1,821 research outputs found
Rotating single-shot acquisition (RoSA) with composite reconstruction for fast high-resolution diffusion imaging
PURPOSE:
To accelerate high-resolution diffusion imaging, rotating single-shot acquisition (RoSA) with composite reconstruction is proposed. Acceleration was achieved by acquiring only one rotating single-shot blade per diffusion direction, and high-resolution diffusion-weighted (DW) images were reconstructed by using similarities of neighboring DW images. A parallel imaging technique was implemented in RoSA to further improve the image quality and acquisition speed. RoSA performance was evaluated by simulation and human experiments.
METHODS:
A brain tensor phantom was developed to determine an optimal blade size and rotation angle by considering similarity in DW images, off-resonance effects, and k-space coverage. With the optimal parameters, RoSA MR pulse sequence and reconstruction algorithm were developed to acquire human brain data. For comparison, multishot echo planar imaging (EPI) and conventional single-shot EPI sequences were performed with matched scan time, resolution, field of view, and diffusion directions.
RESULTS:
The simulation indicated an optimal blade size of 48 × 256 and a 30 ° rotation angle. For 1 × 1 mm2 in-plane resolution, RoSA was 12 times faster than the multishot acquisition with comparable image quality. With the same acquisition time as SS-EPI, RoSA provided superior image quality and minimum geometric distortion.
CONCLUSION:
RoSA offers fast, high-quality, high-resolution diffusion images. The composite image reconstruction is model-free and compatible with various diffusion computation approaches including parametric and nonparametric analyses. Magn Reson Med 79:264-275, 2018. © 2017 International Society for Magnetic Resonance in Medicine
Simultaneous use of Individual and Joint Regularization Terms in Compressive Sensing: Joint Reconstruction of Multi-Channel Multi-Contrast MRI Acquisitions
Purpose: A time-efficient strategy to acquire high-quality multi-contrast
images is to reconstruct undersampled data with joint regularization terms that
leverage common information across contrasts. However, these terms can cause
leakage of uncommon features among contrasts, compromising diagnostic utility.
The goal of this study is to develop a compressive sensing method for
multi-channel multi-contrast magnetic resonance imaging (MRI) that optimally
utilizes shared information while preventing feature leakage.
Theory: Joint regularization terms group sparsity and colour total variation
are used to exploit common features across images while individual sparsity and
total variation are also used to prevent leakage of distinct features across
contrasts. The multi-channel multi-contrast reconstruction problem is solved
via a fast algorithm based on Alternating Direction Method of Multipliers.
Methods: The proposed method is compared against using only individual and
only joint regularization terms in reconstruction. Comparisons were performed
on single-channel simulated and multi-channel in-vivo datasets in terms of
reconstruction quality and neuroradiologist reader scores.
Results: The proposed method demonstrates rapid convergence and improved
image quality for both simulated and in-vivo datasets. Furthermore, while
reconstructions that solely use joint regularization terms are prone to
leakage-of-features, the proposed method reliably avoids leakage via
simultaneous use of joint and individual terms.
Conclusion: The proposed compressive sensing method performs fast
reconstruction of multi-channel multi-contrast MRI data with improved image
quality. It offers reliability against feature leakage in joint
reconstructions, thereby holding great promise for clinical use.Comment: 13 pages, 13 figures. Submitted for possible publicatio
Diffusion imaging and tractography of congenital brain malformations.
Diffusion imaging is an MRI modality that measures the microscopic molecular motion of water in order to investigate white matter microstructure. The modality has been used extensively in recent years to investigate the neuroanatomical basis of congenital brain malformations. We review the basic principles of diffusion imaging and of specific techniques, including diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI). We show how DTI and HARDI, and their application to fiber tractography, has elucidated the aberrant connectivity underlying a number of congenital brain malformations. Finally, we discuss potential uses for diffusion imaging of developmental disorders in the clinical and research realms
A model-based method with joint sparsity constant for direct diffusion tensor estimation
Diffusion tensor imaging (DTI) has been widely used for nondestructive characterization of microstructures of myocardium or brain connectivity. It requires repeated acquisition with different diffusion gradients. The long acquisition time greatly limits the clinical application of DTI. In this paper, a novel method, named model-based method with joint sparsity constraint (MB-JSC), effectively incorporates the prior information on the joint sparsity of different diffusion-weighted images in direct estimation of the diffusion tensor from highly undersampled k-space data. Experimental results demonstrate that the proposed method is able to estimate the diffusion tensors more accurately than the existing method when a high net reduction factor is used.published_or_final_versionThe 9th IEEE International Symposium on Biomedical Imaging (ISBI 2012), Barcelona, Spain, 2-5 May 2012. In Proceedings of the 9th ISBI, 2012, p. 510-51
Highly efficient MRI through multi-shot echo planar imaging
Multi-shot echo planar imaging (msEPI) is a promising approach to achieve
high in-plane resolution with high sampling efficiency and low T2* blurring.
However, due to the geometric distortion, shot-to-shot phase variations and
potential subject motion, msEPI continues to be a challenge in MRI. In this
work, we introduce acquisition and reconstruction strategies for robust,
high-quality msEPI without phase navigators. We propose Blip Up-Down
Acquisition (BUDA) using interleaved blip-up and -down phase encoding, and
incorporate B0 forward-modeling into Hankel structured low-rank model to enable
distortion- and navigator-free msEPI. We improve the acquisition efficiency and
reconstruction quality by incorporating simultaneous multi-slice acquisition
and virtual-coil reconstruction into the BUDA technique. We further combine
BUDA with the novel RF-encoded gSlider acquisition, dubbed BUDA-gSlider, to
achieve rapid high isotropic-resolution MRI. Deploying BUDA-gSlider with
model-based reconstruction allows for distortion-free whole-brain 1mm isotropic
T2 mapping in about 1 minute. It also provides whole-brain 1mm isotropic
diffusion imaging with high geometric fidelity and SNR efficiency. We finally
incorporate sinusoidal wave gradients during the EPI readout to better use coil
sensitivity encoding with controlled aliasing.Comment: 13 pages, 10 figure
Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain
In the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain to axonal orientation measurements from polarization-sensitive optical coherence tomography (PSOCT), we compare the accuracy of orientation estimates from various dMRI sampling schemes and reconstruction methods. We find that, if the reconstruction approach is chosen carefully, single-shell dMRI data can yield the same accuracy as multi-shell data, and only moderately lower accuracy than a full Cartesian-grid sampling scheme. Our results suggest that current dMRI reconstruction approaches do not benefit substantially from ultra-high b-values or from very large numbers of diffusion-encoding directions. We also show that accuracy remains stable across dMRI voxel sizes of 1 ​mm or smaller but degrades at 2 ​mm, particularly in areas of complex white-matter architecture. We also show that, as the spatial resolution is reduced, axonal configurations in a dMRI voxel can no longer be modeled as a small set of distinct axon populations, violating an assumption that is sometimes made by dMRI reconstruction techniques. Our findings have implications for in vivo studies and illustrate the value of PSOCT as a source of ground-truth measurements of white-matter organization that does not suffer from the distortions typical of histological techniques.Published versio
High efficiency, low distortion 3D diffusion tensor imaging with variable density spiral fast spin echoes (3D DW VDS RARE)
We present an acquisition and reconstruction method designed to acquire high resolution 3D fast spin echo diffusion tensor images while mitigating the major sources of artifacts in DTI-field distortions, eddy currents and motion. The resulting images, being 3D, are of high SNR, and being fast spin echoes, exhibit greatly reduced field distortions. This sequence utilizes variable density spiral acquisition gradients, which allow for the implementation of a self-navigation scheme by which both eddy current and motion artifacts are removed. The result is that high resolution 3D DTI images are produced without the need for eddy current compensating gradients or B_0 field correction. In addition, a novel method for fast and accurate reconstruction of the non-Cartesian data is employed. Results are demonstrated in the brains of normal human volunteers
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