Current results and open questions on PH and MAP characterization

Stochastic processes with matrix exponential kernels have a wide range of applications due to the availability of efficient matrix analytic methods. The characterization of these processes is in progress in recent years. Basic questions like the flexibility, the degree of freedom, the most efficient (canonical) representation of these models are under study. The presentation collects a set of available results and related open questions

Generalized Flow and Determinism in Measurement-based Quantum Computation

We extend the notion of quantum information flow defined by Danos and Kashefi for the one-way model and present a necessary and sufficient condition for the deterministic computation in this model. The generalized flow also applied in the extended model with measurements in the X-Y, X-Z and Y-Z planes. We apply both measurement calculus and the stabiliser formalism to derive our main theorem which for the first time gives a full characterization of the deterministic computation in the one-way model. We present several examples to show how our result improves over the traditional notion of flow, such as geometries (entanglement graph with input and output) with no flow but having generalized flow and we discuss how they lead to an optimal implementation of the unitaries. More importantly one can also obtain a better quantum computation depth with the generalized flow rather than with flow. We believe our characterization result is particularly essential for the study of the algorithms and complexity in the one-way model.Comment: 16 pages, 10 figure

Generalized Flow and Determinism in Measurement-based Quantum Computation

We extend the notion of quantum information flow defined by Danos and Kashefi for the one-way model and present a necessary and sufficient condition for the deterministic computation in this model. The generalized flow also applied in the extended model with measurements in the X-Y, X-Z and Y-Z planes. We apply both measurement calculus and the stabiliser formalism to derive our main theorem which for the first time gives a full characterization of the deterministic computation in the one-way model. We present several examples to show how our result improves over the traditional notion of flow, such as geometries (entanglement graph with input and output) with no flow but having generalized flow and we discuss how they lead to an optimal implementation of the unitaries. More importantly one can also obtain a better quantum computation depth with the generalized flow rather than with flow. We believe our characterization result is particularly essential for the study of the algorithms and complexity in the one-way model.Comment: 16 pages, 10 figure

Separability and distillability in composite quantum systems -a primer-

Quantum mechanics is already 100 years old, but remains alive and full of challenging open problems. On one hand, the problems encountered at the frontiers of modern theoretical physics like Quantum Gravity, String Theories, etc. concern Quantum Theory, and are at the same time related to open problems of modern mathematics. But even within non-relativistic quantum mechanics itself there are fundamental unresolved problems that can be formulated in elementary terms. These problems are also related to challenging open questions of modern mathematics; linear algebra and functional analysis in particular. Two of these problems will be discussed in this article: a) the separability problem, i.e. the question when the state of a composite quantum system does not contain any quantum correlations or entanglement and b) the distillability problem, i.e. the question when the state of a composite quantum system can be transformed to an entangled pure state using local operations (local refers here to component subsystems of a given system). Although many results concerning the above mentioned problems have been obtained (in particular in the last few years in the framework of Quantum Information Theory), both problems remain until now essentially open. We will present a primer on the current state of knowledge concerning these problems, and discuss the relation of these problems to one of the most challenging questions of linear algebra: the classification and characterization of positive operator maps.Comment: 11 pages latex, 1 eps figure. Final version, to appear in J. Mod. Optics, minor typos corrected, references adde

Patient-centric trials for therapeutic development in precision oncology

An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours. Considerable associated challenges include how to advance and implement targeted drug-development strategies. Precision medicine centres on delivering the most appropriate therapy to a patient on the basis of clinical and molecular features of their disease. The development of therapeutic agents that target molecular mechanisms is driving innovation in clinical-trial strategies. Although progress has been made, modifications to existing core paradigms in oncology drug development will be required to realize fully the promise of precision medicine

On quantum non-signalling boxes

A classical non-signalling (or causal) box is an operation on classical bipartite input with classical bipartite output such that no signal can be sent from a party to the other through the use of the box. The quantum counterpart of such boxes, i.e. completely positive trace-preserving maps on bipartite states, though studied in literature, have been investigated less intensively than classical boxes. We present here some results and remarks about such maps. In particular, we analyze: the relations among properties as causality, non-locality and entanglement; the connection between causal and entanglement breaking maps; the characterization of causal maps in terms of the classification of states with fixed reductions. We also provide new proofs of the fact that every non-product unitary transformation is not causal, as well as for the equivalence of the so-called semicausality and semilocalizability properties.Comment: 18 pages, 7 figures, revtex

Review of the Synergies Between Computational Modeling and Experimental Characterization of Materials Across Length Scales

With the increasing interplay between experimental and computational approaches at multiple length scales, new research directions are emerging in materials science and computational mechanics. Such cooperative interactions find many applications in the development, characterization and design of complex material systems. This manuscript provides a broad and comprehensive overview of recent trends where predictive modeling capabilities are developed in conjunction with experiments and advanced characterization to gain a greater insight into structure-properties relationships and study various physical phenomena and mechanisms. The focus of this review is on the intersections of multiscale materials experiments and modeling relevant to the materials mechanics community. After a general discussion on the perspective from various communities, the article focuses on the latest experimental and theoretical opportunities. Emphasis is given to the role of experiments in multiscale models, including insights into how computations can be used as discovery tools for materials engineering, rather than to "simply" support experimental work. This is illustrated by examples from several application areas on structural materials. This manuscript ends with a discussion on some problems and open scientific questions that are being explored in order to advance this relatively new field of research.Comment: 25 pages, 11 figures, review article accepted for publication in J. Mater. Sc

Bifurcation currents and equidistribution on parameter space

In this paper we review the use of techniques of positive currents for the study of parameter spaces of one-dimensional holomorphic dynamical systems (rational mappings on P^1 or subgroups of the Moebius group PSL(2,C)). The topics covered include: the construction of bifurcation currents and the characterization of their supports, the equidistribution properties of dynamically defined subvarieties on parameter space.Comment: Revised version, 46 pages, to appear in the proceedings of the conference "Frontiers in complex dynamics (Celebrating John Milnor's 80th birthday)