Multi-modal matching of 2D images with 3D medical data

Image registration is the process of aligning images of the same object taken at different time points or with different imaging modalities with the aim to compare them in one coordinate system. Image registration is particularly important in biomedical imaging, where a multitude of imaging modalities exist. For example, images can be obtained with X-ray computed tomography (CT) which is based on the object’s X-ray beam attenuation whereas magnetic resonance imaging (MRI) underlines its local proton density. The gold standard in pathology for tissue analysis is histology. Histology, however, provides only 2D information in the selected sections of the 3D tissue. To evaluate the tissue’s 3D structure, volume imaging techniques, such as CT or MRI, are preferable. The combination of functional information from histology with 3D morphological data from CT is essential for tissue analysis. Furthermore, histology can validate anatomical features identified in CT data. Therefore, the registration of these two modalities is indispensable to provide a more complete overview of the tissue. Previously proposed algorithms for the registration of histological slides into 3D volumes usually rely on manual interactions, which is time-consuming and prone to bias. The high complexity of this type of registration originates from the large number of degrees of freedom. The goal of my thesis was to develop an automatic method for histology to 3D volume registration to master these challenges. The first stage of the developed algorithm uses a scale-invariant feature detector to find common matches between the histology slide and each tomography slice in a 3D dataset. A plane of the most likely position is then fitted into the feature point cloud using a robust model fitting algorithm. The second stage builds upon the first one and introduces fine-tuning of the slice position using normalized Mutual Information (NMI). Additionally, using previously developed 2D-2D registration techniques we find the rotation and translation of the histological slide within the plane. Moreover, the framework takes into account any potential nonlinear deformations of the histological slides that might occur during tissue preparation. The application of the algorithm to MRI data is investigated in our third work. The developed extension of the multi-modal feature detector showed promising results, however, the registration of a histological slide to the direct MRI volume remains a challenging task

Medical image registration and soft tissue deformation for image guided surgery system

In parallel with the developments in imaging modalities, image-guided surgery (IGS) can now provide the surgeon with high quality three-dimensional images depicting human anatomy. Although IGS is now in widely use in neurosurgery, there remain some limitations that must be overcome before it can be employed in more general minimally invasive procedures. In this thesis, we have developed several contributions to the field of medical image registration and brain tissue deformation modeling. From the methodology point of view, medical image registration algorithms can be classified into feature-based and intensity-based methods. One of the challenges faced by feature-based registration would be to determine which specific type of feature is desired for a given task and imaging type. For this reason, a point set registration using points and curves feature is proposed, which has the accuracy of registration based on points and the robustness of registration based on lines or curves. We have also tackled the problem on rigid registration of multimodal images using intensity-based similarity measures. Mutual information (MI) has emerged in recent years as a popular similarity metric and widely being recognized in the field of medical image registration. Unfortunately, it ignores the spatial information contained in the images such as edges and corners that might be useful in the image registration. We introduce a new similarity metric, called Adaptive Mutual Information (AMI) measure which incorporates the gradient spatial information. Salient pixels in the regions with high gradient value will contribute more in the estimation of mutual information of image pairs being registered. Experimental results showed that our proposed method improves registration accuracy and it is more robust to noise images which have large deviation from the reference image. Along with this direction, we further improve the technique to simultaneously use all information obtained from multiple features. Using multiple spatial features, the proposed algorithm is less sensitive to the effect of noise and some inherent variations, giving more accurate registration. Brain shift is a complex phenomenon and there are many different reasons causing brain deformation. We have investigated the pattern of brain deformation with respect to location and magnitude and to consider the implications of this pattern for correcting brain deformation in IGS systems. A computational finite element analysis was carried out to analyze the deformation and stress tensor experienced by the brain tissue during surgical operations. Finally, we have developed a prototype visualization display and navigation platform for interpretation of IGS. The system is based upon Qt (cross-platform GUI toolkit) and it integrates VTK (an object-oriented visualization library) as the rendering kernel. Based on the construction of a visualization software platform, we have laid a foundation on the future research to be extended to implement brain tissue deformation into the system

Book of Abstracts 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 3rd Conference on Imaging and Visualization

In this edition, the two events will run together as a single conference, highlighting the strong connection with the Taylor & Francis journals: Computer Methods in Biomechanics and Biomedical Engineering (John Middleton and Christopher Jacobs, Eds.) and Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization (JoãoManuel R.S. Tavares, Ed.). The conference has become a major international meeting on computational biomechanics, imaging andvisualization. In this edition, the main program includes 212 presentations. In addition, sixteen renowned researchers will give plenary keynotes, addressing current challenges in computational biomechanics and biomedical imaging. In Lisbon, for the first time, a session dedicated to award the winner of the Best Paper in CMBBE Journal will take place. We believe that CMBBE2018 will have a strong impact on the development of computational biomechanics and biomedical imaging and visualization, identifying emerging areas of research and promoting the collaboration and networking between participants. This impact is evidenced through the well-known research groups, commercial companies and scientific organizations, who continue to support and sponsor the CMBBE meeting series. In fact, the conference is enriched with five workshops on specific scientific topics and commercial software.info:eu-repo/semantics/draf

Medical image registration and soft tissue deformation for image guided surgery system

In parallel with the developments in imaging modalities, image-guided surgery (IGS) can now provide the surgeon with high quality three-dimensional images depicting human anatomy. Although IGS is now in widely use in neurosurgery, there remain some limitations that must be overcome before it can be employed in more general minimally invasive procedures. In this thesis, we have developed several contributions to the field of medical image registration and brain tissue deformation modeling. From the methodology point of view, medical image registration algorithms can be classified into feature-based and intensity-based methods. One of the challenges faced by feature-based registration would be to determine which specific type of feature is desired for a given task and imaging type. For this reason, a point set registration using points and curves feature is proposed, which has the accuracy of registration based on points and the robustness of registration based on lines or curves. We have also tackled the problem on rigid registration of multimodal images using intensity-based similarity measures. Mutual information (MI) has emerged in recent years as a popular similarity metric and widely being recognized in the field of medical image registration. Unfortunately, it ignores the spatial information contained in the images such as edges and corners that might be useful in the image registration. We introduce a new similarity metric, called Adaptive Mutual Information (AMI) measure which incorporates the gradient spatial information. Salient pixels in the regions with high gradient value will contribute more in the estimation of mutual information of image pairs being registered. Experimental results showed that our proposed method improves registration accuracy and it is more robust to noise images which have large deviation from the reference image. Along with this direction, we further improve the technique to simultaneously use all information obtained from multiple features. Using multiple spatial features, the proposed algorithm is less sensitive to the effect of noise and some inherent variations, giving more accurate registration. Brain shift is a complex phenomenon and there are many different reasons causing brain deformation. We have investigated the pattern of brain deformation with respect to location and magnitude and to consider the implications of this pattern for correcting brain deformation in IGS systems. A computational finite element analysis was carried out to analyze the deformation and stress tensor experienced by the brain tissue during surgical operations. Finally, we have developed a prototype visualization display and navigation platform for interpretation of IGS. The system is based upon Qt (cross-platform GUI toolkit) and it integrates VTK (an object-oriented visualization library) as the rendering kernel. Based on the construction of a visualization software platform, we have laid a foundation on the future research to be extended to implement brain tissue deformation into the system

Friction Force Microscopy of Deep Drawing Made Surfaces

Aim of this paper is to contribute to micro-tribology understanding and friction in micro-scale interpretation in case of metal beverage production, particularly the deep drawing process of cans. In order to bridging the gap between engineering and trial-and-error principles, an experimental AFM-based micro-tribological approach is adopted. For that purpose, the can’s surfaces are imaged with atomic force microscopy (AFM) and the frictional force signal is measured with frictional force microscopy (FFM). In both techniques, the sample surface is scanned with a stylus attached to a cantilever. Vertical motion of the cantilever is recorded in AFM and horizontal motion is recorded in FFM. The presented work evaluates friction over a micro-scale on various samples gathered from cylindrical, bottom and round parts of cans, made of same the material but with different deep drawing process parameters. The main idea is to link the experimental observation with the manufacturing process. Results presented here can advance the knowledge in order to comprehend the tribological phenomena at the contact scales, too small for conventional tribology

Towards a Conceptual Design of an Intelligent Material Transport Based on Machine Learning and Axiomatic Design Theory

Reliable and efficient material transport is one of the basic requirements that affect productivity in sheet metal industry. This paper presents a methodology for conceptual design of intelligent material transport using mobile robot, based on axiomatic design theory, graph theory and artificial intelligence. Developed control algorithm was implemented and tested on the mobile robot system Khepera II within the laboratory model of manufacturing environment. Matlab© software package was used for manufacturing process simulation, implementation of search algorithms and neural network training. Experimental results clearly show that intelligent mobile robot can learn and predict optimal material transport flows thanks to the use of artificial neural networks. Achieved positioning error of mobile robot indicates that conceptual design approach can be used for material transport and handling tasks in intelligent manufacturing systems

Towards a Conceptual Design of an Intelligent Material Transport Based on Machine Learning and Axiomatic Design Theory

Reliable and efficient material transport is one of the basic requirements that affect productivity in sheet metal industry. This paper presents a methodology for conceptual design of intelligent material transport using mobile robot, based on axiomatic design theory, graph theory and artificial intelligence. Developed control algorithm was implemented and tested on the mobile robot system Khepera II within the laboratory model of manufacturing environment. Matlab© software package was used for manufacturing process simulation, implementation of search algorithms and neural network training. Experimental results clearly show that intelligent mobile robot can learn and predict optimal material transport flows thanks to the use of artificial neural networks. Achieved positioning error of mobile robot indicates that conceptual design approach can be used for material transport and handling tasks in intelligent manufacturing systems

MS FT-2-2 7 Orthogonal polynomials and quadrature: Theory, computation, and applications

Quadrature rules find many applications in science and engineering. Their analysis is a classical area of applied mathematics and continues to attract considerable attention. This seminar brings together speakers with expertise in a large variety of quadrature rules. It is the aim of the seminar to provide an overview of recent developments in the analysis of quadrature rules. The computation of error estimates and novel applications also are described

Generalized averaged Gaussian quadrature and applications

A simple numerical method for constructing the optimal generalized averaged Gaussian quadrature formulas will be presented. These formulas exist in many cases in which real positive GaussKronrod formulas do not exist, and can be used as an adequate alternative in order to estimate the error of a Gaussian rule. We also investigate the conditions under which the optimal averaged Gaussian quadrature formulas and their truncated variants are internal