Data Analysis in Automotive Industrial Cells

The manufacturing industry always has been one of the leading energy consumers, so companies in this area are always trying to use the best tools provided by the evolution of the technology, to analyse and lower the production costs. Many known studies don’t mind inconveniences such as stopping the production of the factory to perform studies or deep architecture improvements in the transport system. The proposed solution offers two different sets of tools. A device adapter, that targets the gather and storage of data, from industrial robotic cells devices, being the main requirement for a data analysis application, and a data analysis system, that analyses the stored data, without changing the existing production model. The analysis procedure aims the energy usage of a cell and its robot, and the duration of the executed processes. This solution was tested in two different robotic cells, that execute the same process. Multiple executions with different robot velocities were performed in order to gather the required data to provide an analysis and the conclusion was that, for both cells, the energy usage for each executed product was lower when the robot speed was higher, and that one of the cells is more efficient that other cell when executing at high speed but less efficient on lower velocities

Machine Tool Communication (MTComm) Method and Its Applications in a Cyber-Physical Manufacturing Cloud

The integration of cyber-physical systems and cloud manufacturing has the potential to revolutionize existing manufacturing systems by enabling better accessibility, agility, and efficiency. To achieve this, it is necessary to establish a communication method of manufacturing services over the Internet to access and manage physical machines from cloud applications. Most of the existing industrial automation protocols utilize Ethernet based Local Area Network (LAN) and are not designed specifically for Internet enabled data transmission. Recently MTConnect has been gaining popularity as a standard for monitoring status of machine tools through RESTful web services and an XML based messaging structure, but it is only designed for data collection and interpretation and lacks remote operation capability. This dissertation presents the design, development, optimization, and applications of a service-oriented Internet-scale communication method named Machine Tool Communication (MTComm) for exchanging manufacturing services in a Cyber-Physical Manufacturing Cloud (CPMC) to enable manufacturing with heterogeneous physically connected machine tools from geographically distributed locations over the Internet. MTComm uses an agent-adapter based architecture and a semantic ontology to provide both remote monitoring and operation capabilities through RESTful services and XML messages. MTComm was successfully used to develop and implement multi-purpose applications in in a CPMC including remote and collaborative manufacturing, active testing-based and edge-based fault diagnosis and maintenance of machine tools, cross-domain interoperability between Internet-of-things (IoT) devices and supply chain robots etc. To improve MTComm’s overall performance, efficiency, and acceptability in cyber manufacturing, the concept of MTComm’s edge-based middleware was introduced and three optimization strategies for data catching, transmission, and operation execution were developed and adopted at the edge. Finally, a hardware prototype of the middleware was implemented on a System-On-Chip based FPGA device to reduce computational and transmission latency. At every stage of its development, MTComm’s performance and feasibility were evaluated with experiments in a CPMC testbed with three different types of manufacturing machine tools. Experimental results demonstrated MTComm’s excellent feasibility for scalable cyber-physical manufacturing and superior performance over other existing approaches

Machine Tool Communication (MTComm) Method and Its Applications in a Cyber-Physical Manufacturing Cloud

The integration of cyber-physical systems and cloud manufacturing has the potential to revolutionize existing manufacturing systems by enabling better accessibility, agility, and efficiency. To achieve this, it is necessary to establish a communication method of manufacturing services over the Internet to access and manage physical machines from cloud applications. Most of the existing industrial automation protocols utilize Ethernet based Local Area Network (LAN) and are not designed specifically for Internet enabled data transmission. Recently MTConnect has been gaining popularity as a standard for monitoring status of machine tools through RESTful web services and an XML based messaging structure, but it is only designed for data collection and interpretation and lacks remote operation capability. This dissertation presents the design, development, optimization, and applications of a service-oriented Internet-scale communication method named Machine Tool Communication (MTComm) for exchanging manufacturing services in a Cyber-Physical Manufacturing Cloud (CPMC) to enable manufacturing with heterogeneous physically connected machine tools from geographically distributed locations over the Internet. MTComm uses an agent-adapter based architecture and a semantic ontology to provide both remote monitoring and operation capabilities through RESTful services and XML messages. MTComm was successfully used to develop and implement multi-purpose applications in in a CPMC including remote and collaborative manufacturing, active testing-based and edge-based fault diagnosis and maintenance of machine tools, cross-domain interoperability between Internet-of-things (IoT) devices and supply chain robots etc. To improve MTComm’s overall performance, efficiency, and acceptability in cyber manufacturing, the concept of MTComm’s edge-based middleware was introduced and three optimization strategies for data catching, transmission, and operation execution were developed and adopted at the edge. Finally, a hardware prototype of the middleware was implemented on a System-On-Chip based FPGA device to reduce computational and transmission latency. At every stage of its development, MTComm’s performance and feasibility were evaluated with experiments in a CPMC testbed with three different types of manufacturing machine tools. Experimental results demonstrated MTComm’s excellent feasibility for scalable cyber-physical manufacturing and superior performance over other existing approaches

UBIDEV: a homogeneous service framework for pervasive computing environments

This dissertation studies the heterogeneity problem of pervasive computing system from the viewpoint of an infrastructure aiming to provide a service-oriented application model. From Distributed System passing through mobile computing, pervasive computing is presented as a step forward in ubiquitous availability of services and proliferation of interacting autonomous entities. To better understand the problems related to the heterogeneous and dynamic nature of pervasive computing environments, we need to analyze the structure of a pervasive computing system from its physical and service dimension. The physical dimension describes the physical environment together wit the technology infrastructure that characterizes the interactions and the relations within the environment; the service dimension represents the services (being them software or not) the environment is able to provide [Nor99]. To better separate the constrains and the functionalities of a pervasive computing system, this dissertation classifies it in terms of resources, context, classification, services, coordination and application. UBIDEV, as the key result of this dissertation, introduces a unified model helping the design and the implementation of applications for heterogeneous and dynamic environments. This model is composed of the following concepts: • Resource: all elements of the environment that are manipulated by the application, they are the atomic abstraction unit of the model. • Context: all information coming from the environment that is used by the application to adapts its behavior. Context contains resources and services and defines their role in the application. • Classification: the environment is classified according to the application ontology in order to ground the generic conceptual model of the application to the specific environment. It defines the basic semantic level of interoperability. • Service: the functionalities supported by the system; each service manipulates one or more resources. Applications are defined as a coordination and adaptation of services. • Coordination: all aspects related to service composition and execution as well as the use of the contextual information are captured by the coordination concept. • Application Ontology: represents the viewpoint of the application on the specific context; it defines the high level semantic of resources, services and context. Applying the design paradigm proposed by UBIDEV, allows to describe applications according to a Service Oriented Architecture[Bie02], and to focus on application functionalities rather than their relations with the physical devices. Keywords: pervasive computing, homogenous environment, service-oriented, heterogeneity problem, coordination model, context model, resource management, service management, application interfaces, ontology, semantic services, interaction logic, description logic.Questa dissertazione studia il problema della eterogeneit`a nei sistemi pervasivi proponendo una infrastruttura basata su un modello orientato ai servizi. I sistemi pervasivi sono presentati come un’evoluzione naturale dei sistemi distribuiti, passando attraverso mobile computing, grazie ad una disponibilit`a ubiqua di servizi (sempre, ovunque ed in qualunque modo) e ad loro e con l’ambiente stesso. Al fine di meglio comprendere i problemi legati allintrinseca eterogeneit`a dei sistemi pervasivi, dobbiamo prima descrivere la struttura fondamentale di questi sistemi classificandoli attraverso la loro dimensione fisica e quella dei loro servizi. La dimensione fisica descrive l’ambiente fisico e tutti i dispositivi che fanno parte del contesto della applicazione. La dimensione dei servizi descrive le funzionalit`a (siano esse software o no) che l’ambiente `e in grado di fornire [Nor99]. I sistemi pervasivi vengono cos`ı classificati attraverso una metrica pi `u formale del tipo risorse, contesto, servizi, coordinazione ed applicazione. UBIDEV, come risultato di questa dissertazione, introduce un modello uniforme per la descrizione e lo sviluppo di applicazioni in ambienti dinamici ed eterogenei. Il modello `e composto dai seguenti concetti di base: • Risorse: gli elementi dell’ambiente fisico che fanno parte del modello dellapplicazione. Questi rappresentano l’unit`a di astrazione atomica di tutto il modello UBIDEV. • Contesto: le informazioni sullo stato dell’ambiente che il sistema utilizza per adattare il comportamento dell’applicazione. Il contesto include informazioni legate alle risorse, ai servizi ed alle relazioni che li legano. • Classificazione: l’ambiente viene classificato sulla base di una ontologia che rappresenta il punto di accordo a cui tutti i moduli di sistema fanno riferimento. Questa classificazione rappresenta il modello concettuale dell’applicazione che si riflette sull’intero ambiente. Si definisce cos`ı la semantica di base per tutto il sistema. • Servizi: le funzionalit`a che il sistema `e in grado di fornire; ogni servizio `e descritto in termini di trasformazione di una o pi `u risorse. Le applicazioni sono cos`ı definite in termini di cooperazione tra servizi autonomi. • Coordinazione: tutti gli aspetti legati alla composizione ed alla esecuzione di servizi cos`ı come l’elaborazione dell’informazione contestuale. • Ontologia dell’Applicazione: rappresenta il punto di vista dell’applicazione; definisce la semantica delle risorse, dei servizi e dell’informazione contestuale. Applicando il paradigma proposto da UBIDEV, si possono descrivere applicazioni in accordo con un modello Service-oriented [Bie02] ed, al tempo stesso, ridurre l’applicazione stessa alle sue funzionalit`a di alto livello senza intervenire troppo su come queste funzionalit` a devono essere realizzate dalle singole componenti fisiche

Multiplexed combinatorial drug screening using droplet-based microfluidics

The therapy of most cancers has greatly benefited from the use of targeted drugs. However, their effects are often short-lived since many tumors develop resistance against these drugs. Resistance of tumor cells against drugs can be adaptive or acquired and is often caused by genetic or non-genetic heterogeneity between tumor cells. A potential solution to overcome drug resistance is the use of drug combinations addressing multiple targets at once. Finding potent drug combinations against heterogeneous tumors is challenging. One reason is the high number of possible combinations. Another reason is the possibility of inter-patient heterogeneity in drug responses, making patient tailored treatments necessary. These require screens on patient material, which would drastically benefit from miniaturization, as it is the case in droplet-based microfluidics. However, drug screens in droplets against primary tumor cells have so far only been performed at a modest chemical complexity (55 treatment conditions) and with low content readouts. In this thesis we aimed at developing a droplet-based microfluidic workflow that allows the generation of high numbers of drug combinations in picolitre-sized droplets and their multiplexed analysis. To this end, we have established a pipeline to produce up to 420 drug combinations in droplets. We were able to significantly increase the number of possible combinations by building a microfluidic setup that comprises valve and micro-titer plate based injection of drugs into microfluidic devices for droplet generation Furthermore, we integrated a DNA-based barcoding approach to encode each treatment condition, enabling their multiplexed analyses since all droplets can be stored and processed together, which highly increases the throughput. With the established approach we can perform barcoding of each cells’ transcriptome according to the drugs it was exposed to in the droplet. Thereby, the effects of drug combinations on gene expression can be studied in a highly multiplexed way using RNA-Sequencing. We applied the developed approach to run combinatorial drug screens in droplets and analysed the effects of in total 630 drug combinations on gene expression in K562 cells. The low number of cells needed (max. 2 million cells) for such screens, could enable their application directly on tumor biopsies, thus paving the way for personalized therapy approaches. Since the established workflow is compatible with single cell readouts, we also envision its application to analyse drug resistances in heterogeneous tumor samples on the single cell level

System architectures for Industrie 4.0 applications

Industrie 4.0 principles demand increasing flexibility and modularity for automated production systems. Current system architectures provide an isolated view of specific applications and use cases, but lack a global, more generic approach. Based on the specific architectures of two EU projects and one German Industrie 4.0 project, a generic system architecture is proposed. This system architecture features the strengths of the three isolated proposals, such as cross-enterprise data sharing, service orchestration, and real-time capabilities, and can be applied to a wide field of applications. Future research should be directed towards considering the applicability of the architecture to other equal applications.info:eu-repo/semantics/publishedVersio

Component-based control system development for agile manufacturing machine systems

It is now a common sense that manufactures including machine suppliers and system integrators of the 21 st century will need to compete on global marketplaces, which are frequently shifting and fragmenting, with new technologies continuously emerging. Future production machines and manufacturing systems need to offer the "agility" required in providing responsiveness to product changes and the ability to reconfigure. The primary aim for this research is to advance studies in machine control system design, in the context of the European project VIR-ENG - "Integrated Design, Simulation and Distributed Control of Agile Modular Machinery"