in thickness can have an important mechanical effect on the properties of the wall, in particular on the phenomenon of mucosal folding induced by smooth muscle contraction. In this paper, we present a model for mucosal folding of the airway in the context of growth. The airway is modeled as a bi-layered cylindrical tube, with both geometric and material nonlinearities accounted for via the theory of finite elasticity. Growth is incorporated into the model through the theory of morphoelasticity. We explore a range of growth possibilities, allowing for anisotropic growth as well as different growth rates in each layer. Such nonuniform growth, referred to as differential growth, can change the properties of the material beyond geometrical changes through the generation of residual stresses. We demonstrate that differential growth can have a dramatic impact on mucosal folding, in particular on the critical pressure needed to induce folding, the buckling pattern, as well as airway narrowing. We conclude that growth may be an important component in airway remodeling
Towards retrieving force feedback in robotic-assisted surgery: a supervised neuro-recurrent-vision approach
Robotic-assisted minimally invasive surgeries have gained a lot of popularity over conventional procedures as they offer many benefits to both surgeons and patients. Nonetheless, they still suffer from some limitations that affect their outcome. One of them is the lack of force feedback which restricts the surgeon's sense of touch and might reduce precision during a procedure. To overcome this limitation, we propose a novel force estimation approach that combines a vision based solution with supervised learning to estimate the applied force and provide the surgeon with a suitable representation of it. The proposed solution starts with extracting the geometry of motion of the heart's surface by minimizing an energy functional to recover its 3D deformable structure. A deep network, based on a LSTM-RNN architecture, is then used to learn the relationship between the extracted visual-geometric information and the applied force, and to find accurate mapping between the two. Our proposed force estimation solution avoids the drawbacks usually associated with force sensing devices, such as biocompatibility and integration issues. We evaluate our approach on phantom and realistic tissues in which we report an average root-mean square error of 0.02 N.Peer ReviewedPostprint (author's final draft
Elastica-based strain energy functions for soft biological tissue
Continuum strain energy functions are developed for soft biological tissues
that possess long fibrillar components. The treatment is based on the model of
an elastica, which is our fine scale model, and is homogenized in a simple
fashion to obtain a continuum strain energy function. Notably, we avoid solving
the full fourth-order, nonlinear, partial differential equation for the
elastica by resorting to other assumptions, kinematic and energetic, on the
response of the individual, elastica-like fibrils.Comment: To appear in J. Mech. Phys. Solid
A computational framework for the morpho-elastic development of molluskan shells by surface and volume growth
Mollusk shells are an ideal model system for understanding the morpho-elastic
basis of morphological evolution of invertebrates' exoskeletons. During the
formation of the shell, the mantle tissue secretes proteins and minerals that
calcify to form a new incremental layer of the exoskeleton. Most of the
existing literature on the morphology of mollusks is descriptive. The
mathematical understanding of the underlying coupling between pre-existing
shell morphology, de novo surface deposition and morpho-elastic volume growth
is at a nascent stage, primarily limited to reduced geometric representations.
Here, we propose a general, three-dimensional computational framework coupling
pre-existing morphology, incremental surface growth by accretion, and
morpho-elastic volume growth. We exercise this framework by applying it to
explain the stepwise morphogenesis of seashells during growth: new material
surfaces are laid down by accretive growth on the mantle whose form is
determined by its morpho-elastic growth. Calcification of the newest surfaces
extends the shell as well as creates a new scaffold that constrains the next
growth step. We study the effects of surface and volumetric growth rates, and
of previously deposited shell geometries on the resulting modes of mantle
deformation, and therefore of the developing shell's morphology. Connections
are made to a range of complex shells ornamentations.Comment: Main article is 20 pages long with 15 figures. Supplementary material
is 4 pages long with 6 figures and 6 attached movies. To be published in PLOS
Computational Biolog
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