982 research outputs found
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration: A united approach
Item does not contain fulltextCerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive deficits, physical disabilities, and other symptoms of neurodegeneration. Terminology and definitions for imaging the features of SVD vary widely, which is also true for protocols for image acquisition and image analysis. This lack of consistency hampers progress in identifying the contribution of SVD to the pathophysiology and clinical features of common neurodegenerative diseases. We are an international working group from the Centres of Excellence in Neurodegeneration. We completed a structured process to develop definitions and imaging standards for markers and consequences of SVD. We aimed to achieve the following: first, to provide a common advisory about terms and definitions for features visible on MRI; second, to suggest minimum standards for image acquisition and analysis; third, to agree on standards for scientific reporting of changes related to SVD on neuroimaging; and fourth, to review emerging imaging methods for detection and quantification of preclinical manifestations of SVD. Our findings and recommendations apply to research studies, and can be used in the clinical setting to standardise image interpretation, acquisition, and reporting. This Position Paper summarises the main outcomes of this international effort to provide the STandards for ReportIng Vascular changes on nEuroimaging (STRIVE)
Segmentation of perivascular spaces in 7 T MR image using auto-context model with orientation-normalized features
Quantitative study of perivascular spaces (PVSs) in brain magnetic resonance (MR) images is important for understanding the brain lymphatic system and its relationship with neurological diseases. One of major challenges is the accurate extraction of PVSs that have very thin tubular structures with various directions in three-dimensional (3D) MR images. In this paper, we propose a learning-based PVS segmentation method to address this challenge. Specifically, we first determine a region of interest (ROI) by using the anatomical brain structure and the vesselness information derived from eigenvalues of image derivatives. Then, in the ROI, we extract a number of randomized Haar features which are normalized with respect to the principal directions of the underlying image derivatives. The classifier is trained by the random forest model that can effectively learn both discriminative features and classifier parameters to maximize the information gain. Finally, a sequential learning strategy is used to further enforce various contextual patterns around the thin tubular structures into the classifier. For evaluation, we apply our proposed method to the 7T brain MR images scanned from 17 healthy subjects aged from 25 to 37. The performance is measured by voxel-wise segmentation accuracy, cluster- wise classification accuracy, and similarity of geometric properties, such as volume, length, and diameter distributions between the predicted and the true PVSs. Moreover, the accuracies are also evaluated on the simulation images with motion artifacts and lacunes to demonstrate the potential of our method in segmenting PVSs from elderly and patient populations. The experimental results show that our proposed method outperforms all existing PVS segmentation methods
Cerebrovascular dysfunction in cerebral small vessel disease
INTRODUCTION:
Cerebral small vessel disease (SVD) is the cause of a quarter of all ischaemic strokes and is postulated to have a role in up to half of all dementias. SVD pathophysiology remains unclear but cerebrovascular dysfunction may be important. If confirmed many licensed medications have mechanisms of action targeting vascular function, potentially enabling new treatments via drug repurposing. Knowledge is limited however, as most studies assessing cerebrovascular dysfunction are small, single centre, single imaging modality studies due to the complexities in measuring cerebrovascular dysfunctions in humans. This thesis describes the development and application of imaging techniques measuring several cerebrovascular dysfunctions to investigate SVD pathophysiology and trial medications that may improve small blood vessel function in SVD.
METHODS:
Participants with minor ischaemic strokes were recruited to a series of studies utilising advanced MRI techniques to measure cerebrovascular dysfunction. Specifically MRI scans measured the ability of different tissues in the brain to change blood flow in response to breathing carbon dioxide (cerebrovascular reactivity; CVR) and the flow and pulsatility through the cerebral arteries, venous sinuses and CSF spaces. A single centre observational study optimised and established feasibility of the techniques and tested associations of cerebrovascular dysfunctions with clinical and imaging phenotypes. Then a randomised pilot clinical trial tested two medicationsâ (cilostazol and isosorbide mononitrate) ability to improve CVR and pulsatility over a period of eight weeks. The techniques were then expanded to include imaging of blood brain barrier permeability and utilised in multi-centre studies investigating cerebrovascular dysfunction in both sporadic and monogenetic SVDs.
RESULTS:
Imaging protocols were feasible, consistently being completed with usable data in over 85% of participants. After correcting for the effects of age, sex and systolic blood pressure, lower CVR was associated with higher white matter hyperintensity volume, Fazekas score and perivascular space counts. Lower CVR was associated with higher pulsatility of blood flow in the superior sagittal sinus and lower CSF flow stroke volume at the foramen magnum. Cilostazol and isosorbide mononitrate increased CVR in white matter. The CVR, intra-cranial flow and pulsatility techniques, alongside blood brain barrier permeability and microstructural integrity imaging were successfully employed in a multi-centre observational study. A clinical trial assessing the effects of drugs targeting blood pressure variability is nearing completion.
DISCUSSION:
Cerebrovascular dysfunction in SVD has been confirmed and may play a more direct role in disease pathogenesis than previously established risk factors. Advanced imaging measures assessing cerebrovascular dysfunction are feasible in multi-centre studies and trials. Identifying drugs that improve cerebrovascular dysfunction using these techniques may be useful in selecting candidates for definitive clinical trials which require large sample sizes and long follow up periods to show improvement against outcomes of stroke and dementia incidence and cognitive function
Neuroimaging of cerebral small vessel disease
Lacunar stroke accounts for one quarter of all ischaemic stroke and in the long term
carries a greater risk of death and disability than was previously realised. Much of
our current knowledge originated from neuropathological studies in the 1950s and
1960s. In the last thirty years, brain computed tomography (CT) and magnetic
resonance imaging (MRI) have revolutionised our understanding of lacunar stroke
and associated features of cerebral small vessel disease (SVD), namely white matter
lesions (WML), enlarged perivascular spaces (EPVS) and brain microbleeds (BMB).
The purpose of the projects which led to the writing of this thesis was to improve
understanding of imaging characteristics of cerebral SVD. We aimed to assess (i)
clinical and imaging features which might explain misclassification of lacunar
infarcts as cortical infarcts and vice versa, (ii) the proportion of symptomatic lacunar
infarcts progressing to lacunar cavities and associations of cavitation, (iii)
completeness of reporting of lacunar lesions in the lacunar stroke literature, (iv)
definitions and detection of lacunar lesions amongst SVD researchers, (v) the
relationship between WML and carotid stenosis, (vi) clinical and imaging
associations of EPVS and, (vii) observer variability in the assessment of EPVS and
BMB, in order to develop visual rating scales.
Section one describes neuroimaging of lacunar stroke. To investigate features which
might explain clinical stroke subtype misclassification (âclinical-imaging
dissociationâ), I used data from a stroke study. The main factor associated with
clinical-imaging dissociation was diabetes, and in patients with acute lacunar
infarction, proximity of the lacunar infarct to the cortex, age, diabetes and left hemisphere location. To investigate the proportion of symptomatic lacunar infarcts
progressing to cavities, I used data from two stroke studies. A fifth of patients with
acute lacunar ischaemic stroke showed definite cavitation on follow-up imaging at a
median of 227 days; cavitation was associated with increasing time to follow-up. To
assess completeness of reporting of lacunar lesions in the lacunar stroke literature, I
reviewed 50 articles from three journals with a stroke focus. There was marked
variation in terminology and descriptions of imaging definitions of lacunar lesions.
To assess lacunar lesion definitions and detection amongst SVD researchers, I used
an online survey consisting of case-based and non-case-based questions. There was
marked variation in definitions and descriptions. Cavitated lesions were detected
with the highest degree of confidence.
Section two describes neuroimaging of associated features of cerebral SVD. Using
data from two stroke studies, I examined the relationship between WML and
ipsilateral carotid artery stenosis. There was no association between carotid stenosis
and WML. I tested the association of EPVS with WML and lacunar stroke subtype
using data from a stroke study. Total EPVS were associated with age and deep
WML; basal ganglia (BG) EPVS were associated with age, centrum semiovale (CS)
EPVS, cerebral atrophy and lacunar stroke subtype. Quantification of observer
variability in EPVS rating was assessed on 60 MRI scans selected from a stroke
study and an ageing cohort. Intrarater agreement was good and interrater agreement
was moderate. Main reasons for interrater disagreement included the visualisation of
very small EPVS and the presence of concomitant WML and lacunar lesions.
Observer variability in BMB rating was quantified using MRI scans from a stroke
study. Interrater agreement was moderate but improved following modification of the pilot rating scale (BOMBS; Brain Observer MicroBleed Scale), which had its main
effect by differentiating âcertainâ BMB from âuncertainâ BMB and BMB âmimicsâ.
In conclusion, neuroimaging, particularly MRI, is a valuable tool for the
investigation of lacunar stroke and associated features of cerebral SVD. With recent
technological advances in both CT and MRI, neuroimaging will remain central to
future SVD studies, hopefully leading to a much improved understanding of this
important disease
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On the neurobiology of apathy and depression in cerebral small vessel disease
Cerebral small vessel disease (SVD) is a cerebrovascular pathology that affects the small vessels of the brain, resulting in heterogeneous brain tissue changes. These can lead to neuropsychiatric symptoms such as apathy, a loss of motivation, and depression, which is characterised by low mood and a loss of pleasure. Apathy and depression are both prevalent symptoms in SVD, but an understanding of the relationship between underlying disease processes and the expression of these neuropsychiatric symptoms remains poor.
This thesis uses magnetic resonance imaging techniques to examine the neurobiological basis of apathy and depression in SVD. We show that apathy is related to focal grey matter damage and distributed white matter microstructural change. These microstructural changes underlie large-scale white matter network disruption, which is related to apathy, but not depression. We then show that depression, as a construct, can be dissociated into distinct symptoms which are associated with overlapping and distinct areas of cortical atrophy over time. This suggests that depression as a general syndrome may be characterised by atrophy in core structures, while different symptoms are associated with atrophy in more specialised areas. Consistent with these patterns of overarching tissue damage, we find that apathy, but not depression, predicts conversion to dementia in patients with SVD.
Our findings suggest that different types of SVD-related pathology lead to apathy and depression. Diffuse white matter damage may lead to widespread network disruption, resulting in apathy and cognitive impairment. In contrast, depressive symptoms are associated with focal patterns of grey matter atrophy over time. This highlights the importance of differentiating neuropsychiatric symptoms, and paves the way for targeted treatment approaches.Cambridge International Scholarship (Cambridge Trust)
Clinical application of perfusion computed tomography in the early diagnosis of acute ischemic stroke and hemorrhagic transformation prediction
Department of Radiology and Neuroimaging,
Department of Neurology Institute of Neurology and Neurosurgery, Chisinau, the Republic of Moldova, Department of Molecular Biology and Human Genetics, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: Our study was designed to evaluate the efficacy of perfusion computed tomography (PCT) in patients with acute phase of stroke for the early diagnosis of this pathology and prediction of hemorrhagic transformation in the ischemic area. Material and methods: We studied the functional PCT maps obtained at admission from 23 patients with acute ischemic stroke, compared to follow-up computer tomography or magnetic resonance imaging. Results: Mean Transit Time(MTT) map showed that the highest sensitivity (80.3%) and parameters of relative Cerebral Blood Flow (rCBF) and Cerebral Blood Volume (rCBV) were the most specific (95.0% and 96.9%, respectively) in the early diagnosis of ischemic stroke. Automatic technique âTissue Classificationâ showed the highest value of the overall accuracy (91.7%), a significant correlation with the final stroke extension and differentiation of potentially salvageable regions from the irreversibly damaged, which plays an important role in the treatment management. Evaluation of permeability function of the blood-brain barrier with a Permeability Surface area product (PS) showed high values of specificity, sensitivity and overall accuracy (89.5%, 75.0% and 87.0%) in the prediction ability of hemorrhagic transformation. Conclusions: Quantitative analysis of functional parameters of dynamic cerebral perfusion computed tomography has significant efficacy in emergency diagnosis of acute ischemic stroke and hemorrhagic transformation prediction in tissue exposed to ischemia
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